HECTD4 (HECT domain E3 ubiquitin protein ligase 4) - Rat Genome Database

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Gene: HECTD4 (HECT domain E3 ubiquitin protein ligase 4) Sus scrofa
Analyze
Symbol: HECTD4
Name: HECT domain E3 ubiquitin protein ligase 4
RGD ID: 13866796
Description: ENCODES a protein that exhibits ubiquitin-protein transferase activity (inferred); INVOLVED IN glucose metabolic process (ortholog); ASSOCIATED WITH alcohol-induced mental disorder (ortholog); autism spectrum disorder (ortholog); coronary artery disease (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: probable E3 ubiquitin-protein ligase HECTD4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,326,792 - 39,536,693 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,326,695 - 39,537,921 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,829,770 - 42,040,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
HECTD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,326,792 - 39,536,693 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,326,695 - 39,537,921 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21441,829,770 - 42,040,718 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HECTD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812112,160,195 - 112,382,431 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12112,160,188 - 112,382,439 (-)EnsemblGRCh38hg38GRCh38
GRCh3712112,597,999 - 112,820,235 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612111,082,494 - 111,228,421 (-)NCBINCBI36Build 36hg18NCBI36
Celera12112,223,478 - 112,446,926 (-)NCBICelera
Cytogenetic Map12q24.13NCBI
HuRef12109,611,135 - 109,832,758 (-)NCBIHuRef
CHM1_112112,566,184 - 112,788,132 (-)NCBICHM1_1
T2T-CHM13v2.012112,137,101 - 112,359,329 (-)NCBIT2T-CHM13v2.0
Hectd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,357,323 - 121,506,633 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,358,282 - 121,506,640 (+)EnsemblGRCm39 Ensembl
GRCm385121,219,513 - 121,368,577 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,220,219 - 121,368,577 (+)EnsemblGRCm38mm10GRCm38
MGSCv375121,670,214 - 121,818,586 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,585,831 - 121,629,192 (+)NCBIMGSCv36mm8
Celera5118,310,100 - 118,458,521 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.72NCBI
Hectd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,800,232 - 40,991,584 (-)NCBIGRCr8
mRatBN7.21235,182,165 - 35,330,935 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,182,154 - 35,330,987 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01240,712,078 - 40,860,930 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,713,841 - 40,822,159 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,579,193 - 42,728,149 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,318,373 - 36,423,169 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11236,183,146 - 36,299,948 (-)NCBI
Celera1236,847,681 - 36,995,299 (-)NCBICelera
Cytogenetic Map12q16NCBI
Hectd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,716,092 - 8,847,979 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,714,100 - 8,847,975 (-)NCBIChiLan1.0ChiLan1.0
HECTD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210120,250,769 - 120,472,956 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112120,247,162 - 120,469,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,756,303 - 109,978,510 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112113,150,901 - 113,309,528 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12113,151,017 - 113,311,809 (-)Ensemblpanpan1.1panPan2
HECTD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,764,437 - 9,954,274 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,767,169 - 9,954,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,883,238 - 10,071,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02610,002,501 - 10,193,532 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2610,003,319 - 10,193,589 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,979,339 - 10,168,130 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02610,042,607 - 10,231,400 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02610,090,235 - 10,279,116 (-)NCBIUU_Cfam_GSD_1.0
Hectd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118147,892,128 - 148,068,653 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366682,390,405 - 2,514,708 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366682,390,902 - 2,514,653 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HECTD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,403,854 - 107,624,534 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,405,887 - 107,596,312 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037137,465,425 - 137,688,609 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hectd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474719,843,720 - 20,029,225 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474719,843,434 - 20,031,188 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HECTD4
3338 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2 3 3 23 3 1
Low 8 2 2 2 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010835   ⟹   ENSSSCP00000010552
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1439,326,792 - 39,536,693 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000023139   ⟹   ENSSSCP00000024549
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1439,326,792 - 39,536,693 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000048879   ⟹   ENSSSCP00000056908
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1439,326,792 - 39,536,693 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000062948   ⟹   ENSSSCP00000047903
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1439,326,671 - 39,537,916 (+)Ensembl
RefSeq Acc Id: XM_005657322   ⟹   XP_005657379
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,326,695 - 39,537,921 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005657323   ⟹   XP_005657380
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,326,695 - 39,537,921 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005657324   ⟹   XP_005657381
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,326,695 - 39,537,921 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005657325   ⟹   XP_005657382
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,326,695 - 39,537,921 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013990365   ⟹   XP_013845819
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,326,695 - 39,537,921 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021072836   ⟹   XP_020928495
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11439,371,639 - 39,537,921 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005657379   ⟸   XM_005657322
- Peptide Label: isoform X1
- UniProtKB: A0A8D0P934 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005657380   ⟸   XM_005657323
- Peptide Label: isoform X2
- UniProtKB: A0A4X1TFV1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013845819   ⟸   XM_013990365
- Peptide Label: isoform X4
- UniProtKB: A0A8D0P934 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005657381   ⟸   XM_005657324
- Peptide Label: isoform X3
- UniProtKB: A0A8D0P934 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005657382   ⟸   XM_005657325
- Peptide Label: isoform X5
- UniProtKB: A0A8D0P934 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020928495   ⟸   XM_021072836
- Peptide Label: isoform X6
- UniProtKB: A0A0B8RVU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000056908   ⟸   ENSSSCT00000048879
RefSeq Acc Id: ENSSSCP00000010552   ⟸   ENSSSCT00000010835
RefSeq Acc Id: ENSSSCP00000024549   ⟸   ENSSSCT00000023139
RefSeq Acc Id: ENSSSCP00000047903   ⟸   ENSSSCT00000062948
Protein Domains
HECT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009885 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015055496 UniProtKB/TrEMBL
  ENSSSCG00030056966 UniProtKB/TrEMBL
  ENSSSCG00050041550 UniProtKB/TrEMBL
  ENSSSCG00065028895 UniProtKB/TrEMBL
  ENSSSCG00070008413 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010835 ENTREZGENE
  ENSSSCT00000010835.5 UniProtKB/TrEMBL
  ENSSSCT00000023139.4 UniProtKB/TrEMBL
  ENSSSCT00000048879 ENTREZGENE
  ENSSSCT00000048879.3 UniProtKB/TrEMBL
  ENSSSCT00015074759.1 UniProtKB/TrEMBL
  ENSSSCT00015075217.1 UniProtKB/TrEMBL
  ENSSSCT00015075439.1 UniProtKB/TrEMBL
  ENSSSCT00015075616.1 UniProtKB/TrEMBL
  ENSSSCT00015075749.1 UniProtKB/TrEMBL
  ENSSSCT00030080220.1 UniProtKB/TrEMBL
  ENSSSCT00030080361.1 UniProtKB/TrEMBL
  ENSSSCT00030080463.1 UniProtKB/TrEMBL
  ENSSSCT00030080598.1 UniProtKB/TrEMBL
  ENSSSCT00030080663.1 UniProtKB/TrEMBL
  ENSSSCT00050056411.1 UniProtKB/TrEMBL
  ENSSSCT00050056416.1 UniProtKB/TrEMBL
  ENSSSCT00050056425.1 UniProtKB/TrEMBL
  ENSSSCT00050056438.1 UniProtKB/TrEMBL
  ENSSSCT00050056451.1 UniProtKB/TrEMBL
  ENSSSCT00065038996.1 UniProtKB/TrEMBL
  ENSSSCT00065039005.1 UniProtKB/TrEMBL
  ENSSSCT00065039024.1 UniProtKB/TrEMBL
  ENSSSCT00070016858.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  HECT_dom UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  HECTD4 UniProtKB/TrEMBL
  SPRY_HECTD4 UniProtKB/TrEMBL
NCBI Gene HECTD4 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
SMART HECTc UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF56204 UniProtKB/TrEMBL
UniProt A0A0B8RVU4 ENTREZGENE
  A0A287BJY5_PIG UniProtKB/TrEMBL
  A0A4X1TFV1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0P934 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0P9L2_PIG UniProtKB/TrEMBL
  A0A8D0PEK4_PIG UniProtKB/TrEMBL
  A0A8D0XGP2_PIG UniProtKB/TrEMBL
  A0A8D0XH31_PIG UniProtKB/TrEMBL
  A0A8D0XIY8_PIG UniProtKB/TrEMBL
  A0A8D0XJB1_PIG UniProtKB/TrEMBL
  A0A8D0XMS5_PIG UniProtKB/TrEMBL
  A0A8D1MK80_PIG UniProtKB/TrEMBL
  A0A8D1Y7U0_PIG UniProtKB/TrEMBL
  F1RJM5_PIG UniProtKB/TrEMBL
  I3LKD5_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88834 ENTREZGENE