SLC7A11 (solute carrier family 7 member 11) - Rat Genome Database

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Gene: SLC7A11 (solute carrier family 7 member 11) Sus scrofa
Analyze
Symbol: SLC7A11
Name: solute carrier family 7 member 11
RGD ID: 13864470
Description: ENCODES a protein that exhibits cystine:glutamate antiporter activity (inferred); L-kynurenine transmembrane transporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN adult behavior (ortholog); brain development (ortholog); cellular response to oxidative stress (ortholog); ASSOCIATED WITH contact dermatitis (ortholog); Hermansky-Pudlak syndrome (ortholog); Neoplasm Metastasis (ortholog); FOUND IN apical part of cell (inferred); astrocyte projection (inferred); brush border membrane (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cystine/glutamate transporter; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl888,608,174 - 88,687,250 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1888,608,083 - 88,690,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult behavior  (IEA,ISO)
amino acid transmembrane transport  (IEA)
amino acid transport  (IEA)
brain development  (IEA,ISO)
cellular response to oxidative stress  (IEA,ISO)
cellular response to stress  (IEA,ISO)
dipeptide import across plasma membrane  (IEA,ISO)
glutathione metabolic process  (IEA,ISO)
glutathione transmembrane transport  (IEA,ISO)
intracellular glutamate homeostasis  (IEA,ISO)
L-cystine transport  (IEA)
L-glutamate import across plasma membrane  (IEA,ISO)
L-glutamate transmembrane transport  (IEA)
L-kynurenine transmembrane transport  (IEA)
lens fiber cell differentiation  (ISO)
limb development  (IEA,ISO)
lung alveolus development  (IEA,ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation of ferroptosis  (IEA)
neutral amino acid transport  (IEA)
platelet aggregation  (IEA,ISO)
regulation of AMPA glutamate receptor clustering  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of cellular response to oxidative stress  (IEA,ISO)
regulation of cysteine metabolic process  (IEA,ISO)
regulation of glutamate metabolic process  (IEA,ISO)
regulation of glutathione biosynthetic process  (IEA,ISO)
regulation of melanin biosynthetic process  (IEA,ISO)
regulation of neutrophil apoptotic process  (IEA,ISO)
regulation of protein transport  (IEA,ISO)
regulation of synapse organization  (IEA,ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (IEA,ISO)
response to oxidative stress  (ISO)
response to redox state  (IEA,ISO)
response to toxic substance  (IEA)
striatum development  (IEA,ISO)
transmembrane transport  (IEA)
ventricular system development  (IEA,ISO)
visual learning  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SLC7A11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl888,608,174 - 88,687,250 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1888,608,083 - 88,690,589 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC7A11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384138,164,097 - 138,312,671 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4138,164,097 - 138,242,349 (-)EnsemblGRCh38hg38GRCh38
GRCh374139,085,251 - 139,163,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364139,304,698 - 139,382,953 (-)NCBINCBI36Build 36hg18NCBI36
Build 344139,449,092 - 139,520,828NCBI
Celera4136,424,509 - 136,502,906 (-)NCBICelera
Cytogenetic Map4q28.3NCBI
HuRef4134,820,291 - 134,898,999 (-)NCBIHuRef
CHM1_14139,061,708 - 139,139,961 (-)NCBICHM1_1
T2T-CHM13v2.04141,487,564 - 141,636,430 (-)NCBIT2T-CHM13v2.0
Slc7a11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39350,319,385 - 50,403,947 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl349,846,975 - 50,398,063 (-)EnsemblGRCm39 Ensembl
GRCm38350,364,936 - 50,499,087 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl349,892,526 - 50,443,614 (-)EnsemblGRCm38mm10GRCm38
MGSCv37350,168,858 - 50,247,535 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36350,461,131 - 50,539,808 (-)NCBIMGSCv36mm8
Celera350,149,206 - 50,227,932 (-)NCBICelera
Cytogenetic Map3CNCBI
cM Map321.72NCBI
Slc7a11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82136,532,912 - 136,668,560 (-)NCBIGRCr8
mRatBN7.22134,382,002 - 134,517,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2133,963,107 - 134,517,536 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2141,015,140 - 141,089,464 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02139,127,676 - 139,201,998 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02133,756,818 - 133,831,146 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02139,453,774 - 139,528,479 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2139,453,774 - 139,528,162 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02158,930,294 - 159,004,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42139,241,142 - 139,317,101 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12139,198,359 - 139,266,947 (-)NCBI
Celera2128,949,395 - 129,023,474 (-)NCBICelera
Cytogenetic Map2q26NCBI
Slc7a11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554285,237,865 - 5,309,085 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554285,238,460 - 5,309,085 (+)NCBIChiLan1.0ChiLan1.0
SLC7A11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23136,031,904 - 136,178,341 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14136,428,877 - 136,575,218 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04130,529,677 - 130,601,396 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14141,841,526 - 141,919,678 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4141,849,343 - 141,959,849 (-)Ensemblpanpan1.1panPan2
SLC7A11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1194,289,792 - 4,379,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl194,289,850 - 4,389,048 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha194,539,704 - 4,608,064 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0194,364,717 - 4,454,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl194,264,457 - 4,464,477 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1194,293,544 - 4,361,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0194,655,537 - 4,724,650 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0195,019,875 - 5,088,260 (+)NCBIUU_Cfam_GSD_1.0
Slc7a11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530151,740,115 - 51,806,268 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365359,177,143 - 9,242,566 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365359,177,305 - 9,242,743 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1785,149,810 - 85,225,061 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl785,154,068 - 85,225,144 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603764,647,689 - 64,726,569 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477718,546,799 - 18,619,947 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477718,540,006 - 18,619,881 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SLC7A11
904 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000025645   ⟹   ENSSSCP00000027777
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl888,608,174 - 88,687,250 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000062233   ⟹   ENSSSCP00000053676
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl888,608,147 - 88,940,100 (+)Ensembl
RefSeq Acc Id: XM_021101587   ⟹   XP_020957246
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1888,608,083 - 88,690,589 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020957246   ⟸   XM_021101587
- UniProtKB: A0A4X1VFG3 (UniProtKB/TrEMBL),   I3LUH7 (UniProtKB/TrEMBL),   K9J6I4 (UniProtKB/TrEMBL),   A0A4X1VFH1 (UniProtKB/TrEMBL),   A0A8D0Z6D8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000027777   ⟸   ENSSSCT00000025645
Ensembl Acc Id: ENSSSCP00000053676   ⟸   ENSSSCT00000062233


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000022649 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015018429 UniProtKB/TrEMBL
  ENSSSCG00025010386 UniProtKB/TrEMBL
  ENSSSCG00030055355 UniProtKB/TrEMBL
  ENSSSCG00035025957 UniProtKB/TrEMBL
  ENSSSCG00040013671 UniProtKB/TrEMBL
  ENSSSCG00050013386 UniProtKB/TrEMBL
  ENSSSCG00055018348 UniProtKB/TrEMBL
  ENSSSCG00060043509 UniProtKB/TrEMBL
  ENSSSCG00065069458 UniProtKB/TrEMBL
  ENSSSCG00070024040 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000025645 ENTREZGENE
  ENSSSCT00000025645.4 UniProtKB/TrEMBL
  ENSSSCT00015024326.1 UniProtKB/TrEMBL
  ENSSSCT00015024478.1 UniProtKB/TrEMBL
  ENSSSCT00015024603.1 UniProtKB/TrEMBL
  ENSSSCT00025013668.1 UniProtKB/TrEMBL
  ENSSSCT00030077130.1 UniProtKB/TrEMBL
  ENSSSCT00035034211.1 UniProtKB/TrEMBL
  ENSSSCT00040018210.1 UniProtKB/TrEMBL
  ENSSSCT00050018068.1 UniProtKB/TrEMBL
  ENSSSCT00055035909.1 UniProtKB/TrEMBL
  ENSSSCT00055036046.1 UniProtKB/TrEMBL
  ENSSSCT00060059018.1 UniProtKB/TrEMBL
  ENSSSCT00060059032.1 UniProtKB/TrEMBL
  ENSSSCT00065095371.1 UniProtKB/TrEMBL
  ENSSSCT00070047977.1 UniProtKB/TrEMBL
  ENSSSCT00070047982.1 UniProtKB/TrEMBL
  ENSSSCT00070047985.1 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/TrEMBL
  AminoAcid_Transporter UniProtKB/TrEMBL
  L_AA_transporter UniProtKB/TrEMBL
NCBI Gene SLC7A11 ENTREZGENE
PANTHER AMINO ACID TRANSPORTER UniProtKB/TrEMBL
  CYSTINE/GLUTAMATE TRANSPORTER UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/TrEMBL
PIRSF AA_transporter UniProtKB/TrEMBL
UniProt A0A4X1VFF7_PIG UniProtKB/TrEMBL
  A0A4X1VFG3 ENTREZGENE
  A0A4X1VFH1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Z6D8 ENTREZGENE, UniProtKB/TrEMBL
  A5A787_PIG UniProtKB/TrEMBL
  I3LUH7 ENTREZGENE
  K9J6I4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A4X1VFG3 UniProtKB/TrEMBL
  I3LUH7 UniProtKB/TrEMBL
VGNC ID VGNC:93171 ENTREZGENE