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Gene: CA6 (carbonic anhydrase 6) Sus scrofa

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Symbol:

CA6

Name:

carbonic anhydrase 6

RGD ID:

13894938

Description:

ENCODES a protein that exhibits carbonate dehydratase activity (inferred); lyase activity (inferred); metal ion binding (inferred); INVOLVED IN detection of chemical stimulus involved in sensory perception of bitter taste (inferred); ASSOCIATED WITH chromosome 1p36 deletion syndrome (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); extracellular region (inferred)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

carbonic anhydrase VI

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CA6 (carbonic anhydrase 6)	HGNC	EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Car6 (carbonic anhydrase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Car6 (carbonic anhydrase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ca6 (carbonic anhydrase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CA6 (carbonic anhydrase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CA6 (carbonic anhydrase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ca6 (carbonic anhydrase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CA6 (carbonic anhydrase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ca6 (carbonic anhydrase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	69,447,439 - 69,468,821 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	69,447,662 - 69,468,819 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	63,673,124 - 63,695,013 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chromosome 1p36 deletion syndrome (ISO)

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of chemical stimulus involved in sensory perception of bitter taste (IEA)

one-carbon metabolic process (IBA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

extracellular region (IEA)

extracellular space (IBA,IEA)

Molecular Function

carbonate dehydratase activity (IBA,IEA)

lyase activity (IEA)

metal ion binding (IEA)

protein binding (ISO)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:14681463	PMID:17145712	PMID:22301074	PMID:24576305	PMID:30032202

Genomics

Comparative Map Data

CA6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	69,447,439 - 69,468,821 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	69,447,662 - 69,468,819 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	63,673,124 - 63,695,013 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CA6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	8,945,868 - 8,975,092 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	8,945,867 - 8,975,092 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	9,005,927 - 9,035,151 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	8,928,509 - 8,957,738 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	8,940,207 - 8,969,412	NCBI
Celera	1	8,114,641 - 8,143,865 (+)	NCBI		Celera
Cytogenetic Map	1	p36.23	NCBI
HuRef	1	8,155,174 - 8,184,890 (+)	NCBI		HuRef
CHM1_1	1	8,995,837 - 9,025,073 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	8,479,556 - 8,508,762 (+)	NCBI		T2T-CHM13v2.0

Car6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	150,271,472 - 150,285,592 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	150,271,472 - 150,285,789 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	150,187,015 - 150,201,135 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	150,187,015 - 150,201,332 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	149,561,124 - 149,575,244 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	149,030,815 - 149,042,270 (-)	NCBI		MGSCv36	mm8
Celera	4	152,461,682 - 152,476,184 (-)	NCBI		Celera
Cytogenetic Map	4	E2	NCBI
cM Map	4	81.12	NCBI

Car6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	165,941,028 - 165,959,566 (-)	NCBI		GRCr8
mRatBN7.2	5	160,658,104 - 160,676,644 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	160,658,105 - 160,676,644 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	163,374,562 - 163,393,131 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	165,196,252 - 165,214,842 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	165,153,125 - 165,171,662 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	167,226,246 - 167,244,786 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	167,226,246 - 167,244,786 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	170,854,181 - 170,872,721 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	167,332,219 - 167,350,880 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	167,342,413 - 167,361,042 (-)	NCBI
Celera	5	158,915,352 - 158,933,838 (-)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Ca6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955486	4,234,235 - 4,247,876 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955486	4,234,293 - 4,249,026 (-)	NCBI	ChiLan1.0	ChiLan1.0

CA6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	219,257,247 - 219,285,951 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	217,902,001 - 217,930,699 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	7,703,187 - 7,732,409 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	8,938,158 - 8,966,305 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	8,938,164 - 8,966,300 (+)	Ensembl	panpan1.1		panPan2

CA6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	62,358,521 - 62,379,901 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	62,358,403 - 62,379,897 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	62,375,992 - 62,397,372 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	62,580,266 - 62,606,464 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	62,584,896 - 62,606,460 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	62,583,427 - 62,604,811 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	62,447,719 - 62,469,108 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	62,851,948 - 62,873,335 (+)	NCBI		UU_Cfam_GSD_1.0

Ca6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	32,675,341 - 32,703,732 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936623	3,169,089 - 3,188,956 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936623	3,169,095 - 3,188,947 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CA6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	122,777,961 - 122,817,689 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	122,777,895 - 122,810,359 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	26,799,675 - 26,832,454 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ca6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624818	3,180,356 - 3,192,928 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624818	3,179,847 - 3,193,699 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CA6
601 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

ectoderm	nervous system
10	10

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001144116	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB333806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AEMK02000044	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK350048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU457415	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000003762 ⟹ ENSSSCP00000003676

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	6	69,447,439 - 69,468,820 (+)	Ensembl

Ensembl Acc Id:

ENSSSCT00000091113 ⟹ ENSSSCP00000068986

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	6	69,448,925 - 69,468,821 (+)	Ensembl

RefSeq Acc Id:

NM_001144116 ⟹ NP_001137588

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	6	69,447,662 - 69,468,819 (+)	NCBI

Sequence:

show sequence

GATCCCAGACCTGCAGCATCATGACAGCTCTGGTCACGCTGCTGTTCCTGCTCCTGCTGGGGGC
CCAGACCCAGCATGGGGCTGAGTGGACCTACTCAGATGGGGAGCTGGATGAAGCACACTGGTCC
AGGGAGTACCCCGACTGCGATGGGAGGAGACAGTCGCCCATCGACGTGCAGAGGAAGAGCGTGC
AGTACAACCCTGCCCTGAGGGCCCTGAGCCTGACAGGCTACGAGGCCCAGGAGGGGGAGTTCTC
CATGATCAACAACGGCCACACAGTACAGATCAGCCTGCCCTCCACCATGCGCTTGACGGCCCCC
GACGGCACCCAGTACATAGCCAAGCAGATGCACTTCCACTGGGGCGGCGCGTTCTCCGAGATCA
GTGGCTCCGAGCACACCATTGATGGGATCAGATATGTGACCGAGGTTCACGTTGTCCACTACAA
TTCCAAATACAAGAGCTACGATGAAGCCCAGACGGCCCCGGACGGCTTGGCTGTGCTGGCAGCC
CTCTTCGAGATCAAGGATTACGCCGAAAACACTTACTACAGTGACTTCATTTCTCACCTGAAGA
ACATCCGGATTCCAGGACAAACCACAGTTCTGAGCAGCCTTAACCTTCAGGACATGCTCCCTGA
GAACCTCCACTCCTACTACAGCTACCAGGGCTCACTCACGACTCCTCCCTGTACTGAGAATGTC
CACTGGTTTGTGCTTGCAGATACCGTCAAGCTCTCCAGGACGCAGGTTTGGAAGCTACAGAATT
CCTTGTTGAATGACCAGAACAAGACCATCCACAACGATTACCGCAGAACCCAGCCCCTGAACCA
CAGAGTGGTGGAGGCCAACTTCAAGTCTCTCCCTAACCCTCGCTCTGAGCTCCATTTTTATCTA
AACAATATTGACAATAACCTGGAATACCTGAGAAGAGTTATTGAACAGAAGAAAGCAAAGGGAA
AAGGACCATGGTAATGACCTTGACACGTAAGCCCCGCCTTGTCTCCACGGAGTCAAAATGACCT
TGACGTGTAAGCCCTGCCTTGTCTCCACGGAGTCCTGGAATCCTGAATATCCGATCGCACCGCT
CCCATTGAGGCACCTGGTTCATCTCCGACTGAAGCAGGAGACACCATCACCCATGAAGGGAAGT
GAGAAGGGACTGAGTTAGACATTACCCGTGGAAATTGACTGGAAGAGACTTTTAAAGAACCCGG
AGCCTTAACCAGCCTCCTCTAGAATCAAGCACATTGATTTGACTGCCTTTCAAACCCGCCCTGT
AGCATTTAGATGGAATAAAATAACTGCGGAAATTTGCTATAAAAAAAAAAAAAAAAAAAAAAAA
AAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001137588	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAH03533	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000003676
	ENSSSCP00000003676.2
	ENSSSCP00000068986.1
	ENSSSCP00015029288.1
	ENSSSCP00025045526.1
	ENSSSCP00035032019.1
	ENSSSCP00050018397.1
	ENSSSCP00055041938.1
	ENSSSCP00065008808.1
	ENSSSCP00070050530.1
	ENSSSCP00070050531.1

RefSeq Acc Id:	NP_001137588 ⟸ NM_001144116
- Peptide Label:	precursor
- UniProtKB:	B7X727 (UniProtKB/TrEMBL), A0A4X1W9S1 (UniProtKB/TrEMBL), A0A8D1S1L7 (UniProtKB/TrEMBL), F1RIH8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTALVTLLFLLLLGAQTQHGAEWTYSDGELDEAHWSREYPDCDGRRQSPIDVQRKSVQYNPALR ALSLTGYEAQEGEFSMINNGHTVQISLPSTMRLTAPDGTQYIAKQMHFHWGGAFSEISGSEHTI DGIRYVTEVHVVHYNSKYKSYDEAQTAPDGLAVLAALFEIKDYAENTYYSDFISHLKNIRIPGQ TTVLSSLNLQDMLPENLHSYYSYQGSLTTPPCTENVHWFVLADTVKLSRTQVWKLQNSLLNDQN KTIHNDYRRTQPLNHRVVEANFKSLPNPRSELHFYLNNIDNNLEYLRRVIEQKKAKGKGPW hide sequence

Ensembl Acc Id:

ENSSSCP00000003676 ⟸ ENSSSCT00000003762

Ensembl Acc Id:

ENSSSCP00000068986 ⟸ ENSSSCT00000091113

Protein Domains

Alpha-carbonic anhydrase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000003391	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00015054455	UniProtKB/TrEMBL
	ENSSSCG00025074513	UniProtKB/TrEMBL
	ENSSSCG00035058428	UniProtKB/TrEMBL
	ENSSSCG00050033364	UniProtKB/TrEMBL
	ENSSSCG00055026492	UniProtKB/TrEMBL
	ENSSSCG00065016355	UniProtKB/TrEMBL
	ENSSSCG00070029530	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000003762	ENTREZGENE
	ENSSSCT00000003762.4	UniProtKB/TrEMBL
	ENSSSCT00000091113.1	UniProtKB/TrEMBL
	ENSSSCT00015072998.1	UniProtKB/TrEMBL
	ENSSSCT00025102799.1	UniProtKB/TrEMBL
	ENSSSCT00035078195.1	UniProtKB/TrEMBL
	ENSSSCT00050044750.1	UniProtKB/TrEMBL
	ENSSSCT00055052518.1	UniProtKB/TrEMBL
	ENSSSCT00065021731.1	UniProtKB/TrEMBL
	ENSSSCT00070059346.1	UniProtKB/TrEMBL
	ENSSSCT00070059347.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.200.10	UniProtKB/TrEMBL
InterPro	CA_dom	UniProtKB/TrEMBL
	CA_dom_sf	UniProtKB/TrEMBL
	Carbonic_anhydrase_a-class	UniProtKB/TrEMBL
	Carbonic_anhydrase_a-class_CS	UniProtKB/TrEMBL
KEGG Report	ssc:100240717	UniProtKB/TrEMBL
NCBI Gene	CA6	ENTREZGENE
PANTHER	PTHR18952	UniProtKB/TrEMBL
	PTHR18952:SF110	UniProtKB/TrEMBL
Pfam	Carb_anhydrase	UniProtKB/TrEMBL
PROSITE	ALPHA_CA_1	UniProtKB/TrEMBL
	ALPHA_CA_2	UniProtKB/TrEMBL
SMART	Carb_anhydrase	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51069	UniProtKB/TrEMBL
UniProt	A0A4X1W7S7_PIG	UniProtKB/TrEMBL
	A0A4X1W9S1	ENTREZGENE, UniProtKB/TrEMBL
	A0A5G2RDW1_PIG	UniProtKB/TrEMBL
	A0A8D1S1L7	ENTREZGENE, UniProtKB/TrEMBL
	B7X727	ENTREZGENE, UniProtKB/TrEMBL
	F1RIH8	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:86103	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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