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Gene: CDKL5 (cyclin dependent kinase like 5) Homo sapiens
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Symbol: CDKL5
Name: cyclin dependent kinase like 5
Description: Exhibits ATP binding activity and protein kinase activity. Involved in protein autophosphorylation; regulation of cilium assembly; and regulation of postsynapse organization. Localizes to several cellular components, including the ciliary tip; glutamatergic synapse; and microtubule organizing center. Predicted to colocalize with the ruffle membrane. Implicated in Rett syndrome; early infantile epileptic encephalopathy 2; intellectual disability; and visual epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CFAP247; cyclin dependent kinase 5 transcript; cyclin-dependent kinase-like 5; EIEE2; ISSX; serine/threonine kinase 9; serine/threonine-protein kinase 9; STK9
Orthologs:
Mus musculus (house mouse) : Cdkl5 (cyclin-dependent kinase-like 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cdkl5 (cyclin-dependent kinase-like 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdkl5 (cyclin dependent kinase like 5)
Pan paniscus (bonobo/pygmy chimpanzee) : CDKL5 (cyclin dependent kinase like 5)
Canis lupus familiaris (dog) : CDKL5 (cyclin dependent kinase like 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdkl5 (cyclin dependent kinase like 5)
Sus scrofa (pig) : CDKL5 (cyclin dependent kinase like 5)
Chlorocebus sabaeus (African green monkey) : CDKL5 (cyclin dependent kinase like 5)
Heterocephalus glaber (naked mole-rat) : Cdkl5 (cyclin dependent kinase like 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX18,425,583 - 18,653,629 (+)Ensembl
GRCh38X18,425,605 - 18,653,629 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X18,443,725 - 18,671,749 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X18,353,646 - 18,581,670 (+)NCBINCBI36hg18NCBI36
Build 34X18,203,413 - 18,431,402NCBI
CeleraX22,563,823 - 22,791,841 (+)NCBI
Cytogenetic MapXp22.13NCBI
HuRefX16,199,185 - 16,425,423 (+)NCBIHuRef
CHM1_1X18,474,049 - 18,702,829 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CDKL5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353625
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.