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Gene: BTNL2 (butyrophilin like 2) Homo sapiens
Symbol: BTNL2
Name: butyrophilin like 2
Description: Predicted to have signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-2 production. Predicted to localize to external side of plasma membrane. Implicated in several diseases, including Graves' disease; Kawasaki disease; berylliosis; rheumatoid arthritis; and ulcerative colitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BTL-II; BTN7; butyrophilin-like 2 (MHC class II associated); butyrophilin-like protein 2; HSBLMHC1; SS2; truncated BTNL2
Mus musculus (house mouse) : Btnl2 (butyrophilin-like 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Btnl2 (butyrophilin-like 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Btnl2 (butyrophilin like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : BTNL2 (butyrophilin like 2)
Canis lupus familiaris (dog) : BTNL2 (butyrophilin like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Btnl2 (butyrophilin like 2)
Sus scrofa (pig) : BTNL2 (butyrophilin like 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl632,393,963 - 32,407,128 (-)EnsemblGRCh38hg38GRCh38
GRCh38632,393,339 - 32,408,879 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37632,362,513 - 32,374,900 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,470,491 - 32,482,878 (-)NCBINCBI36hg18NCBI36
Build 34632,470,490 - 32,482,878NCBI
Celera633,929,258 - 33,941,628 (-)NCBI
Cytogenetic Map6p21.32NCBI
HuRef632,116,435 - 32,128,672 (-)NCBIHuRef
CHM1_1632,363,584 - 32,377,375 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on BTNL2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353557
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.