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Gene: LIFR (LIF receptor subunit alpha) Homo sapiens
Symbol: LIFR
Name: LIF receptor subunit alpha
Description: Exhibits ciliary neurotrophic factor receptor binding activity; growth factor binding activity; and leukemia inhibitory factor receptor activity. Contributes to ciliary neurotrophic factor receptor activity and oncostatin-M receptor activity. Involved in cell surface receptor signaling pathway and positive regulation of cell population proliferation. Localizes to receptor complex. Implicated in osteochondrodysplasia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD118; CD118 antigen; FLJ98106; FLJ99923; leukemia inhibitory factor receptor; leukemia inhibitory factor receptor alpha; LIF receptor; LIF receptor alpha; LIF-R; SJS2; STWS; SWS
Mus musculus (house mouse) : Lifr (LIF receptor alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lifr (LIF receptor subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lifr (LIF receptor subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : LIFR (LIF receptor subunit alpha)
Canis lupus familiaris (dog) : LIFR (LIF receptor subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lifr (LIF receptor subunit alpha)
Sus scrofa (pig) : LOC102167255 (leukemia inhibitory factor receptor)
Chlorocebus sabaeus (African green monkey) : LIFR (LIF receptor subunit alpha)
Heterocephalus glaber (naked mole-rat) : Lifr (LIF receptor subunit alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl538,474,668 - 38,608,354 (-)EnsemblGRCh38hg38GRCh38
GRCh38538,474,668 - 38,606,290 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37538,475,065 - 38,595,507 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36538,510,822 - 38,631,253 (-)NCBINCBI36hg18NCBI36
Build 34538,515,661 - 38,631,253NCBI
Celera538,361,644 - 38,482,099 (-)NCBI
Cytogenetic Map5p13.1NCBI
HuRef538,427,081 - 38,547,293 (-)NCBIHuRef
CHM1_1538,476,985 - 38,597,458 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LIFR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1354198
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.