MIR219A2 (microRNA 219a-2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MIR219A2 (microRNA 219a-2) Homo sapiens
Analyze
Symbol: MIR219A2
Name: microRNA 219a-2
RGD ID: 1353680
HGNC Page HGNC
Description: Predicted to act upstream of or within several processes, including cellular response to growth factor stimulus; cellular response to leukemia inhibitory factor; and regulation of nervous system development. Predicted to be part of RISC complex.
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-219a-2; mir-219a-2; MIR219-2; MIRN219-2
RGD Orthologs
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9128,392,618 - 128,392,714 (-)EnsemblGRCh38hg38GRCh38
GRCh389128,392,618 - 128,392,714 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379131,154,897 - 131,154,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,194,717 - 130,194,813 (-)NCBINCBI36hg18NCBI36
Celera9101,805,800 - 101,805,896 (-)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9100,767,720 - 100,767,816 (-)NCBIHuRef
CHM1_19131,305,922 - 131,306,018 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
RISC complex  (ISO)

References
Additional References at PubMed
PMID:12624257   PMID:15634332   PMID:16381832   PMID:17604727   PMID:18548097   PMID:21037258   PMID:22957142   PMID:23637748   PMID:25574843   PMID:26363795   PMID:26965827   PMID:27855391  
PMID:28890378   PMID:29077787   PMID:29202778   PMID:30338788   PMID:30766610   PMID:31077370   PMID:31161607   PMID:31215169   PMID:31673844   PMID:32111564   PMID:32364222   PMID:32443717  


Genomics

Comparative Map Data
MIR219A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9128,392,618 - 128,392,714 (-)EnsemblGRCh38hg38GRCh38
GRCh389128,392,618 - 128,392,714 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379131,154,897 - 131,154,993 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,194,717 - 130,194,813 (-)NCBINCBI36hg18NCBI36
Celera9101,805,800 - 101,805,896 (-)NCBI
Cytogenetic Map9q34.11NCBI
HuRef9100,767,720 - 100,767,816 (-)NCBIHuRef
CHM1_19131,305,922 - 131,306,018 (-)NCBICHM1_1
Mir219a-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39229,735,643 - 29,735,739 (-)NCBIGRCm39mm39
GRCm39 Ensembl229,735,643 - 29,735,739 (-)Ensembl
GRCm38229,845,631 - 29,845,727 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl229,845,631 - 29,845,727 (-)EnsemblGRCm38mm10GRCm38
MGSCv37229,701,151 - 29,701,247 (-)NCBIGRCm37mm9NCBIm37
Celera229,552,725 - 29,552,821 (-)NCBICelera
Cytogenetic Map2BNCBI
MIR219-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,139,107 - 55,139,171 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,139,107 - 55,139,171 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,334,083 - 54,334,147 (+)NCBI
ROS_Cfam_1.0956,061,208 - 56,061,272 (+)NCBI
UMICH_Zoey_3.1954,820,802 - 54,820,866 (+)NCBI
UNSW_CanFamBas_1.0955,135,067 - 55,135,131 (+)NCBI
UU_Cfam_GSD_1.0955,226,958 - 55,227,022 (+)NCBI
MIR219B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,816,961 - 268,817,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,816,967 - 268,817,050 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,806,853 - 302,806,936 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
GPC3hsa-miR-219-5pOncomiRDBexternal_infoNANA22449976

Predicted Targets
Summary Value
Count of predictions:16114
Count of gene targets:6814
Count of transcripts:12182
Interacting mature miRNAs:hsa-miR-219-5p, hsa-miR-219a-2-3p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385220
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl9128,392,618 - 128,392,714 (-)Ensembl
RefSeq Acc Id: NR_029837
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389128,392,618 - 128,392,714 (-)NCBI
GRCh379131,154,897 - 131,154,993 (-)RGD
Celera9101,805,800 - 101,805,896 (-)RGD
HuRef9100,767,720 - 100,767,816 (-)RGD
CHM1_19131,305,922 - 131,306,018 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121073102-138179445)x3 copy number gain See cases [RCV000134920] Chr9:121073102..138179445 [GRCh38]
Chr9:123835380..141073897 [GRCh37]
Chr9:122875201..140193718 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9q33.3-34.11(chr9:125055865-128637946)x1 copy number loss See cases [RCV000137787] Chr9:125055865..128637946 [GRCh38]
Chr9:127818144..131400225 [GRCh37]
Chr9:126857965..130440046 [NCBI36]
Chr9:9q33.3-34.11
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic|conflicting data from submitters
GRCh38/hg38 9q34.11(chr9:128236347-128912067)x1 copy number loss See cases [RCV000138929] Chr9:128236347..128912067 [GRCh38]
Chr9:130998626..131674346 [GRCh37]
Chr9:130038447..130714167 [NCBI36]
Chr9:9q34.11
pathogenic
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121112395-138075224)x3 copy number gain See cases [RCV000051009] Chr9:121112395..138075224 [GRCh38]
Chr9:123874673..140969676 [GRCh37]
Chr9:122914494..140089497 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:122792658-138124532)x3 copy number gain See cases [RCV000051040] Chr9:122792658..138124532 [GRCh38]
Chr9:125554937..141018984 [GRCh37]
Chr9:124594758..140138805 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q34.11(chr9:127874581-130421811)x1 copy number loss See cases [RCV000052934] Chr9:127874581..130421811 [GRCh38]
Chr9:130636860..133297198 [GRCh37]
Chr9:129676681..132287019 [NCBI36]
Chr9:9q34.11
pathogenic
GRCh38/hg38 9q33.3-34.11(chr9:125993583-129682375)x1 copy number loss See cases [RCV000052923] Chr9:125993583..129682375 [GRCh38]
Chr9:128755862..132444654 [GRCh37]
Chr9:127795683..131484475 [NCBI36]
Chr9:9q33.3-34.11
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3
pathogenic
GRCh38/hg38 9q34.11(chr9:127919476-130079974)x3 copy number gain See cases [RCV000053777] Chr9:127919476..130079974 [GRCh38]
Chr9:130681755..132842253 [GRCh37]
Chr9:129721576..131882074 [NCBI36]
Chr9:9q34.11
pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121586837-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|See cases [RCV000053776] Chr9:121586837..138179445 [GRCh38]
Chr9:124349116..141073897 [GRCh37]
Chr9:123388937..140193718 [NCBI36]
Chr9:9q33.2-34.3
pathogenic
NC_000009.11:g.(?_130911805)_(131302617_?)dup duplication Coenzyme Q10 deficiency, primary, 7 [RCV000708297] Chr9:128149526..128540338 [GRCh38]
Chr9:130911805..131302617 [GRCh37]
Chr9:9q34.11
uncertain significance
NC_000009.12:g.(?_127612384)_(128566997_?)del deletion Coenzyme Q10 deficiency, primary, 7 [RCV001387712]|Early infantile epileptic encephalopathy with suppression bursts [RCV000819894] Chr9:127612384..128566997 [GRCh38]
Chr9:130374663..131329276 [GRCh37]
Chr9:9q34.11
pathogenic|uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31598 AgrOrtholog
COSMIC MIR219A2 COSMIC
Ensembl Genes ENSG00000284185 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385220 ENTREZGENE
GTEx ENSG00000284185 GTEx
HGNC ID HGNC:31598 ENTREZGENE
Human Proteome Map MIR219A2 Human Proteome Map
miRBase MI0000740 ENTREZGENE
NCBI Gene 407003 ENTREZGENE
PharmGKB PA164722604 PharmGKB
RNAcentral URS00004ACAAA RNACentral
  URS0000565C8D RNACentral
  URS000075B0B0 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-26 MIR219A2  microRNA 219a-2  MIR219-2  microRNA 219-2  Symbol and/or name change 5135510 APPROVED
2011-07-27 MIR219-2  microRNA 219-2  MIR219-2  microRNA 219-2  Symbol and/or name change 5135510 APPROVED