VTI1B (vesicle transport through interaction with t-SNAREs 1B) - Rat Genome Database

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Gene: VTI1B (vesicle transport through interaction with t-SNAREs 1B) Homo sapiens
Analyze
Symbol: VTI1B
Name: vesicle transport through interaction with t-SNAREs 1B
RGD ID: 1352901
HGNC Page HGNC:17793
Description: Enables SNARE binding activity and chloride channel inhibitor activity. Involved in regulation of protein localization to plasma membrane. Located in several cellular components, including endosome membrane; lysosomal membrane; and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: v-SNARE; vesicle transport through interaction with t-SNAREs homolog 1B; vesicle transport v-SNARE protein Vti1-like 1; vesicle-associated soluble NSF attachment protein receptor; VTI1; VTI1-LIKE; vti1-rp1; VTI1L; VTI2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: VTI1BP1   VTI1BP2   VTI1BP3   VTI1BP4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381467,647,085 - 67,674,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1467,647,085 - 67,674,820 (-)EnsemblGRCh38hg38GRCh38
GRCh371468,113,802 - 68,141,349 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361467,187,619 - 67,211,301 (-)NCBINCBI36Build 36hg18NCBI36
Build 341467,187,618 - 67,211,301NCBI
Celera1448,176,927 - 48,200,645 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1448,287,563 - 48,311,281 (-)NCBIHuRef
CHM1_11468,056,646 - 68,080,381 (-)NCBICHM1_1
T2T-CHM13v2.01461,854,218 - 61,881,753 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9446565   PMID:9636656   PMID:10683148   PMID:11101518   PMID:11252894   PMID:11278762   PMID:11786915   PMID:11839770   PMID:11927603   PMID:12067063   PMID:12114520   PMID:12175335  
PMID:12477932   PMID:12853575   PMID:14769786   PMID:15371541   PMID:15489334   PMID:16169070   PMID:16189514   PMID:18033301   PMID:18570918   PMID:19224922   PMID:20089838   PMID:20562859  
PMID:21516116   PMID:21562157   PMID:21674799   PMID:21873635   PMID:22875976   PMID:23217709   PMID:24550300   PMID:24623722   PMID:25416956   PMID:26186194   PMID:26496610   PMID:27173435  
PMID:27432908   PMID:27791468   PMID:28298427   PMID:28514442   PMID:29180619   PMID:29509190   PMID:29568061   PMID:29615496   PMID:29656893   PMID:29987050   PMID:29997244   PMID:30194290  
PMID:30659120   PMID:30833792   PMID:30945947   PMID:31056421   PMID:31073040   PMID:31515488   PMID:31871319   PMID:32296183   PMID:32707033   PMID:33112705   PMID:33144569   PMID:33452816  
PMID:33845483   PMID:33961781   PMID:34079125   PMID:34369648   PMID:34432599   PMID:34597346   PMID:35156780   PMID:35271311   PMID:35944360   PMID:36012204   PMID:36042349   PMID:36300783  
PMID:36610398   PMID:37689310   PMID:37774976   PMID:37827155   PMID:38117590  


Genomics

Comparative Map Data
VTI1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381467,647,085 - 67,674,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1467,647,085 - 67,674,820 (-)EnsemblGRCh38hg38GRCh38
GRCh371468,113,802 - 68,141,349 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361467,187,619 - 67,211,301 (-)NCBINCBI36Build 36hg18NCBI36
Build 341467,187,618 - 67,211,301NCBI
Celera1448,176,927 - 48,200,645 (-)NCBICelera
Cytogenetic Map14q24.1NCBI
HuRef1448,287,563 - 48,311,281 (-)NCBIHuRef
CHM1_11468,056,646 - 68,080,381 (-)NCBICHM1_1
T2T-CHM13v2.01461,854,218 - 61,881,753 (-)NCBIT2T-CHM13v2.0
Vti1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391279,202,791 - 79,219,428 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1279,202,791 - 79,219,441 (-)EnsemblGRCm39 Ensembl
GRCm381279,156,017 - 79,172,685 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1279,156,017 - 79,172,667 (-)EnsemblGRCm38mm10GRCm38
MGSCv371280,257,004 - 80,273,445 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361280,075,098 - 80,091,217 (-)NCBIMGSCv36mm8
Celera1280,620,461 - 80,636,902 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1235.51NCBI
Vti1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86103,694,342 - 103,709,544 (-)NCBIGRCr8
mRatBN7.2697,957,700 - 97,976,491 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl697,961,346 - 97,976,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx698,392,592 - 98,405,961 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0698,691,744 - 98,705,104 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0698,077,883 - 98,091,234 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06102,340,261 - 102,353,612 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6102,339,857 - 102,353,403 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06115,026,935 - 115,040,283 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46101,928,449 - 101,943,347 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera696,346,498 - 96,361,515 (-)NCBICelera
Cytogenetic Map6q24NCBI
Vti1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554662,527,753 - 2,549,568 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554662,527,750 - 2,549,599 (+)NCBIChiLan1.0ChiLan1.0
VTI1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21568,761,673 - 68,786,707 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11467,978,185 - 68,001,944 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01448,227,203 - 48,254,990 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11467,105,160 - 67,134,351 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1467,105,160 - 67,134,351 (-)Ensemblpanpan1.1panPan2
VTI1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1841,619,365 - 41,650,389 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2919,153,616 - 19,154,245 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl841,614,921 - 41,669,576 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha841,312,675 - 41,341,742 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0841,848,085 - 41,879,357 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl841,829,333 - 41,879,799 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1841,467,045 - 41,496,369 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0841,540,458 - 41,569,783 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0841,900,036 - 41,929,107 (-)NCBIUU_Cfam_GSD_1.0
Vti1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864063,127,656 - 63,147,822 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649511,045,429 - 11,064,206 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649511,043,813 - 11,064,113 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VTI1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl791,374,640 - 91,413,607 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1791,386,020 - 91,413,480 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2797,693,164 - 97,720,791 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VTI1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12444,884,082 - 44,907,819 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2444,884,315 - 44,907,771 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605333,110,909 - 33,137,704 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vti1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473433,299,373 - 33,321,199 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473433,299,732 - 33,341,672 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in VTI1B
19 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_006370.2(VTI1B):c.135C>T (p.Ile45=) single nucleotide variant Malignant melanoma [RCV000070581] Chr14:67662516 [GRCh38]
Chr14:68129233 [GRCh37]
Chr14:67198986 [NCBI36]
Chr14:14q24.1		 not provided
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
NM_001172.4(ARG2):c.974A>G (p.Gln325Arg) single nucleotide variant Inborn genetic diseases [RCV003305110] Chr14:67650829 [GRCh38]
Chr14:68117546 [GRCh37]
Chr14:14q24.1		 uncertain significance
GRCh37/hg19 14q24.1-24.2(chr14:68035240-73568130)x1 copy number loss See cases [RCV000512344] Chr14:68035240..73568130 [GRCh37]
Chr14:14q24.1-24.2		 likely pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33		 pathogenic
NM_001172.4(ARG2):c.924G>A (p.Ala308=) single nucleotide variant not provided [RCV000949371] Chr14:67650779 [GRCh38]
Chr14:68117496 [GRCh37]
Chr14:14q24.1		 benign|likely benign
NM_006370.3(VTI1B):c.174+10A>G single nucleotide variant not provided [RCV000949372] Chr14:67662467 [GRCh38]
Chr14:68129184 [GRCh37]
Chr14:14q24.1		 benign
GRCh37/hg19 14q24.1(chr14:68126321-68269053)x3 copy number gain Blepharophimosis [RCV000787291] Chr14:68126321..68269053 [GRCh37]
Chr14:14q24.1		 uncertain significance
GRCh37/hg19 14q24.1(chr14:68130744-68275342)x3 copy number gain not provided [RCV000848866] Chr14:68130744..68275342 [GRCh37]
Chr14:14q24.1		 uncertain significance
GRCh37/hg19 14q23.3-24.1(chr14:67331167-68451970)x3 copy number gain not provided [RCV001006646] Chr14:67331167..68451970 [GRCh37]
Chr14:14q23.3-24.1		 uncertain significance
NM_001172.4(ARG2):c.956T>C (p.Ile319Thr) single nucleotide variant Inborn genetic diseases [RCV003268464] Chr14:67650811 [GRCh38]
Chr14:68117528 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_006370.3(VTI1B):c.102G>A (p.Gly34=) single nucleotide variant not provided [RCV000947573] Chr14:67674388 [GRCh38]
Chr14:68141105 [GRCh37]
Chr14:14q24.1		 benign
GRCh37/hg19 14q24.1(chr14:68037409-68278365)x3 copy number gain not provided [RCV001006647] Chr14:68037409..68278365 [GRCh37]
Chr14:14q24.1		 uncertain significance
NC_000014.8:g.(?_65937790)_(68354021_?)dup duplication Leber congenital amaurosis 13 [RCV001341311]|not provided [RCV001314756] Chr14:65937790..68354021 [GRCh37]
Chr14:14q23.3-24.1		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 14q22.2-24.3(chr14:54654001-75828024)x3 copy number gain 14q22.2q24.3 duplication [RCV001506967] Chr14:54654001..75828024 [GRCh37]
Chr14:14q22.2-24.3		 likely pathogenic
GRCh37/hg19 14q23.3-24.1(chr14:67443801-68153682) copy number gain not specified [RCV002053109] Chr14:67443801..68153682 [GRCh37]
Chr14:14q23.3-24.1		 uncertain significance
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33		 pathogenic
NM_006370.3(VTI1B):c.178G>T (p.Ala60Ser) single nucleotide variant Inborn genetic diseases [RCV002970378] Chr14:67659919 [GRCh38]
Chr14:68126636 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_006370.3(VTI1B):c.370C>T (p.Arg124Trp) single nucleotide variant Inborn genetic diseases [RCV002734552] Chr14:67656586 [GRCh38]
Chr14:68123303 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_006370.3(VTI1B):c.604G>T (p.Val202Leu) single nucleotide variant Inborn genetic diseases [RCV002864424] Chr14:67651480 [GRCh38]
Chr14:68118197 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_006370.3(VTI1B):c.226C>A (p.Pro76Thr) single nucleotide variant Inborn genetic diseases [RCV002926463] Chr14:67659871 [GRCh38]
Chr14:68126588 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_001172.4(ARG2):c.1018C>T (p.Pro340Ser) single nucleotide variant Inborn genetic diseases [RCV002764413] Chr14:67650873 [GRCh38]
Chr14:68117590 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_006370.3(VTI1B):c.373C>A (p.Leu125Ile) single nucleotide variant Inborn genetic diseases [RCV002672432] Chr14:67656583 [GRCh38]
Chr14:68123300 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_006370.3(VTI1B):c.649C>T (p.Leu217Phe) single nucleotide variant Inborn genetic diseases [RCV002672433] Chr14:67651435 [GRCh38]
Chr14:68118152 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_001172.4(ARG2):c.727C>A (p.Gln243Lys) single nucleotide variant Inborn genetic diseases [RCV002714667] Chr14:67648051 [GRCh38]
Chr14:68114768 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_006370.3(VTI1B):c.391A>G (p.Met131Val) single nucleotide variant Inborn genetic diseases [RCV002648720] Chr14:67656565 [GRCh38]
Chr14:68123282 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_006370.3(VTI1B):c.490A>G (p.Ile164Val) single nucleotide variant Inborn genetic diseases [RCV003193283] Chr14:67656466 [GRCh38]
Chr14:68123183 [GRCh37]
Chr14:14q24.1		 uncertain significance
NM_001172.4(ARG2):c.988G>A (p.Gly330Arg) single nucleotide variant Inborn genetic diseases [RCV003285431] Chr14:67650843 [GRCh38]
Chr14:68117560 [GRCh37]
Chr14:14q24.1		 uncertain significance
GRCh37/hg19 14q24.1(chr14:67906151-68183185)x3 copy number gain not provided [RCV003485040] Chr14:67906151..68183185 [GRCh37]
Chr14:14q24.1		 uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3 copy number gain not provided [RCV003485036] Chr14:58894502..107227240 [GRCh37]
Chr14:14q23.1-32.33		 pathogenic
GRCh37/hg19 14q22.3-24.1(chr14:57588965-68334517)x3 copy number gain not provided [RCV003485034] Chr14:57588965..68334517 [GRCh37]
Chr14:14q22.3-24.1		 likely pathogenic
GRCh37/hg19 14q23.3-24.1(chr14:67443098-68423187)x3 copy number gain not provided [RCV003485037] Chr14:67443098..68423187 [GRCh37]
Chr14:14q23.3-24.1		 uncertain significance
GRCh37/hg19 14q23.3-24.1(chr14:67491176-68153682)x3 copy number gain not specified [RCV003987055] Chr14:67491176..68153682 [GRCh37]
Chr14:14q23.3-24.1		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR16-1hsa-miR-16-5pMirtarbaseexternal_infopSILAC//ProteomicsFunctional MTI (Weak)18668040
MIR16-2hsa-miR-16-5pMirtarbaseexternal_infopSILAC//ProteomicsFunctional MTI (Weak)18668040

Predicted Target Of
Summary Value
Count of predictions:2392
Count of miRNA genes:1066
Interacting mature miRNAs:1292
Transcripts:ENST00000216456, ENST00000553619, ENST00000554636, ENST00000554659, ENST00000555543, ENST00000556461
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
WI-19297  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371468,117,549 - 68,117,797UniSTSGRCh37
Build 361467,187,302 - 67,187,550RGDNCBI36
Celera1448,176,610 - 48,176,858RGD
Cytogenetic Map14q24.1UniSTS
HuRef1448,287,246 - 48,287,494UniSTS
GeneMap99-GB4 RH Map14161.28UniSTS
Whitehead-RH Map14247.4UniSTS
RH44731  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371468,116,010 - 68,116,175UniSTSGRCh37
Build 361467,185,763 - 67,185,928RGDNCBI36
Celera1448,175,071 - 48,175,236RGD
Cytogenetic Map14q24.1UniSTS
HuRef1448,285,707 - 48,285,872UniSTS
GeneMap99-GB4 RH Map14161.28UniSTS
D14S721E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371468,115,339 - 68,115,427UniSTSGRCh37
Build 361467,185,092 - 67,185,180RGDNCBI36
Celera1448,174,400 - 48,174,488RGD
Cytogenetic Map14q24.1UniSTS
HuRef1448,285,036 - 48,285,124UniSTS
SHGC-132208  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371468,114,677 - 68,114,883UniSTSGRCh37
Build 361467,184,430 - 67,184,636RGDNCBI36
Celera1448,173,738 - 48,173,944RGD
Cytogenetic Map14q24.1UniSTS
HuRef1448,284,374 - 48,284,580UniSTS
TNG Radiation Hybrid Map1422850.0UniSTS
SHGC-30820  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371468,127,849 - 68,127,982UniSTSGRCh37
Build 361467,197,602 - 67,197,735RGDNCBI36
Celera1448,186,890 - 48,187,023RGD
Cytogenetic Map14q24.1UniSTS
HuRef1448,297,527 - 48,297,660UniSTS
TNG Radiation Hybrid Map1422863.0UniSTS
Stanford-G3 RH Map142381.0UniSTS
GeneMap99-GB4 RH Map14161.28UniSTS
Whitehead-RH Map14247.5UniSTS
NCBI RH Map14658.6UniSTS
GeneMap99-G3 RH Map142429.0UniSTS
D14S1294  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371468,114,677 - 68,114,823UniSTSGRCh37
Build 361467,184,430 - 67,184,576RGDNCBI36
Celera1448,173,738 - 48,173,884RGD
Cytogenetic Map14q24.1UniSTS
HuRef1448,284,374 - 48,284,520UniSTS
GeneMap99-G3 RH Map142407.0UniSTS
A007B39  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371468,113,982 - 68,114,090UniSTSGRCh37
Build 361467,183,735 - 67,183,843RGDNCBI36
Celera1448,173,043 - 48,173,151RGD
Cytogenetic Map14q24.1UniSTS
HuRef1448,283,679 - 48,283,787UniSTS
GeneMap99-GB4 RH Map14161.28UniSTS
RH68231  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371468,113,810 - 68,113,949UniSTSGRCh37
Build 361467,183,563 - 67,183,702RGDNCBI36
Celera1448,172,871 - 48,173,010RGD
Cytogenetic Map14q24.1UniSTS
HuRef1448,283,507 - 48,283,646UniSTS
GeneMap99-GB4 RH Map14161.28UniSTS
WI-18578  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371468,114,665 - 68,114,772UniSTSGRCh37
Build 361467,184,418 - 67,184,525RGDNCBI36
Celera1448,173,726 - 48,173,833RGD
Cytogenetic Map14q24.1UniSTS
HuRef1448,284,362 - 48,284,469UniSTS
GeneMap99-GB4 RH Map14161.28UniSTS
Whitehead-RH Map14247.5UniSTS
A008X14  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371468,119,190 - 68,119,405UniSTSGRCh37
Build 361467,188,943 - 67,189,158RGDNCBI36
Celera1448,178,251 - 48,178,466RGD
Cytogenetic Map14q24.1UniSTS
HuRef1448,288,887 - 48,289,102UniSTS
GeneMap99-GB4 RH Map14161.28UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2427 2566 1645 551 1659 393 4352 2076 3651 412 1444 1606 171 1204 2785 4
Low 8 424 81 73 291 72 4 121 82 7 13 5 4 1 3 1 2
Below cutoff 1 1 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF035824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF060902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL049779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI597967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000216456   ⟹   ENSP00000216456
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1467,651,264 - 67,674,610 (-)Ensembl
RefSeq Acc Id: ENST00000553619
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1467,656,480 - 67,660,194 (-)Ensembl
RefSeq Acc Id: ENST00000554636   ⟹   ENSP00000451661
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1467,651,152 - 67,659,791 (-)Ensembl
RefSeq Acc Id: ENST00000554659   ⟹   ENSP00000450731
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1467,647,085 - 67,674,632 (-)Ensembl
RefSeq Acc Id: ENST00000555543   ⟹   ENSP00000452366
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1467,656,510 - 67,674,820 (-)Ensembl
RefSeq Acc Id: ENST00000556461   ⟹   ENSP00000451759
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1467,651,261 - 67,659,845 (-)Ensembl
RefSeq Acc Id: NM_006370   ⟹   NP_006361
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381467,647,085 - 67,674,632 (-)NCBI
GRCh371468,113,621 - 68,141,700 (-)NCBI
Build 361467,187,619 - 67,211,301 (-)NCBI Archive
HuRef1448,287,563 - 48,311,281 (-)ENTREZGENE
CHM1_11468,056,646 - 68,080,381 (-)NCBI
T2T-CHM13v2.01461,854,218 - 61,881,753 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_006361   ⟸   NM_006370
- UniProtKB: O43547 (UniProtKB/Swiss-Prot),   Q96J28 (UniProtKB/Swiss-Prot),   Q9UEU0 (UniProtKB/Swiss-Prot),   A8K6M4 (UniProtKB/TrEMBL),   B2RE64 (UniProtKB/TrEMBL),   Q5TZX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000452366   ⟸   ENST00000555543
RefSeq Acc Id: ENSP00000451759   ⟸   ENST00000556461
RefSeq Acc Id: ENSP00000216456   ⟸   ENST00000216456
RefSeq Acc Id: ENSP00000450731   ⟸   ENST00000554659
RefSeq Acc Id: ENSP00000451661   ⟸   ENST00000554636
Protein Domains
t-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UEU0-F1-model_v2 AlphaFold Q9UEU0 1-232 view protein structure

Promoters
RGD ID:6792032
Promoter ID:HG_KWN:19632
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_006370,   UC001XJU.1,   UC010AQP.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361467,211,026 - 67,211,962 (-)MPROMDB
RGD ID:7227959
Promoter ID:EPDNEW_H19724
Type:initiation region
Name:VTI1B_3
Description:vesicle transport through interaction with t-SNAREs 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19725  EPDNEW_H19727  EPDNEW_H19726  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381467,659,903 - 67,659,963EPDNEW
RGD ID:7227957
Promoter ID:EPDNEW_H19725
Type:initiation region
Name:VTI1B_4
Description:vesicle transport through interaction with t-SNAREs 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19724  EPDNEW_H19727  EPDNEW_H19726  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381467,674,378 - 67,674,438EPDNEW
RGD ID:7227963
Promoter ID:EPDNEW_H19726
Type:initiation region
Name:VTI1B_1
Description:vesicle transport through interaction with t-SNAREs 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19725  EPDNEW_H19724  EPDNEW_H19727  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381467,674,632 - 67,674,692EPDNEW
RGD ID:7227961
Promoter ID:EPDNEW_H19727
Type:initiation region
Name:VTI1B_2
Description:vesicle transport through interaction with t-SNAREs 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H19725  EPDNEW_H19724  EPDNEW_H19726  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381467,674,852 - 67,674,912EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:17793 AgrOrtholog
COSMIC VTI1B COSMIC
Ensembl Genes ENSG00000100568 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000216456.6 UniProtKB/TrEMBL
  ENST00000554636.1 UniProtKB/TrEMBL
  ENST00000554659 ENTREZGENE
  ENST00000554659.6 UniProtKB/Swiss-Prot
  ENST00000555543.1 UniProtKB/TrEMBL
  ENST00000556461.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.400 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000100568 GTEx
HGNC ID HGNC:17793 ENTREZGENE
Human Proteome Map VTI1B Human Proteome Map
InterPro SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T_SNARE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  v-SNARE_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vesicle_trsprt_v-SNARE_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10490 UniProtKB/Swiss-Prot
NCBI Gene 10490 ENTREZGENE
OMIM 603207 OMIM
PANTHER VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam V-SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-SNARE_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134861090 PharmGKB
SMART t_SNARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47661 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K6M4 ENTREZGENE, UniProtKB/TrEMBL
  B2RE64 ENTREZGENE, UniProtKB/TrEMBL
  G3V5I2_HUMAN UniProtKB/TrEMBL
  H0YJJ5_HUMAN UniProtKB/TrEMBL
  H0YJL5_HUMAN UniProtKB/TrEMBL
  J3KMW2_HUMAN UniProtKB/TrEMBL
  O43547 ENTREZGENE
  Q5TZX9 ENTREZGENE, UniProtKB/TrEMBL
  Q96J28 ENTREZGENE
  Q9UEU0 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O43547 UniProtKB/Swiss-Prot
  Q96J28 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-12 VTI1B  vesicle transport through interaction with t-SNAREs 1B    vesicle transport through interaction with t-SNAREs homolog 1B (yeast)  Symbol and/or name change 5135510 APPROVED