MRGPRX2 (MAS related GPR family member X2) - Rat Genome Database

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Gene: MRGPRX2 (MAS related GPR family member X2) Sus scrofa
Analyze
Symbol: MRGPRX2
Name: MAS related GPR family member X2
RGD ID: 13865537
Description: ENCODES a protein that exhibits mast cell secretagogue receptor activity (ortholog); neuropeptide binding (ortholog); INVOLVED IN mast cell activation (ortholog); mast cell degranulation (ortholog); positive regulation of cytokinesis (ortholog); ASSOCIATED WITH genetic disease (ortholog); hypertrophic cardiomyopathy 12 (ortholog); intellectual disability (ortholog); FOUND IN membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: mas-related G-protein coupled receptor member X2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1240,372,994 - 40,376,693 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,379,885 - 43,383,239 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MRGPRX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1240,372,994 - 40,376,693 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,379,885 - 43,383,239 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MRGPRX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,054,455 - 19,060,717 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,054,455 - 19,060,717 (-)EnsemblGRCh38hg38GRCh38
GRCh371119,076,002 - 19,082,264 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361119,032,578 - 19,038,804 (-)NCBINCBI36Build 36hg18NCBI36
Celera1119,208,469 - 19,214,692 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,759,875 - 18,766,099 (-)NCBIHuRef
CHM1_11119,075,324 - 19,081,548 (-)NCBICHM1_1
T2T-CHM13v2.01119,174,588 - 19,180,847 (-)NCBIT2T-CHM13v2.0
Mrgprx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39748,128,367 - 48,149,018 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl748,128,367 - 48,149,069 (-)EnsemblGRCm39 Ensembl
GRCm38748,478,619 - 48,499,270 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl748,478,619 - 48,499,321 (-)EnsemblGRCm38mm10GRCm38
MGSCv37755,733,989 - 55,754,640 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36748,346,641 - 48,367,222 (-)NCBIMGSCv36mm8
Celera743,927,960 - 43,948,585 (-)NCBICelera
Cytogenetic Map7B4NCBI
cM Map731.11NCBI
Mrgprx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81107,252,467 - 107,271,809 (-)NCBIGRCr8
mRatBN7.2198,116,192 - 98,135,534 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1103,474,866 - 103,475,750 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,946,809 - 111,947,693 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01105,267,615 - 105,268,499 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01103,743,746 - 103,760,945 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1103,741,503 - 103,760,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01104,802,660 - 104,822,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4198,260,012 - 98,260,896 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1198,338,122 - 98,339,007 (-)NCBI
Celera192,335,047 - 92,335,931 (-)NCBICelera
Cytogenetic Map1q22NCBI
MRGPRX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2921,360,160 - 21,366,392 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11121,320,453 - 21,326,691 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01119,080,807 - 19,087,039 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,994,557 - 19,000,749 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,995,499 - 18,996,488 (-)Ensemblpanpan1.1panPan2
MRGPRX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12141,195,255 - 41,235,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,674,486 - 40,715,351 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02142,318,790 - 42,359,654 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2142,318,869 - 42,359,654 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12141,321,564 - 41,362,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,499,021 - 41,539,666 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,876,490 - 41,917,010 (-)NCBIUU_Cfam_GSD_1.0
MRGPRX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1145,925,912 - 45,932,284 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl145,930,332 - 45,931,324 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038143,263,976 - 143,269,960 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in MRGPRX2
98 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system
High
Medium
Low 1 2
Below cutoff 6 2 1 2 16

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013994496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_013994496   ⟹   XP_013849950
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1240,372,994 - 40,376,693 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013849950 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00005014853.1
  ENSSSCP00035029312.1
  ENSSSCP00040014607.1
Reference Protein Sequences
RefSeq Acc Id: XP_013849950   ⟸   XM_013994496
- UniProtKB: A0A8D0IW57 (UniProtKB/TrEMBL),   A0A8D1CY94 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00005015771 UniProtKB/TrEMBL
  ENSSSCG00035054092 UniProtKB/TrEMBL
  ENSSSCG00040026346 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00005024669.1 UniProtKB/TrEMBL
  ENSSSCT00035072188.1 UniProtKB/TrEMBL
  ENSSSCT00040035235.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/TrEMBL
NCBI Gene MRGPRX2 ENTREZGENE
PANTHER MAS-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  MAS-RELATED G-PROTEIN COUPLED RECEPTOR MRG-RELATED UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  MRGPCRFAMILY UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8D0IW57 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CY94 ENTREZGENE, UniProtKB/TrEMBL