Prps1l3 (phosphoribosyl pyrophosphate synthetase 1-like 3) - Rat Genome Database

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Gene: Prps1l3 (phosphoribosyl pyrophosphate synthetase 1-like 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prps1l3 (Ensembl: LOC314140)
Name: phosphoribosyl pyrophosphate synthetase 1-like 3 (Ensembl:ribose-phosphate pyrophosphokinase I -like)
RGD ID: 1359636
Description: Predicted to enable ATP binding activity; protein homodimerization activity; and ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC314140; ribose-phosphate pyrophosphokinase 1; ribose-phosphate pyrophosphokinase I -like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8680,490,353 - 80,498,539 (+)NCBIGRCr8
mRatBN7.2674,755,331 - 74,763,493 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl674,755,310 - 74,766,465 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx675,174,695 - 75,182,842 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0675,474,007 - 75,482,154 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0674,901,490 - 74,909,637 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0678,172,762 - 78,181,608 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl678,172,762 - 78,180,924 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0687,689,010 - 87,697,170 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4677,685,499 - 77,693,687 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1677,688,624 - 77,696,789 (+)NCBI
Celera673,554,016 - 73,562,177 (+)NCBICelera
Cytogenetic Map6q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Genomics

Variants

.
Variants in Prps1l3
11 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)67222764181132889Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat

Markers in Region
RH143437  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2674,754,168 - 74,754,373 (+)MAPPERmRatBN7.2
Rnor_6.0678,171,601 - 78,171,805NCBIRnor6.0
Rnor_5.0687,687,649 - 87,687,853UniSTSRnor5.0
RGSC_v3.4677,684,338 - 77,684,542UniSTSRGSC3.4
Celera673,552,855 - 73,553,059UniSTS
RH 3.4 Map6528.39UniSTS
Cytogenetic Map6q23UniSTS
RH143688  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2674,763,566 - 74,763,712 (+)MAPPERmRatBN7.2
Rnor_6.0678,180,996 - 78,181,141NCBIRnor6.0
Rnor_5.0687,697,242 - 87,697,387UniSTSRnor5.0
RGSC_v3.4677,693,735 - 77,693,880UniSTSRGSC3.4
Celera673,562,250 - 73,562,395UniSTS
RH 3.4 Map6541.8UniSTS
Cytogenetic Map6q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 24 55 41 19 41 47 33 39 11
Low 19 2 8 11 27 2 2 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000083110   ⟹   ENSRNOP00000069706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl674,755,319 - 74,764,251 (+)Ensembl
Rnor_6.0 Ensembl678,172,762 - 78,180,924 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096140   ⟹   ENSRNOP00000092432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl674,755,556 - 74,764,251 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109586   ⟹   ENSRNOP00000083067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl674,755,310 - 74,766,465 (+)Ensembl
RefSeq Acc Id: NM_001009694   ⟹   NP_001009694
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8680,490,353 - 80,498,539 (+)NCBI
mRatBN7.2674,755,331 - 74,763,493 (+)NCBI
Rnor_6.0678,172,762 - 78,180,948 (+)NCBI
Rnor_5.0687,689,010 - 87,697,170 (+)NCBI
RGSC_v3.4677,685,499 - 77,693,687 (+)RGD
Celera673,554,016 - 73,562,177 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009694 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88149 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069706.1
  ENSRNOP00000071101.2
  ENSRNOP00000083067
  ENSRNOP00000083067.1
  ENSRNOP00000092432.1
RefSeq Acc Id: NP_001009694   ⟸   NM_001009694
- UniProtKB: A0A0G2JSV3 (UniProtKB/TrEMBL),   A0A8L2R3X1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069706   ⟸   ENSRNOT00000083110
RefSeq Acc Id: ENSRNOP00000092432   ⟸   ENSRNOT00000096140
RefSeq Acc Id: ENSRNOP00000083067   ⟸   ENSRNOT00000109586
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JSV3-F1-model_v2 AlphaFold A0A0G2JSV3 1-318 view protein structure
AF-P60892-F1-model_v2 AlphaFold P60892 1-318 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359636 AgrOrtholog
BioCyc Gene G2FUF-37411 BioCyc
BioCyc Pathway PWY0-662 [PRPP biosynthesis] BioCyc
BioCyc Pathway Image PWY0-662 BioCyc
Ensembl Genes ENSRNOG00000056011 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000060262 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078582.2 UniProtKB/TrEMBL
  ENSRNOT00000083110.2 UniProtKB/TrEMBL
  ENSRNOT00000096140.1 UniProtKB/TrEMBL
  ENSRNOT00000109586 ENTREZGENE
  ENSRNOT00000109586.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7380332 IMAGE-MGC_LOAD
InterPro PRib_PP_synth_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRTase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rib-P_diPkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rib-P_diPkinase_bac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29562 UniProtKB/Swiss-Prot
  rno:314140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108713 IMAGE-MGC_LOAD
NCBI Gene 314140 ENTREZGENE
PANTHER PTHR10210 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSE-PHOSPHATE DIPHOSPHOKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pribosyl_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pribosyltran_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prps1l3 PhenoGen
PROSITE PRPP_SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056011 RatGTEx
  ENSRNOG00000060262 RatGTEx
SMART Pribosyltran_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSV3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R3X1 ENTREZGENE, UniProtKB/TrEMBL
  PRPS1_RAT UniProtKB/Swiss-Prot
UniProt Secondary P09329 UniProtKB/Swiss-Prot
  Q5M8A4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Prps1l3  phosphoribosyl pyrophosphate synthetase 1-like 3  LOC314140  ribose-phosphate pyrophosphokinase I -like  Symbol and Name Changed 1299863 APPROVED
2005-07-29 LOC314140  ribose-phosphate pyrophosphokinase I -like      Symbol and Name status set to provisional 70820 PROVISIONAL