MIR206 (microRNA 206) - Rat Genome Database

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Gene: MIR206 (microRNA 206) Homo sapiens
Analyze
Symbol: MIR206
Name: microRNA 206
RGD ID: 1352988
HGNC Page HGNC:31584
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing post-transcriptional repressor activity. Involved in several processes, including negative regulation of cell adhesion molecule production; negative regulation of cell migration involved in sprouting angiogenesis; and regulation of gene expression. Acts upstream of or within positive regulation of gene expression. Part of RISC complex. Implicated in stomach cancer. Biomarker of stomach cancer.
Type: ncrna
RefSeq Status: PROVISIONAL
Previously known as: mir-206; MIRN206; miRNA206
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,144,349 - 52,144,434 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl652,144,349 - 52,144,434 (+)EnsemblGRCh38hg38GRCh38
GRCh37652,009,147 - 52,009,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,117,105 - 52,117,190 (+)NCBINCBI36hg18NCBI36
Celera653,670,284 - 53,670,369 (+)NCBI
Cytogenetic Map6p12.2NCBI
HuRef651,840,140 - 51,840,225 (+)NCBIHuRef
CHM1_1652,011,355 - 52,011,440 (+)NCBICHM1_1
T2T-CHM13v2.0651,983,057 - 51,983,142 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use. Ehinger Y, etal., Addict Biol. 2020 Mar 5:e12890. doi: 10.1111/adb.12890.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Prognostic significance of combined microRNA-206 and CyclinD2 in gastric cancer patients after curative surgery: A retrospective cohort study. Shi H, etal., Biomed Pharmacother. 2015 Apr;71:210-5. doi: 10.1016/j.biopha.2014.12.037. Epub 2015 Jan 9.
4. miR-206 inhibits gastric cancer proliferation in part by repressing cyclinD2. Zhang L, etal., Cancer Lett. 2013 May 10;332(1):94-101. doi: 10.1016/j.canlet.2013.01.023. Epub 2013 Jan 21.
Additional References at PubMed
PMID:12554859   PMID:16381832   PMID:17604727   PMID:18593897   PMID:19423651   PMID:19620785   PMID:19684618   PMID:19710019   PMID:19723635   PMID:20346098   PMID:20347265   PMID:20388878  
PMID:20487562   PMID:20519629   PMID:20696132   PMID:21037258   PMID:21157919   PMID:21518959   PMID:21637854   PMID:21645416   PMID:21983130   PMID:22110210   PMID:22308266   PMID:22330340  
PMID:22508046   PMID:22912879   PMID:22926857   PMID:23071643   PMID:23466356   PMID:23499676   PMID:23696595   PMID:23751352   PMID:23886177   PMID:23921124   PMID:24040336   PMID:24107628  
PMID:24288551   PMID:24289491   PMID:24390803   PMID:24460924   PMID:24586506   PMID:24603323   PMID:24767015   PMID:24919811   PMID:24935473   PMID:25120799   PMID:25146754   PMID:25202123  
PMID:25436301   PMID:25452104   PMID:25481410   PMID:25500542   PMID:25522678   PMID:25572712   PMID:25589731   PMID:25607234   PMID:25644430   PMID:25653235   PMID:25660363   PMID:25678853  
PMID:25792468   PMID:25955685   PMID:26045823   PMID:26075299   PMID:26093295   PMID:26125274   PMID:26143374   PMID:26175229   PMID:26186594   PMID:26213997   PMID:26221902   PMID:26325180  
PMID:26406866   PMID:26515696   PMID:26685009   PMID:26718123   PMID:26775359   PMID:26808577   PMID:26879016   PMID:26918941   PMID:26919096   PMID:27014910   PMID:27014911   PMID:27031991  
PMID:27100732   PMID:27169691   PMID:27221739   PMID:27223121   PMID:27277332   PMID:27277678   PMID:27279635   PMID:27291149   PMID:27424800   PMID:27435395   PMID:27529242   PMID:27538595  
PMID:27541266   PMID:27558109   PMID:27614739   PMID:27662297   PMID:27806334   PMID:27826039   PMID:27893428   PMID:27906963   PMID:27924503   PMID:27994218   PMID:28005074   PMID:28342807  
PMID:28391353   PMID:28431233   PMID:28454844   PMID:28598253   PMID:28755962   PMID:28765968   PMID:28822708   PMID:28940993   PMID:28987947   PMID:29115490   PMID:29222472   PMID:29295729  
PMID:29325455   PMID:29410711   PMID:29484422   PMID:29542173   PMID:29549926   PMID:29664235   PMID:29807226   PMID:29886033   PMID:29916897   PMID:29935234   PMID:29936177   PMID:29956750  
PMID:29971911   PMID:29989852   PMID:30076726   PMID:30111166   PMID:30119190   PMID:30135139   PMID:30155690   PMID:30156374   PMID:30250188   PMID:30272362   PMID:30335896   PMID:30565392  
PMID:30569129   PMID:30582709   PMID:30633352   PMID:30636484   PMID:30657558   PMID:30666838   PMID:30779067   PMID:30804229   PMID:30805592   PMID:30878364   PMID:30904818   PMID:30920079  
PMID:30982495   PMID:31046876   PMID:31048362   PMID:31069797   PMID:31099134   PMID:31121484   PMID:31245877   PMID:31279225   PMID:31297902   PMID:31379181   PMID:31400488   PMID:31408569  
PMID:31431298   PMID:31485634   PMID:31506061   PMID:31507089   PMID:31579977   PMID:31599407   PMID:31742336   PMID:31766231   PMID:31774373   PMID:31850679   PMID:31899480   PMID:32049790  
PMID:32075715   PMID:32084582   PMID:32107418   PMID:32206066   PMID:32277852   PMID:32286127   PMID:32363688   PMID:32373955   PMID:32376265   PMID:32627519   PMID:32682951   PMID:32800545  
PMID:32900244   PMID:32921119   PMID:33086901   PMID:33099847   PMID:33111654   PMID:33145343   PMID:33445560   PMID:33461610   PMID:33540574   PMID:33653250   PMID:33830643   PMID:33945391  
PMID:33945508   PMID:33965771   PMID:34038520   PMID:34147072   PMID:34196215   PMID:34240323   PMID:34268933   PMID:34418889   PMID:34481913   PMID:34558643   PMID:34868522   PMID:35107852  
PMID:35126948   PMID:35342753   PMID:35351345   PMID:35360546   PMID:35401927  


Genomics

Comparative Map Data
MIR206
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,144,349 - 52,144,434 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl652,144,349 - 52,144,434 (+)EnsemblGRCh38hg38GRCh38
GRCh37652,009,147 - 52,009,232 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,117,105 - 52,117,190 (+)NCBINCBI36hg18NCBI36
Celera653,670,284 - 53,670,369 (+)NCBI
Cytogenetic Map6p12.2NCBI
HuRef651,840,140 - 51,840,225 (+)NCBIHuRef
CHM1_1652,011,355 - 52,011,440 (+)NCBICHM1_1
T2T-CHM13v2.0651,983,057 - 51,983,142 (+)NCBI
Mir206
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39120,749,234 - 20,749,306 (+)NCBIGRCm39mm39
GRCm39 Ensembl120,749,234 - 20,749,306 (+)Ensembl
GRCm38120,679,010 - 20,679,082 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl120,679,010 - 20,679,082 (+)EnsemblGRCm38mm10GRCm38
MGSCv37120,669,091 - 20,669,163 (+)NCBIGRCm37mm9NCBIm37
Celera120,553,851 - 20,553,923 (+)NCBICelera
Cytogenetic Map1A4NCBI
Mir206
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2923,094,249 - 23,094,332 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl923,094,249 - 23,094,332 (+)Ensembl
Rnor_6.0926,791,764 - 26,791,847 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl926,791,764 - 26,791,847 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0925,648,214 - 25,648,297 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera920,674,100 - 20,674,183 (+)NCBICelera
Cytogenetic Map9q13NCBI
MIR206
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11219,805,523 - 19,805,582 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1219,805,523 - 19,805,582 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1219,701,736 - 19,701,795 (+)NCBI
ROS_Cfam_1.01220,304,504 - 20,304,563 (+)NCBI
ROS_Cfam_1.0 Ensembl1220,304,504 - 20,304,563 (+)Ensembl
UMICH_Zoey_3.11219,809,950 - 19,810,009 (+)NCBI
UNSW_CanFamBas_1.01219,912,903 - 19,912,962 (+)NCBI
UU_Cfam_GSD_1.01220,050,920 - 20,050,979 (+)NCBI
MIR206
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl745,976,293 - 45,976,372 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1745,976,293 - 45,976,372 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2752,426,445 - 52,426,524 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
METhsa-miR-206Mirtarbaseexternal_infoWestern blotFunctional MTI19620785
METhsa-miR-206Mirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19710019
METhsa-miR-206Mirtarbaseexternal_infoqRT-PCR//ChIP//Luciferase reporter assay//Western Functional MTI20388878
NOTCH3hsa-miR-206Mirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI19723635
ESR1hsa-miR-206Mirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI17312270
ESR1hsa-miR-206Mirtarbaseexternal_infoLuciferase reporter assay//MicroarrayFunctional MTI19684618
ESR1hsa-miR-206Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18593897
ESR1hsa-miR-206Mirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRNon-Functional MTI19414598
UTRNhsa-miR-206Mirtarbaseexternal_infoReporter assayFunctional MTI17030984
TAC1hsa-miR-206Mirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI17855557
PAX3hsa-miR-206Mirtarbaseexternal_infoChIP-seq//Immunoblot//Luciferase reporter assay//qFunctional MTI20956382
TPPPhsa-miR-206Mirtarbaseexternal_infoImmunoblot//Immunocytochemistry//Luciferase reportFunctional MTI19606501
CCND2hsa-miR-206Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23348698
CCND2hsa-miR-206Mirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23466356
GJA1hsa-miR-206Mirtarbaseexternal_infoWestern blotFunctional MTI17062625
GJA1hsa-miR-206Tarbaseexternal_infoWesternblitPOSITIVE
TAC1hsa-miR-206Tarbaseexternal_infoReporter GenePOSITIVE
ESR1hsa-miR-206Tarbaseexternal_infoqPCRNEGATIVE
GJA1hsa-miR-206Mirecordsexternal_infoNANA18155131
TAC1hsa-miR-206Mirecordsexternal_infoNANA17855557
ESR1hsa-miR-206Mirecordsexternal_info{changed}{changed}NA17312270
METhsa-miR-206Mirecordsexternal_infoNANA19710019
ESR1hsa-miR-206Mirecordsexternal_infoNANA19684618
CCND2hsa-miR-206OncomiRDBexternal_infoNANA23466356
OTX2hsa-miR-206OncomiRDBexternal_infoNANA22508046
METhsa-miR-206OncomiRDBexternal_infoNANA20388878
NOTCH3hsa-miR-206OncomiRDBexternal_infoNANA19723635
METhsa-miR-206OncomiRDBexternal_infoNANA19710019
ESR1hsa-miR-206OncomiRDBexternal_infoNANA19684618
ESR1hsa-miR-206OncomiRDBexternal_infoNANA17312270

Predicted Targets
Summary Value
Count of predictions:16228
Count of gene targets:6462
Count of transcripts:12098
Interacting mature miRNAs:hsa-miR-206
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage
High
Medium 2 3 2
Low 3 1 3 2 19 2 10 8 4 24 6 9 2 8
Below cutoff 2 2 3 2 7 5 6 3 1 6 5

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000384872
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl652,144,349 - 52,144,434 (+)Ensembl
RefSeq Acc Id: NR_029713
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38652,144,349 - 52,144,434 (+)NCBI
GRCh37652,009,147 - 52,009,232 (+)ENTREZGENE
HuRef651,840,140 - 51,840,225 (+)ENTREZGENE
CHM1_1652,011,355 - 52,011,440 (+)NCBI
T2T-CHM13v2.0651,983,057 - 51,983,142 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p12.3-11.2(chr6:50971182-57432788)x1 copy number loss See cases [RCV000134922] Chr6:50971182..57432788 [GRCh38]
Chr6:50938895..57297586 [GRCh37]
Chr6:51046854..57405545 [NCBI36]
Chr6:6p12.3-11.2
pathogenic
GRCh38/hg38 6p12.3-12.1(chr6:51093754-53859634)x4 copy number gain See cases [RCV000137095] Chr6:51093754..53859634 [GRCh38]
Chr6:51061467..53724432 [GRCh37]
Chr6:51169426..53832391 [NCBI36]
Chr6:6p12.3-12.1
pathogenic
GRCh38/hg38 6p12.2(chr6:51803422-52698500)x1 copy number loss See cases [RCV000136613] Chr6:51803422..52698500 [GRCh38]
Chr6:51668220..52563298 [GRCh37]
Chr6:51776179..52671257 [NCBI36]
Chr6:6p12.2
pathogenic
GRCh38/hg38 6p21.1-12.1(chr6:45681671-54212044)x1 copy number loss See cases [RCV000138349] Chr6:45681671..54212044 [GRCh38]
Chr6:45649408..54076842 [GRCh37]
Chr6:45757386..54184801 [NCBI36]
Chr6:6p21.1-12.1
pathogenic|uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
GRCh37/hg19 6p12.3-12.2(chr6:51637152-52303162)x3 copy number gain not provided [RCV000849320] Chr6:51637152..52303162 [GRCh37]
Chr6:6p12.3-12.2
uncertain significance
GRCh37/hg19 6p12.3-12.2(chr6:51695623-52371918) copy number loss Autosomal recessive polycystic kidney disease [RCV001195156] Chr6:51695623..52371918 [GRCh37]
Chr6:6p12.3-12.2
pathogenic
GRCh37/hg19 6p12.3-12.1(chr6:48626041-55575545)x1 copy number loss See cases [RCV001263045] Chr6:48626041..55575545 [GRCh37]
Chr6:6p12.3-12.1
likely pathogenic
NC_000006.11:g.(?_51930764)_(52906034_?)del deletion not provided [RCV001346439] Chr6:51930764..52906034 [GRCh37]
Chr6:6p12.2-12.1
uncertain significance
GRCh37/hg19 6p21.1-q12(chr6:43636308-64947206)x3 copy number gain not provided [RCV002221457] Chr6:43636308..64947206 [GRCh37]
Chr6:6p21.1-q12
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31584 AgrOrtholog
COSMIC MIR206 COSMIC
Ensembl Genes ENSG00000207604 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000384872 ENTREZGENE
GTEx ENSG00000207604 GTEx
HGNC ID HGNC:31584 ENTREZGENE
Human Proteome Map MIR206 Human Proteome Map
miRBase MI0000490 ENTREZGENE
NCBI Gene 406989 ENTREZGENE
OMIM 611599 OMIM
PharmGKB PA164722585 PharmGKB
RNAcentral URS000034B6F5 RNACentral
  URS0000389B41 RNACentral