ACTN3 (actinin alpha 3) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: ACTN3 (actinin alpha 3) Sus scrofa
Analyze
Symbol: ACTN3
Name: actinin alpha 3
RGD ID: 13849689
Description: ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); calcium ion binding (inferred); INVOLVED IN muscle contraction (ortholog); osteoblast differentiation (ortholog); regulation of aerobic respiration (ortholog); ASSOCIATED WITH familial temporal lobe epilepsy 8 (ortholog); intellectual disability (ortholog); FOUND IN sarcomere (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: alpha-actinin-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,858,845 - 5,874,124 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,860,386 - 5,873,779 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.224,936,279 - 4,949,682 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
brush border  (IEA)
focal adhesion  (IEA)
sarcomere  (ISO)
Z disc  (IEA)

Molecular Function

References

Genomics

Comparative Map Data
ACTN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl25,858,845 - 5,874,124 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.125,860,386 - 5,873,779 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.224,936,279 - 4,949,682 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACTN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1166,546,395 - 66,563,334 (+)EnsemblGRCh38hg38GRCh38
GRCh381166,546,395 - 66,563,334 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371166,313,866 - 66,330,805 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361166,070,967 - 66,087,373 (+)NCBINCBI36hg18NCBI36
Build 341166,070,966 - 66,087,373NCBI
Celera1163,634,667 - 63,651,076 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1162,641,774 - 62,658,713 (+)NCBIHuRef
CHM1_11166,197,591 - 66,214,533 (+)NCBICHM1_1
Actn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,911,244 - 4,927,937 (-)NCBIGRCm39mm39
GRCm39 Ensembl194,911,244 - 4,927,937 (-)Ensembl
GRCm38194,861,216 - 4,877,909 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,861,216 - 4,877,909 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,861,223 - 4,877,884 (-)NCBIGRCm37mm9NCBIm37
MGSCv36194,861,223 - 4,877,884 (-)NCBImm8
Celera194,732,270 - 4,748,828 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.12NCBI
Actn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21202,159,081 - 202,175,012 (-)NCBI
Rnor_6.0 Ensembl1220,120,533 - 220,136,470 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01220,120,532 - 220,136,460 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01227,051,530 - 227,067,458 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41207,475,569 - 207,492,267 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11207,629,022 - 207,645,720 (-)NCBI
Celera1199,698,703 - 199,714,632 (-)NCBICelera
Cytogenetic Map1q43NCBI
Actn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542218,799,372 - 18,812,711 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542218,799,372 - 18,812,458 (-)NCBIChiLan1.0ChiLan1.0
ACTN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11165,229,043 - 65,245,429 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1165,228,713 - 65,245,429 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01161,905,722 - 61,922,227 (+)NCBIMhudiblu_PPA_v0panPan3
ACTN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11850,787,353 - 50,801,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1850,787,353 - 50,801,197 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1849,396,057 - 49,409,780 (-)NCBI
ROS_Cfam_1.01851,819,196 - 51,832,924 (-)NCBI
UMICH_Zoey_3.11850,920,215 - 50,933,937 (-)NCBI
UNSW_CanFamBas_1.01850,500,258 - 50,513,996 (-)NCBI
UU_Cfam_GSD_1.01851,290,188 - 51,303,909 (-)NCBI
Actn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049476,591,510 - 6,604,021 (-)NCBI
SpeTri2.0NW_0049365993,033,854 - 3,046,364 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTN3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.117,708,595 - 7,724,634 (-)NCBI
ChlSab1.1 Ensembl17,705,725 - 7,724,589 (-)Ensembl
Vero_WHO_p1.0NW_023666038104,992,438 - 105,008,258 (-)NCBI
Actn3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476719,844,996 - 19,859,274 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system musculoskeletal system nervous system
High 2
Medium
Low
Below cutoff 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000014141   ⟹   ENSSSCP00000013755
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl25,860,395 - 5,873,737 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000014153   ⟹   ENSSSCP00000013767
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl25,860,391 - 5,874,124 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000071841   ⟹   ENSSSCP00000073196
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl25,858,845 - 5,873,739 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000081024   ⟹   ENSSSCP00000067659
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl25,860,401 - 5,873,736 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000088276   ⟹   ENSSSCP00000073454
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl25,858,845 - 5,873,739 (-)Ensembl
RefSeq Acc Id: XM_003122492   ⟹   XP_003122540
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.125,860,386 - 5,873,779 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005660645   ⟹   XP_005660702
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.125,860,386 - 5,873,760 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003122540 (Get FASTA)   NCBI Sequence Viewer  
  XP_005660702 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003122540   ⟸   XM_003122492
- Peptide Label: isoform X2
- UniProtKB: F1RU49 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005660702   ⟸   XM_005660645
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000073454   ⟸   ENSSSCT00000088276
RefSeq Acc Id: ENSSSCP00000067659   ⟸   ENSSSCT00000081024
RefSeq Acc Id: ENSSSCP00000073196   ⟸   ENSSSCT00000071841
RefSeq Acc Id: ENSSSCP00000013755   ⟸   ENSSSCT00000014141
RefSeq Acc Id: ENSSSCP00000013767   ⟸   ENSSSCT00000014153
Protein Domains
Calponin-homology (CH)   EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038323 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000013755 UniProtKB/TrEMBL
  ENSSSCP00000013767 UniProtKB/TrEMBL
  ENSSSCP00000067659 UniProtKB/TrEMBL
  ENSSSCP00000073196 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000073454 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000014141 UniProtKB/TrEMBL
  ENSSSCT00000014153 UniProtKB/TrEMBL
  ENSSSCT00000071841 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000081024 UniProtKB/TrEMBL
  ENSSSCT00000088276 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL
  EF-hand_Ca_insen UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/TrEMBL
KEGG Report ssc:100519531 UniProtKB/TrEMBL
NCBI Gene ACTN3 ENTREZGENE
Pfam EFhand_Ca_insen UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  Spectrin UniProtKB/TrEMBL
PROSITE ACTININ_1 UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SPEC UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
UniProt A0A480REY2_PIG UniProtKB/TrEMBL
  A0A5G2QU26_PIG UniProtKB/TrEMBL
  A0A5G2RET9_PIG UniProtKB/TrEMBL
  F1RU49 ENTREZGENE, UniProtKB/TrEMBL
  F1RUT3_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96785 ENTREZGENE