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Gene: TREX2 (three prime repair exonuclease 2) Homo sapiens
Symbol: TREX2
Name: three prime repair exonuclease 2
Description: Exhibits 3'-5'-exodeoxyribonuclease activity; magnesium ion binding activity; and protein homodimerization activity. Involved in DNA metabolic process. Predicted to localize to the nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3'-5' exonuclease TREX2 long form
Mus musculus (house mouse) : Trex2 (three prime repair exonuclease 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trex2 (three prime repair exonuclease 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trex2 (three prime repair exonuclease 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TREX2 (three prime repair exonuclease 2)
Canis lupus familiaris (dog) : TREX2 (three prime repair exonuclease 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trex2 (three prime repair exonuclease 2)
Sus scrofa (pig) : TREX2 (three prime repair exonuclease 2)
Chlorocebus sabaeus (green monkey) : TREX2 (three prime repair exonuclease 2)
Heterocephalus glaber (naked mole-rat) : Trex2 (three prime repair exonuclease 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX153,444,720 - 153,470,587 (-)Ensembl
GRCh38X153,444,720 - 153,446,487 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X152,710,178 - 152,711,945 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,363,372 - 152,365,139 (-)NCBINCBI36hg18NCBI36
Build 34X152,231,024 - 152,231,735NCBI
CeleraX152,943,888 - 152,945,655 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,369,186 - 141,370,953 (-)NCBIHuRef
CHM1_1X152,584,603 - 152,586,370 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TREX2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1354135
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.