HOGA1 (4-hydroxy-2-oxoglutarate aldolase 1) - Rat Genome Database

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Gene: HOGA1 (4-hydroxy-2-oxoglutarate aldolase 1) Sus scrofa
Analyze
Symbol: HOGA1
Name: 4-hydroxy-2-oxoglutarate aldolase 1
RGD ID: 13850049
Description: ENCODES a protein that exhibits (R,S)-4-hydroxy-2-oxoglutarate aldolase activity (inferred); lyase activity (inferred); oxo-acid-lyase activity (inferred); INVOLVED IN 4-hydroxyproline catabolic process (inferred); glyoxylate catabolic process (inferred); glyoxylate metabolic process (inferred); ASSOCIATED WITH cholestasis (ortholog); genetic disease (ortholog); primary hyperoxaluria (ortholog); FOUND IN mitochondrion (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; DHDPSL; dihydrodipicolinate synthase-like, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14108,958,973 - 108,986,707 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114108,958,812 - 108,986,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214118,462,772 - 118,490,341 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:30032202  


Genomics

Comparative Map Data
HOGA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14108,958,973 - 108,986,707 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114108,958,812 - 108,986,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214118,462,772 - 118,490,341 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HOGA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381097,584,389 - 97,612,802 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1097,584,323 - 97,612,802 (+)EnsemblGRCh38hg38GRCh38
GRCh371099,344,146 - 99,372,559 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361099,334,108 - 99,362,549 (+)NCBINCBI36Build 36hg18NCBI36
Build 341099,334,110 - 99,362,543NCBI
Celera1093,081,405 - 93,109,870 (+)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1092,970,152 - 92,998,506 (+)NCBIHuRef
CHM1_11099,625,834 - 99,654,292 (+)NCBICHM1_1
T2T-CHM13v2.01098,464,572 - 98,493,008 (+)NCBIT2T-CHM13v2.0
Hoga1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391942,033,998 - 42,060,128 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1942,034,049 - 42,059,392 (+)EnsemblGRCm39 Ensembl
GRCm381942,045,559 - 42,071,689 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1942,045,610 - 42,070,953 (+)EnsemblGRCm38mm10GRCm38
MGSCv371942,120,341 - 42,145,429 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361942,099,162 - 42,124,250 (+)NCBIMGSCv36mm8
Celera1942,849,723 - 42,874,820 (+)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1935.67NCBI
Hoga1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81250,806,430 - 250,833,544 (+)NCBIGRCr8
mRatBN7.21240,856,991 - 240,884,243 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1240,857,126 - 240,884,568 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1249,002,512 - 249,029,695 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01255,699,654 - 255,726,828 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01248,352,684 - 248,379,857 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01261,291,742 - 261,319,743 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1261,291,870 - 261,318,984 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01268,744,219 - 268,772,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41248,779,289 - 248,806,403 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11249,038,615 - 249,065,045 (-)NCBI
Celera1236,691,611 - 236,718,741 (+)NCBICelera
Cytogenetic Map1q54NCBI
Hoga1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555073,687,769 - 3,711,151 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555073,687,449 - 3,711,939 (+)NCBIChiLan1.0ChiLan1.0
HOGA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28109,496,181 - 109,524,859 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110109,501,500 - 109,531,789 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01094,204,627 - 94,233,312 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11097,697,683 - 97,726,289 (+)NCBIpanpan1.1PanPan1.1panPan2
HOGA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12810,849,037 - 10,872,238 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2810,849,046 - 10,871,853 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2811,033,727 - 11,060,294 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02811,173,637 - 11,200,481 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2811,173,896 - 11,197,428 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12810,834,716 - 10,859,086 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02810,895,424 - 10,922,168 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02811,035,386 - 11,061,987 (+)NCBIUU_Cfam_GSD_1.0
Hoga1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721336,062,068 - 36,085,956 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366362,102,036 - 2,125,532 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366362,101,184 - 2,125,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOGA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1990,745,969 - 90,772,953 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl990,746,373 - 90,773,932 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604851,644,096 - 51,671,723 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hoga1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247379,228,605 - 9,254,024 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247379,228,748 - 9,258,136 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HOGA1
764 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000011513   ⟹   ENSSSCP00000011212
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14108,959,134 - 108,986,707 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000069049   ⟹   ENSSSCP00000065596
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14108,959,134 - 108,985,534 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000073256   ⟹   ENSSSCP00000072670
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14108,958,973 - 108,986,707 (+)Ensembl
Ensembl Acc Id: ENSSSCT00000074436   ⟹   ENSSSCP00000071768
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl14108,959,139 - 108,978,204 (+)Ensembl
RefSeq Acc Id: NM_001190169   ⟹   NP_001177098
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.114108,958,812 - 108,986,373 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001177098   ⟸   NM_001190169
- UniProtKB: A0A4X1UAM4 (UniProtKB/TrEMBL),   A0A8D0WBW8 (UniProtKB/TrEMBL),   A0A8D0TM74 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000071768   ⟸   ENSSSCT00000074436
Ensembl Acc Id: ENSSSCP00000011212   ⟸   ENSSSCT00000011513
Ensembl Acc Id: ENSSSCP00000065596   ⟸   ENSSSCT00000069049
Ensembl Acc Id: ENSSSCP00000072670   ⟸   ENSSSCT00000073256


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010523 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005046028 UniProtKB/TrEMBL
  ENSSSCG00015017348 UniProtKB/TrEMBL
  ENSSSCG00025075243 UniProtKB/TrEMBL
  ENSSSCG00030029725 UniProtKB/TrEMBL
  ENSSSCG00035017622 UniProtKB/TrEMBL
  ENSSSCG00040039086 UniProtKB/TrEMBL
  ENSSSCG00045006055 UniProtKB/TrEMBL
  ENSSSCG00050071817 UniProtKB/TrEMBL
  ENSSSCG00055018939 UniProtKB/TrEMBL
  ENSSSCG00060035861 UniProtKB/TrEMBL
  ENSSSCG00065021045 UniProtKB/TrEMBL
  ENSSSCG00070015284 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011513 ENTREZGENE
  ENSSSCT00000011513.5 UniProtKB/TrEMBL
  ENSSSCT00000073256.2 UniProtKB/TrEMBL
  ENSSSCT00000074436.2 UniProtKB/TrEMBL
  ENSSSCT00005074580.1 UniProtKB/TrEMBL
  ENSSSCT00005074582.1 UniProtKB/TrEMBL
  ENSSSCT00005074583.1 UniProtKB/TrEMBL
  ENSSSCT00015022866.1 UniProtKB/TrEMBL
  ENSSSCT00015022978.1 UniProtKB/TrEMBL
  ENSSSCT00015023056.1 UniProtKB/TrEMBL
  ENSSSCT00015023185.1 UniProtKB/TrEMBL
  ENSSSCT00015023254.1 UniProtKB/TrEMBL
  ENSSSCT00025103751.1 UniProtKB/TrEMBL
  ENSSSCT00025103812.1 UniProtKB/TrEMBL
  ENSSSCT00025103845.1 UniProtKB/TrEMBL
  ENSSSCT00025103876.1 UniProtKB/TrEMBL
  ENSSSCT00030041325.1 UniProtKB/TrEMBL
  ENSSSCT00035022667.1 UniProtKB/TrEMBL
  ENSSSCT00035022670.1 UniProtKB/TrEMBL
  ENSSSCT00035022678.1 UniProtKB/TrEMBL
  ENSSSCT00035022687.1 UniProtKB/TrEMBL
  ENSSSCT00040052294.1 UniProtKB/TrEMBL
  ENSSSCT00040052345.1 UniProtKB/TrEMBL
  ENSSSCT00040052399.1 UniProtKB/TrEMBL
  ENSSSCT00040052463.1 UniProtKB/TrEMBL
  ENSSSCT00045010064.1 UniProtKB/TrEMBL
  ENSSSCT00045010083.1 UniProtKB/TrEMBL
  ENSSSCT00045010094.1 UniProtKB/TrEMBL
  ENSSSCT00045010101.1 UniProtKB/TrEMBL
  ENSSSCT00050097998.1 UniProtKB/TrEMBL
  ENSSSCT00055037096.1 UniProtKB/TrEMBL
  ENSSSCT00055037196.1 UniProtKB/TrEMBL
  ENSSSCT00055037273.1 UniProtKB/TrEMBL
  ENSSSCT00055037352.1 UniProtKB/TrEMBL
  ENSSSCT00060048587.1 UniProtKB/TrEMBL
  ENSSSCT00060048592.1 UniProtKB/TrEMBL
  ENSSSCT00060048599.1 UniProtKB/TrEMBL
  ENSSSCT00060048602.1 UniProtKB/TrEMBL
  ENSSSCT00065028003.1 UniProtKB/TrEMBL
  ENSSSCT00065028008.1 UniProtKB/TrEMBL
  ENSSSCT00065028013.1 UniProtKB/TrEMBL
  ENSSSCT00070030022.1 UniProtKB/TrEMBL
  ENSSSCT00070030032.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  DapA-like UniProtKB/TrEMBL
  Schiff_base-form_aldolases_AS UniProtKB/TrEMBL
KEGG Report ssc:100153961 UniProtKB/TrEMBL
NCBI Gene HOGA1 ENTREZGENE
PANTHER 4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR12128 UniProtKB/TrEMBL
Pfam DHDPS UniProtKB/TrEMBL
PIRSF DHDPS UniProtKB/TrEMBL
PRINTS DHPICSNTHASE UniProtKB/TrEMBL
PROSITE DHDPS_2 UniProtKB/TrEMBL
SMART DHDPS UniProtKB/TrEMBL
Superfamily-SCOP Aldolase UniProtKB/TrEMBL
UniProt A0A4X1UA32_PIG UniProtKB/TrEMBL
  A0A4X1UAM4 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2RDV5_PIG UniProtKB/TrEMBL
  A0A8D0MA82_PIG UniProtKB/TrEMBL
  A0A8D0TM74 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0WBW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1R8Y1_PIG UniProtKB/TrEMBL
  A0A8D1V7Z3_PIG UniProtKB/TrEMBL
  A0A8D2C1H7_PIG UniProtKB/TrEMBL
  F1S8X9_PIG UniProtKB/TrEMBL
UniProt Secondary A0A5G2R3I9 UniProtKB/TrEMBL
VGNC ID VGNC:88927 ENTREZGENE