DHFR (dihydrofolate reductase) - Rat Genome Database

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Gene: DHFR (dihydrofolate reductase) Sus scrofa
Analyze
Symbol: DHFR
Name: dihydrofolate reductase
RGD ID: 13874704
Description: ENCODES a protein that exhibits dihydrofolate reductase activity (ortholog); dihydrofolic acid binding (ortholog); folic acid binding (ortholog); INVOLVED IN axon regeneration (ortholog); dihydrofolate metabolic process (ortholog); folic acid metabolic process (ortholog); PARTICIPATES IN altered folate cycle metabolic pathway; dopa responsive dystonia pathway; folate cycle metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); autistic disorder (ortholog); Breast Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); INTERACTS WITH Estradiol 17beta-cyclopentylpropionate
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1289,230,660 - 89,255,830 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2291,077,865 - 91,102,076 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:15679890  


Genomics

Comparative Map Data
DHFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1289,230,660 - 89,255,830 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2291,077,865 - 91,102,076 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl580,626,226 - 80,654,983 (-)EnsemblGRCh38hg38GRCh38
GRCh38580,626,226 - 80,654,983 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37579,922,045 - 79,950,802 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,957,801 - 79,986,556 (-)NCBINCBI36hg18NCBI36
Build 34579,957,803 - 79,986,572NCBI
Celera575,825,049 - 75,854,857 (-)NCBI
Cytogenetic Map5q14.1NCBI
HuRef575,130,997 - 75,159,721 (-)NCBIHuRef
CHM1_1579,355,281 - 79,384,046 (-)NCBICHM1_1
Dhfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,491,291 - 92,525,561 (+)NCBIGRCm39mm39
GRCm39 Ensembl1392,491,234 - 92,525,561 (+)Ensembl
GRCm381392,354,783 - 92,389,053 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,354,726 - 92,389,053 (+)EnsemblGRCm38mm10GRCm38
MGSCv371393,124,738 - 93,159,008 (+)NCBIGRCm37mm9NCBIm37
MGSCv361393,455,536 - 93,489,806 (+)NCBImm8
Celera1395,961,012 - 95,994,907 (+)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.64NCBI
Dhfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2223,585,876 - 23,611,199 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl221,931,493 - 21,962,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0221,931,887 - 21,958,927 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0241,137,784 - 41,149,417 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0241,162,308 - 41,162,496 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,607,093 - 22,828,487 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1222,527,461 - 22,748,856 (+)NCBI
Celera219,675,965 - 19,700,103 (+)NCBICelera
Cytogenetic Map2q12NCBI
Dhfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541829,274,170 - 29,283,028 (+)NCBIChiLan1.0ChiLan1.0
DHFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1534,938,548 - 34,967,003 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl534,938,548 - 34,967,003 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0534,663,210 - 34,689,467 (+)NCBIMhudiblu_PPA_v0panPan3
Dhfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,542,580 - 182,561,929 (+)NCBI
SpeTri2.0NW_00493646967,962 - 83,116 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1474,787,292 - 74,811,196 (-)NCBI
ChlSab1.1 Ensembl474,787,629 - 74,810,960 (-)Ensembl
Vero_WHO_p1.0NW_02366604923,650,277 - 23,674,290 (-)NCBI
Dhfr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247431,446,643 - 1,462,319 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 2 5 3
Low 7 2 3 2 23 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: NM_001244064   ⟹   NP_001230993
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1289,230,918 - 89,255,480 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021079623   ⟹   XP_020935282
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1289,230,660 - 89,255,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021079627   ⟹   XP_020935286
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1289,230,660 - 89,255,830 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021079635   ⟹   XP_020935294
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1289,230,660 - 89,255,470 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001230993 (Get FASTA)   NCBI Sequence Viewer  
  XP_020935282 (Get FASTA)   NCBI Sequence Viewer  
  XP_020935286 (Get FASTA)   NCBI Sequence Viewer  
  XP_020935294 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein P00377 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020935286   ⟸   XM_021079627
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020935282   ⟸   XM_021079623
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020935294   ⟸   XM_021079635
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001230993   ⟸   NM_001244064
- Sequence:
Protein Domains
DHFR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000031117 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070006620 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000041285 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000061098 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070010415 UniProtKB/TrEMBL
  ENSSSCP00070010424 UniProtKB/TrEMBL
  ENSSSCP00070010433 UniProtKB/TrEMBL
  ENSSSCP00070010437 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000053472 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000084719 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070012669 UniProtKB/TrEMBL
  ENSSSCT00070012680 UniProtKB/TrEMBL
  ENSSSCT00070012690 UniProtKB/TrEMBL
  ENSSSCT00070012694 UniProtKB/TrEMBL
Gene3D-CATH 3.40.430.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DHFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHFR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHFR_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHFR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene DHFR ENTREZGENE
PANTHER PTHR48069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DHFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DHFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DHFR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53597 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287ABU6_PIG UniProtKB/TrEMBL
  A0A4X1T3P5_PIG UniProtKB/TrEMBL
  A0A4X1T4X9_PIG UniProtKB/TrEMBL
  A0A4X1T678_PIG UniProtKB/TrEMBL
  A0A4X1T6N5_PIG UniProtKB/TrEMBL
  A0A5G2QSC9_PIG UniProtKB/TrEMBL
  DYR_PIG UniProtKB/Swiss-Prot, ENTREZGENE