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Gene: TRIB1 (tribbles pseudokinase 1) Homo sapiens
Symbol: TRIB1
Name: tribbles pseudokinase 1
Description: Exhibits mitogen-activated protein kinase kinase binding activity; protein kinase inhibitor activity; and transcription factor binding activity. Involved in several processes, including negative regulation of DNA-binding transcription factor activity; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Localizes to the cytoplasm and nucleus; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-fluoro-2,4-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C8FW; G-protein-coupled receptor induced protein; G-protein-coupled receptor-induced gene 2 protein; G-protein-coupled receptor-induced protein 2; GIG-2; GIG2; phosphoprotein regulated by mitogenic pathways; SKIP1; TRB-1; TRB1; tribbles homolog 1; tribbles-like protein 1
Mus musculus (house mouse) : Trib1 (tribbles pseudokinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trib1 (tribbles pseudokinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trib1 (tribbles pseudokinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TRIB1 (tribbles pseudokinase 1)
Canis lupus familiaris (dog) : TRIB1 (tribbles pseudokinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trib1 (tribbles pseudokinase 1)
Sus scrofa (pig) : TRIB1 (tribbles pseudokinase 1)
Chlorocebus sabaeus (African green monkey) : TRIB1 (tribbles pseudokinase 1)
Heterocephalus glaber (naked mole-rat) : Trib1 (tribbles pseudokinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8125,430,358 - 125,438,403 (+)Ensembl
GRCh388125,430,290 - 125,438,405 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378126,442,563 - 126,450,647 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368126,511,745 - 126,519,827 (+)NCBINCBI36hg18NCBI36
Build 348126,511,744 - 126,519,824NCBI
Celera8122,631,533 - 122,639,615 (+)NCBI
Cytogenetic Map8q24.13NCBI
HuRef8121,766,406 - 121,774,484 (+)NCBIHuRef
CHM1_18126,482,807 - 126,490,886 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TRIB1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1354037
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.