SIGLEC9 (sialic acid binding Ig like lectin 9) - Rat Genome Database

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Gene: SIGLEC9 (sialic acid binding Ig like lectin 9) Homo sapiens
Analyze
Symbol: SIGLEC9
Name: sialic acid binding Ig like lectin 9
RGD ID: 1353065
HGNC Page HGNC:10878
Description: Predicted to enable monosaccharide binding activity and sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis, engulfment. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD329; CDw329; FOAP-9; OB binding protein-like; OBBP-LIKE; sialic acid binding Ig-like lectin 9; sialic acid-binding Ig-like lectin 9; siglec-9
RGD Orthologs
Mouse
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,119,778 - 51,136,263 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,124,906 - 51,136,651 (+)EnsemblGRCh38hg38GRCh38
GRCh371951,628,137 - 51,639,520 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,319,977 - 56,325,379 (+)NCBINCBI36Build 36hg18NCBI36
Build 341956,319,976 - 56,325,378NCBI
Celera1948,680,251 - 48,685,654 (+)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1947,961,338 - 47,972,723 (+)NCBIHuRef
CHM1_11951,630,121 - 51,641,674 (+)NCBICHM1_1
T2T-CHM13v2.01954,211,244 - 54,230,912 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10652563   PMID:10801860   PMID:10801862   PMID:10903842   PMID:12477932   PMID:12975309   PMID:14693915   PMID:15057824   PMID:15292262   PMID:15342556   PMID:15557178   PMID:15703304  
PMID:15827126   PMID:16732727   PMID:16828866   PMID:18325328   PMID:18558361   PMID:19196661   PMID:19295491   PMID:19542910   PMID:20237496   PMID:20497550   PMID:20733319   PMID:20971061  
PMID:21821708   PMID:21873635   PMID:24045940   PMID:24145038   PMID:24569453   PMID:24882272   PMID:25187624   PMID:25225409   PMID:25320078   PMID:25747723   PMID:26186194   PMID:26694037  
PMID:26923638   PMID:27595232   PMID:27878892   PMID:27893774   PMID:28273363   PMID:28416510   PMID:28514442   PMID:28860481   PMID:29899741   PMID:30130255   PMID:30988027   PMID:31901888  
PMID:32296183   PMID:32322597   PMID:32391973   PMID:33431669   PMID:33961781   PMID:34837059   PMID:35854240   PMID:36688997   PMID:36728420   PMID:37460871   PMID:37865296   PMID:38412768  


Genomics

Comparative Map Data
SIGLEC9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,119,778 - 51,136,263 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,124,906 - 51,136,651 (+)EnsemblGRCh38hg38GRCh38
GRCh371951,628,137 - 51,639,520 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,319,977 - 56,325,379 (+)NCBINCBI36Build 36hg18NCBI36
Build 341956,319,976 - 56,325,378NCBI
Celera1948,680,251 - 48,685,654 (+)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1947,961,338 - 47,972,723 (+)NCBIHuRef
CHM1_11951,630,121 - 51,641,674 (+)NCBICHM1_1
T2T-CHM13v2.01954,211,244 - 54,230,912 (+)NCBIT2T-CHM13v2.0
Siglece
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,300,494 - 43,309,585 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,300,494 - 43,309,585 (-)EnsemblGRCm39 Ensembl
GRCm38743,648,882 - 43,672,044 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,651,070 - 43,660,161 (-)EnsemblGRCm38mm10GRCm38
MGSCv37750,906,440 - 50,915,531 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,519,112 - 43,528,187 (-)NCBIMGSCv36mm8
Celera739,115,187 - 39,124,273 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.25NCBI
SIGLEC9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,193,585 - 57,206,288 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11959,115,723 - 59,127,762 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01948,092,042 - 48,104,097 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11956,979,583 - 56,991,039 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1956,979,583 - 56,985,098 (+)Ensemblpanpan1.1panPan2
LOC102152131
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,551,488 - 105,555,358 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,124,176 - 105,128,044 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,060,788 - 106,064,656 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11105,732,807 - 105,736,675 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,374,108 - 105,378,144 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,168,988 - 106,173,068 (+)NCBIUU_Cfam_GSD_1.0
LOC100515209
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1658,440,468 - 58,448,682 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2651,741,737 - 51,749,870 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SIGLEC9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,132,958 - 44,139,941 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,134,688 - 44,139,733 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607324,180,145 - 24,187,555 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in SIGLEC9
39 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19q13.33-13.43(chr19:50191219-58535818)x3 copy number gain See cases [RCV000050883] Chr19:50191219..58535818 [GRCh38]
Chr19:50694476..59047185 [GRCh37]
Chr19:55386288..63738997 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:49907832-58557889)x3 copy number gain See cases [RCV000052925] Chr19:49907832..58557889 [GRCh38]
Chr19:50411089..59069256 [GRCh37]
Chr19:55102901..63761068 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47908540-58539965)x3 copy number gain See cases [RCV000052914] Chr19:47908540..58539965 [GRCh38]
Chr19:48411797..59051332 [GRCh37]
Chr19:53103609..63743144 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh38/hg38 19q13.33-13.43(chr19:47929575-58572206)x3 copy number gain See cases [RCV000052915] Chr19:47929575..58572206 [GRCh38]
Chr19:48432832..59083573 [GRCh37]
Chr19:53124644..63775385 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
NM_001198558.1(SIGLEC9):c.274C>T (p.His92Tyr) single nucleotide variant Malignant melanoma [RCV000072275] Chr19:51125248 [GRCh38]
Chr19:51628505 [GRCh37]
Chr19:56320317 [NCBI36]
Chr19:19q13.41		 not provided
NM_001198558.1(SIGLEC9):c.551C>T (p.Ser184Phe) single nucleotide variant Malignant melanoma [RCV000063604] Chr19:51125726 [GRCh38]
Chr19:51628983 [GRCh37]
Chr19:56320795 [NCBI36]
Chr19:19q13.41		 not provided
GRCh38/hg38 19q13.33-13.43(chr19:50152520-58581203)x3 copy number gain See cases [RCV000135843] Chr19:50152520..58581203 [GRCh38]
Chr19:50655777..59092570 [GRCh37]
Chr19:55347589..63784382 [NCBI36]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:50489390-59095359)x3 copy number gain See cases [RCV000445925] Chr19:50489390..59095359 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888) copy number gain See cases [RCV000512296] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:260912-58956888)x3 copy number gain See cases [RCV000511289] Chr19:260912..58956888 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic|uncertain significance
GRCh37/hg19 19p13.3-q13.43(chr19:260912-59097160)x3 copy number gain not provided [RCV000752444] Chr19:260912..59097160 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19p13.3-q13.43(chr19:68029-59110290)x3 copy number gain not provided [RCV000752439] Chr19:68029..59110290 [GRCh37]
Chr19:19p13.3-q13.43		 pathogenic
GRCh37/hg19 19q13.33-13.43(chr19:50740074-59097160)x3 copy number gain not provided [RCV000740208] Chr19:50740074..59097160 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
NM_014441.3(SIGLEC9):c.1146G>A (p.Ala382=) single nucleotide variant not provided [RCV000965458] Chr19:51128453 [GRCh38]
Chr19:51631710 [GRCh37]
Chr19:19q13.41		 benign
NM_014441.3(SIGLEC9):c.1179C>T (p.Asn393=) single nucleotide variant not provided [RCV000969326] Chr19:51128486 [GRCh38]
Chr19:51631743 [GRCh37]
Chr19:19q13.41		 benign
NM_014441.3(SIGLEC9):c.164C>T (p.Pro55Leu) single nucleotide variant Inborn genetic diseases [RCV003244722] Chr19:51125138 [GRCh38]
Chr19:51628395 [GRCh37]
Chr19:19q13.41		 uncertain significance
GRCh37/hg19 19q13.31-13.42(chr19:44738088-53621561)x3 copy number gain not provided [RCV001007050] Chr19:44738088..53621561 [GRCh37]
Chr19:19q13.31-13.42		 pathogenic
NM_014441.3(SIGLEC9):c.374G>A (p.Ser125Asn) single nucleotide variant not provided [RCV000955571] Chr19:51125348 [GRCh38]
Chr19:51628605 [GRCh37]
Chr19:19q13.41		 benign
GRCh37/hg19 19q13.33-13.41(chr19:50469730-51916485)x3 copy number gain not provided [RCV001007055] Chr19:50469730..51916485 [GRCh37]
Chr19:19q13.33-13.41		 uncertain significance
GRCh37/hg19 19q13.32-13.42(chr19:47939842-54626871) copy number gain not provided [RCV001249294] Chr19:47939842..54626871 [GRCh37]
Chr19:19q13.32-13.42		 not provided
GRCh37/hg19 19q13.33-13.43(chr19:48463931-57095254)x3 copy number gain not provided [RCV001259944] Chr19:48463931..57095254 [GRCh37]
Chr19:19q13.33-13.43		 pathogenic
GRCh37/hg19 19q13.33-13.41(chr19:49911081-53127438) copy number gain not specified [RCV002052689] Chr19:49911081..53127438 [GRCh37]
Chr19:19q13.33-13.41		 likely pathogenic
NM_014441.3(SIGLEC9):c.199A>G (p.Asn67Asp) single nucleotide variant Inborn genetic diseases [RCV002749626] Chr19:51125173 [GRCh38]
Chr19:51628430 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.553G>A (p.Val185Met) single nucleotide variant Inborn genetic diseases [RCV002945310] Chr19:51125728 [GRCh38]
Chr19:51628985 [GRCh37]
Chr19:19q13.41		 uncertain significance
GRCh37/hg19 19q13.41(chr19:51623330-51694022)x1 copy number loss not provided [RCV002475699] Chr19:51623330..51694022 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.742G>A (p.Gly248Ser) single nucleotide variant Inborn genetic diseases [RCV002882928] Chr19:51126122 [GRCh38]
Chr19:51629379 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.112C>T (p.His38Tyr) single nucleotide variant Inborn genetic diseases [RCV002860416] Chr19:51125086 [GRCh38]
Chr19:51628343 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.1130C>T (p.Ser377Leu) single nucleotide variant Inborn genetic diseases [RCV002946242] Chr19:51128437 [GRCh38]
Chr19:51631694 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.359G>A (p.Arg120His) single nucleotide variant Inborn genetic diseases [RCV002782092] Chr19:51125333 [GRCh38]
Chr19:51628590 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.979G>A (p.Gly327Ser) single nucleotide variant Inborn genetic diseases [RCV002951906] Chr19:51127260 [GRCh38]
Chr19:51630517 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.88A>T (p.Thr30Ser) single nucleotide variant Inborn genetic diseases [RCV002691297] Chr19:51125062 [GRCh38]
Chr19:51628319 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.1067C>T (p.Thr356Ile) single nucleotide variant Inborn genetic diseases [RCV002742474] Chr19:51128000 [GRCh38]
Chr19:51631257 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.1145C>T (p.Ala382Val) single nucleotide variant Inborn genetic diseases [RCV003004352] Chr19:51128452 [GRCh38]
Chr19:51631709 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.969G>T (p.Gln323His) single nucleotide variant Inborn genetic diseases [RCV002719610] Chr19:51127250 [GRCh38]
Chr19:51630507 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.526C>T (p.Pro176Ser) single nucleotide variant Inborn genetic diseases [RCV002961419] Chr19:51125701 [GRCh38]
Chr19:51628958 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.151A>G (p.Ile51Val) single nucleotide variant Inborn genetic diseases [RCV002792176] Chr19:51125125 [GRCh38]
Chr19:51628382 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.905C>T (p.Pro302Leu) single nucleotide variant Inborn genetic diseases [RCV002988050] Chr19:51127186 [GRCh38]
Chr19:51630443 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.150G>C (p.Trp50Cys) single nucleotide variant Inborn genetic diseases [RCV003202583] Chr19:51125124 [GRCh38]
Chr19:51628381 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.972C>A (p.Asn324Lys) single nucleotide variant Inborn genetic diseases [RCV003309468] Chr19:51127253 [GRCh38]
Chr19:51630510 [GRCh37]
Chr19:19q13.41		 uncertain significance
NM_014441.3(SIGLEC9):c.1061G>C (p.Gly354Ala) single nucleotide variant Inborn genetic diseases [RCV003357847] Chr19:51127994 [GRCh38]
Chr19:51631251 [GRCh37]
Chr19:19q13.41		 uncertain significance
GRCh37/hg19 19q13.33-13.43(chr19:49625130-57647352)x3 copy number gain not provided [RCV003485200] Chr19:49625130..57647352 [GRCh37]
Chr19:19q13.33-13.43		 likely pathogenic
NM_014441.3(SIGLEC9):c.18G>A (p.Leu6=) single nucleotide variant not provided [RCV003425387] Chr19:51124992 [GRCh38]
Chr19:51628249 [GRCh37]
Chr19:19q13.41		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:466
Count of miRNA genes:399
Interacting mature miRNAs:427
Transcripts:ENST00000250360, ENST00000440804, ENST00000599948
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 13 704 10 5 897 5 77 5 47 14 49 303 109 18 1
Low 2020 1804 1482 530 486 401 2471 1083 2105 292 1165 990 129 1085 1577 1
Below cutoff 291 472 210 72 114 40 1591 1051 1486 83 149 143 36 10 1178

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001198558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_014441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006723146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011526732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017026595 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017026596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047438615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047438616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054320570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001753663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001753664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB026265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC011473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC063977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF135027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF227924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF247180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK297043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY532663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP305376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000250360   ⟹   ENSP00000250360
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,124,906 - 51,130,310 (+)Ensembl
RefSeq Acc Id: ENST00000440804   ⟹   ENSP00000413861
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,124,908 - 51,136,651 (+)Ensembl
RefSeq Acc Id: ENST00000599948   ⟹   ENSP00000472483
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1951,127,030 - 51,128,958 (+)Ensembl
RefSeq Acc Id: NM_001198558   ⟹   NP_001185487
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,124,880 - 51,136,263 (+)NCBI
GRCh371951,628,137 - 51,639,520 (+)ENTREZGENE
HuRef1947,961,338 - 47,972,723 (+)ENTREZGENE
CHM1_11951,630,121 - 51,641,674 (+)NCBI
T2T-CHM13v2.01954,213,488 - 54,224,872 (+)NCBI
Sequence:
RefSeq Acc Id: NM_014441   ⟹   NP_055256
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,124,906 - 51,130,310 (+)NCBI
GRCh371951,628,137 - 51,639,520 (+)ENTREZGENE
Build 361956,319,977 - 56,325,379 (+)NCBI Archive
HuRef1947,961,338 - 47,972,723 (+)ENTREZGENE
CHM1_11951,630,121 - 51,635,551 (+)NCBI
T2T-CHM13v2.01954,213,514 - 54,218,918 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011526732   ⟹   XP_011525034
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,122,631 - 51,129,041 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047438615   ⟹   XP_047294571
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,119,778 - 51,130,310 (+)NCBI
RefSeq Acc Id: XM_047438616   ⟹   XP_047294572
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,122,631 - 51,130,310 (+)NCBI
RefSeq Acc Id: XM_054320564   ⟹   XP_054176539
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01954,213,488 - 54,225,460 (+)NCBI
RefSeq Acc Id: XM_054320565   ⟹   XP_054176540
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01954,211,244 - 54,217,748 (+)NCBI
RefSeq Acc Id: XM_054320566   ⟹   XP_054176541
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01954,211,244 - 54,218,918 (+)NCBI
RefSeq Acc Id: XM_054320567   ⟹   XP_054176542
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01954,213,488 - 54,230,912 (+)NCBI
RefSeq Acc Id: XM_054320568   ⟹   XP_054176543
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01954,213,488 - 54,215,814 (+)NCBI
RefSeq Acc Id: XM_054320569   ⟹   XP_054176544
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01954,213,488 - 54,215,630 (+)NCBI
RefSeq Acc Id: XM_054320570   ⟹   XP_054176545
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01954,213,488 - 54,215,469 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001185487   ⟸   NM_001198558
- Peptide Label: isoform 1 precursor
- UniProtKB: Q9Y336 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_055256   ⟸   NM_014441
- Peptide Label: isoform 2 precursor
- UniProtKB: Q6GTU4 (UniProtKB/Swiss-Prot),   Q9BYI9 (UniProtKB/Swiss-Prot),   Q9Y336 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011525034   ⟸   XM_011526732
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000472483   ⟸   ENST00000599948
RefSeq Acc Id: ENSP00000413861   ⟸   ENST00000440804
RefSeq Acc Id: ENSP00000250360   ⟸   ENST00000250360
RefSeq Acc Id: XP_047294571   ⟸   XM_047438615
- Peptide Label: isoform X2
- UniProtKB: Q9Y336 (UniProtKB/Swiss-Prot),   Q6GTU4 (UniProtKB/Swiss-Prot),   Q9BYI9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047294572   ⟸   XM_047438616
- Peptide Label: isoform X2
- UniProtKB: Q9Y336 (UniProtKB/Swiss-Prot),   Q6GTU4 (UniProtKB/Swiss-Prot),   Q9BYI9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054176541   ⟸   XM_054320566
- Peptide Label: isoform X2
- UniProtKB: Q9Y336 (UniProtKB/Swiss-Prot),   Q6GTU4 (UniProtKB/Swiss-Prot),   Q9BYI9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054176540   ⟸   XM_054320565
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054176542   ⟸   XM_054320567
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054176539   ⟸   XM_054320564
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054176543   ⟸   XM_054320568
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054176544   ⟸   XM_054320569
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054176545   ⟸   XM_054320570
- Peptide Label: isoform X7
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Y336-F1-model_v2 AlphaFold Q9Y336 1-463 view protein structure

Promoters
RGD ID:13205345
Promoter ID:EPDNEW_H26253
Type:initiation region
Name:SIGLEC9_1
Description:sialic acid binding Ig like lectin 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381951,124,893 - 51,124,953EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10878 AgrOrtholog
COSMIC SIGLEC9 COSMIC
Ensembl Genes ENSG00000129450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000250360 ENTREZGENE
  ENST00000250360.8 UniProtKB/Swiss-Prot
  ENST00000440804 ENTREZGENE
  ENST00000440804.7 UniProtKB/Swiss-Prot
  ENST00000599948.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000129450 GTEx
HGNC ID HGNC:10878 ENTREZGENE
Human Proteome Map SIGLEC9 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
KEGG Report hsa:27180 UniProtKB/Swiss-Prot
NCBI Gene 27180 ENTREZGENE
OMIM 605640 OMIM
PANTHER SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIALIC ACID-BINDING IG-LIKE LECTIN 9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/Swiss-Prot
  V-set UniProtKB/Swiss-Prot
PharmGKB PA35779 PharmGKB
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt M0R2D4_HUMAN UniProtKB/TrEMBL
  Q6GTU4 ENTREZGENE
  Q9BYI9 ENTREZGENE
  Q9Y336 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6GTU4 UniProtKB/Swiss-Prot
  Q9BYI9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 SIGLEC9  sialic acid binding Ig like lectin 9    sialic acid binding Ig-like lectin 9  Symbol and/or name change 5135510 APPROVED