Lefty2 (Left-right determination factor 2) - Rat Genome Database

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Gene: Lefty2 (Left-right determination factor 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Lefty2
Name: Left-right determination factor 2
RGD ID: 1359679
Description: Predicted to enable cytokine activity. Predicted to be involved in anterior/posterior axis specification. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human LEFTY1 (left-right determination factor 1) and LEFTY2 (left-right determination factor 2); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ebaf2; endometrial bleeding associated factor
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81395,147,139 - 95,151,657 (+)NCBIGRCr8
mRatBN7.21392,610,185 - 92,620,918 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,615,360 - 92,619,880 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1395,120,680 - 95,125,196 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01396,520,608 - 96,525,125 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01393,695,310 - 93,699,826 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01399,173,484 - 99,178,037 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1399,173,484 - 99,178,037 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013104,172,508 - 104,176,284 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,621,422 - 96,626,509 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,810,357 - 96,815,445 (+)NCBI
Celera1392,160,323 - 92,164,628 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation and function of LEFTY-A/EBAF in the human endometrium. mRNA expression during the menstrual cycle, control by progesterone, and effect on matrix metalloprotineases. Cornet PB, etal., J Biol Chem 2002 Nov 8;277(45):42496-504. Epub 2002 Sep 4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Meno C, etal., Genes Cells 1997 Aug;2(8):513-24.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Dysregulated expression of ebaf, a novel molecular defect in the endometria of patients with infertility. Tabibzadeh S, etal., J Clin Endocrinol Metab. 2000 Jul;85(7):2526-36.
11. Circular RNA CREBBP Suppresses Hepatic Fibrosis Via Targeting the hsa-miR-1291/LEFTY2 Axis. Yang YR, etal., Front Pharmacol. 2021 Nov 22;12:741151. doi: 10.3389/fphar.2021.741151. eCollection 2021.
Additional References at PubMed
PMID:17507784   PMID:21205391   PMID:31418961   PMID:32745796   PMID:34737126  


Genomics

Variants

.
Variants in Lefty2
19 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 105 82 81 50 25 50 6 206 97 85 42 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000080574   ⟹   ENSRNOP00000071113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1399,173,484 - 99,178,037 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088654   ⟹   ENSRNOP00000074915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1392,615,360 - 92,619,880 (+)Ensembl
Rnor_6.0 Ensembl1399,173,548 - 99,177,808 (+)Ensembl
RefSeq Acc Id: NM_001007556   ⟹   NP_001007557
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81395,147,139 - 95,151,657 (+)NCBI
mRatBN7.21392,615,360 - 92,619,880 (+)NCBI
Rnor_6.01399,173,484 - 99,178,037 (+)NCBI
Rnor_5.013104,172,508 - 104,176,284 (+)NCBI
RGSC_v3.41396,621,422 - 96,626,509 (+)RGD
Celera1392,160,323 - 92,164,628 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001007557 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAV31601 (Get FASTA)   NCBI Sequence Viewer  
  EDL94836 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074915.2
RefSeq Acc Id: NP_001007557   ⟸   NM_001007556
- Peptide Label: precursor
- UniProtKB: Q5UCE3 (UniProtKB/TrEMBL),   A0A0G2K998 (UniProtKB/TrEMBL),   A0A9K3Y743 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071113   ⟸   ENSRNOT00000080574
Ensembl Acc Id: ENSRNOP00000074915   ⟸   ENSRNOT00000088654
Protein Domains
TGF-beta family profile

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359679 AgrOrtholog
BioCyc Gene G2FUF-17110 BioCyc
Ensembl Genes ENSRNOG00000060325 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000088654.2 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGFb UniProtKB/TrEMBL
  TGFb4 UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
  TGFb_N UniProtKB/TrEMBL
  TGFbeta UniProtKB/TrEMBL
KEGG Report rno:289316 UniProtKB/TrEMBL
NCBI Gene 289316 ENTREZGENE
PANTHER LEFT-RIGHT DETERMINATION FACTOR 2 UniProtKB/TrEMBL
  TGFbeta UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PhenoGen Lefty2 PhenoGen
PIRSF TGFb4 UniProtKB/TrEMBL
PRINTS TGFBETA4 UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000060325 RatGTEx
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A0G2K998 ENTREZGENE
  A0A9K3Y743 ENTREZGENE, UniProtKB/TrEMBL
  Q5UCE3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2K998 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Lefty2  Left-right determination factor 2  Ebaf2  endometrial bleeding associated factor  Symbol and Name updated 1299863 APPROVED
2005-07-29 Ebaf2  endometrial bleeding associated factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression strongly expressed on the left side of the lateral plate mesoderm during embryonic development 1549577
gene_function human homolog may also be involved in control of endometrial breakdown and bleeding during menstruation 1556734