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Gene: IQSEC2 (IQ motif and Sec7 domain ArfGEF 2) Homo sapiens
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Symbol: IQSEC2
Name: IQ motif and Sec7 domain ArfGEF 2
Description: Exhibits ARF guanyl-nucleotide exchange factor activity. Involved in modulation of chemical synaptic transmission and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Localizes to the Schaffer collateral - CA1 synapse. Implicated in non-syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BRAG1; brefeldin A resistant Arf-guanine nucleotide exchange factor 1; brefeldin A resistant Arf-guanine nucleotide exchange factor 1b; brefeldin A resistant Arf-guanine nucleotide exchange factor 1c; IQ motif and Sec7 domain 2; IQ motif and SEC7 domain-containing protein 2; IQ-ArfGEF; KIAA0522; mental retardation, X-linked 1 (non-dysmorphic); mental retardation, X-linked 18; mental retardation, X-linked 78; MRX1; MRX18; MRX78
Orthologs:
Mus musculus (house mouse) : Iqsec2 (IQ motif and Sec7 domain 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Iqsec2 (IQ motif and Sec7 domain ArfGEF 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Iqsec2 (IQ motif and Sec7 domain ArfGEF 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IQSEC2 (IQ motif and Sec7 domain ArfGEF 2)
Canis lupus familiaris (dog) : IQSEC2 (IQ motif and Sec7 domain ArfGEF 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Iqsec2 (IQ motif and Sec7 domain ArfGEF 2)
Sus scrofa (pig) : IQSEC2 (IQ motif and Sec7 domain ArfGEF 2)
Chlorocebus sabaeus (African green monkey) : IQSEC2 (IQ motif and Sec7 domain ArfGEF 2)
Heterocephalus glaber (naked mole-rat) : Iqsec2 (IQ motif and Sec7 domain ArfGEF 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 EnsemblX53,225,828 - 53,321,350 (-)Ensembl
GRCh38X53,225,784 - 53,321,356 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X53,262,058 - 53,350,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,278,783 - 53,327,521 (-)NCBINCBI36hg18NCBI36
CeleraX57,091,294 - 57,179,759 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX50,327,195 - 50,414,951 (-)NCBIHuRef
CHM1_1X53,252,281 - 53,340,767 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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RNA-SEQ Expression

Sequence

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Nomenclature History
 
More on IQSEC2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1353175
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.