E2F6 (E2F transcription factor 6) - Rat Genome Database

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Gene: E2F6 (E2F transcription factor 6) Sus scrofa
Analyze
Symbol: E2F6
Name: E2F transcription factor 6
RGD ID: 13849204
Description: ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN regulation of DNA-templated transcription (ortholog); regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH genetic disease (ortholog); lung non-small cell carcinoma (ortholog); schizophrenia (ortholog); FOUND IN MLL1 complex (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcription factor E2F6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3125,249,269 - 125,271,037 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13125,248,232 - 125,271,039 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23134,011,073 - 134,023,696 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
E2F6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3125,249,269 - 125,271,037 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13125,248,232 - 125,271,039 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23134,011,073 - 134,023,696 (+)NCBISscrofa10.2Sscrofa10.2susScr3
E2F6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38211,444,375 - 11,466,161 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl211,444,375 - 11,466,177 (-)EnsemblGRCh38hg38GRCh38
GRCh37211,584,501 - 11,606,287 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36211,501,952 - 11,523,748 (-)NCBINCBI36Build 36hg18NCBI36
Celera211,501,299 - 11,523,094 (-)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef211,434,688 - 11,456,488 (-)NCBIHuRef
CHM1_1211,514,147 - 11,535,955 (-)NCBICHM1_1
T2T-CHM13v2.0211,477,385 - 11,499,173 (-)NCBIT2T-CHM13v2.0
E2f6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391216,860,932 - 16,876,753 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1216,860,964 - 16,889,743 (+)EnsemblGRCm39 Ensembl
GRCm381216,810,909 - 16,826,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1216,810,963 - 16,839,742 (+)EnsemblGRCm38mm10GRCm38
MGSCv371216,817,771 - 16,833,558 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361216,836,508 - 16,852,232 (+)NCBIMGSCv36mm8
Celera1217,134,343 - 17,150,005 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map128.04NCBI
E2f6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8645,320,993 - 45,337,437 (+)NCBIGRCr8
mRatBN7.2639,592,224 - 39,608,685 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl639,592,228 - 39,608,683 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx639,925,167 - 39,941,452 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0640,239,874 - 40,256,158 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0639,673,145 - 39,689,432 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0642,092,513 - 42,108,692 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl642,092,467 - 42,108,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0651,811,952 - 51,828,133 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4640,494,286 - 40,534,152 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1640,497,319 - 40,506,745 (+)NCBI
Celera638,900,917 - 38,917,081 (+)NCBICelera
Cytogenetic Map6q16NCBI
E2f6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554876,011,798 - 6,029,501 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554876,014,476 - 6,029,090 (-)NCBIChiLan1.0ChiLan1.0
E2F6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212115,060,801 - 115,085,200 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A115,066,683 - 115,089,189 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A11,429,887 - 11,452,080 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A11,577,950 - 11,599,732 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A11,577,950 - 11,599,732 (-)Ensemblpanpan1.1panPan2
E2F6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1178,156,535 - 8,178,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl178,157,723 - 8,170,941 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha178,087,626 - 8,109,839 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0178,259,457 - 8,281,868 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl178,260,522 - 8,281,856 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1178,144,343 - 8,166,581 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0178,148,116 - 8,170,364 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0178,167,391 - 8,189,717 (-)NCBIUU_Cfam_GSD_1.0
E2f6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629252,601,479 - 52,619,669 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365327,356,510 - 7,375,536 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365327,356,525 - 7,375,173 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
E2F6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11496,152,374 - 96,172,783 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1496,152,649 - 96,173,708 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604516,080,626 - 16,118,693 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
E2f6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,399,077 - 4,412,422 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248654,399,056 - 4,412,131 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in E2F6
1400 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2
Low 10 4 3 5 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000028641   ⟹   ENSSSCP00000022506
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl3125,249,269 - 125,271,037 (+)Ensembl
RefSeq Acc Id: XM_005655271   ⟹   XP_005655328
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13125,248,244 - 125,271,039 (+)NCBI
Sequence:
RefSeq Acc Id: XR_002342859
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.13125,248,232 - 125,271,039 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005655328 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000022506.1
Reference Protein Sequences
RefSeq Acc Id: XP_005655328   ⟸   XM_005655271
- Sequence:
RefSeq Acc Id: ENSSSCP00000022506   ⟸   ENSSSCT00000028641
Protein Domains
E2F/DP family winged-helix DNA-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000026161 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000028641 ENTREZGENE
  ENSSSCT00000028641.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  6.10.250.540 UniProtKB/TrEMBL
InterPro E2F UniProtKB/TrEMBL
  E2F-DP_heterodim UniProtKB/TrEMBL
  E2F_CC-MB UniProtKB/TrEMBL
  E2F_WHTH_DNA-bd_dom UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene E2F6 ENTREZGENE
PANTHER PTHR12081 UniProtKB/TrEMBL
  PTHR12081:SF19 UniProtKB/TrEMBL
Pfam E2F_CC-MB UniProtKB/TrEMBL
  E2F_TDP UniProtKB/TrEMBL
SMART E2F_TDP UniProtKB/TrEMBL
Superfamily-SCOP SSF144074 UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt I3LEL8_PIG UniProtKB/TrEMBL
VGNC ID VGNC:87517 ENTREZGENE