AMT (aminomethyltransferase) - Rat Genome Database

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Gene: AMT (aminomethyltransferase) Sus scrofa
Analyze
Symbol: AMT
Name: aminomethyltransferase
RGD ID: 13862090
Description: ENCODES a protein that exhibits aminomethyltransferase activity (inferred); transaminase activity (inferred); transferase activity (inferred); INVOLVED IN glycine catabolic process (inferred); methylation (inferred); PARTICIPATES IN dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; folate cycle metabolic pathway; ASSOCIATED WITH Acidoses (ortholog); autosomal recessive limb-girdle muscular dystrophy type 2P (ortholog); epilepsy (ortholog); FOUND IN nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: aminomethyltransferase, mitochondrial; glycine cleavage system T-protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,995,595 - 32,002,470 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,995,600 - 32,002,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,IEA)
nucleoplasm  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:12297544   PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
AMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,995,595 - 32,002,470 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,995,600 - 32,002,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,416,775 - 49,422,753 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl349,416,778 - 49,422,685 (-)EnsemblGRCh38hg38GRCh38
GRCh38349,416,778 - 49,422,473 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,454,211 - 49,459,906 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,429,215 - 49,435,016 (-)NCBINCBI36hg18NCBI36
Build 34349,429,215 - 49,435,016NCBI
Celera349,418,998 - 49,424,898 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,513,933 - 49,519,839 (-)NCBIHuRef
CHM1_1349,406,978 - 49,412,879 (-)NCBICHM1_1
Amt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,174,104 - 108,179,501 (+)NCBIGRCm39mm39
GRCm39 Ensembl9108,174,052 - 108,179,501 (+)Ensembl
GRCm389108,296,905 - 108,302,302 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,296,853 - 108,302,302 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,199,253 - 108,203,928 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,155,015 - 108,159,690 (+)NCBImm8
Celera9107,905,964 - 107,910,640 (+)NCBICelera
Cytogenetic Map9F2NCBI
Amt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,981,620 - 108,988,127 (+)NCBI
Rnor_6.0 Ensembl8117,068,582 - 117,077,913 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08117,068,388 - 117,078,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08116,421,237 - 116,427,437 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,284,894 - 108,291,149 (+)NCBICelera
Cytogenetic Map8q32NCBI
Amt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,351,743 - 1,358,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,351,743 - 1,358,220 (-)NCBIChiLan1.0ChiLan1.0
AMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,589,193 - 50,594,968 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,589,193 - 50,594,968 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0349,344,590 - 49,350,383 (-)NCBIMhudiblu_PPA_v0panPan3
AMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,815,449 - 39,820,907 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,815,814 - 39,820,506 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,734,265 - 39,738,979 (+)NCBI
ROS_Cfam_1.02040,171,089 - 40,177,135 (+)NCBI
UMICH_Zoey_3.12039,539,587 - 39,544,295 (+)NCBI
UNSW_CanFamBas_1.02039,943,207 - 39,947,921 (+)NCBI
UU_Cfam_GSD_1.02040,222,791 - 40,227,505 (+)NCBI
Amt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,288,867 - 64,293,920 (-)NCBI
SpeTri2.0NW_0049365291,049,364 - 1,054,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,813,601 - 10,820,628 (-)NCBI
ChlSab1.1 Ensembl2210,814,358 - 10,819,632 (-)Ensembl
Amt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,366,023 - 3,372,266 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 2 3 1 2 23 2 2
Below cutoff 2 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000031431   ⟹   ENSSSCP00000023970
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,995,603 - 32,002,470 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000046843   ⟹   ENSSSCP00000049954
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,995,595 - 32,002,207 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000056786   ⟹   ENSSSCP00000057807
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,995,602 - 32,002,151 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000073405   ⟹   ENSSSCP00000072552
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,995,603 - 32,002,470 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000077114   ⟹   ENSSSCP00000073508
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,995,603 - 32,002,470 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000086025   ⟹   ENSSSCP00000073615
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,996,333 - 32,002,470 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000087792   ⟹   ENSSSCP00000060210
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1331,995,603 - 32,002,470 (-)Ensembl
RefSeq Acc Id: NM_001244426   ⟹   NP_001231355
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11331,995,601 - 32,002,440 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021068508   ⟹   XP_020924167
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11331,995,600 - 32,002,514 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001231355 (Get FASTA)   NCBI Sequence Viewer  
  XP_020924167 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF68432 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020924167   ⟸   XM_021068508
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001231355   ⟸   NM_001244426
- UniProtKB: I3LIR4 (UniProtKB/TrEMBL),   Q9GLL4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000072552   ⟸   ENSSSCT00000073405
RefSeq Acc Id: ENSSSCP00000023970   ⟸   ENSSSCT00000031431
RefSeq Acc Id: ENSSSCP00000073615   ⟸   ENSSSCT00000086025
RefSeq Acc Id: ENSSSCP00000049954   ⟸   ENSSSCT00000046843
RefSeq Acc Id: ENSSSCP00000057807   ⟸   ENSSSCT00000056786
RefSeq Acc Id: ENSSSCP00000073508   ⟸   ENSSSCT00000077114
RefSeq Acc Id: ENSSSCP00000060210   ⟸   ENSSSCT00000087792
Protein Domains
GCV_T   GCV_T_C


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000022975 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070003707 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000023970 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000049954 UniProtKB/TrEMBL
  ENSSSCP00000057807 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000060210 UniProtKB/TrEMBL
  ENSSSCP00000072552 UniProtKB/TrEMBL
  ENSSSCP00000073508 UniProtKB/TrEMBL
  ENSSSCP00000073615 UniProtKB/TrEMBL
  ENSSSCP00070005822 UniProtKB/TrEMBL
  ENSSSCP00070005827 UniProtKB/TrEMBL
  ENSSSCP00070005852 UniProtKB/TrEMBL
  ENSSSCP00070005854 UniProtKB/TrEMBL
  ENSSSCP00070005857 UniProtKB/TrEMBL
  ENSSSCP00070005862 UniProtKB/TrEMBL
  ENSSSCP00070005866 UniProtKB/TrEMBL
  ENSSSCP00070005869 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000031431 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000046843 UniProtKB/TrEMBL
  ENSSSCT00000056786 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000073405 UniProtKB/TrEMBL
  ENSSSCT00000077114 UniProtKB/TrEMBL
  ENSSSCT00000086025 UniProtKB/TrEMBL
  ENSSSCT00000087792 UniProtKB/TrEMBL
  ENSSSCT00070007123 UniProtKB/TrEMBL
  ENSSSCT00070007128 UniProtKB/TrEMBL
  ENSSSCT00070007154 UniProtKB/TrEMBL
  ENSSSCT00070007156 UniProtKB/TrEMBL
  ENSSSCT00070007159 UniProtKB/TrEMBL
  ENSSSCT00070007165 UniProtKB/TrEMBL
  ENSSSCT00070007169 UniProtKB/TrEMBL
  ENSSSCT00070007173 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1360.120 UniProtKB/TrEMBL
InterPro GCS_T UniProtKB/TrEMBL
  GCST/YgfZ/DmdA UniProtKB/TrEMBL
  GCV_T_C UniProtKB/TrEMBL
  GCV_T_N UniProtKB/TrEMBL
  GcvT/YgfZ_C UniProtKB/TrEMBL
  TrmE/GcvT_dom1 UniProtKB/TrEMBL
KEGG Report ssc:396679 UniProtKB/TrEMBL
NCBI Gene AMT ENTREZGENE
PANTHER PTHR43757 UniProtKB/TrEMBL
Pfam GCV_T UniProtKB/TrEMBL
  GCV_T_C UniProtKB/TrEMBL
PIRSF GcvT UniProtKB/TrEMBL
Superfamily-SCOP SSF101790 UniProtKB/TrEMBL
TIGRFAMs gcvT UniProtKB/TrEMBL
UniProt A0A287B0L3_PIG UniProtKB/TrEMBL
  A0A287BNZ7_PIG UniProtKB/TrEMBL
  A0A4X1SSW3_PIG UniProtKB/TrEMBL
  A0A4X1SSX9_PIG UniProtKB/TrEMBL
  A0A4X1SU77_PIG UniProtKB/TrEMBL
  A0A4X1SU81_PIG UniProtKB/TrEMBL
  A0A4X1SU86_PIG UniProtKB/TrEMBL
  A0A4X1SU90_PIG UniProtKB/TrEMBL
  A0A4X1SUG2_PIG UniProtKB/TrEMBL
  A0A4X1SUG8_PIG UniProtKB/TrEMBL
  A0A5G2QDT1_PIG UniProtKB/TrEMBL
  A0A5G2R8B0_PIG UniProtKB/TrEMBL
  A0A5G2RBB5_PIG UniProtKB/TrEMBL
  A0A5G2RKE1_PIG UniProtKB/TrEMBL
  I3LIR4 ENTREZGENE, UniProtKB/TrEMBL
  Q9GLL4 ENTREZGENE, UniProtKB/TrEMBL