TTLL8 (tubulin tyrosine ligase like 8) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: TTLL8 (tubulin tyrosine ligase like 8) Sus scrofa
Analyze
Symbol: TTLL8
Name: tubulin tyrosine ligase like 8
RGD ID: 13855390
Description: ENCODES a protein that exhibits protein-glycine ligase activity (inferred); protein-glycine ligase activity, initiating (inferred); INVOLVED IN cilium assembly (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); chromosome 22q13 duplication syndrome (ortholog); congenital disorder of glycosylation Ig (ortholog); FOUND IN axoneme (inferred); cilium (inferred); cytoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: protein monoglycylase TTLL8; tubulin tyrosine ligase-like family, member 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5602,886 - 629,882 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15594,614 - 645,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25110,869,422 - 110,906,449 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
axoneme  (IBA,IEA)
cilium  (IEA)
cytoplasm  (IEA)
microtubule cytoskeleton  (IBA,IEA)
sperm flagellum  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
TTLL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5602,886 - 629,882 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15594,614 - 645,705 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25110,869,422 - 110,906,449 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTLL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,018,575 - 50,058,298 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,018,575 - 50,058,298 (-)EnsemblGRCh38hg38GRCh38
GRCh372250,457,004 - 50,496,656 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362248,795,679 - 48,835,182 (-)NCBINCBI36Build 36hg18NCBI36
Celera2234,329,184 - 34,368,139 (-)NCBICelera
Cytogenetic Map22q13.33NCBI
HuRef2233,363,855 - 33,394,447 (-)NCBIHuRef
CHM1_12250,415,898 - 50,455,656 (-)NCBICHM1_1
T2T-CHM13v2.02250,523,480 - 50,564,968 (-)NCBIT2T-CHM13v2.0
Ttll8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391588,773,981 - 88,839,258 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1588,774,836 - 88,838,621 (-)EnsemblGRCm39 Ensembl
GRCm381588,889,778 - 88,955,051 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1588,890,633 - 88,954,418 (-)EnsemblGRCm38mm10GRCm38
MGSCv371588,744,328 - 88,784,848 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361588,741,664 - 88,782,176 (-)NCBIMGSCv36mm8
Celera1591,040,890 - 91,081,416 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.39NCBI
Ttll8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87121,860,192 - 121,926,344 (-)NCBIGRCr8
mRatBN7.27120,000,638 - 120,046,556 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,001,794 - 120,045,075 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.07129,906,998 - 129,948,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7129,885,383 - 129,947,991 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.07129,591,520 - 129,634,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,217,744 - 127,264,569 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,256,061 - 127,298,091 (-)NCBI
Celera7116,475,112 - 116,518,433 (-)NCBICelera
Cytogenetic Map7q34NCBI
Ttll8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541333,088,932 - 33,119,031 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541333,086,528 - 33,119,801 (-)NCBIChiLan1.0ChiLan1.0
TTLL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22359,919,250 - 59,963,604 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12262,605,653 - 62,650,091 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,242,515 - 30,286,759 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12249,249,507 - 49,296,096 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2249,245,796 - 49,286,113 (-)Ensemblpanpan1.1panPan2
TTLL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11017,165,586 - 17,237,608 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1017,164,294 - 17,213,924 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1017,143,010 - 17,191,354 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01017,892,621 - 17,940,969 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1017,904,405 - 17,940,954 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11017,616,018 - 17,664,338 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,939,369 - 17,987,716 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01018,071,340 - 18,119,662 (+)NCBIUU_Cfam_GSD_1.0
Ttll8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945720,335 - 791,758 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936629720,842 - 766,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTLL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11932,519,898 - 32,556,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1932,520,001 - 32,555,079 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604592,802,850 - 92,878,035 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttll8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624752686,043 - 694,256 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TTLL8
1496 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system hemolymphoid system nervous system reproductive system respiratory system
High
Medium
Low 4
Below cutoff 3 2 3 1 1

Sequence


RefSeq Acc Id: ENSSSCT00000001072   ⟹   ENSSSCP00000001050
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl5602,886 - 629,882 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000062630   ⟹   ENSSSCP00000056462
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl5594,221 - 647,897 (+)Ensembl
RefSeq Acc Id: XM_021091344   ⟹   XP_020947003
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.15594,614 - 645,705 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091345   ⟹   XP_020947004
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.15603,033 - 634,608 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091346   ⟹   XP_020947005
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.15609,380 - 634,608 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020947003   ⟸   XM_021091344
- Peptide Label: isoform X1
- UniProtKB: A0A8D1KGG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020947004   ⟸   XM_021091345
- Peptide Label: isoform X2
- UniProtKB: A0A8D0RDQ5 (UniProtKB/TrEMBL),   A0A8D1AT21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020947005   ⟸   XM_021091346
- Peptide Label: isoform X3
- UniProtKB: A0A8D0RDQ5 (UniProtKB/TrEMBL),   A0A8D1AT21 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001050   ⟸   ENSSSCT00000001072
RefSeq Acc Id: ENSSSCP00000056462   ⟸   ENSSSCT00000062630


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000982 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025019097 UniProtKB/TrEMBL
  ENSSSCG00035060324 UniProtKB/TrEMBL
  ENSSSCG00040057153 UniProtKB/TrEMBL
  ENSSSCG00045021621 UniProtKB/TrEMBL
  ENSSSCG00055023194 UniProtKB/TrEMBL
  ENSSSCG00065010706 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001072 ENTREZGENE
  ENSSSCT00000001072.5 UniProtKB/TrEMBL
  ENSSSCT00025026026.1 UniProtKB/TrEMBL
  ENSSSCT00035080974.1 UniProtKB/TrEMBL
  ENSSSCT00040078301.1 UniProtKB/TrEMBL
  ENSSSCT00045037395.1 UniProtKB/TrEMBL
  ENSSSCT00055046119.1 UniProtKB/TrEMBL
  ENSSSCT00065014327.1 UniProtKB/TrEMBL
Gene3D-CATH ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro TTL/TTLL_fam UniProtKB/TrEMBL
NCBI Gene TTLL8 ENTREZGENE
PANTHER PROTEIN MONOGLYCYLASE TTLL8 UniProtKB/TrEMBL
  TUBULIN MONOGLYCYLASE TTLL3 UniProtKB/TrEMBL
Pfam TTL UniProtKB/TrEMBL
PROSITE TTL UniProtKB/TrEMBL
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/TrEMBL
UniProt A0A8D0RDQ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1AT21 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1KGG8 ENTREZGENE, UniProtKB/TrEMBL
  F1RXQ1_PIG UniProtKB/TrEMBL
VGNC ID VGNC:94572 ENTREZGENE