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Gene: MAST1 (microtubule associated serine/threonine kinase 1) Homo sapiens
Symbol: MAST1
Name: microtubule associated serine/threonine kinase 1
Description: This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: KIAA0973; MCCCHCM; microtubule-associated serine/threonine-protein kinase 1; SAST; SAST170; syntrophin associated serine/threonine kinase; syntrophin-associated serine/threonine-protein kinase
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381912,838,515 - 12,874,952 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,949,259 - 12,985,766 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,810,348 - 12,846,765 (+)NCBINCBI36hg18NCBI36
Build 341912,810,347 - 12,846,765NCBI
Celera1912,838,964 - 12,875,474 (+)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,520,853 - 12,557,622 (+)NCBIHuRef
CHM1_11912,949,779 - 12,986,286 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MAST1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1354102
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.