DKK3 (dickkopf WNT signaling pathway inhibitor 3) - Rat Genome Database

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Gene: DKK3 (dickkopf WNT signaling pathway inhibitor 3) Homo sapiens
Analyze
Symbol: DKK3
Name: dickkopf WNT signaling pathway inhibitor 3
RGD ID: 1353433
HGNC Page HGNC
Description: Predicted to enable co-receptor binding activity and receptor antagonist activity. Involved in adrenal gland development; negative regulation of canonical Wnt signaling pathway; and negative regulation of cellular biosynthetic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dickkopf 3; dickkopf 3 homolog; dickkopf homolog 3; dickkopf-3; dickkopf-related protein 3; dkk-3; hDkk-3; regulated in glioma; REIC; RIG; RIG-like 5-6; RIG-like 7-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1111,956,207 - 12,009,769 (-)EnsemblGRCh38hg38GRCh38
GRCh381111,963,036 - 12,009,827 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371111,984,583 - 12,030,883 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,941,119 - 11,987,493 (-)NCBINCBI36hg18NCBI36
Build 341111,941,228 - 11,987,205NCBI
Celera1112,109,802 - 12,156,171 (-)NCBI
Cytogenetic Map11p15.3NCBI
HuRef1111,660,573 - 11,706,919 (-)NCBIHuRef
CHM1_11111,983,471 - 12,029,827 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
aldrin  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
avobenzone  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
carbon nanotube  (ISO)
casticin  (EXP)
chloroethene  (ISO)
chloropicrin  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
cyclosporin A  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
diazinon  (ISO)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ethanol  (ISO)
etoposide  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
indometacin  (EXP)
L-methionine  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
mitomycin C  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
naphthalenes  (ISO)
nickel atom  (EXP,ISO)
ozone  (EXP)
pentanal  (EXP)
phenylmercury acetate  (EXP)
pirinixic acid  (EXP)
progesterone  (EXP)
propanal  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP)
Sporidesmin  (EXP)
sulforaphane  (EXP)
sunitinib  (EXP)
temozolomide  (EXP)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
triclosan  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. GOA_HUMAN data from the GO Consortium
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8125298   PMID:8619474   PMID:9070656   PMID:9110174   PMID:10570958   PMID:10652205   PMID:11814687   PMID:12477932   PMID:12527209   PMID:12844346   PMID:12857724   PMID:12975309  
PMID:14702039   PMID:14767340   PMID:15087387   PMID:15226763   PMID:15340161   PMID:15489334   PMID:15516983   PMID:15998302   PMID:16568085   PMID:16609023   PMID:16712791   PMID:16713569  
PMID:16751809   PMID:16981135   PMID:17347849   PMID:18033687   PMID:18048388   PMID:18059033   PMID:18247400   PMID:18443132   PMID:18461655   PMID:18654608   PMID:18826564   PMID:18922905  
PMID:19003969   PMID:19051296   PMID:19192722   PMID:19279003   PMID:19437037   PMID:19453261   PMID:19457090   PMID:19493271   PMID:19496188   PMID:19562778   PMID:19570204   PMID:19859801  
PMID:20050020   PMID:20379614   PMID:20514419   PMID:20532910   PMID:20616171   PMID:20627041   PMID:20666943   PMID:20811686   PMID:20978717   PMID:21042718   PMID:21042779   PMID:21323747  
PMID:21572098   PMID:21796614   PMID:21796842   PMID:21835165   PMID:21873635   PMID:21879258   PMID:21932035   PMID:21987623   PMID:22071168   PMID:22076283   PMID:22274868   PMID:22421143  
PMID:22473694   PMID:22529687   PMID:22555103   PMID:22589738   PMID:23006423   PMID:23154266   PMID:23320751   PMID:23354949   PMID:23529184   PMID:23538390   PMID:23567267   PMID:23702469  
PMID:23765731   PMID:23934736   PMID:24309205   PMID:24325785   PMID:24431302   PMID:24449494   PMID:24498395   PMID:24676838   PMID:24743782   PMID:24909558   PMID:25301448   PMID:25344678  
PMID:25514350   PMID:25573172   PMID:25604390   PMID:25640309   PMID:25760729   PMID:25823913   PMID:26093488   PMID:26119087   PMID:26278164   PMID:26395974   PMID:26397159   PMID:26457595  
PMID:26503968   PMID:26643412   PMID:26687825   PMID:26689513   PMID:26836118   PMID:27010856   PMID:27229929   PMID:27349317   PMID:27354306   PMID:27467270   PMID:27625116   PMID:27788486  
PMID:27801786   PMID:27827955   PMID:27959428   PMID:28168749   PMID:28218426   PMID:28249601   PMID:28299863   PMID:28458155   PMID:28470144   PMID:28514442   PMID:29284609   PMID:29341059  
PMID:29512745   PMID:29673070   PMID:29674765   PMID:29843219   PMID:29858602   PMID:30181180   PMID:30279273   PMID:30355799   PMID:30569110   PMID:30631061   PMID:30779066   PMID:30816803  
PMID:30926679   PMID:31561329   PMID:31682048   PMID:31763724   PMID:31844121   PMID:31918729   PMID:32032750   PMID:32148193   PMID:32296183   PMID:32345717   PMID:32492155   PMID:32577022  
PMID:32814053   PMID:33109534   PMID:33191341   PMID:33281184  


Genomics

Comparative Map Data
DKK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1111,956,207 - 12,009,769 (-)EnsemblGRCh38hg38GRCh38
GRCh381111,963,036 - 12,009,827 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371111,984,583 - 12,030,883 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,941,119 - 11,987,493 (-)NCBINCBI36hg18NCBI36
Build 341111,941,228 - 11,987,205NCBI
Celera1112,109,802 - 12,156,171 (-)NCBI
Cytogenetic Map11p15.3NCBI
HuRef1111,660,573 - 11,706,919 (-)NCBIHuRef
CHM1_11111,983,471 - 12,029,827 (-)NCBICHM1_1
Dkk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397111,715,226 - 111,758,689 (-)NCBIGRCm39mm39
GRCm39 Ensembl7111,715,224 - 111,758,264 (-)Ensembl
GRCm387112,116,019 - 112,159,482 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7112,116,017 - 112,159,057 (-)EnsemblGRCm38mm10GRCm38
MGSCv377119,259,533 - 119,302,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv367111,907,200 - 111,950,238 (-)NCBImm8
Celera7112,091,357 - 112,134,444 (-)NCBICelera
Cytogenetic Map7F1NCBI
Dkk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21166,237,969 - 166,281,271 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1176,940,693 - 176,983,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01176,940,424 - 176,983,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01183,919,812 - 183,962,473 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41169,924,617 - 169,964,692 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,043,564 - 170,084,626 (-)NCBI
Celera1164,115,480 - 164,157,817 (-)NCBICelera
Cytogenetic Map1q33NCBI
Dkk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541427,456,770 - 27,508,109 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541427,466,636 - 27,507,186 (-)NCBIChiLan1.0ChiLan1.0
DKK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11111,824,955 - 11,871,139 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1111,824,955 - 11,871,139 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01112,131,306 - 12,177,906 (-)NCBIMhudiblu_PPA_v0panPan3
DKK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12135,032,501 - 35,074,664 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2135,033,552 - 35,074,664 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2134,597,515 - 34,637,913 (-)NCBI
ROS_Cfam_1.02135,909,311 - 35,949,713 (-)NCBI
UMICH_Zoey_3.12135,170,822 - 35,211,124 (-)NCBI
UNSW_CanFamBas_1.02135,348,672 - 35,389,042 (-)NCBI
UU_Cfam_GSD_1.02135,635,088 - 35,675,523 (-)NCBI
Dkk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494750,394,918 - 50,443,027 (+)NCBI
SpeTri2.0NW_0049365286,428,824 - 6,477,007 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DKK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl247,385,191 - 47,446,538 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1247,385,244 - 47,444,664 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2250,699,247 - 50,758,562 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DKK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1152,823,415 - 52,868,804 (+)NCBI
ChlSab1.1 Ensembl152,824,176 - 52,868,885 (+)Ensembl
Vero_WHO_p1.0NW_023666038150,424,876 - 150,470,271 (+)NCBI
Dkk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247664,042,307 - 4,085,613 (-)NCBI

Position Markers
1794  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371111,985,111 - 11,985,187UniSTSGRCh37
Build 361111,941,687 - 11,941,763RGDNCBI36
Celera1112,110,370 - 12,110,446RGD
Cytogenetic Map11p15.2UniSTS
HuRef1111,661,141 - 11,661,217UniSTS
GeneMap99-GB4 RH Map1148.69UniSTS
RH65665  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371112,022,503 - 12,022,691UniSTSGRCh37
Build 361111,979,079 - 11,979,267RGDNCBI36
Celera1112,147,757 - 12,147,945RGD
Cytogenetic Map11p15.2UniSTS
HuRef1111,698,528 - 11,698,716UniSTS
GeneMap99-GB4 RH Map1147.27UniSTS
NCBI RH Map1160.0UniSTS
D11S2261E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371111,984,653 - 11,984,802UniSTSGRCh37
Build 361111,941,229 - 11,941,378RGDNCBI36
Celera1112,109,912 - 12,110,061RGD
Cytogenetic Map11p15.2UniSTS
HuRef1111,660,683 - 11,660,832UniSTS
GeneMap99-GB4 RH Map1147.27UniSTS
NCBI RH Map1160.0UniSTS
D11S1381E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371111,985,207 - 11,985,286UniSTSGRCh37
Build 361111,941,783 - 11,941,862RGDNCBI36
Celera1112,110,466 - 12,110,545RGD
Cytogenetic Map11p15.2UniSTS
HuRef1111,661,237 - 11,661,316UniSTS
G19726  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371111,984,749 - 11,984,979UniSTSGRCh37
Build 361111,941,325 - 11,941,555RGDNCBI36
Celera1112,110,008 - 12,110,238RGD
Cytogenetic Map11p15.2UniSTS
HuRef1111,660,779 - 11,661,009UniSTS
A001W38  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371111,984,749 - 11,984,979UniSTSGRCh37
Build 361111,941,325 - 11,941,555RGDNCBI36
Celera1112,110,008 - 12,110,238RGD
Cytogenetic Map11p15.2UniSTS
HuRef1111,660,779 - 11,661,009UniSTS
GeneMap99-GB4 RH Map1148.79UniSTS
D11S2388  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371111,984,654 - 11,984,854UniSTSGRCh37
Build 361111,941,230 - 11,941,430RGDNCBI36
Celera1112,109,913 - 12,110,113RGD
Cytogenetic Map11p15.2UniSTS
HuRef1111,660,684 - 11,660,884UniSTS
GeneMap99-GB4 RH Map1150.89UniSTS
Whitehead-RH Map1150.6UniSTS
Whitehead-YAC Contig Map11 UniSTS
NCBI RH Map1159.6UniSTS
T03598  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371111,984,654 - 11,984,839UniSTSGRCh37
Build 361111,941,230 - 11,941,415RGDNCBI36
Celera1112,109,913 - 12,110,098RGD
Cytogenetic Map11p15.2UniSTS
HuRef1111,660,684 - 11,660,869UniSTS
Whitehead-YAC Contig Map11 UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR19B2hsa-miR-19b-3pOncomiRDBexternal_infoNANA21796614
MIR19B1hsa-miR-19b-3pOncomiRDBexternal_infoNANA21796614
MIR92A2hsa-miR-92a-3pOncomiRDBexternal_infoNANA21796614
MIR92A2hsa-miR-92a-3pOncomiRDBexternal_infoNANA21572098
MIR92Bhsa-miR-92b-3pOncomiRDBexternal_infoNANA21572098

Predicted Target Of
Summary Value
Count of predictions:5630
Count of miRNA genes:1182
Interacting mature miRNAs:1530
Transcripts:ENST00000326932, ENST00000396505, ENST00000450094, ENST00000525493, ENST00000525927, ENST00000526218, ENST00000527132, ENST00000528188, ENST00000529338, ENST00000530694, ENST00000531309, ENST00000532372, ENST00000532873, ENST00000533813, ENST00000533900, ENST00000534479, ENST00000534511
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 1 232 1 3 9 1 1 1
Medium 2256 1967 1272 249 447 92 3485 1399 3689 285 1350 1418 166 995 2054 1
Low 101 446 443 368 537 366 855 780 33 130 86 160 7 1 209 733 3
Below cutoff 45 337 6 3 522 5 6 11 2 4 19 25 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001018057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_015881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006718178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB033421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB034203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB035182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB057591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB057804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF052161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF177396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF400439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK225156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL535720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY587550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF724383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ690088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ690888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ894810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB156451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  H18461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000326932   ⟹   ENSP00000314910
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,963,106 - 12,009,370 (-)Ensembl
RefSeq Acc Id: ENST00000396505   ⟹   ENSP00000379762
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,956,207 - 12,009,082 (-)Ensembl
RefSeq Acc Id: ENST00000525493   ⟹   ENSP00000433112
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,964,391 - 12,009,769 (-)Ensembl
RefSeq Acc Id: ENST00000525927
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,965,873 - 11,979,916 (-)Ensembl
RefSeq Acc Id: ENST00000526218
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,978,840 - 12,009,725 (-)Ensembl
RefSeq Acc Id: ENST00000527132
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,963,106 - 12,008,630 (-)Ensembl
RefSeq Acc Id: ENST00000528188
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,964,615 - 11,994,719 (-)Ensembl
RefSeq Acc Id: ENST00000529338   ⟹   ENSP00000431604
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,968,443 - 12,009,137 (-)Ensembl
RefSeq Acc Id: ENST00000530694
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,001,675 - 12,009,737 (-)Ensembl
RefSeq Acc Id: ENST00000531309
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,998,200 - 12,002,426 (-)Ensembl
RefSeq Acc Id: ENST00000532372
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,965,850 - 11,968,746 (-)Ensembl
RefSeq Acc Id: ENST00000532873
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,965,880 - 12,008,897 (-)Ensembl
RefSeq Acc Id: ENST00000533813   ⟹   ENSP00000435269
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,965,935 - 12,009,211 (-)Ensembl
RefSeq Acc Id: ENST00000533900
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,001,904 - 12,009,212 (-)Ensembl
RefSeq Acc Id: ENST00000534479
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1112,001,749 - 12,009,330 (-)Ensembl
RefSeq Acc Id: ENST00000534511   ⟹   ENSP00000436645
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,966,993 - 12,008,624 (-)Ensembl
RefSeq Acc Id: ENST00000683431   ⟹   ENSP00000506835
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1111,963,036 - 12,008,626 (-)Ensembl
RefSeq Acc Id: NM_001018057   ⟹   NP_001018067
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,963,036 - 12,008,626 (-)NCBI
GRCh371111,984,543 - 12,031,373 (-)NCBI
Build 361111,941,119 - 11,986,762 (-)NCBI Archive
HuRef1111,660,573 - 11,706,919 (-)ENTREZGENE
CHM1_11111,983,471 - 12,029,096 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001330220   ⟹   NP_001317149
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,963,036 - 12,009,336 (-)NCBI
Sequence:
RefSeq Acc Id: NM_013253   ⟹   NP_037385
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,963,036 - 12,009,336 (-)NCBI
GRCh371111,984,543 - 12,031,373 (-)NCBI
Build 361111,941,119 - 11,987,493 (-)NCBI Archive
HuRef1111,660,573 - 11,706,919 (-)ENTREZGENE
CHM1_11111,983,471 - 12,029,827 (-)NCBI
Sequence:
RefSeq Acc Id: NM_015881   ⟹   NP_056965
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,963,036 - 12,009,140 (-)NCBI
GRCh371111,984,543 - 12,031,373 (-)NCBI
Build 361111,941,119 - 11,987,205 (-)NCBI Archive
HuRef1111,660,573 - 11,706,919 (-)ENTREZGENE
CHM1_11111,983,471 - 12,029,539 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006718178   ⟹   XP_006718241
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,963,106 - 12,009,064 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017554   ⟹   XP_016873043
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,963,106 - 12,009,056 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017555   ⟹   XP_016873044
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,963,106 - 12,009,064 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024448440   ⟹   XP_024304208
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,995,419 - 12,009,827 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024448441   ⟹   XP_024304209
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381111,963,106 - 11,966,757 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001018067 (Get FASTA)   NCBI Sequence Viewer  
  NP_001317149 (Get FASTA)   NCBI Sequence Viewer  
  NP_037385 (Get FASTA)   NCBI Sequence Viewer  
  NP_056965 (Get FASTA)   NCBI Sequence Viewer  
  XP_006718241 (Get FASTA)   NCBI Sequence Viewer  
  XP_016873043 (Get FASTA)   NCBI Sequence Viewer  
  XP_016873044 (Get FASTA)   NCBI Sequence Viewer  
  XP_024304208 (Get FASTA)   NCBI Sequence Viewer  
  XP_024304209 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC35996 (Get FASTA)   NCBI Sequence Viewer  
  AAF02676 (Get FASTA)   NCBI Sequence Viewer  
  AAH07660 (Get FASTA)   NCBI Sequence Viewer  
  AAK92488 (Get FASTA)   NCBI Sequence Viewer  
  AAQ88744 (Get FASTA)   NCBI Sequence Viewer  
  AAS86757 (Get FASTA)   NCBI Sequence Viewer  
  BAA85488 (Get FASTA)   NCBI Sequence Viewer  
  BAA87044 (Get FASTA)   NCBI Sequence Viewer  
  BAA90548 (Get FASTA)   NCBI Sequence Viewer  
  BAB84360 (Get FASTA)   NCBI Sequence Viewer  
  BAB84361 (Get FASTA)   NCBI Sequence Viewer  
  BAC03555 (Get FASTA)   NCBI Sequence Viewer  
  BAF82586 (Get FASTA)   NCBI Sequence Viewer  
  BAG52632 (Get FASTA)   NCBI Sequence Viewer  
  BAG58381 (Get FASTA)   NCBI Sequence Viewer  
  BAG58448 (Get FASTA)   NCBI Sequence Viewer  
  EAW68533 (Get FASTA)   NCBI Sequence Viewer  
  EAW68534 (Get FASTA)   NCBI Sequence Viewer  
  EAW68535 (Get FASTA)   NCBI Sequence Viewer  
  EAW68536 (Get FASTA)   NCBI Sequence Viewer  
  EAW68537 (Get FASTA)   NCBI Sequence Viewer  
  EAW68538 (Get FASTA)   NCBI Sequence Viewer  
  EAW68539 (Get FASTA)   NCBI Sequence Viewer  
  Q9UBP4 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037385   ⟸   NM_013253
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9UBP4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_056965   ⟸   NM_015881
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9UBP4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001018067   ⟸   NM_001018057
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9UBP4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006718241   ⟸   XM_006718178
- Peptide Label: isoform X2
- UniProtKB: Q9UBP4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016873044   ⟸   XM_017017555
- Peptide Label: isoform X1
- UniProtKB: F6SYF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016873043   ⟸   XM_017017554
- Peptide Label: isoform X1
- UniProtKB: F6SYF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001317149   ⟸   NM_001330220
- Peptide Label: isoform 2 precursor
- UniProtKB: Q9UBP4 (UniProtKB/Swiss-Prot),   F6SYF8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024304209   ⟸   XM_024448441
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_024304208   ⟸   XM_024448440
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000435269   ⟸   ENST00000533813
RefSeq Acc Id: ENSP00000436645   ⟸   ENST00000534511
RefSeq Acc Id: ENSP00000314910   ⟸   ENST00000326932
RefSeq Acc Id: ENSP00000433112   ⟸   ENST00000525493
RefSeq Acc Id: ENSP00000379762   ⟸   ENST00000396505
RefSeq Acc Id: ENSP00000431604   ⟸   ENST00000529338
RefSeq Acc Id: ENSP00000506835   ⟸   ENST00000683431
Protein Domains
Dickkopf_N

Promoters
RGD ID:7219675
Promoter ID:EPDNEW_H15583
Type:initiation region
Name:DKK3_2
Description:dickkopf WNT signaling pathway inhibitor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15584  EPDNEW_H15585  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,008,626 - 12,008,686EPDNEW
RGD ID:7219677
Promoter ID:EPDNEW_H15584
Type:initiation region
Name:DKK3_3
Description:dickkopf WNT signaling pathway inhibitor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15583  EPDNEW_H15585  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,009,075 - 12,009,135EPDNEW
RGD ID:7219679
Promoter ID:EPDNEW_H15585
Type:initiation region
Name:DKK3_1
Description:dickkopf WNT signaling pathway inhibitor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H15583  EPDNEW_H15584  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381112,009,331 - 12,009,391EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13
pathogenic
GRCh38/hg38 11p15.5-15.1(chr11:446754-18904742)x3 copy number gain See cases [RCV000133997] Chr11:446754..18904742 [GRCh38]
Chr11:446754..18926289 [GRCh37]
Chr11:436754..18882865 [NCBI36]
Chr11:11p15.5-15.1
pathogenic
GRCh38/hg38 11p15.4-15.2(chr11:9989516-16825806)x1 copy number loss See cases [RCV000136773] Chr11:9989516..16825806 [GRCh38]
Chr11:10011063..16847353 [GRCh37]
Chr11:9967639..16803929 [NCBI36]
Chr11:11p15.4-15.2
pathogenic
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-15.3(chr11:193146-12643136) copy number gain Russell-Silver syndrome [RCV000767567] Chr11:193146..12643136 [GRCh37]
Chr11:11p15.5-15.3
pathogenic
GRCh37/hg19 11p15.5-14.3(chr11:230615-25584362)x3 copy number gain See cases [RCV000512225] Chr11:230615..25584362 [GRCh37]
Chr11:11p15.5-14.3
pathogenic
GRCh37/hg19 11p15.5-13(chr11:230615-31995219)x3 copy number gain See cases [RCV000512477] Chr11:230615..31995219 [GRCh37]
Chr11:11p15.5-13
pathogenic
GRCh37/hg19 11p15.5-15.1(chr11:230615-17099213)x3 copy number gain not provided [RCV000683372] Chr11:230615..17099213 [GRCh37]
Chr11:11p15.5-15.1
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.3(chr11:11970971-11986061)x3 copy number gain not provided [RCV000737431] Chr11:11970971..11986061 [GRCh37]
Chr11:11p15.3
benign
NM_015881.5(DKK3):c.277A>G (p.Ser93Gly) single nucleotide variant not provided [RCV000883320] Chr11:12002374 [GRCh38]
Chr11:12023921 [GRCh37]
Chr11:11p15.3
benign
NM_015881.5(DKK3):c.920A>G (p.Glu307Gly) single nucleotide variant not provided [RCV000947327] Chr11:11964597 [GRCh38]
Chr11:11986144 [GRCh37]
Chr11:11p15.3
benign
GRCh37/hg19 11p15.3-13(chr11:11053978-34732891)x3 copy number gain not provided [RCV001006387] Chr11:11053978..34732891 [GRCh37]
Chr11:11p15.3-13
pathogenic
NM_001018057.1(DKK3):c.505C>A (p.Gln169Lys) single nucleotide variant Marfanoid habitus and intellectual disability [RCV000850437] Chr11:11968418 [GRCh38]
Chr11:11989965 [GRCh37]
Chr11:11p15.3
uncertain significance
GRCh37/hg19 11p15.3(chr11:11461387-12258307)x1 copy number loss not provided [RCV000845634] Chr11:11461387..12258307 [GRCh37]
Chr11:11p15.3
uncertain significance
GRCh37/hg19 11p15.5-13(chr11:235934-33826995)x3 copy number gain not provided [RCV001006372] Chr11:235934..33826995 [GRCh37]
Chr11:11p15.5-13
pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2893 AgrOrtholog
COSMIC DKK3 COSMIC
Ensembl Genes ENSG00000050165 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000314910 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000379762 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000431604 UniProtKB/TrEMBL
  ENSP00000433112 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000435269 UniProtKB/TrEMBL
  ENSP00000436645 UniProtKB/TrEMBL
  ENSP00000506835 ENTREZGENE
Ensembl Transcript ENST00000326932 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000396505 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000525493 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000529338 UniProtKB/TrEMBL
  ENST00000533813 UniProtKB/TrEMBL
  ENST00000534511 UniProtKB/TrEMBL
  ENST00000683431 ENTREZGENE
GTEx ENSG00000050165 GTEx
HGNC ID HGNC:2893 ENTREZGENE
Human Proteome Map DKK3 Human Proteome Map
InterPro Dickkopf_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DKK-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:27122 UniProtKB/Swiss-Prot
NCBI Gene 27122 ENTREZGENE
OMIM 605416 OMIM
PANTHER PTHR12113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Dickkopf_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA27347 PharmGKB
UniProt D3DQW3_HUMAN UniProtKB/TrEMBL
  DKK3_HUMAN UniProtKB/Swiss-Prot
  E9PHY3_HUMAN UniProtKB/TrEMBL
  E9PKK9_HUMAN UniProtKB/TrEMBL
  E9PKW6_HUMAN UniProtKB/TrEMBL
  F6SYF8 ENTREZGENE, UniProtKB/TrEMBL
  Q6PQ81_HUMAN UniProtKB/TrEMBL
  Q9UBP4 ENTREZGENE
UniProt Secondary A8K1I2 UniProtKB/Swiss-Prot
  D3DQW1 UniProtKB/Swiss-Prot
  Q9ULB7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-21 DKK3  dickkopf WNT signaling pathway inhibitor 3    dickkopf 3 homolog (Xenopus laevis)  Symbol and/or name change 5135510 APPROVED
2011-11-22 DKK3  dickkopf 3 homolog (Xenopus laevis)  DKK3  dickkopf homolog 3 (Xenopus laevis)  Symbol and/or name change 5135510 APPROVED
2011-08-16 DKK3  dickkopf homolog 3 (Xenopus laevis)  DKK3  dickkopf homolog 3 (Xenopus laevis)  Symbol and/or name change 5135510 APPROVED