Dock8<sup>m1Ztm</sup> (dedicator of cytokinesis 8;mutant 1, Ztm) - Rat Genome Database

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Gene: Dock8m1Ztm (dedicator of cytokinesis 8;mutant 1, Ztm) Rattus norvegicus
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Symbol: Dock8m1Ztm
Name: dedicator of cytokinesis 8;mutant 1, Ztm
RGD ID: 13830868
Description: A spontaneous mutation from C to G in Dock8 in exon 44 at position 228, 622, 763 (RGSC Genome Assembly v3.4) on RNO1 was identified. This mutation caused the change of glutamine to glutamate (Q1864E). The mutation is located in β4 of the DOCK homology region (DHR)-2 involved in CDC42 binding.
ASSOCIATED WITH type 1 diabetes mellitus
Type: allele  of Dock8  
Previously known as: Dock8^[m1Ztm]
Is Marker For: Strains:   LEW.1AR1-iddm/Ztm  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes. Arndt T, etal., Diabetologia. 2015 Dec;58(12):2800-9. doi: 10.1007/s00125-015-3757-7. Epub 2015 Sep 12.

Genomics


Related Rat Strains
The following Strains have been annotated to Dock8m1Ztm
LEW.1AR1-iddm/Ztm    


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences


Additional Information