PLK1 (polo like kinase 1) - Rat Genome Database

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Gene: PLK1 (polo like kinase 1) Sus scrofa
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Symbol: PLK1
Name: polo like kinase 1
RGD ID: 13849992
Description: ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN establishment of protein localization (ortholog); female meiosis chromosome segregation (ortholog); homologous chromosome segregation (ortholog); ASSOCIATED WITH breast carcinoma (ortholog); COVID-19 (ortholog); endometriosis (ortholog); FOUND IN centrosome (ortholog); chromosome, centromeric region (ortholog); condensed chromosome, centromeric region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: polo-like protein kinase; serine/threonine-protein kinase PLK1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl322,537,816 - 22,555,023 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1322,537,814 - 22,550,901 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
centrosome cycle  (IEA)
establishment of mitotic spindle orientation  (IEA)
establishment of protein localization  (IEA,ISO)
female meiosis chromosome segregation  (IEA,ISO)
G2/M transition of mitotic cell cycle  (IEA)
homologous chromosome segregation  (IEA,ISO)
microtubule bundle formation  (IEA)
mitotic cell cycle  (IBA)
mitotic cytokinesis  (IEA)
mitotic G2 DNA damage checkpoint signaling  (IEA)
mitotic sister chromatid segregation  (IEA)
mitotic spindle assembly checkpoint signaling  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
nuclear membrane disassembly  (IEA)
peptidyl-serine phosphorylation  (IEA,ISO)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (IEA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of proteolysis  (ISO)
positive regulation of ubiquitin protein ligase activity  (IEA)
positive regulation of ubiquitin-protein transferase activity  (ISO)
protein destabilization  (IEA)
protein localization to chromatin  (IEA)
protein localization to nuclear envelope  (IEA)
protein localization to organelle  (ISO)
protein phosphorylation  (ISO)
protein ubiquitination  (IEA)
regulation of cytokinesis  (IBA)
regulation of mitotic cell cycle  (ISO)
regulation of mitotic metaphase/anaphase transition  (ISO)
regulation of mitotic spindle assembly  (IEA)
regulation of protein binding  (IEA,ISO)
regulation of protein localization to cell cortex  (IEA)
response to antibiotic  (ISO)
synaptonemal complex disassembly  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:15278898   PMID:26820885   PMID:28074435   PMID:28851440  


Genomics

Comparative Map Data
PLK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl322,537,816 - 22,555,023 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1322,537,814 - 22,550,901 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1623,677,656 - 23,690,367 (+)EnsemblGRCh38hg38GRCh38
GRCh381623,678,889 - 23,690,367 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371623,690,210 - 23,701,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,597,702 - 23,609,189 (+)NCBINCBI36hg18NCBI36
Build 341623,597,701 - 23,609,191NCBI
Celera1622,468,373 - 22,479,857 (+)NCBI
Cytogenetic Map16p12.2NCBI
HuRef1621,779,829 - 21,791,312 (+)NCBIHuRef
CHM1_11624,701,920 - 24,713,407 (+)NCBICHM1_1
Plk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,758,658 - 121,769,107 (+)NCBIGRCm39mm39
GRCm39 Ensembl7121,758,662 - 121,769,096 (+)Ensembl
GRCm387122,159,435 - 122,169,884 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7122,159,439 - 122,169,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv377129,302,951 - 129,313,389 (+)NCBIGRCm37mm9NCBIm37
MGSCv367121,950,641 - 121,961,011 (+)NCBImm8
Celera7122,049,692 - 122,060,205 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.52NCBI
Plk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21176,716,420 - 176,726,400 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1176,716,420 - 176,726,400 (+)Ensembl
Rnor_6.01192,115,990 - 192,125,969 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1192,115,966 - 192,125,989 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01199,178,259 - 199,188,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41181,002,811 - 181,012,741 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11181,142,728 - 181,152,656 (+)NCBI
Celera1174,424,809 - 174,434,922 (+)NCBICelera
Cytogenetic Map1q36NCBI
Plk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554932,206,353 - 2,217,231 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554932,206,353 - 2,217,231 (+)NCBIChiLan1.0ChiLan1.0
PLK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11623,928,773 - 23,940,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1623,928,773 - 23,940,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01614,420,972 - 14,432,821 (-)NCBIMhudiblu_PPA_v0panPan3
PLK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1622,165,338 - 22,176,847 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl622,165,338 - 22,176,441 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha623,732,161 - 23,743,926 (-)NCBI
ROS_Cfam_1.0622,309,120 - 22,320,926 (-)NCBI
UMICH_Zoey_3.1622,112,754 - 22,124,540 (-)NCBI
UNSW_CanFamBas_1.0622,014,857 - 22,026,662 (-)NCBI
UU_Cfam_GSD_1.0622,410,301 - 22,422,125 (-)NCBI
Plk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344120,223,455 - 120,234,564 (+)NCBI
SpeTri2.0NW_0049365018,321,415 - 8,332,414 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,388,957 - 21,408,574 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl521,396,204 - 21,410,718 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660688,388,349 - 8,407,454 (-)NCBIVero_WHO_p1.0
Plk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247828,811,593 - 8,823,060 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1
Low 9 2 4 3 2 3
Below cutoff 1 3 1 15 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000022635   ⟹   ENSSSCP00000023889
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl322,537,816 - 22,555,023 (-)Ensembl
RefSeq Acc Id: XM_021086465   ⟹   XP_020942124
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1322,537,814 - 22,550,895 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002342378
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1322,537,814 - 22,550,901 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020942124 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK28550 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020942124   ⟸   XM_021086465
- Sequence:
RefSeq Acc Id: ENSSSCP00000023889   ⟸   ENSSSCT00000022635
Protein Domains
POLO box   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026748 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000023889 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000022635 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 3.30.1120.30 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  PLK1_cat UniProtKB/TrEMBL
  POLO_box_1 UniProtKB/TrEMBL
  POLO_box_2 UniProtKB/TrEMBL
  POLO_box_dom UniProtKB/TrEMBL
  POLO_box_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene PLK1 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
  POLO_box UniProtKB/TrEMBL
PROSITE POLO_BOX UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt I3LII4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:91562 ENTREZGENE