TRGV2 (T cell receptor gamma variable 2) - Rat Genome Database

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Gene: TRGV2 (T cell receptor gamma variable 2) Homo sapiens
Analyze
No known orthologs.
Symbol: TRGV2
Name: T cell receptor gamma variable 2
RGD ID: 1353564
HGNC Page HGNC:12287
Description: Predicted to be involved in adaptive immune response and innate immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. Predicted to be active in external side of plasma membrane.
Type: gene (Ensembl: TR_V_gene)
RefSeq Status: VALIDATED
Previously known as: TCRGV2; VIS2
RGD Orthologs
Alliance Genes
More Info homologs ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38738,362,864 - 38,363,328 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl738,362,864 - 38,363,518 (-)EnsemblGRCh38hg38GRCh38
GRCh37738,402,465 - 38,402,929 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36738,368,990 - 38,369,454 (-)NCBINCBI36Build 36hg18NCBI36
Celera738,390,293 - 38,390,757 (-)NCBICelera
Cytogenetic Map7p14.1NCBI
HuRef738,286,460 - 38,286,924 (-)NCBIHuRef
CHM1_1738,405,112 - 38,405,576 (-)NCBICHM1_1
T2T-CHM13v2.0738,519,743 - 38,520,207 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2527426   PMID:2938743   PMID:2969332   PMID:12477932   PMID:21873635  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p14.1-12.3(chr7:37303478-48660738)x1 copy number loss See cases [RCV000137139] Chr7:37303478..48660738 [GRCh38]
Chr7:37343082..48700334 [GRCh37]
Chr7:37309607..48670880 [NCBI36]
Chr7:7p14.1-12.3		 pathogenic
GRCh38/hg38 7p14.2-14.1(chr7:35460776-42013800)x1 copy number loss See cases [RCV000138190] Chr7:35460776..42013800 [GRCh38]
Chr7:35500386..42053399 [GRCh37]
Chr7:35466911..42019924 [NCBI36]
Chr7:7p14.2-14.1		 pathogenic
GRCh38/hg38 7p14.3-14.1(chr7:32678391-41044983)x1 copy number loss See cases [RCV000140283] Chr7:32678391..41044983 [GRCh38]
Chr7:32718003..41084581 [GRCh37]
Chr7:32684528..41051106 [NCBI36]
Chr7:7p14.3-14.1		 pathogenic
GRCh38/hg38 7p14.1(chr7:38208739-38687927)x3 copy number gain See cases [RCV000140885] Chr7:38208739..38687927 [GRCh38]
Chr7:38248340..38727527 [GRCh37]
Chr7:38214865..38694052 [NCBI36]
Chr7:7p14.1		 likely benign|uncertain significance
GRCh38/hg38 7p14.1-13(chr7:38177999-45304100)x1 copy number loss See cases [RCV000142297] Chr7:38177999..45304100 [GRCh38]
Chr7:38217601..45343699 [GRCh37]
Chr7:38184126..45310224 [NCBI36]
Chr7:7p14.1-13		 pathogenic
GRCh38/hg38 7p22.3-14.1(chr7:54185-41875885)x3 copy number gain See cases [RCV000051159] Chr7:54185..41875885 [GRCh38]
Chr7:54185..41915483 [GRCh37]
Chr7:149268..41882008 [NCBI36]
Chr7:7p22.3-14.1		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7p14.3-q11.21(chr7:33328312-62377476)x3 copy number gain See cases [RCV000053532] Chr7:33328312..62377476 [GRCh38]
Chr7:33367924..61831899 [GRCh37]
Chr7:33334449..61469334 [NCBI36]
Chr7:7p14.3-q11.21		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:202
Count of miRNA genes:199
Interacting mature miRNAs:200
Transcripts:ENST00000426402
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH11095  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37738,402,439 - 38,402,745UniSTSGRCh37
GRCh37738,393,290 - 38,393,596UniSTSGRCh37
Build 36738,359,815 - 38,360,121RGDNCBI36
Celera738,390,267 - 38,390,573UniSTS
Celera738,381,116 - 38,381,422RGD
Cytogenetic Map7p14UniSTS
HuRef738,277,285 - 38,277,591UniSTS
HuRef738,286,434 - 38,286,740UniSTS
CRA_TCAGchr7v2738,440,110 - 38,440,416UniSTS
CRA_TCAGchr7v2738,430,960 - 38,431,266UniSTS
GeneMap99-GB4 RH Map7172.24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 3 66 1 127 1 1 15 1 1
Low 516 621 505 170 1323 135 245 42 213 114 572 735 35 279 105
Below cutoff 1076 1165 849 328 302 227 1551 834 1697 166 537 540 104 641 853 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000426402   ⟹   ENSP00000404928
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl738,362,864 - 38,363,518 (-)Ensembl
Protein Sequences
GenBank Protein A0A075B6R0 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000404928.2
Reference Protein Sequences
RefSeq Acc Id: ENSP00000404928   ⟸   ENST00000426402
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A075B6R0-F1-model_v2 AlphaFold A0A075B6R0 1-118 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12287 AgrOrtholog
COSMIC TRGV2 COSMIC
Ensembl Genes ENSG00000233306 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000426402.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
GTEx ENSG00000233306 GTEx
HGNC ID HGNC:12287 ENTREZGENE
Human Proteome Map TRGV2 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
NCBI Gene TRGV2 ENTREZGENE
PANTHER T CELL RECEPTOR GAMMA VARIABLE 2-RELATED UniProtKB/Swiss-Prot
  T-CELL RECEPTOR GAMMA CHAIN UniProtKB/Swiss-Prot
Pfam V-set UniProtKB/Swiss-Prot
PharmGKB PA36967 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A075B6R0 ENTREZGENE, UniProtKB/Swiss-Prot