CERS2 (ceramide synthase 2) - Rat Genome Database
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Gene: CERS2 (ceramide synthase 2) Sus scrofa
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Symbol: CERS2
Name: ceramide synthase 2
RGD ID: 13886877
Description: ENCODES a protein that exhibits sphingosine N-acyltransferase activity (ortholog); INVOLVED IN ceramide biosynthetic process (ortholog); negative regulation of axon regeneration (ortholog); negative regulation of Schwann cell migration (ortholog); ASSOCIATED WITH Marfanoid Mental Retardation Syndrome, Autosomal (ortholog); FOUND IN endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LAG1 homolog, ceramide synthase 2; LASS2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,250,490 - 98,260,495 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,250,773 - 98,260,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,504,661 - 107,514,743 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
CERS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl498,250,490 - 98,260,495 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1498,250,773 - 98,260,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24107,504,661 - 107,514,743 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CERS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1150,960,583 - 150,975,004 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1150,960,583 - 150,975,003 (-)EnsemblGRCh38hg38GRCh38
GRCh381150,965,184 - 150,974,835 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371150,937,662 - 150,947,311 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371150,937,649 - 150,947,479 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,204,273 - 149,214,064 (-)NCBINCBI36hg18NCBI36
Celera1124,053,344 - 124,063,135 (-)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1122,314,777 - 122,324,583 (-)NCBIHuRef
CHM1_11152,332,969 - 152,342,798 (-)NCBICHM1_1
Cers2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39395,222,077 - 95,230,910 (+)NCBIGRCm39mm39
GRCm38395,314,771 - 95,323,599 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl395,314,791 - 95,323,599 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,119,174 - 95,127,492 (+)NCBIGRCm37mm9NCBIm37
MGSCv36395,400,656 - 95,408,974 (+)NCBImm8
Celera396,746,553 - 96,754,871 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
Cers2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22182,890,527 - 182,898,805 (+)NCBI
Rnor_6.0 Ensembl2196,487,656 - 196,496,986 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02196,487,656 - 196,495,930 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02215,986,084 - 215,994,362 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,224,017 - 190,232,275 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12190,186,196 - 190,195,027 (+)NCBI
Celera2175,424,025 - 175,432,283 (+)NCBICelera
Cytogenetic Map2q34NCBI
Cers2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955588336,083 - 342,599 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955588338,381 - 342,139 (-)NCBIChiLan1.0ChiLan1.0
CERS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11129,962,894 - 129,973,074 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1129,962,022 - 129,972,722 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01126,314,483 - 126,324,312 (-)NCBIMhudiblu_PPA_v0panPan3
CERS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1760,070,585 - 60,081,502 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11760,069,723 - 60,073,622 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cers2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365801,192,843 - 1,201,863 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CERS2
(Chlorocebus sabaeus - African green monkey)
No map positions available.
Cers2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477218,851,681 - 18,855,267 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3
Low 9 4 3 5 2 20 2 3 3
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000007280   ⟹   ENSSSCP00000007085
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl498,251,474 - 98,259,560 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000041938   ⟹   ENSSSCP00000040155
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl498,250,808 - 98,260,495 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000043640   ⟹   ENSSSCP00000033905
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl498,250,490 - 98,260,416 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000044773   ⟹   ENSSSCP00000041152
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl498,250,490 - 98,259,560 (+)Ensembl
RefSeq Acc Id: XM_001929667   ⟹   XP_001929702
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1498,251,488 - 98,260,504 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005663489   ⟹   XP_005663546
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1498,251,313 - 98,260,504 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005663490   ⟹   XP_005663547
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1498,250,773 - 98,260,504 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005663491   ⟹   XP_005663548
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1498,250,886 - 98,260,504 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021089892   ⟹   XP_020945551
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1498,251,900 - 98,260,504 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005663547   ⟸   XM_005663490
- Peptide Label: isoform X1
- UniProtKB: F1SS96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005663548   ⟸   XM_005663491
- Peptide Label: isoform X1
- UniProtKB: F1SS96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005663546   ⟸   XM_005663489
- Peptide Label: isoform X1
- UniProtKB: F1SS96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001929702   ⟸   XM_001929667
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020945551   ⟸   XM_021089892
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000041152   ⟸   ENSSSCT00000044773
RefSeq Acc Id: ENSSSCP00000040155   ⟸   ENSSSCT00000041938
RefSeq Acc Id: ENSSSCP00000007085   ⟸   ENSSSCT00000007280
RefSeq Acc Id: ENSSSCP00000033905   ⟸   ENSSSCT00000043640
Protein Domains
Homeobox   TLC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006644 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000007085 UniProtKB/TrEMBL
  ENSSSCP00000033905 UniProtKB/TrEMBL
  ENSSSCP00000040155 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000041152 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007280 UniProtKB/TrEMBL
  ENSSSCT00000041938 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000043640 UniProtKB/TrEMBL
  ENSSSCT00000044773 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Lag1/Lac1-like UniProtKB/TrEMBL
  TLC-dom UniProtKB/TrEMBL
KEGG Report ssc:100156737 UniProtKB/TrEMBL
NCBI Gene CERS2 ENTREZGENE
PANTHER PTHR12560 UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
  TRAM_LAG1_CLN8 UniProtKB/TrEMBL
PIRSF LAG1_LAC1 UniProtKB/TrEMBL
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
  TLC UniProtKB/TrEMBL
SMART TLC UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A286ZR11_PIG UniProtKB/TrEMBL
  A0A287A843_PIG UniProtKB/TrEMBL
  A0A287AB79_PIG UniProtKB/TrEMBL
  F1SS96 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:86587 ENTREZGENE