CRY1 (cryptochrome circadian regulator 1) - Rat Genome Database
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Gene: CRY1 (cryptochrome circadian regulator 1) Homo sapiens
Analyze
Symbol: CRY1
Name: cryptochrome circadian regulator 1
RGD ID: 1353919
HGNC Page HGNC
Description: Exhibits double-stranded DNA binding activity; nuclear hormone receptor binding activity; and phosphatase binding activity. Involved in negative regulation of transcription by RNA polymerase II. Localizes to nucleus. Implicated in advanced sleep phase syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cryptochrome 1 (photolyase-like); cryptochrome circadian clock 1; cryptochrome-1; DSPD; PHLL1; photolyase-like cryptochrome 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12106,991,364 - 107,093,549 (-)EnsemblGRCh38hg38GRCh38
GRCh3812106,991,364 - 107,093,872 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712107,385,142 - 107,487,327 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh3712107,385,142 - 107,487,635 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612105,909,272 - 106,011,455 (-)NCBINCBI36hg18NCBI36
Build 3412105,887,608 - 105,989,792NCBI
Celera12107,050,701 - 107,153,165 (-)NCBI
Cytogenetic Map12q23.3NCBI
HuRef12104,445,641 - 104,548,152 (-)NCBIHuRef
CHM1_112107,350,774 - 107,453,198 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-epicatechin-3-O-gallate  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-methylcholine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
acrolein  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
alpha-pinene  (EXP)
aristolochic acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
buspirone  (ISO)
buta-1,3-diene  (ISO)
cadmium dichloride  (ISO)
cefaloridine  (ISO)
chloroprene  (ISO)
cisplatin  (EXP)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper(II) sulfate  (EXP)
cortisol  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
dichloromethane  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
Enterolactone  (EXP)
ethanol  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
folpet  (ISO)
furan  (ISO)
gallic acid  (EXP)
gallocatechin  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
methamphetamine  (ISO)
mitomycin C  (ISO)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
N-nitrosodimethylamine  (EXP,ISO)
nefazodone  (ISO)
nickel atom  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
phenformin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
prednisolone  (EXP)
rotenone  (ISO)
silicon dioxide  (ISO)
streptozocin  (ISO)
sunitinib  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
titanium dioxide  (ISO)
trichostatin A  (EXP)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IEA,ISO)
nucleus  (IBA,IDA,ISO,ISS)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:8600518   PMID:8909283   PMID:8921389   PMID:9383998   PMID:9801304   PMID:10217146   PMID:10428031   PMID:10531061   PMID:11533252   PMID:11875063   PMID:12397359   PMID:12477932  
PMID:12782655   PMID:12846824   PMID:14507900   PMID:14672706   PMID:15123698   PMID:15147242   PMID:15489334   PMID:15722957   PMID:16189514   PMID:16628007   PMID:17073458   PMID:17376600  
PMID:17463251   PMID:17852344   PMID:18195715   PMID:18228528   PMID:18430226   PMID:19181792   PMID:19500131   PMID:19693801   PMID:19934327   PMID:20072116   PMID:20174623   PMID:20222832  
PMID:20360068   PMID:20379614   PMID:20560679   PMID:20852621   PMID:20877624   PMID:20978934   PMID:21613214   PMID:21628572   PMID:21680841   PMID:21690409   PMID:21846818   PMID:21873635  
PMID:21988832   PMID:22081238   PMID:22170608   PMID:22427812   PMID:22470559   PMID:22538398   PMID:22669941   PMID:22692217   PMID:23133559   PMID:23242607   PMID:23317246   PMID:23455922  
PMID:23546644   PMID:23555304   PMID:23584858   PMID:23626715   PMID:24085301   PMID:24158435   PMID:24449901   PMID:24548145   PMID:24581835   PMID:25103245   PMID:25344870   PMID:25391456  
PMID:25707907   PMID:25756610   PMID:26168277   PMID:26186194   PMID:26218278   PMID:26247999   PMID:26319354   PMID:26431207   PMID:26496610   PMID:26562092   PMID:26673895   PMID:26768731  
PMID:26923944   PMID:26966073   PMID:27123980   PMID:27267441   PMID:27412556   PMID:27565346   PMID:27721187   PMID:27834218   PMID:28017587   PMID:28514442   PMID:28572861   PMID:28751364  
PMID:28790135   PMID:28884705   PMID:29128257   PMID:29874863   PMID:29937374   PMID:29940771   PMID:30235329   PMID:30425162   PMID:30530698   PMID:30985214   PMID:31155351   PMID:31550045  
PMID:32538895   PMID:33106415   PMID:33452241  


Genomics

Comparative Map Data
CRY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12106,991,364 - 107,093,549 (-)EnsemblGRCh38hg38GRCh38
GRCh3812106,991,364 - 107,093,872 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712107,385,142 - 107,487,327 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh3712107,385,142 - 107,487,635 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612105,909,272 - 106,011,455 (-)NCBINCBI36hg18NCBI36
Build 3412105,887,608 - 105,989,792NCBI
Celera12107,050,701 - 107,153,165 (-)NCBI
Cytogenetic Map12q23.3NCBI
HuRef12104,445,641 - 104,548,152 (-)NCBIHuRef
CHM1_112107,350,774 - 107,453,198 (-)NCBICHM1_1
Cry1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391084,967,564 - 85,020,918 (-)NCBIGRCm39mm39
GRCm381085,131,700 - 85,185,054 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1085,131,700 - 85,185,064 (-)EnsemblGRCm38mm10GRCm38
MGSCv371084,594,445 - 84,647,799 (-)NCBIGRCm37mm9NCBIm37
MGSCv361084,561,499 - 84,614,853 (-)NCBImm8
Celera1087,108,048 - 87,162,027 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.63NCBI
Cry1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2718,529,823 - 18,594,092 (+)NCBI
Rnor_6.0 Ensembl724,534,615 - 24,634,097 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0724,534,593 - 24,634,098 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0724,684,038 - 24,784,329 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0726,277,264 - 26,278,124 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4720,643,879 - 20,709,216 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1720,664,607 - 20,729,486 (+)NCBI
Celera715,758,113 - 15,822,171 (+)NCBICelera
Cytogenetic Map7q13NCBI
Cry1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540540,874,322 - 40,941,664 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540540,878,227 - 40,941,664 (-)NCBIChiLan1.0ChiLan1.0
CRY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112107,952,836 - 108,052,484 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12107,954,262 - 108,052,484 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012104,558,874 - 104,658,833 (-)NCBIMhudiblu_PPA_v0panPan3
CRY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1031,681,288 - 31,780,306 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11031,681,098 - 31,792,995 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cry1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364927,929,138 - 7,994,797 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl513,275,544 - 13,364,594 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1513,275,265 - 13,429,566 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2513,128,680 - 13,217,202 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CRY1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111102,200,822 - 102,306,165 (-)NCBI
ChlSab1.1 Ensembl11102,204,224 - 102,306,182 (-)Ensembl
Cry1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247502,465,999 - 2,529,251 (+)NCBI

Position Markers
RH93858  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712107,385,303 - 107,385,444UniSTSGRCh37
Build 3612105,909,433 - 105,909,574RGDNCBI36
Celera12107,050,862 - 107,051,003RGD
Cytogenetic Map12q23-q24.1UniSTS
HuRef12104,445,802 - 104,445,943UniSTS
GeneMap99-GB4 RH Map12421.91UniSTS
RH79737  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712107,393,568 - 107,393,796UniSTSGRCh37
Build 3612105,917,698 - 105,917,926RGDNCBI36
Celera12107,059,130 - 107,059,358RGD
Cytogenetic Map12q23-q24.1UniSTS
HuRef12104,454,071 - 104,454,299UniSTS
G54218  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712107,420,422 - 107,420,587UniSTSGRCh37
Build 3612105,944,552 - 105,944,717RGDNCBI36
Celera12107,085,988 - 107,086,153RGD
Cytogenetic Map12q23-q24.1UniSTS
HuRef12104,480,978 - 104,481,143UniSTS
CRY1_1267  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3712107,385,133 - 107,385,776UniSTSGRCh37
Build 3612105,909,263 - 105,909,906RGDNCBI36
Celera12107,050,692 - 107,051,335RGD
HuRef12104,445,632 - 104,446,275UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:457
Count of miRNA genes:378
Interacting mature miRNAs:401
Transcripts:ENST00000008527, ENST00000546722, ENST00000549356, ENST00000550633, ENST00000552790
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1946 1562 1148 253 441 156 3216 1111 1696 220 1292 1563 110 1048 1929 3
Low 493 1353 578 371 1327 309 1140 1084 2037 198 167 49 63 1 156 859 3 2
Below cutoff 76 110 1 1 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_004075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017018832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC078929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC017466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BJ993835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D83702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D84657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB454192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF015898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT585061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000008527   ⟹   ENSP00000008527
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12106,991,364 - 107,093,549 (-)Ensembl
RefSeq Acc Id: ENST00000546722
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12106,999,789 - 107,001,851 (-)Ensembl
RefSeq Acc Id: ENST00000549356   ⟹   ENSP00000447738
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12106,992,487 - 106,997,539 (-)Ensembl
RefSeq Acc Id: ENST00000550633
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12107,072,935 - 107,093,513 (-)Ensembl
RefSeq Acc Id: ENST00000552790
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12106,991,367 - 107,050,359 (-)Ensembl
RefSeq Acc Id: NM_004075   ⟹   NP_004066
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812106,991,364 - 107,093,549 (-)NCBI
GRCh3712107,385,142 - 107,487,635 (-)NCBI
Build 3612105,909,272 - 106,011,455 (-)NCBI Archive
HuRef12104,445,641 - 104,548,152 (-)NCBI
CHM1_112107,350,774 - 107,453,198 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017018832   ⟹   XP_016874321
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812106,991,364 - 107,093,274 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024448844   ⟹   XP_024304612
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812106,991,364 - 107,093,274 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024448845   ⟹   XP_024304613
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812106,991,364 - 107,093,872 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004066   ⟸   NM_004075
- UniProtKB: Q16526 (UniProtKB/Swiss-Prot),   A2I2P0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016874321   ⟸   XM_017018832
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_024304613   ⟸   XM_024448845
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_024304612   ⟸   XM_024448844
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000008527   ⟸   ENST00000008527
RefSeq Acc Id: ENSP00000447738   ⟸   ENST00000549356
Promoters
RGD ID:6789831
Promoter ID:HG_KWN:16549
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_004075
Position:
Human AssemblyChrPosition (strand)Source
Build 3612106,010,836 - 106,011,837 (-)MPROMDB
RGD ID:7225287
Promoter ID:EPDNEW_H18389
Type:initiation region
Name:CRY1_1
Description:cryptochrome circadian clock 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18390  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812107,093,549 - 107,093,609EPDNEW
RGD ID:7225289
Promoter ID:EPDNEW_H18390
Type:initiation region
Name:CRY1_2
Description:cryptochrome circadian clock 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18389  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812107,093,851 - 107,093,911EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12q23.3-24.13(chr12:105234677-112194686)x1 copy number loss See cases [RCV000050807] Chr12:105234677..112194686 [GRCh38]
Chr12:105628455..112632490 [GRCh37]
Chr12:104152585..111116873 [NCBI36]
Chr12:12q23.3-24.13
pathogenic
GRCh38/hg38 12q23.1-23.3(chr12:100670616-108583607)x1 copy number loss See cases [RCV000051320] Chr12:100670616..108583607 [GRCh38]
Chr12:101064394..108977383 [GRCh37]
Chr12:99588525..107501512 [NCBI36]
Chr12:12q23.1-23.3
pathogenic
NM_004075.4(CRY1):c.230G>A (p.Arg77His) single nucleotide variant Malignant melanoma [RCV000069789] Chr12:107022121 [GRCh38]
Chr12:107415899 [GRCh37]
Chr12:105940029 [NCBI36]
Chr12:12q23.3
not provided
GRCh38/hg38 12q23.3-24.11(chr12:105644967-108994840)x1 copy number loss See cases [RCV000138537] Chr12:105644967..108994840 [GRCh38]
Chr12:106038745..109432645 [GRCh37]
Chr12:104562875..107917026 [NCBI36]
Chr12:12q23.3-24.11
uncertain significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q23.3(chr12:106804832-107556040)x3 copy number gain See cases [RCV000141770] Chr12:106804832..107556040 [GRCh38]
Chr12:107198610..107949817 [GRCh37]
Chr12:105722740..106473947 [NCBI36]
Chr12:12q23.3
uncertain significance
GRCh38/hg38 12q21.33-24.11(chr12:91044318-109133210)x3 copy number gain See cases [RCV000142447] Chr12:91044318..109133210 [GRCh38]
Chr12:91438095..109571015 [GRCh37]
Chr12:89962226..108055398 [NCBI36]
Chr12:12q21.33-24.11
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
GRCh37/hg19 12q23.2-24.11(chr12:103044333-111639805)x1 copy number loss See cases [RCV000445832] Chr12:103044333..111639805 [GRCh37]
Chr12:12q23.2-24.11
likely pathogenic
GRCh37/hg19 12q23.3(chr12:107404513-108108729)x3 copy number gain See cases [RCV000447920] Chr12:107404513..108108729 [GRCh37]
Chr12:12q23.3
likely benign
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_004075.5(CRY1):c.1657+3A>C single nucleotide variant Sleep-wake schedule disorder, delayed phase type [RCV000490555] Chr12:106992962 [GRCh38]
Chr12:107386740 [GRCh37]
Chr12:12q23.3
risk factor
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
NM_004075.5(CRY1):c.993G>A (p.Ala331=) single nucleotide variant not provided [RCV000903786] Chr12:106999695 [GRCh38]
Chr12:107393473 [GRCh37]
Chr12:12q23.3
benign
NM_004075.5(CRY1):c.1503A>T (p.Ala501=) single nucleotide variant not provided [RCV000962475] Chr12:106997376 [GRCh38]
Chr12:107391154 [GRCh37]
Chr12:12q23.3
benign
GRCh37/hg19 12q23.3-24.12(chr12:106498814-112252906)x1 copy number loss not provided [RCV001259630] Chr12:106498814..112252906 [GRCh37]
Chr12:12q23.3-24.12
pathogenic
GRCh37/hg19 12q23.3-24.11(chr12:107197584-109830564)x1 copy number loss not provided [RCV001270637] Chr12:107197584..109830564 [GRCh37]
Chr12:12q23.3-24.11
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2384 AgrOrtholog
COSMIC CRY1 COSMIC
Ensembl Genes ENSG00000008405 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000008527 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000447738 UniProtKB/TrEMBL
Ensembl Transcript ENST00000008527 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000549356 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.620 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000008405 GTEx
HGNC ID HGNC:2384 ENTREZGENE
Human Proteome Map CRY1 Human Proteome Map
InterPro Crypto/Photolyase_FAD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Crypto/Photolyase_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cryptochr/Photolyase_FAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_photolyase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1407 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 1407 ENTREZGENE
OMIM 601933 OMIM
  614163 OMIM
Pfam DNA_photolyase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_binding_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA26904 PharmGKB
PROSITE PHR_CRY_ALPHA_BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48173 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52425 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2I2P0 ENTREZGENE, UniProtKB/TrEMBL
  CRY1_HUMAN UniProtKB/Swiss-Prot
  H0YHT0_HUMAN UniProtKB/TrEMBL
  Q16526 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-04 CRY1  cryptochrome circadian regulator 1    cryptochrome circadian clock 1  Symbol and/or name change 5135510 APPROVED
2014-01-21 CRY1  cryptochrome circadian clock 1    cryptochrome 1 (photolyase-like)  Symbol and/or name change 5135510 APPROVED
2012-08-21 CRY1  cryptochrome 1 (photolyase-like)  CRY1  cryptochrome 1 (photolyase-like)  Symbol and/or name change 5135510 APPROVED