MAML3 (mastermind like transcriptional coactivator 3) - Rat Genome Database

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Gene: MAML3 (mastermind like transcriptional coactivator 3) Sus scrofa
Analyze
Symbol: MAML3
Name: mastermind like transcriptional coactivator 3
RGD ID: 13874497
Description: ENCODES a protein that exhibits transcription coactivator activity (inferred); INVOLVED IN Notch signaling pathway (inferred); positive regulation of transcription by RNA polymerase II (inferred); positive regulation of transcription of Notch receptor target (inferred); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); congenital heart disease (ortholog); genetic disease (ortholog); FOUND IN nuclear speck (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mastermind-like 3; mastermind-like protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl886,879,974 - 87,323,117 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1886,879,353 - 87,323,123 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2892,666,095 - 92,869,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nuclear speck  (IEA)
nucleoplasm  (IBA,IEA)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAML3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl886,879,974 - 87,323,117 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1886,879,353 - 87,323,123 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2892,666,095 - 92,869,847 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAML3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384139,716,753 - 140,154,184 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4139,716,753 - 140,154,184 (-)EnsemblGRCh38hg38GRCh38
GRCh374140,637,907 - 141,075,338 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364140,856,995 - 141,294,683 (-)NCBINCBI36Build 36hg18NCBI36
Build 344140,996,585 - 141,432,838NCBI
Celera4137,970,363 - 138,407,341 (-)NCBICelera
Cytogenetic Map4q31.1NCBI
HuRef4136,366,643 - 136,804,681 (-)NCBIHuRef
CHM1_14140,614,745 - 141,052,502 (-)NCBICHM1_1
T2T-CHM13v2.04143,036,385 - 143,473,944 (-)NCBIT2T-CHM13v2.0
Maml3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39351,595,032 - 52,012,740 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl351,593,328 - 52,012,497 (-)EnsemblGRCm39 Ensembl
GRCm38351,687,320 - 52,105,319 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl351,685,907 - 52,105,076 (-)EnsemblGRCm38mm10GRCm38
MGSCv37351,491,533 - 51,908,928 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36351,777,350 - 51,944,213 (-)NCBIMGSCv36mm8
Celera351,418,977 - 51,838,299 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map322.54NCBI
Maml3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82137,871,267 - 138,288,615 (-)NCBIGRCr8
mRatBN7.22135,720,431 - 136,137,829 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2135,721,021 - 136,137,814 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2142,298,472 - 142,712,794 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02140,410,732 - 140,825,064 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02135,042,696 - 135,461,048 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02140,734,138 - 141,276,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02160,716,326 - 160,966,457 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02160,209,608 - 160,218,015 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42140,574,982 - 140,740,461 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12140,525,137 - 140,692,236 (-)NCBI
Celera2130,217,186 - 130,632,633 (-)NCBICelera
Cytogenetic Map2q26NCBI
Maml3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,603,101 - 4,008,781 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,602,255 - 4,009,994 (+)NCBIChiLan1.0ChiLan1.0
MAML3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23137,591,832 - 138,028,089 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14137,984,218 - 138,421,076 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04132,082,120 - 132,518,928 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14143,389,048 - 143,824,445 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4143,391,606 - 143,562,699 (-)Ensemblpanpan1.1panPan2
MAML3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1192,461,784 - 3,061,878 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl192,656,370 - 3,060,769 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha192,708,254 - 2,901,368 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0192,526,092 - 2,723,009 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1192,462,961 - 2,656,179 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0192,824,721 - 3,017,946 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,180,472 - 3,373,749 (+)NCBIUU_Cfam_GSD_1.0
Maml3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530150,462,056 - 50,554,980 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365357,599,660 - 7,989,952 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365357,537,420 - 7,991,983 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAML3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1786,673,649 - 87,107,768 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl786,673,346 - 86,848,086 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603766,196,080 - 66,632,842 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Maml3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477719,927,024 - 20,093,002 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477719,928,442 - 20,353,784 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAML3
14090 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 2 3 5 23 2 3 1
Below cutoff 1 2 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000061458   ⟹   ENSSSCP00000040851
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl886,879,974 - 87,323,117 (+)Ensembl
RefSeq Acc Id: XM_021100677   ⟹   XP_020956336
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1886,879,353 - 87,323,123 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020956336 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000040851
  ENSSSCP00000040851.2
  ENSSSCP00025037426.1
  ENSSSCP00030001397.1
  ENSSSCP00035000070.1
  ENSSSCP00065016400.1
Reference Protein Sequences
RefSeq Acc Id: XP_020956336   ⟸   XM_021100677
- UniProtKB: A0A287AAC7 (UniProtKB/TrEMBL),   A0A8D0SVH4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000040851   ⟸   ENSSSCT00000061458
Protein Domains
Neurogenic mastermind-like N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009060 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025062839 UniProtKB/TrEMBL
  ENSSSCG00030002786 UniProtKB/TrEMBL
  ENSSSCG00035000377 UniProtKB/TrEMBL
  ENSSSCG00065028761 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000061458 ENTREZGENE
  ENSSSCT00000061458.3 UniProtKB/TrEMBL
  ENSSSCT00025086042.1 UniProtKB/TrEMBL
  ENSSSCT00030003559.1 UniProtKB/TrEMBL
  ENSSSCT00035000410.1 UniProtKB/TrEMBL
  ENSSSCT00065038796.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.970 UniProtKB/TrEMBL
InterPro MAML1-3 UniProtKB/TrEMBL
  MAML1_3_TAD1 UniProtKB/TrEMBL
  MAML1_3_TAD2 UniProtKB/TrEMBL
  MAML_N_sf UniProtKB/TrEMBL
  Neuroggenic_mastermind-like_N UniProtKB/TrEMBL
NCBI Gene MAML3 ENTREZGENE
PANTHER MASTERMIND-LIKE PROTEIN 3 UniProtKB/TrEMBL
  PTHR15692 UniProtKB/TrEMBL
Pfam MamL-1 UniProtKB/TrEMBL
  MAML1_3_TAD1 UniProtKB/TrEMBL
  MAML1_3_TAD2 UniProtKB/TrEMBL
SMART MamL-1 UniProtKB/TrEMBL
UniProt A0A287AAC7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0SVH4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:98938 ENTREZGENE