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Gene: DKK3 (dickkopf WNT signaling pathway inhibitor 3) Homo sapiens
Symbol: DKK3
Name: dickkopf WNT signaling pathway inhibitor 3
Description: Predicted to have co-receptor binding activity and receptor antagonist activity. Involved in adrenal gland development; negative regulation of canonical Wnt signaling pathway; and negative regulation of cellular biosynthetic process. Predicted to localize to extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dickkopf 3; dickkopf 3 homolog; dickkopf homolog 3; dickkopf-3; dickkopf-related protein 3; dkk-3; hDkk-3; regulated in glioma; REIC; RIG; RIG-like 5-6; RIG-like 7-1
Mus musculus (house mouse) : Dkk3 (dickkopf WNT signaling pathway inhibitor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dkk3 (dickkopf WNT signaling pathway inhibitor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dkk3 (dickkopf WNT signaling pathway inhibitor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DKK3 (dickkopf WNT signaling pathway inhibitor 3)
Canis lupus familiaris (dog) : DKK3 (dickkopf WNT signaling pathway inhibitor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dkk3 (dickkopf WNT signaling pathway inhibitor 3)
Sus scrofa (pig) : DKK3 (dickkopf WNT signaling pathway inhibitor 3)
Chlorocebus sabaeus (African green monkey) : DKK3 (dickkopf WNT signaling pathway inhibitor 3)
Heterocephalus glaber (naked mole-rat) : Dkk3 (dickkopf WNT signaling pathway inhibitor 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1111,956,207 - 12,009,769 (-)EnsemblGRCh38hg38GRCh38
GRCh381111,962,979 - 12,009,827 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371111,984,543 - 12,031,373 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,941,119 - 11,987,493 (-)NCBINCBI36hg18NCBI36
Build 341111,941,228 - 11,987,205NCBI
Celera1112,109,802 - 12,156,171 (-)NCBI
Cytogenetic Map11p15.3NCBI
HuRef1111,660,573 - 11,706,919 (-)NCBIHuRef
CHM1_11111,983,471 - 12,029,827 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DKK3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353433
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.