LAPTM5 (lysosomal protein transmembrane 5)

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Gene: LAPTM5 (lysosomal protein transmembrane 5) Homo sapiens

Analyze

Symbol:

LAPTM5

Name:

lysosomal protein transmembrane 5

RGD ID:

1354375

HGNC Page

HGNC:29612

Description:

Enables ubiquitin protein ligase binding activity and ubiquitin-dependent protein binding activity. Involved in several processes, including defense response to tumor cell; negative regulation of autophagic cell death; and positive regulation of lysosomal membrane permeability. Located in several cellular components, including lysosomal membrane; perinuclear region of cytoplasm; and transport vesicle. Part of protein-containing complex.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

CD40-ligand-activated specific transcripts; CLAST6; FLJ61683; FLJ97251; human retinoic acid-inducible E3 protein; lysosomal associated multispanning membrane protein 5; lysosomal multispanning membrane protein 5; lysosomal-associated multitransmembrane protein 5; lysosomal-associated transmembrane protein 5; MGC125860; MGC125861; retinoic acid-inducible E3 protein

RGD Orthologs

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	30,732,469 - 30,757,774 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	30,732,469 - 30,757,774 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	31,205,316 - 31,230,621 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	30,977,903 - 31,003,254 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	30,874,408 - 30,899,760	NCBI
Celera	1	29,461,191 - 29,486,564 (-)	NCBI		Celera
Cytogenetic Map	1	p35.2	NCBI
HuRef	1	29,311,671 - 29,337,045 (-)	NCBI		HuRef
CHM1_1	1	31,321,732 - 31,347,104 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	30,584,986 - 30,610,292 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Experimental Liver Cirrhosis (EXP)

genetic disease (IAGP)

IgA glomerulonephritis (EXP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (ISO)

2-butoxyethanol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (ISO)

aflatoxin B1 (EXP)

all-trans-retinoic acid (EXP)

ammonium chloride (ISO)

antirheumatic drug (EXP)

aristolochic acid A (EXP)

arsane (EXP)

arsenic atom (EXP)

arsenous acid (EXP)

atrazine (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (ISO)

cyclosporin A (EXP)

dextran sulfate (ISO)

diarsenic trioxide (EXP)

dioxygen (ISO)

diquat (ISO)

doxorubicin (EXP)

emodin (ISO)

ethanol (ISO)

ethyl methanesulfonate (EXP)

flavonoids (ISO)

flutamide (ISO)

fonofos (EXP)

formaldehyde (EXP,ISO)

furan (ISO)

Genipin (ISO)

gentamycin (ISO)

hydrogen peroxide (ISO)

isotretinoin (EXP)

ketamine (ISO)

lidocaine (ISO)

lipopolysaccharide (ISO)

N-nitrosodimethylamine (ISO)

nickel atom (EXP)

ozone (ISO)

paracetamol (ISO)

parathion (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

quercetin (EXP)

quinolin-8-ol (ISO)

resveratrol (ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium arsenite (EXP)

Soman (ISO)

sotorasib (EXP)

streptozocin (ISO)

terbufos (EXP)

tert-butyl hydroperoxide (EXP)

testosterone (ISO)

testosterone enanthate (EXP)

tetrachloromethane (ISO)

thioacetamide (ISO)

trametinib (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

triticonazole (ISO)

valproic acid (EXP)

vancomycin (ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leukemia inhibitory factor (ISO)

defense response to tumor cell (IDA)

Golgi to lysosome transport (ISS)

induction of programmed cell death (IDA)

intracellular protein transport (ISS)

negative regulation of activated T cell proliferation (ISO)

negative regulation of autophagic cell death (IDA)

negative regulation of B cell activation (ISS)

negative regulation of interleukin-2 production (ISS)

negative regulation of pre-B cell receptor expression (ISO)

negative regulation of T cell activation (ISS)

negative regulation of T cell receptor signaling pathway (ISS)

negative regulation of type II interferon production (ISS)

positive regulation of cytokine production involved in immune response (ISS)

positive regulation of interleukin-12 production (ISS)

positive regulation of interleukin-6 production (ISO)

positive regulation of lysosomal membrane permeability (IDA)

positive regulation of macrophage cytokine production (ISS)

positive regulation of MAPK cascade (ISS)

positive regulation of non-canonical NF-kappaB signal transduction (ISS)

positive regulation of protein ubiquitination (ISS)

positive regulation of proteolysis involved in protein catabolic process (ISO)

positive regulation of receptor catabolic process (ISS)

positive regulation of tumor necrosis factor-mediated signaling pathway (ISS)

positive regulation of ubiquitin-dependent protein catabolic process (ISS)

protein localization to lysosome (ISO)

protein targeting to lysosome (ISS)

Cellular Component

cytoplasmic vesicle (IDA)

cytosol (IEA)

lysosomal membrane (IBA,IDA,IEA)

lysosome (IDA,IEA)

membrane (IEA)

perinuclear region of cytoplasm (IMP)

plasma membrane (IDA)

protein-containing complex (IDA)

transport vesicle (IDA)

Molecular Function

enzyme binding (ISO)

protein binding (IPI)

protein sequestering activity (ISS)

ubiquitin protein ligase binding (IPI)

ubiquitin-dependent protein binding (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7788527	PMID:8661146	PMID:12477932	PMID:12527926	PMID:12886255	PMID:15231748	PMID:17116753	PMID:18187620	PMID:18202799	PMID:18203646	PMID:19787053	PMID:19953087
PMID:21224396	PMID:21873635	PMID:21890473	PMID:21906983	PMID:22009753	PMID:22096579	PMID:22505724	PMID:22733818	PMID:22880058	PMID:23284306	PMID:23824909	PMID:25015289
PMID:25416956	PMID:25998573	PMID:26903547	PMID:27058622	PMID:27922670	PMID:28464033	PMID:30021884	PMID:31318583	PMID:32296183	PMID:33961781	PMID:34140527	PMID:35091468
PMID:35157609	PMID:35225654	PMID:35294039	PMID:35842443	PMID:36037300	PMID:36037365	PMID:36799186

Genomics

Comparative Map Data

LAPTM5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	30,732,469 - 30,757,774 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	30,732,469 - 30,757,774 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	31,205,316 - 31,230,621 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	30,977,903 - 31,003,254 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	30,874,408 - 30,899,760	NCBI
Celera	1	29,461,191 - 29,486,564 (-)	NCBI		Celera
Cytogenetic Map	1	p35.2	NCBI
HuRef	1	29,311,671 - 29,337,045 (-)	NCBI		HuRef
CHM1_1	1	31,321,732 - 31,347,104 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	30,584,986 - 30,610,292 (-)	NCBI		T2T-CHM13v2.0

Laptm5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	130,640,627 - 130,663,459 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	130,640,436 - 130,663,452 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	130,912,890 - 130,936,148 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	130,913,125 - 130,936,141 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	130,469,249 - 130,492,063 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	130,183,341 - 130,208,215 (+)	NCBI		MGSCv36	mm8
Celera	4	129,075,831 - 129,099,969 (+)	NCBI		Celera
Cytogenetic Map	4	D2.2	NCBI
cM Map	4	64.0	NCBI

Laptm5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	5	143,087,759 - 143,109,807 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	143,087,759 - 143,109,807 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	145,787,261 - 145,809,419 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	147,557,078 - 147,579,236 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	147,552,786 - 147,574,739 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	149,015,793 - 149,069,719 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	149,047,681 - 149,069,719 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	152,749,594 - 152,771,632 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	149,775,904 - 149,797,951 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	149,785,942 - 149,807,990 (+)	NCBI
Celera	5	141,549,551 - 141,571,574 (+)	NCBI		Celera
Cytogenetic Map	5	q36	NCBI

Laptm5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	9,334,587 - 9,358,444 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	9,335,481 - 9,358,177 (-)	NCBI	ChiLan1.0	ChiLan1.0

LAPTM5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	195,199,639 - 195,225,059 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	30,005,941 - 30,031,366 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	31,032,963 - 31,058,385 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	31,032,963 - 31,058,385 (-)	Ensembl	panpan1.1		panPan2

LAPTM5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	70,188,382 - 70,215,361 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	70,152,739 - 70,333,073 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	66,763,871 - 66,790,833 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	70,748,385 - 70,775,429 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	70,748,388 - 70,775,427 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	67,583,493 - 67,610,219 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	68,582,446 - 68,609,409 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	69,580,796 - 69,607,573 (+)	NCBI		UU_Cfam_GSD_1.0

Laptm5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	48,277,298 - 48,295,129 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	14,102,423 - 14,119,558 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936474	14,102,080 - 14,119,592 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LAPTM5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	87,363,912 - 87,390,288 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	87,363,911 - 87,390,371 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	81,068,830 - 81,095,229 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LAPTM5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	102,080,500 - 102,106,649 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	102,080,508 - 102,106,729 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	14,543,899 - 14,569,756 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Laptm5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	14,207,094 - 14,228,135 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	14,208,144 - 14,277,208 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in LAPTM5
14 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 1p36.11-35.2(chr1:26963045-32279045)x3	copy number gain	See cases [RCV000051801]	Chr1:26963045..32279045 [GRCh38] Chr1:27289536..32744646 [GRCh37] Chr1:27162123..32517233 [NCBI36] Chr1:1p36.11-35.2	pathogenic
GRCh38/hg38 1p35.3-35.2(chr1:29015141-30983083)x3	copy number gain	See cases [RCV000134933]	Chr1:29015141..30983083 [GRCh38] Chr1:29341653..31455930 [GRCh37] Chr1:29214240..31228517 [NCBI36] Chr1:1p35.3-35.2	uncertain significance
GRCh38/hg38 1p35.3-35.1(chr1:28424867-33122854)x1	copy number loss	See cases [RCV000135447]	Chr1:28424867..33122854 [GRCh38] Chr1:28751378..33588455 [GRCh37] Chr1:28623965..33361042 [NCBI36] Chr1:1p35.3-35.1	pathogenic
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3	copy number gain	See cases [RCV000138891]	Chr1:24381206..41401517 [GRCh38] Chr1:24707696..41886350 [GRCh37] Chr1:24580283..41658937 [NCBI36] Chr1:1p36.11-34.2	pathogenic
GRCh38/hg38 1p35.3-35.2(chr1:29860227-30864901)x3	copy number gain	See cases [RCV000141607]	Chr1:29860227..30864901 [GRCh38] Chr1:30333074..31337748 [GRCh37] Chr1:30105661..31110335 [NCBI36] Chr1:1p35.3-35.2	uncertain significance
GRCh38/hg38 1p35.3-35.2(chr1:29274476-31126076)x1	copy number loss	See cases [RCV000142463]	Chr1:29274476..31126076 [GRCh38] Chr1:29600988..31598923 [GRCh37] Chr1:29473575..31371510 [NCBI36] Chr1:1p35.3-35.2	pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3	copy number loss	not provided [RCV000762767]	Chr1:20608823..120546301 [GRCh37] Chr1:1p36.12-12	likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3	copy number gain	See cases [RCV000510383]	Chr1:849467..249224684 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p35.2(chr1:30242068-31367845)x4	copy number gain	See cases [RCV000511074]	Chr1:30242068..31367845 [GRCh37] Chr1:1p35.2	uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)	copy number gain	See cases [RCV000510926]	Chr1:849467..249224684 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3	copy number gain	not provided [RCV000736305]	Chr1:82154..249218992 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3	copy number gain	not provided [RCV000736295]	Chr1:47851..249228449 [GRCh37] Chr1:1p36.33-q44	pathogenic
GRCh37/hg19 1p35.2(chr1:31145762-31233480)x1	copy number loss	not provided [RCV000748948]	Chr1:31145762..31233480 [GRCh37] Chr1:1p35.2	benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3	copy number gain	Global developmental delay [RCV000787285]	Chr1:103343285..103455144 [GRCh37] Chr1:1p36.22-21.1	uncertain significance
GRCh37/hg19 1p35.2-35.1(chr1:30819875-34380419)x3	copy number gain	not provided [RCV001005079]	Chr1:30819875..34380419 [GRCh37] Chr1:1p35.2-35.1	likely pathogenic
GRCh37/hg19 1p36.11-35.1(chr1:27543877-32819121)	copy number gain	not specified [RCV002052559]	Chr1:27543877..32819121 [GRCh37] Chr1:1p36.11-35.1	uncertain significance
NM_006762.3(LAPTM5):c.428A>G (p.Asp143Gly)	single nucleotide variant	Inborn genetic diseases [RCV002882988]	Chr1:30739022 [GRCh38] Chr1:31211869 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.11G>A (p.Arg4His)	single nucleotide variant	Inborn genetic diseases [RCV002779543]	Chr1:30757735 [GRCh38] Chr1:31230582 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.754G>T (p.Gly252Trp)	single nucleotide variant	Inborn genetic diseases [RCV002978898]	Chr1:30733863 [GRCh38] Chr1:31206710 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.662C>T (p.Ser221Leu)	single nucleotide variant	Inborn genetic diseases [RCV002911064]	Chr1:30735210 [GRCh38] Chr1:31208057 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.52C>T (p.Arg18Cys)	single nucleotide variant	Inborn genetic diseases [RCV002744566]	Chr1:30757694 [GRCh38] Chr1:31230541 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.10C>T (p.Arg4Cys)	single nucleotide variant	Inborn genetic diseases [RCV002873494]	Chr1:30757736 [GRCh38] Chr1:31230583 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.735G>C (p.Leu245Phe)	single nucleotide variant	Inborn genetic diseases [RCV002917091]	Chr1:30733882 [GRCh38] Chr1:31206729 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.11G>C (p.Arg4Pro)	single nucleotide variant	Inborn genetic diseases [RCV002836332]	Chr1:30757735 [GRCh38] Chr1:31230582 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.251T>C (p.Val84Ala)	single nucleotide variant	Inborn genetic diseases [RCV002920352]	Chr1:30741647 [GRCh38] Chr1:31214494 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.458G>C (p.Ser153Thr)	single nucleotide variant	Inborn genetic diseases [RCV003190595]	Chr1:30738992 [GRCh38] Chr1:31211839 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.626T>C (p.Val209Ala)	single nucleotide variant	Inborn genetic diseases [RCV003286760]	Chr1:30735246 [GRCh38] Chr1:31208093 [GRCh37] Chr1:1p35.2	uncertain significance
NM_006762.3(LAPTM5):c.10C>G (p.Arg4Gly)	single nucleotide variant	Inborn genetic diseases [RCV003173488]	Chr1:30757736 [GRCh38] Chr1:31230583 [GRCh37] Chr1:1p35.2	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1718
Count of miRNA genes:	766
Interacting mature miRNAs:	908
Transcripts:	ENST00000294507, ENST00000464569, ENST00000476492
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

RH25313

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	31,205,596 - 31,205,838	UniSTS	GRCh37
Build 36	1	30,978,183 - 30,978,425	RGD	NCBI36
Celera	1	29,461,472 - 29,461,714	RGD
Cytogenetic Map	1	p34	UniSTS
HuRef	1	29,311,952 - 29,312,194	UniSTS
GeneMap99-GB4 RH Map	1	96.82	UniSTS
NCBI RH Map	1	185.8	UniSTS

AL033732

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	31,208,749 - 31,208,876	UniSTS	GRCh37
Build 36	1	30,981,336 - 30,981,463	RGD	NCBI36
Celera	1	29,464,625 - 29,464,752	RGD
Cytogenetic Map	1	p34	UniSTS
HuRef	1	29,315,105 - 29,315,232	UniSTS

LAPTM5_1436

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	31,205,288 - 31,205,962	UniSTS	GRCh37
Build 36	1	30,977,875 - 30,978,549	RGD	NCBI36
Celera	1	29,461,164 - 29,461,838	RGD
HuRef	1	29,311,644 - 29,312,318	UniSTS

SHGC-12619

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	1	31,206,017 - 31,206,357	UniSTS	GRCh37
Build 36	1	30,978,604 - 30,978,944	RGD	NCBI36
Celera	1	29,461,893 - 29,462,233	RGD
Cytogenetic Map	1	p34	UniSTS
HuRef	1	29,312,373 - 29,312,713	UniSTS
GeneMap99-G3 RH Map	1	1649.0	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

adipose tissue

appendage

entire extraembryonic component

High

521

1065

Medium

2249

1965

1547

474

859

324

3166

1043

2366

323

932

1401

152

1202

1933

Low

111

498

158

135

126

1080

1122

1310

449

855

Below cutoff

103

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_006762	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_011542098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054338660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF401210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK292009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK297014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL137027	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL137857	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC106896	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC106897	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF000809	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT003824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D42042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U30498	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U30499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U51240	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENST00000294507 ⟹ ENSP00000294507

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	30,732,469 - 30,757,774 (-)	Ensembl

RefSeq Acc Id:

ENST00000464569

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	30,733,889 - 30,746,229 (-)	Ensembl

RefSeq Acc Id:

ENST00000476492

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	1	30,741,689 - 30,757,757 (-)	Ensembl

RefSeq Acc Id:

NM_006762 ⟹ NP_006753

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	30,732,469 - 30,757,774 (-)	NCBI
GRCh37	1	31,205,315 - 31,230,683 (-)	RGD
Build 36	1	30,977,903 - 31,003,254 (-)	NCBI Archive
Celera	1	29,461,191 - 29,486,564 (-)	RGD
HuRef	1	29,311,671 - 29,337,045 (-)	ENTREZGENE
CHM1_1	1	31,321,732 - 31,347,104 (-)	NCBI
T2T-CHM13v2.0	1	30,584,986 - 30,610,292 (-)	NCBI

Sequence:

show sequence

AGTGTCTCAGAGGAGGGGACGGCAGCACCATGGACCCCCGCTTGTCCACTGTCCGCCAGACCTG
CTGCTGCTTCAATGTCCGCATCGCAACCACCGCCCTGGCCATCTACCATGTGATCATGAGCGTC
TTGTTGTTCATCGAGCACTCAGTAGAGGTGGCCCATGGCAAGGCGTCCTGCAAGCTCTCCCAGA
TGGGCTACCTCAGGATCGCTGACCTGATCTCCAGCTTCCTGCTCATCACCATGCTCTTCATCAT
CAGCCTGAGCCTACTGATCGGCGTAGTCAAGAACCGGGAGAAGTACCTGCTGCCCTTCCTGTCC
CTGCAAATCATGGACTATCTCCTGTGCCTGCTCACCCTGCTGGGCTCCTACATTGAGCTGCCCG
CCTACCTCAAGTTGGCCTCCCGGAGCCGTGCTAGCTCCTCCAAGTTCCCCCTGATGACGCTGCA
GCTGCTGGACTTCTGCCTGAGCATCCTGACCCTCTGCAGCTCCTACATGGAAGTGCCCACCTAT
CTCAACTTCAAGTCCATGAACCACATGAATTACCTCCCCAGCCAGGAGGATATGCCTCATAACC
AGTTCATCAAGATGATGATCATCTTTTCCATCGCCTTCATCACTGTCCTTATCTTCAAGGTCTA
CATGTTCAAGTGCGTGTGGCGGTGCTACAGATTGATCAAGTGCATGAACTCGGTGGAGGAGAAG
AGAAACTCCAAGATGCTCCAGAAGGTGGTCCTGCCGTCCTACGAGGAAGCCCTGTCTTTGCCAT
CGAAGACCCCAGAGGGGGGCCCAGCACCACCCCCATACTCAGAGGTGTGACCCTCGCCAGGCCC
CAGCCCCAGTGCTGGGAGGGGTGGAGCTGCCTCATAATCTGCTTTTTTGCTTTGGTGGCCCCTG
TGGCCTGGGTGGGCCCTCCCGCCCCTCCCTGGCAGGACAATCTGCTTGTGTCTCCCTCGCTGGC
CTGCTCCTCCTGCAGGGCCTGTGAGCTGCTCACAACTGGGTCAACGCTTTAGGCTGAGTCACTC
CTCGGGTCTCTCCATAATTCAGCCCAACAATGCTTGGTTTATTTCAATCAGCTCTGACACTTGT
TTAGACGATTGGCCATTCTAAAGTTGGTGAGTTTGTCAAGCAACTATCGACTTGATCAGTTCAG
CCAAGCAACTGACAAATCAAAAACCCACTTGTCAGTTCAGTAAAATAATTTGGTCAAACAACAG
TCTATTGCATTGATTTATAAATAGTTGTCAGTTCACATAGCAATTTAATCAAGTAATCATTAAT
TAGTTACCCCCTATATATAAATATATGTAATCAATTTCTTCAAATAGCTTGCTTACATGATAAT
CAATTAGCCAACCATGAGTCATTTAGAATAGTGATAAATAGAATACACAGAATAGTGATGAAAT
TCAATTTAAAAAATCACGTTAGCCTCCAAACCATTTAATTCAAATGAACCCATCAACTGGATGC
CAACTCTGGCGAATGTAGGACCTCTGAGTGGCTGTATAATTGTTAATTCAAATGAAATTCATTT
AAACAGTTGACAAACTGTCATTCAACAATTAGCTCCAGGAAATAACAGTTATTTCATCATAAAA
CAGTCCCTTCAAACACACAATTGTTCTGCTGAAGAGTTGTCATCAACAATCCAATGCTCACCTA
TTCAGTTGCTCTGTGGTCAGTGTGGCTGCATAACAGTGGATTCCATGAAAGGAGTCATTTTAGT
GATGAGCTGCCAGTCCATTCCCAGGCCAGGCTGTCGCTGGCCATCCATTCAGTCGATTCAGTCA
TAGGCGAATCTGTTCTGCCCGAGGCTTGTGGTCAAGCAAAAATTCAGCCCTGAAATCAGGCACA
TCTGTTCGTTGGACTAAACCCACAGGTTAGTTCAGTCAAAGCAGGCAACCCCCTTGTGGGCACT
GACCCTGCCACTGGGGTCATGGCGGTTGTGGCAGCTGGGGAGGTTTGGCCCCAACAGCCCTCCT
GTGCCTGCTTCCCTGTGTGTCGGGGTCCTCCAGGGAGCTGACCCAGAGGTGGAGGCCACGGAGG
CAGGGTCTCTGGGGACTGTCGGGGGGTACAGAGGGAGAAGGCTCTGCAAGAGCTCCCTGGCAAT
ACCCCCTTGTGTAATTGCTTTGTGTGCGACAGGGAGGAAGTTTCAATAAAGCAGCAACAAGCTT
C

hide sequence

RefSeq Acc Id:

XM_011542098 ⟹ XP_011540400

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	30,732,469 - 30,757,774 (-)	NCBI

Sequence:

show sequence

GTGAGGAGGGCAGCCAGCAGCTTCCCCTTCTCTGCCCTGCTCCAGGCACCAGGCTCTTTCCCCT
TCAGTGTCTCAGAGGAGGGGACGGCAGCACCATGGACCCCCGCTTGTCCACTGTCCGCCAGACC
TGCTGCTGCTTCAATGTCCGCATCGCAACCACCGCCCTGGCCATCTACCATGTGAACCGGGAGA
AGTACCTGCTGCCCTTCCTGTCCCTGCAAATCATGGACTATCTCCTGTGCCTGCTCACCCTGCT
GGGCTCCTACATTGAGCTGCCCGCCTACCTCAAGTTGGCCTCCCGGAGCCGTGCTAGCTCCTCC
AAGTTCCCCCTGATGACGCTGCAGCTGCTGGACTTCTGCCTGAGCATCCTGACCCTCTGCAGCT
CCTACATGGAAGTGCCCACCTATCTCAACTTCAAGTCCATGAACCACATGAATTACCTCCCCAG
CCAGGAGGATATGCCTCATAACCAGTTCATCAAGATGATGATCATCTTTTCCATCGCCTTCATC
ACTGTCCTTATCTTCAAGGTCTACATGTTCAAGTGCGTGTGGCGGTGCTACAGATTGATCAAGT
GCATGAACTCGGTGGAGGAGAAGAGAAACTCCAAGATGCTCCAGAAGGTGGTCCTGCCGTCCTA
CGAGGAAGCCCTGTCTTTGCCATCGAAGACCCCAGAGGGGGGCCCAGCACCACCCCCATACTCA
GAGGTGTGACCCTCGCCAGGCCCCAGCCCCAGTGCTGGGAGGGGTGGAGCTGCCTCATAATCTG
CTTTTTTGCTTTGGTGGCCCCTGTGGCCTGGGTGGGCCCTCCCGCCCCTCCCTGGCAGGACAAT
CTGCTTGTGTCTCCCTCGCTGGCCTGCTCCTCCTGCAGGGCCTGTGAGCTGCTCACAACTGGGT
CAACGCTTTAGGCTGAGTCACTCCTCGGGTCTCTCCATAATTCAGCCCAACAATGCTTGGTTTA
TTTCAATCAGCTCTGACACTTGTTTAGACGATTGGCCATTCTAAAGTTGGTGAGTTTGTCAAGC
AACTATCGACTTGATCAGTTCAGCCAAGCAACTGACAAATCAAAAACCCACTTGTCAGTTCAGT
AAAATAATTTGGTCAAACAACAGTCTATTGCATTGATTTATAAATAGTTGTCAGTTCACATAGC
AATTTAATCAAGTAATCATTAATTAGTTACCCCCTATATATAAATATATGTAATCAATTTCTTC
AAATAGCTTGCTTACATGATAATCAATTAGCCAACCATGAGTCATTTAGAATAGTGATAAATAG
AATACACAGAATAGTGATGAAATTCAATTTAAAAAATCACGTTAGCCTCCAAACCATTTAATTC
AAATGAACCCATCAACTGGATGCCAACTCTGGCGAATGTAGGACCTCTGAGTGGCTGTATAATT
GTTAATTCAAATGAAATTCATTTAAACAGTTGACAAACTGTCATTCAACAATTAGCTCCAGGAA
ATAACAGTTATTTCATCATAAAACAGTCCCTTCAAACACACAATTGTTCTGCTGAAGAGTTGTC
ATCAACAATCCAATGCTCACCTATTCAGTTGCTCTGTGGTCAGTGTGGCTGCATAACAGTGGAT
TCCATGAAAGGAGTCATTTTAGTGATGAGCTGCCAGTCCATTCCCAGGCCAGGCTGTCGCTGGC
CATCCATTCAGTCGATTCAGTCATAGGCGAATCTGTTCTGCCCGAGGCTTGTGGTCAAGCAAAA
ATTCAGCCCTGAAATCAGGCACATCTGTTCGTTGGACTAAACCCACAGGTTAGTTCAGTCAAAG
CAGGCAACCCCCTTGTGGGCACTGACCCTGCCACTGGGGTCATGGCGGTTGTGGCAGCTGGGGA
GGTTTGGCCCCAACAGCCCTCCTGTGCCTGCTTCCCTGTGTGTCGGGGTCCTCCAGGGAGCTGA
CCCAGAGGTGGAGGCCACGGAGGCAGGGTCTCTGGGGACTGTCGGGGGGTACAGAGGGAGAAGG
CTCTGCAAGAGCTCCCTGGCAATACCCCCTTGTGTAATTGCTTTGTGTGCGACAGGGAGGAAGT
TTCAATAAAGCAGCAACAAGCTTC

hide sequence

RefSeq Acc Id:

XM_054338660 ⟹ XP_054194635

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	1	30,584,986 - 30,610,292 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_006753	(Get FASTA)	NCBI Sequence Viewer
	XP_011540400	(Get FASTA)	NCBI Sequence Viewer
	XP_054194635	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA74018	(Get FASTA)	NCBI Sequence Viewer
	AAB08975	(Get FASTA)	NCBI Sequence Viewer
	AAI06897	(Get FASTA)	NCBI Sequence Viewer
	AAI06898	(Get FASTA)	NCBI Sequence Viewer
	BAA07643	(Get FASTA)	NCBI Sequence Viewer
	BAF84698	(Get FASTA)	NCBI Sequence Viewer
	BAG59547	(Get FASTA)	NCBI Sequence Viewer
	EAX07640	(Get FASTA)	NCBI Sequence Viewer
	EAX07641	(Get FASTA)	NCBI Sequence Viewer
	Q13571	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_006753 ⟸ NM_006762
- UniProtKB:	Q14698 (UniProtKB/Swiss-Prot), Q13240 (UniProtKB/Swiss-Prot), Q3KP54 (UniProtKB/Swiss-Prot), Q13571 (UniProtKB/Swiss-Prot), Q5TBB8 (UniProtKB/TrEMBL), D3DPN1 (UniProtKB/TrEMBL), B4DLI5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDPRLSTVRQTCCCFNVRIATTALAIYHVIMSVLLFIEHSVEVAHGKASCKLSQMGYLRIADLI SSFLLITMLFIISLSLLIGVVKNREKYLLPFLSLQIMDYLLCLLTLLGSYIELPAYLKLASRSR ASSSKFPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQEDMPHNQFIKMMIIFS IAFITVLIFKVYMFKCVWRCYRLIKCMNSVEEKRNSKMLQKVVLPSYEEALSLPSKTPEGGPAP PPYSEV hide sequence

RefSeq Acc Id:

XP_011540400 ⟸ XM_011542098

- Peptide Label:

isoform X1

- Sequence:

show sequence

MDPRLSTVRQTCCCFNVRIATTALAIYHVNREKYLLPFLSLQIMDYLLCLLTLLGSYIELPAYL
KLASRSRASSSKFPLMTLQLLDFCLSILTLCSSYMEVPTYLNFKSMNHMNYLPSQEDMPHNQFI
KMMIIFSIAFITVLIFKVYMFKCVWRCYRLIKCMNSVEEKRNSKMLQKVVLPSYEEALSLPSKT
PEGGPAPPPYSEV

hide sequence

RefSeq Acc Id:

ENSP00000294507 ⟸ ENST00000294507

RefSeq Acc Id:	XP_054194635 ⟸ XM_054338660
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q13571-F1-model_v2	AlphaFold	Q13571	1-262	view protein structure

Promoters

RGD ID:

6854770

Promoter ID:

EPDNEW_H550

Type:

initiation region

Name:

LAPTM5_1

Description:

lysosomal protein transmembrane 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_H551

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	1	30,757,774 - 30,757,834	EPDNEW

RGD ID:

6814847

Promoter ID:

HG_MRA:320

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

K562

Transcripts:

AF401210, CR626282

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	1	30,977,711 - 30,978,211 (-)	MPROMDB

RGD ID:

6809611

Promoter ID:

HG_ACW:1321

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

K562

Transcripts:

DORDU.AAPR07-UNSPLICED, LAPTM5.EAPR07, LAPTM5.FAPR07

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	1	30,980,811 - 30,981,562 (-)	MPROMDB

RGD ID:

6809608

Promoter ID:

HG_ACW:1322

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

K562

Transcripts:

LAPTM5.GAPR07-UNSPLICED

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	1	30,985,161 - 30,985,661 (-)	MPROMDB

RGD ID:

6785907

Promoter ID:

HG_KWN:1711

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell_12Hour, K562, Lymphoblastoid

Transcripts:

OTTHUMT00000010465

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	1	30,991,186 - 30,992,562 (-)	MPROMDB

RGD ID:

6785908

Promoter ID:

HG_KWN:1712

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, K562, Lymphoblastoid, NB4

Transcripts:

NM_006762, OTTHUMT00000010464

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	1	31,003,136 - 31,004,267 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:29612	AgrOrtholog
COSMIC	LAPTM5	COSMIC
Ensembl Genes	ENSG00000162511	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSP00000294507	ENTREZGENE
	ENSP00000294507.3	UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000294507	ENTREZGENE
	ENST00000294507.4	UniProtKB/Swiss-Prot
GTEx	ENSG00000162511	GTEx
HGNC ID	HGNC:29612	ENTREZGENE
Human Proteome Map	LAPTM5	Human Proteome Map
InterPro	LAPTM4/5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LAPTM_4A/5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:7805	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	7805	ENTREZGENE
OMIM	601476	OMIM
PANTHER	LYSOSOMAL-ASSOCIATED TRANSMEMBRANE PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12479:SF2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Mtp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA134953439	PharmGKB
UniProt	B4DLI5	ENTREZGENE, UniProtKB/TrEMBL
	D3DPN1	ENTREZGENE
	LAPM5_HUMAN	UniProtKB/Swiss-Prot
	Q13240	ENTREZGENE
	Q13571	ENTREZGENE
	Q14698	ENTREZGENE
	Q3KP54	ENTREZGENE
	Q5TBB8	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	D3DPN1	UniProtKB/TrEMBL
	Q13240	UniProtKB/Swiss-Prot
	Q14698	UniProtKB/Swiss-Prot
	Q3KP54	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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