HSPA1L (heat shock protein family A (Hsp70) member 1 like) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: HSPA1L (heat shock protein family A (Hsp70) member 1 like) Homo sapiens
Analyze
Symbol: HSPA1L
Name: heat shock protein family A (Hsp70) member 1 like
RGD ID: 1353078
Description: Exhibits heat shock protein binding activity; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Involved in positive regulation of protein targeting to mitochondrion and protein refolding. Localizes to cytosol. Colocalizes with COP9 signalosome. Implicated in Kawasaki disease; major depressive disorder; schizophrenia; systemic lupus erythematosus; and uveitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: heat shock 10kDa protein 1-like; heat shock 70 kDa protein 1-Hom; heat shock 70 kDa protein 1-like; heat shock 70 kDa protein 1L; heat shock 70kD protein-like 1; heat shock 70kDa protein 1-like; HSP70-1L; HSP70-HOM; HSP70T; hum70t
Orthologs:
Mus musculus (house mouse) : Hspa1l (heat shock protein 1-like)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hspa1l (heat shock protein family A (Hsp70) member 1 like)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : HSPA1L (heat shock protein family A (Hsp70) member 1 like)
Canis lupus familiaris (dog) : LOC474850 (heat shock 70 kDa protein 1-like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hspa1l (heat shock protein family A (Hsp70) member 1 like)
Sus scrofa (pig) : HSPA1L (heat shock protein family A (Hsp70) member 1 like)
Chlorocebus sabaeus (African green monkey) : HSPA1L (heat shock protein family A (Hsp70) member 1 like)
Heterocephalus glaber (naked mole-rat) : Hspa1l (heat shock protein family A (Hsp70) member 1 like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,809,619 - 31,815,283 (-)EnsemblGRCh38hg38GRCh38
GRCh38631,809,619 - 31,815,283 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,777,396 - 31,790,093 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,885,375 - 31,890,814 (-)NCBINCBI36hg18NCBI36
Build 34631,885,374 - 31,890,786NCBI
Celera633,375,646 - 33,381,084 (-)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,563,804 - 31,569,242 (-)NCBIHuRef
CHM1_1631,779,530 - 31,784,969 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP)
amphibole asbestos  (EXP)
antirheumatic drug  (EXP)
apigenin  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
Aurin  (EXP)
benzo[a]pyrene  (EXP)
bisphenol A  (EXP,ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbamazepine  (EXP)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
choline  (ISO)
clofibrate  (ISO)
cobalt atom  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crocin-1  (ISO)
crotonaldehyde  (EXP)
D-penicillamine  (EXP)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
diethylstilbestrol  (ISO)
disulfiram  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ethanol  (ISO)
ferric ammonium citrate  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
gemcitabine  (EXP)
hemin  (EXP)
indometacin  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isoprenaline  (EXP,ISO)
L-methionine  (ISO)
linalool  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
mercury atom  (EXP)
mercury(0)  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
monocrotaline  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (EXP)
nitroprusside  (EXP)
omeprazole  (ISO)
organoselenium compound  (EXP)
oxidopamine  (ISO)
p-chloromercuribenzoic acid  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenytoin  (ISO)
pioglitazone  (EXP)
pirinixic acid  (ISO)
quercitrin  (EXP)
rifampicin  (ISO)
rotenone  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
styrene  (EXP)
sulforaphane  (EXP)
sunitinib  (EXP)
tamoxifen  (ISO)
teriflunomide  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thimerosal  (EXP)
thiostrepton  (EXP)
titanium dioxide  (ISO)
trichostatin A  (EXP)
troglitazone  (EXP)
Tungsten carbide  (EXP)
tunicamycin  (EXP)
urethane  (EXP)
valproic acid  (EXP)
zinc atom  (EXP)
zinc pyrithione  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Schizophrenia  (IAGP)
References

Additional References at PubMed
PMID:1356099   PMID:1700760   PMID:2538825   PMID:2880793   PMID:3470951   PMID:3927293   PMID:8125298   PMID:9349405   PMID:9685725   PMID:11040178   PMID:11076863   PMID:11334675  
PMID:11599570   PMID:11696222   PMID:11779758   PMID:12008944   PMID:12082592   PMID:12477932   PMID:12544996   PMID:12742533   PMID:14574404   PMID:14605873   PMID:14656967   PMID:14743216  
PMID:15165109   PMID:15236755   PMID:15489334   PMID:15489336   PMID:15818324   PMID:15963589   PMID:16202503   PMID:16333988   PMID:16364915   PMID:16381901   PMID:16525348   PMID:16538175  
PMID:16538176   PMID:16565291   PMID:16611259   PMID:17060867   PMID:17110338   PMID:17182002   PMID:17184779   PMID:17578680   PMID:17582394   PMID:17601350   PMID:17620599   PMID:17643375  
PMID:17934269   PMID:18022941   PMID:18247557   PMID:18518860   PMID:18551993   PMID:18813331   PMID:18818748   PMID:18850735   PMID:18977241   PMID:18987644   PMID:19019335   PMID:19085089  
PMID:19116923   PMID:19143821   PMID:19299493   PMID:19343720   PMID:19351530   PMID:19374512   PMID:19380743   PMID:19439993   PMID:19527514   PMID:19626584   PMID:19643584   PMID:19731315  
PMID:19789190   PMID:19840767   PMID:19851445   PMID:19875381   PMID:19913121   PMID:20000738   PMID:20012387   PMID:20069064   PMID:20096741   PMID:20388090   PMID:20391533   PMID:20568452  
PMID:20587610   PMID:20628086   PMID:20704535   PMID:20714140   PMID:20800603   PMID:21081503   PMID:21145461   PMID:21182205   PMID:21231916   PMID:21532586   PMID:21654808   PMID:21726808  
PMID:21873635   PMID:21951318   PMID:22079093   PMID:22516433   PMID:22810585   PMID:22863883   PMID:22939629   PMID:23028341   PMID:23125841   PMID:23246001   PMID:23330093   PMID:23349634  
PMID:23443559   PMID:23490384   PMID:23666708   PMID:23703321   PMID:23824909   PMID:23893339   PMID:24051039   PMID:24169447   PMID:24244333   PMID:24270810   PMID:24399297   PMID:24657165  
PMID:24837172   PMID:25036637   PMID:25044062   PMID:25241761   PMID:25458010   PMID:25609649   PMID:25670202   PMID:25680846   PMID:25798074   PMID:25963833   PMID:26160076   PMID:26186194  
PMID:26460568   PMID:26496610   PMID:26496868   PMID:26582913   PMID:26638075   PMID:26735018   PMID:26745065   PMID:26831064   PMID:27025967   PMID:27129234   PMID:27173435   PMID:27371349  
PMID:27512140   PMID:27593939   PMID:28126021   PMID:28182740   PMID:28291257   PMID:28330616   PMID:28366632   PMID:28759037   PMID:28977666   PMID:29072670   PMID:29229926   PMID:29467282  
PMID:29563501   PMID:29568061   PMID:29735542   PMID:29845934   PMID:29863498   PMID:30001343   PMID:30021884   PMID:30258100   PMID:30342847   PMID:30349055   PMID:30442662   PMID:30455355  
PMID:30575818   PMID:30655611   PMID:30719818   PMID:30792309   PMID:30809309   PMID:30940648   PMID:31006538   PMID:31152661   PMID:31228677   PMID:31253590   PMID:31300519   PMID:31343991  
PMID:31501420   PMID:31586073   PMID:32296183  


Genomics

Comparative Map Data
HSPA1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,809,619 - 31,815,283 (-)EnsemblGRCh38hg38GRCh38
GRCh38631,809,619 - 31,815,283 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,777,396 - 31,790,093 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,885,375 - 31,890,814 (-)NCBINCBI36hg18NCBI36
Build 34631,885,374 - 31,890,786NCBI
Celera633,375,646 - 33,381,084 (-)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,563,804 - 31,569,242 (-)NCBIHuRef
CHM1_1631,779,530 - 31,784,969 (-)NCBICHM1_1
Hspa1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,191,679 - 35,198,204 (+)NCBI
GRCm381734,972,703 - 34,979,228 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,972,703 - 34,979,285 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,109,648 - 35,116,173 (+)NCBIGRCm37mm9NCBIm37
MGSCv361734,580,788 - 34,587,281 (+)NCBImm8
Celera1738,068,927 - 38,075,454 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.51NCBI
Hspa1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0204,879,998 - 4,965,191 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,959,294 - 4,964,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,032,557 - 7,038,454 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera204,171,282 - 4,177,670 (+)NCBICelera
Cytogenetic Map20p12NCBI
HSPA1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,357,626 - 32,370,055 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,358,054 - 32,359,979 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0631,470,745 - 31,483,615 (-)NCBIMhudiblu_PPA_v0panPan3
LOC474850
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl121,281,472 - 1,285,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1121,281,164 - 1,285,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hspa1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367271,735,880 - 1,745,231 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HSPA1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,909,960 - 23,921,723 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,909,960 - 23,938,678 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HSPA1L
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,206,365 - 40,211,996 (+)NCBI
Hspa1l
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,403,438 - 24,423,477 (+)NCBI

Position Markers
RH12516  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,777,559 - 31,777,678UniSTSGRCh37
Build 36631,885,538 - 31,885,657RGDNCBI36
Celera633,375,809 - 33,375,928RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,563,967 - 31,564,086UniSTS
GeneMap99-GB4 RH Map6119.82UniSTS
PMC117401P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,796,074 - 31,796,553UniSTSGRCh37
GRCh37631,783,880 - 31,784,359UniSTSGRCh37
Build 36631,891,859 - 31,892,338RGDNCBI36
Celera633,382,129 - 33,382,608RGD
Celera633,394,325 - 33,394,804UniSTS
HuRef631,570,287 - 31,570,766UniSTS
PMC125271P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,105 - 31,783,386UniSTSGRCh37
Build 36631,891,084 - 31,891,365RGDNCBI36
Celera633,381,354 - 33,381,635RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,512 - 31,569,793UniSTS
PMC125702P4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,469 - 31,783,740UniSTSGRCh37
Build 36631,891,448 - 31,891,719RGDNCBI36
Celera633,381,718 - 33,381,989RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,876 - 31,570,147UniSTS
PMC134733P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,111 - 31,783,372UniSTSGRCh37
Build 36631,891,090 - 31,891,351RGDNCBI36
Celera633,381,360 - 33,381,621RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,518 - 31,569,779UniSTS
PMC138289P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,201 - 31,783,391UniSTSGRCh37
Build 36631,891,180 - 31,891,370RGDNCBI36
Celera633,381,450 - 33,381,640RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,608 - 31,569,798UniSTS
PMC196894P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,469 - 31,783,801UniSTSGRCh37
Build 36631,891,448 - 31,891,780RGDNCBI36
Celera633,381,718 - 33,382,050RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,876 - 31,570,208UniSTS
PMC314357P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,796,096 - 31,796,584UniSTSGRCh37
GRCh37631,783,902 - 31,784,390UniSTSGRCh37
Build 36631,891,881 - 31,892,369RGDNCBI36
Celera633,382,151 - 33,382,639RGD
Celera633,394,347 - 33,394,835UniSTS
HuRef631,570,309 - 31,570,797UniSTS
HSPA1L__1180  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,777,407 - 31,778,173UniSTSGRCh37
Build 36631,885,386 - 31,886,152RGDNCBI36
Celera633,375,657 - 33,376,423RGD
HuRef631,563,815 - 31,564,581UniSTS
D6S2779  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,777,281 - 31,777,463UniSTSGRCh37
Build 36631,885,260 - 31,885,442RGDNCBI36
Celera633,375,527 - 33,375,713RGD
HuRef631,563,689 - 31,563,871UniSTS
RH35868  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,783,376 - 31,783,530UniSTSGRCh37
Build 36631,891,355 - 31,891,509RGDNCBI36
Celera633,381,625 - 33,381,779RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,569,783 - 31,569,937UniSTS
GeneMap99-GB4 RH Map6120.03UniSTS
STS-M59829  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,777,621 - 31,777,797UniSTSGRCh37
Build 36631,885,600 - 31,885,776RGDNCBI36
Celera633,375,871 - 33,376,047RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,564,029 - 31,564,205UniSTS
GeneMap99-GB4 RH Map6119.49UniSTS
N3_2_5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37631,776,984 - 31,777,440UniSTSGRCh37
Build 36631,884,963 - 31,885,419RGDNCBI36
Celera633,375,230 - 33,375,690RGD
Cytogenetic Map6p21.3UniSTS
HuRef631,563,392 - 31,563,848UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:257
Count of miRNA genes:193
Interacting mature miRNAs:199
Transcripts:ENST00000375654, ENST00000417199
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 17 89 31 3 94 3 19 21 69 415 43 3 15
Low 2398 2711 1601 536 1788 378 4319 2042 3612 412 1026 1556 170 1195 2760 4
Below cutoff 17 184 90 83 54 83 17 130 27 6 7 6 6 13

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_011855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF134726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK223386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL662834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL671762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL929592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BA000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG717447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX115051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA443193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR388202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR759915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ383515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY500404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000375654   ⟹   ENSP00000364805
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl631,809,619 - 31,815,283 (-)Ensembl
RefSeq Acc Id: NM_005527   ⟹   NP_005518
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,809,619 - 31,815,283 (-)NCBI
GRCh37631,777,396 - 31,790,093 (-)NCBI
Build 36631,885,375 - 31,890,814 (-)NCBI Archive
HuRef631,563,804 - 31,569,242 (-)ENTREZGENE
CHM1_1631,779,530 - 31,784,969 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_005518   ⟸   NM_005527
- UniProtKB: P34931 (UniProtKB/Swiss-Prot),   A0A1U9X7W7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000364805   ⟸   ENST00000375654

Promoters
RGD ID:6872650
Promoter ID:EPDNEW_H9490
Type:initiation region
Name:HSPA1L_4
Description:heat shock protein family A member 1 like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9491  EPDNEW_H9493  EPDNEW_H9494  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,815,048 - 31,815,108EPDNEW
RGD ID:6872652
Promoter ID:EPDNEW_H9491
Type:initiation region
Name:HSPA1L_1
Description:heat shock protein family A member 1 like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9490  EPDNEW_H9493  EPDNEW_H9494  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,815,362 - 31,815,422EPDNEW
RGD ID:6872656
Promoter ID:EPDNEW_H9493
Type:initiation region
Name:HSPA1L_2
Description:heat shock protein family A member 1 like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9490  EPDNEW_H9491  EPDNEW_H9494  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,815,662 - 31,815,722EPDNEW
RGD ID:6872658
Promoter ID:EPDNEW_H9494
Type:initiation region
Name:HSPA1L_3
Description:heat shock protein family A member 1 like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9490  EPDNEW_H9491  EPDNEW_H9493  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38631,822,196 - 31,822,256EPDNEW
RGD ID:6804149
Promoter ID:HG_KWN:53002
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:ENST00000375652,   OTTHUMT00000076401,   OTTHUMT00000076416
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,890,496 - 31,893,612 (+)MPROMDB
RGD ID:6804361
Promoter ID:HG_KWN:53003
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:UC010JTE.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36631,891,116 - 31,891,616 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_005527.3(HSPA1L):c.1643C>T (p.Ala548Val) single nucleotide variant Malignant melanoma [RCV000061393] Chr6:31810330 [GRCh38]
Chr6:31778107 [GRCh37]
Chr6:31886086 [NCBI36]
Chr6:6p21.33
not provided
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p21.33(chr6:31777500-31831302)x1 copy number loss See cases [RCV000449096] Chr6:31777500..31831302 [GRCh37]
Chr6:6p21.33
likely benign
GRCh37/hg19 6p21.33(chr6:31782789-31797422)x1 copy number loss See cases [RCV000448141] Chr6:31782789..31797422 [GRCh37]
Chr6:6p21.33
benign
GRCh37/hg19 6p21.33(chr6:31384577-31902308)x3 copy number gain See cases [RCV000448679] Chr6:31384577..31902308 [GRCh37]
Chr6:6p21.33
uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_005527.4(HSPA1L):c.800C>T (p.Thr267Ile) single nucleotide variant Inflammatory bowel disease 1 [RCV000494709] Chr6:31811173 [GRCh38]
Chr6:31778950 [GRCh37]
Chr6:6p21.33
association
NM_005527.4(HSPA1L):c.1673A>C (p.Glu558Ala) single nucleotide variant Inflammatory bowel disease 1 [RCV000494712] Chr6:31810300 [GRCh38]
Chr6:31778077 [GRCh37]
Chr6:6p21.33
association
NM_005527.4(HSPA1L):c.229G>A (p.Gly77Ser) single nucleotide variant Inflammatory bowel disease 1 [RCV000494714] Chr6:31811744 [GRCh38]
Chr6:31779521 [GRCh37]
Chr6:6p21.33
association
NM_005527.4(HSPA1L):c.515_517del (p.Leu172del) deletion Inflammatory bowel disease 1 [RCV000494715] Chr6:31811456..31811458 [GRCh38]
Chr6:31779233..31779235 [GRCh37]
Chr6:6p21.33
association
NM_005527.4(HSPA1L):c.802G>A (p.Ala268Thr) single nucleotide variant Inflammatory bowel disease 1 [RCV000494716] Chr6:31811171 [GRCh38]
Chr6:31778948 [GRCh37]
Chr6:6p21.33
association
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-21.32(chr6:28130359-32108367)x3 copy number gain not provided [RCV000745592] Chr6:28130359..32108367 [GRCh37]
Chr6:6p22.1-21.32
uncertain significance
NM_005527.4(HSPA1L):c.1705_1709del (p.Asp568_Lys569insTer) deletion not provided [RCV000895789] Chr6:31810264..31810268 [GRCh38]
Chr6:31778041..31778045 [GRCh37]
Chr6:6p21.33
likely benign
NM_005527.4(HSPA1L):c.1428C>T (p.Ile476=) single nucleotide variant not provided [RCV000972246] Chr6:31810545 [GRCh38]
Chr6:31778322 [GRCh37]
Chr6:6p21.33
benign
NM_005527.4(HSPA1L):c.1436C>T (p.Thr479Met) single nucleotide variant not provided [RCV000965703] Chr6:31810537 [GRCh38]
Chr6:31778314 [GRCh37]
Chr6:6p21.33
benign
NM_005527.4(HSPA1L):c.420T>C (p.Pro140=) single nucleotide variant not provided [RCV000965704] Chr6:31811553 [GRCh38]
Chr6:31779330 [GRCh37]
Chr6:6p21.33
benign
NM_005527.4(HSPA1L):c.584G>A (p.Arg195Gln) single nucleotide variant not provided [RCV000970452] Chr6:31811389 [GRCh38]
Chr6:31779166 [GRCh37]
Chr6:6p21.33
likely benign
NM_005527.4(HSPA1L):c.1443C>T (p.Asp481=) single nucleotide variant not provided [RCV000965205] Chr6:31810530 [GRCh38]
Chr6:31778307 [GRCh37]
Chr6:6p21.33
benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_005527.4(HSPA1L):c.1478C>A (p.Thr493Lys) single nucleotide variant Chronic obstructive pulmonary disease [RCV000856580] Chr6:31810495 [GRCh38]
Chr6:31778272 [GRCh37]
Chr6:6p21.33
association
GRCh37/hg19 6p21.33-21.31(chr6:31036397-34088832)x3 copy number gain not provided [RCV001005791] Chr6:31036397..34088832 [GRCh37]
Chr6:6p21.33-21.31
likely pathogenic
NM_005527.4(HSPA1L):c.1483_1484del (p.Lys495fs) deletion not provided [RCV000929873] Chr6:31810489..31810490 [GRCh38]
Chr6:31778266..31778267 [GRCh37]
Chr6:6p21.33
likely benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:5234 AgrOrtholog
COSMIC HSPA1L COSMIC
Ensembl Genes ENSG00000204390 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSG00000206383 UniProtKB/Swiss-Prot
  ENSG00000226704 UniProtKB/TrEMBL
  ENSG00000234258 UniProtKB/Swiss-Prot
  ENSG00000236251 UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000364805 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000372881 UniProtKB/Swiss-Prot
  ENSP00000396486 UniProtKB/Swiss-Prot
  ENSP00000408347 UniProtKB/Swiss-Prot
  ENSP00000409151 UniProtKB/TrEMBL
Ensembl Transcript ENST00000375654 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000383390 UniProtKB/Swiss-Prot
  ENST00000417601 UniProtKB/Swiss-Prot
  ENST00000426095 UniProtKB/TrEMBL
  ENST00000456772 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.34.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000204390 GTEx
  ENSG00000206383 GTEx
  ENSG00000226704 GTEx
  ENSG00000234258 GTEx
  ENSG00000236251 GTEx
HGNC ID HGNC:5234 ENTREZGENE
Human Proteome Map HSPA1L Human Proteome Map
InterPro ATPase_NBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Heat_shock_70_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hsp_70_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3305 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3305 ENTREZGENE
OMIM 140559 OMIM
PANTHER PTHR19375 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HSP70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29500 PharmGKB
PROSITE HSP70_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HSP70_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF100934 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53067 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Hs.690634 ENTREZGENE
UniProt A0A1U9X7W7 ENTREZGENE, UniProtKB/TrEMBL
  HS71L_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q53FA3_HUMAN UniProtKB/TrEMBL
UniProt Secondary A6NNB0 UniProtKB/Swiss-Prot
  B0UXW8 UniProtKB/Swiss-Prot
  O75634 UniProtKB/Swiss-Prot
  Q2HXR3 UniProtKB/Swiss-Prot
  Q8NE72 UniProtKB/Swiss-Prot
  Q96QC9 UniProtKB/Swiss-Prot
  Q9UQM1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 HSPA1L  heat shock protein family A (Hsp70) member 1 like    heat shock 70kDa protein 1-like  Symbol and/or name change 5135510 APPROVED
2011-08-16 HSPA1L  heat shock 70kDa protein 1-like  HSPA1L  heat shock 70kDa protein 1-like  Symbol and/or name change 5135510 APPROVED