COX4I2 (cytochrome c oxidase subunit 4I2) - Rat Genome Database

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Gene: COX4I2 (cytochrome c oxidase subunit 4I2) Sus scrofa
Analyze
Symbol: COX4I2
Name: cytochrome c oxidase subunit 4I2
RGD ID: 13845454
Description: ENCODES a protein that exhibits cytochrome-c oxidase activity (inferred); INVOLVED IN cellular response to hypoxia (ortholog); ASSOCIATED WITH Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, and Calvarial Hyperostosis (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred); mitochondrial inner membrane (inferred); mitochondrial membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cytochrome c oxidase subunit 4 isoform 2, mitochondrial; LOC110257420
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,341,889 - 35,346,090 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,340,499 - 35,346,090 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
COX4I2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,341,889 - 35,346,090 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,340,499 - 35,346,090 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
COX4I2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382031,637,912 - 31,645,006 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2031,637,912 - 31,645,006 (+)EnsemblGRCh38hg38GRCh38
GRCh372030,225,715 - 30,232,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362029,689,352 - 29,696,461 (+)NCBINCBI36Build 36hg18NCBI36
Build 342029,689,351 - 29,696,461NCBI
Celera2026,982,036 - 26,989,145 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,014,417 - 27,021,500 (+)NCBIHuRef
CHM1_12030,129,576 - 30,136,686 (+)NCBICHM1_1
T2T-CHM13v2.02033,362,179 - 33,369,276 (+)NCBIT2T-CHM13v2.0
Cox4i2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,596,093 - 152,606,957 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,596,093 - 152,606,957 (+)EnsemblGRCm39 Ensembl
GRCm382152,753,916 - 152,765,039 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,754,173 - 152,765,037 (+)EnsemblGRCm38mm10GRCm38
MGSCv372152,579,909 - 152,590,773 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,445,614 - 152,456,478 (+)NCBIMGSCv36mm8
Celera2158,570,176 - 158,581,023 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Cox4i2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,686,193 - 161,699,605 (+)NCBIGRCr8
mRatBN7.23141,228,443 - 141,239,337 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,228,443 - 141,239,331 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,133,387 - 145,144,280 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,717,214 - 153,728,105 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,456,966 - 151,467,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,234,546 - 148,245,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,234,193 - 148,245,416 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03154,637,397 - 154,648,541 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,103,348 - 143,114,236 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,008,969 - 143,019,858 (+)NCBI
Celera3139,977,862 - 139,988,751 (+)NCBICelera
Cytogenetic Map3q41NCBI
LOC102018506
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542229,320,720 - 29,329,127 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542229,320,720 - 29,329,082 (-)NCBIChiLan1.0ChiLan1.0
LOC100980404
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,324,893 - 37,338,299 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,318,011 - 37,331,411 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02027,927,883 - 27,935,305 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12029,060,321 - 29,067,448 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,061,447 - 29,067,440 (+)Ensemblpanpan1.1panPan2
COX4I2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,122,033 - 21,128,368 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,120,213 - 21,128,320 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2420,769,248 - 20,775,512 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02421,808,912 - 21,815,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,809,986 - 21,815,167 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,086,709 - 21,092,973 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,191,943 - 21,198,224 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,622,189 - 21,628,661 (+)NCBIUU_Cfam_GSD_1.0
LOC101956526
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,200,494 - 170,207,563 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493648518,631,826 - 18,637,675 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX4I2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,031,595 - 36,041,419 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,032,458 - 36,041,504 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,877,032 - 90,886,826 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101714003
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741850,551 - 861,313 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741852,104 - 863,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in COX4I2
138 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 3 2 1 1
Low 9 1 3 3 1 22 1 2 1
Below cutoff 1 1

Sequence


RefSeq Acc Id: ENSSSCT00000050736   ⟹   ENSSSCP00000038657
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1735,341,889 - 35,346,090 (+)Ensembl
RefSeq Acc Id: XM_021077841   ⟹   XP_020933500
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11735,340,499 - 35,346,090 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021077842   ⟹   XP_020933501
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11735,340,499 - 35,346,090 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021077843   ⟹   XP_020933502
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11735,340,499 - 35,346,090 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020933500 (Get FASTA)   NCBI Sequence Viewer  
  XP_020933501 (Get FASTA)   NCBI Sequence Viewer  
  XP_020933502 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSSCP00000038657
  ENSSSCP00000038657.1
  ENSSSCP00005024020.1
  ENSSSCP00040012896.1
RefSeq Acc Id: XP_020933502   ⟸   XM_021077843
- Peptide Label: isoform X3
- UniProtKB: A0A8D1DVU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020933500   ⟸   XM_021077841
- Peptide Label: isoform X1
- UniProtKB: A0A287A440 (UniProtKB/TrEMBL),   A0A8D0LPM5 (UniProtKB/TrEMBL),   A0A8D1DVU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020933501   ⟸   XM_021077842
- Peptide Label: isoform X2
- UniProtKB: A0A8D1DVU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000038657   ⟸   ENSSSCT00000050736


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000038384 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005024628 UniProtKB/TrEMBL
  ENSSSCG00040023098 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000050736 ENTREZGENE
  ENSSSCT00000050736.3 UniProtKB/TrEMBL
  ENSSSCT00005039122.1 UniProtKB/TrEMBL
  ENSSSCT00040030980.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.442.10 UniProtKB/TrEMBL
InterPro Cyt_c_oxidase_su4 UniProtKB/TrEMBL
  Cyt_c_oxidase_su4_fam UniProtKB/TrEMBL
  Cyt_c_oxidase_su4_sf UniProtKB/TrEMBL
NCBI Gene LOC110257420 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR10707 UniProtKB/TrEMBL
Pfam COX4 UniProtKB/TrEMBL
PRINTS CYTCOXIDASE4 UniProtKB/TrEMBL
Superfamily-SCOP SSF81406 UniProtKB/TrEMBL
UniProt A0A287A440 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0LPM5 ENTREZGENE
  A0A8D1DVU4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A8D0LPM5 UniProtKB/TrEMBL
VGNC ID VGNC:95794 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-04 COX4I2  cytochrome c oxidase subunit 4I2  LOC110257420  cytochrome c oxidase subunit 4 isoform 2, mitochondrial  Symbol and/or name change 5135510 APPROVED