Uxt (ubiquitously-expressed, prefoldin-like chaperone) - Rat Genome Database

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Gene: Uxt (ubiquitously-expressed, prefoldin-like chaperone) Rattus norvegicus
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Symbol: Uxt
Name: ubiquitously-expressed, prefoldin-like chaperone
RGD ID: 1359326
Description: Predicted to enable beta-tubulin binding activity; chromatin binding activity; and transcription corepressor activity. Predicted to be involved in centrosome cycle and negative regulation of transcription by RNA polymerase II. Predicted to be located in centrosome; cytoplasm; and nucleus. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Orthologous to human UXT (ubiquitously expressed prefoldin like chaperone); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC105797; similar to ubiquitously-expressed transcript isoform 1; ubiquitously expressed transcript
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,679,630 - 3,691,944 (+)NCBIGRCr8
mRatBN7.2X1,126,110 - 1,138,670 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,126,162 - 1,138,663 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,154,446 - 1,166,501 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,630,138 - 4,642,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X950,682 - 962,723 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,275,402 - 1,287,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,275,612 - 1,287,512 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,090,439 - 2,102,802 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,616,439 - 12,628,479 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,621,996 - 12,634,035 (-)NCBI
CeleraX1,695,268 - 1,707,300 (+)NCBICelera
Cytogenetic MapXq11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
centrosome  (ISO,ISS)
cytoplasm  (ISO,ISS)
cytoskeleton  (ISO,ISS)
nucleus  (ISO,ISS)
RPAP3/R2TP/prefoldin-like complex  (ISO)
spindle pole  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue. Schroer A, etal., Genomics 1999 Mar 15;56(3):340-3.
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:12762840   PMID:16221885   PMID:21730289  


Genomics

Comparative Map Data
Uxt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,679,630 - 3,691,944 (+)NCBIGRCr8
mRatBN7.2X1,126,110 - 1,138,670 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,126,162 - 1,138,663 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,154,446 - 1,166,501 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,630,138 - 4,642,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X950,682 - 962,723 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,275,402 - 1,287,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,275,612 - 1,287,512 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,090,439 - 2,102,802 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,616,439 - 12,628,479 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,621,996 - 12,634,035 (-)NCBI
CeleraX1,695,268 - 1,707,300 (+)NCBICelera
Cytogenetic MapXq11NCBI
UXT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,651,796 - 47,659,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,651,796 - 47,659,180 (-)EnsemblGRCh38hg38GRCh38
GRCh37X47,511,195 - 47,518,579 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,396,139 - 47,403,504 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X47,267,449 - 47,274,770NCBI
CeleraX51,706,458 - 51,713,823 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX45,223,944 - 45,231,332 (-)NCBIHuRef
CHM1_1X47,542,327 - 47,549,715 (-)NCBICHM1_1
T2T-CHM13v2.0X47,061,699 - 47,069,083 (-)NCBIT2T-CHM13v2.0
Uxt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,818,162 - 20,828,259 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,807,961 - 20,828,256 (-)EnsemblGRCm39 Ensembl
GRCm38X20,951,665 - 20,962,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,941,722 - 20,962,017 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X20,528,791 - 20,539,104 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,108,624 - 20,118,937 (-)NCBIMGSCv36mm8
CeleraX19,085,804 - 19,096,117 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.46NCBI
Uxt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516420,616 - 430,134 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955516421,402 - 429,804 (+)NCBIChiLan1.0ChiLan1.0
UXT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,278,273 - 49,285,734 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,281,645 - 49,289,111 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,087,712 - 40,095,164 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,983,770 - 47,991,169 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,983,770 - 47,991,148 (-)Ensemblpanpan1.1panPan2
UXT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,271,908 - 41,280,433 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,271,908 - 41,280,340 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,646,536 - 15,655,076 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,405,725 - 41,413,955 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,405,719 - 41,413,934 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,393,272 - 41,401,810 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,381,544 - 41,390,081 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,474,238 - 41,482,772 (-)NCBIUU_Cfam_GSD_1.0
Uxt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,577,677 - 33,587,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,418,403 - 13,427,767 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650213,419,520 - 13,427,777 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UXT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,176,145 - 42,184,079 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,176,142 - 42,184,131 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,294,749 - 47,302,738 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UXT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,828,836 - 44,836,433 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,828,841 - 44,835,985 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607610,083,180 - 10,090,625 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uxt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978208,432 - 217,497 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624978209,222 - 216,909 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uxt
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:170
Count of miRNA genes:116
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000013476
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat

Markers in Region
RH142345  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X1,128,345 - 1,128,774 (+)MAPPERmRatBN7.2
Rnor_6.0X1,277,596 - 1,278,024NCBIRnor6.0
Rnor_5.0X2,092,617 - 2,093,045UniSTSRnor5.0
RGSC_v3.4X12,626,067 - 12,626,495UniSTSRGSC3.4
CeleraX1,697,252 - 1,697,680UniSTS
RH 3.4 Map10422.7UniSTS
Cytogenetic MapXq12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000013476   ⟹   ENSRNOP00000013476
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX1,126,162 - 1,138,663 (+)Ensembl
Rnor_6.0 EnsemblX1,275,612 - 1,287,512 (+)Ensembl
RefSeq Acc Id: NM_001006982   ⟹   NP_001006983
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,679,904 - 3,691,944 (+)NCBI
mRatBN7.2X1,126,362 - 1,138,403 (+)NCBI
Rnor_6.0X1,275,612 - 1,287,514 (+)NCBI
Rnor_5.0X2,090,439 - 2,102,802 (+)NCBI
RGSC_v3.4X12,616,439 - 12,628,479 (-)RGD
CeleraX1,695,268 - 1,707,300 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256611   ⟹   XP_006256673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,679,630 - 3,691,944 (+)NCBI
mRatBN7.2X1,126,110 - 1,138,670 (+)NCBI
Rnor_6.0X1,275,402 - 1,287,781 (+)NCBI
Rnor_5.0X2,090,439 - 2,102,802 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279881   ⟹   XP_063135951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,679,912 - 3,691,944 (+)NCBI
RefSeq Acc Id: XM_063279882   ⟹   XP_063135952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X3,679,709 - 3,691,944 (+)NCBI
RefSeq Acc Id: NP_001006983   ⟸   NM_001006982
- UniProtKB: Q63ZY7 (UniProtKB/Swiss-Prot),   A6JZQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256673   ⟸   XM_006256611
- Peptide Label: isoform X2
- UniProtKB: Q63ZY7 (UniProtKB/Swiss-Prot),   A6JZQ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013476   ⟸   ENSRNOT00000013476
RefSeq Acc Id: XP_063135952   ⟸   XM_063279882
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063135951   ⟸   XM_063279881
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63ZY7-F1-model_v2 AlphaFold Q63ZY7 1-157 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359326 AgrOrtholog
BioCyc Gene G2FUF-3204 BioCyc
Ensembl Genes ENSRNOG00000009893 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055016355 UniProtKB/Swiss-Prot
  ENSRNOG00060019565 UniProtKB/Swiss-Prot
  ENSRNOG00065020248 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013476.8 UniProtKB/Swiss-Prot
  ENSRNOT00055027734 UniProtKB/Swiss-Prot
  ENSRNOT00060033807 UniProtKB/Swiss-Prot
  ENSRNOT00065034173 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7303683 IMAGE-MGC_LOAD
InterPro Prefoldin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prefoldin_subunit_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UXT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:299313 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105797 IMAGE-MGC_LOAD
NCBI Gene 299313 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN UXT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Prefoldin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uxt PhenoGen
PRINTS UXTPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009893 RatGTEx
  ENSRNOG00055016355 RatGTEx
  ENSRNOG00060019565 RatGTEx
  ENSRNOG00065020248 RatGTEx
Superfamily-SCOP Prefoldin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JZQ2 ENTREZGENE, UniProtKB/TrEMBL
  A6JZQ4_RAT UniProtKB/TrEMBL
  A6JZQ6_RAT UniProtKB/TrEMBL
  Q63ZY7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-12-06 Uxt  ubiquitously-expressed, prefoldin-like chaperone  Uxt  ubiquitously expressed transcript  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Uxt  ubiquitously expressed transcript  MGC105797  similar to ubiquitously-expressed transcript isoform 1  Symbol and Name updated 1299863 APPROVED
2005-07-29 MGC105797  similar to ubiquitously-expressed transcript isoform 1      Symbol and Name status set to provisional 70820 PROVISIONAL