ITGA5 (integrin subunit alpha 5) - Rat Genome Database

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Gene: ITGA5 (integrin subunit alpha 5) Sus scrofa
Analyze
Symbol: ITGA5
Name: integrin subunit alpha 5
RGD ID: 13866267
Description: ENCODES a protein that exhibits cell adhesion molecule binding (ortholog); epidermal growth factor receptor binding (ortholog); integrin binding (ortholog); INVOLVED IN cell adhesion (ortholog); cell-cell adhesion mediated by integrin (ortholog); cell-substrate junction assembly (ortholog); PARTICIPATES IN integrin mediated signaling pathway; syndecan signaling pathway; ASSOCIATED WITH genetic disease (ortholog); Gliosis (ortholog); Hyperalgesia (ortholog); FOUND IN glutamatergic synapse (ortholog); integrin alpha5-beta1 complex (ortholog); integrin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin alpha-5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl519,586,746 - 19,610,362 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1519,587,361 - 19,610,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2520,441,721 - 20,465,338 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:20412125   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ITGA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl519,586,746 - 19,610,362 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1519,587,361 - 19,610,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2520,441,721 - 20,465,338 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381254,395,261 - 54,419,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1254,395,261 - 54,419,266 (-)EnsemblGRCh38hg38GRCh38
GRCh371254,789,045 - 54,813,050 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361253,075,312 - 53,099,317 (-)NCBINCBI36Build 36hg18NCBI36
Build 341253,075,313 - 53,099,317NCBI
Celera1254,440,888 - 54,464,894 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1251,828,142 - 51,852,148 (-)NCBIHuRef
CHM1_11254,755,737 - 54,779,741 (-)NCBICHM1_1
T2T-CHM13v2.01254,361,846 - 54,385,852 (-)NCBIT2T-CHM13v2.0
Itga5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915103,252,713 - 103,275,218 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15103,252,713 - 103,275,190 (-)EnsemblGRCm39 Ensembl
GRCm3815103,344,286 - 103,366,791 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15103,344,286 - 103,366,763 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715103,174,717 - 103,197,179 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615103,172,320 - 103,194,797 (-)NCBIMGSCv36mm8
Celera15105,510,278 - 105,532,530 (-)NCBICelera
Cytogenetic Map15F3NCBI
cM Map1558.9NCBI
Itga5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87136,358,097 - 136,381,305 (-)NCBIGRCr8
mRatBN7.27134,478,963 - 134,502,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7134,478,968 - 134,502,837 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7136,234,784 - 136,258,229 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07138,464,152 - 138,487,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07138,450,391 - 138,473,685 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07144,970,444 - 144,993,652 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7144,970,444 - 144,993,652 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07142,749,459 - 142,773,323 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47142,254,256 - 142,277,464 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7130,903,975 - 130,927,190 (-)NCBICelera
Cytogenetic Map7q36NCBI
Itga5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554581,632,282 - 1,658,295 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554581,635,554 - 1,657,609 (-)NCBIChiLan1.0ChiLan1.0
ITGA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21039,753,055 - 39,777,261 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11239,749,994 - 39,774,030 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01234,326,182 - 34,350,050 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11235,052,994 - 35,076,860 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1235,052,994 - 35,075,835 (+)Ensemblpanpan1.1panPan2
ITGA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.127904,892 - 924,757 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl27904,102 - 924,084 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2745,330,567 - 45,350,366 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.027902,131 - 921,978 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl27902,131 - 921,969 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.127893,448 - 913,731 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.027902,991 - 922,682 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02745,734,450 - 45,754,318 (-)NCBIUU_Cfam_GSD_1.0
Itga5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494561,552,202 - 61,576,027 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651211,588,645 - 11,612,669 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651211,588,818 - 11,612,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11150,507,673 - 50,535,358 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1150,510,714 - 50,535,328 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037195,501,908 - 195,526,109 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249042,417,269 - 2,440,087 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249042,418,140 - 2,439,945 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ITGA5
675 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1
Low 9 3 5 2 1 2 3 3
Below cutoff 3 21

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000000314   ⟹   ENSSSCP00000000308
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl519,586,746 - 19,610,361 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000070939   ⟹   ENSSSCP00000062970
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl519,588,321 - 19,610,361 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000075947   ⟹   ENSSSCP00000065218
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl519,586,746 - 19,610,361 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000088499   ⟹   ENSSSCP00000072859
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl519,586,746 - 19,610,361 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090750   ⟹   ENSSSCP00000064504
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl519,587,384 - 19,610,362 (-)Ensembl
RefSeq Acc Id: XM_001925252   ⟹   XP_001925287
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1519,587,361 - 19,610,577 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002343970
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1519,587,368 - 19,610,580 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_001925287   ⟸   XM_001925252
- UniProtKB: F1SR53 (UniProtKB/TrEMBL),   A0A8D0WPM3 (UniProtKB/TrEMBL),   A0A481ALX5 (UniProtKB/TrEMBL),   A0A4X1WAF0 (UniProtKB/TrEMBL),   A0A8D1GCE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000072859   ⟸   ENSSSCT00000088499
RefSeq Acc Id: ENSSSCP00000064504   ⟸   ENSSSCT00000090750
RefSeq Acc Id: ENSSSCP00000065218   ⟸   ENSSSCT00000075947
RefSeq Acc Id: ENSSSCP00000062970   ⟸   ENSSSCT00000070939
RefSeq Acc Id: ENSSSCP00000000308   ⟸   ENSSSCT00000000314
Protein Domains
Integrin alpha first immunoglubulin-like   Integrin alpha second immunoglobulin-like   Integrin alpha third immunoglobulin-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000293 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005016600 UniProtKB/TrEMBL
  ENSSSCG00025055937 UniProtKB/TrEMBL
  ENSSSCG00030037762 UniProtKB/TrEMBL
  ENSSSCG00035010029 UniProtKB/TrEMBL
  ENSSSCG00040075677 UniProtKB/TrEMBL
  ENSSSCG00045002505 UniProtKB/TrEMBL
  ENSSSCG00050001276 UniProtKB/TrEMBL
  ENSSSCG00055015922 UniProtKB/TrEMBL
  ENSSSCG00060023497 UniProtKB/TrEMBL
  ENSSSCG00065036289 UniProtKB/TrEMBL
  ENSSSCG00070029937 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000314 ENTREZGENE
  ENSSSCT00000000314.5 UniProtKB/TrEMBL
  ENSSSCT00000070939.2 UniProtKB/TrEMBL
  ENSSSCT00000075947.1 UniProtKB/TrEMBL
  ENSSSCT00000088499.2 UniProtKB/TrEMBL
  ENSSSCT00000090750.2 UniProtKB/TrEMBL
  ENSSSCT00005026986.1 UniProtKB/TrEMBL
  ENSSSCT00025076909.1 UniProtKB/TrEMBL
  ENSSSCT00030052623.1 UniProtKB/TrEMBL
  ENSSSCT00035012547.1 UniProtKB/TrEMBL
  ENSSSCT00040105086.1 UniProtKB/TrEMBL
  ENSSSCT00045003957.1 UniProtKB/TrEMBL
  ENSSSCT00050001560.1 UniProtKB/TrEMBL
  ENSSSCT00055031366.1 UniProtKB/TrEMBL
  ENSSSCT00060031868.1 UniProtKB/TrEMBL
  ENSSSCT00065049594.1 UniProtKB/TrEMBL
  ENSSSCT00070060176.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/TrEMBL
InterPro FG-GAP UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100155091 UniProtKB/TrEMBL
NCBI Gene ITGA5 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/TrEMBL
  INTEGRIN ALPHA-5 UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/TrEMBL
PRINTS INTEGRINA UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/TrEMBL
SMART Int_alpha UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/TrEMBL
  SSF69318 UniProtKB/TrEMBL
UniProt A0A481ALX5 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WAF0 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QK84_PIG UniProtKB/TrEMBL
  A0A5G2QLL7_PIG UniProtKB/TrEMBL
  A0A5G2R957_PIG UniProtKB/TrEMBL
  A0A8D0WPM3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1GCE9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1USE0_PIG UniProtKB/TrEMBL
  D0G772_PIG UniProtKB/TrEMBL
  F1SR53 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A5G2QKI7 UniProtKB/TrEMBL
VGNC ID VGNC:89236 ENTREZGENE