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Gene: PPP4C (protein phosphatase 4 catalytic subunit) Homo sapiens
Symbol: PPP4C
Name: protein phosphatase 4 catalytic subunit
RGD ID: 1352781
Description: Exhibits protein serine/threonine phosphatase activity. Involved in regulation of double-strand break repair via homologous recombination. Localizes to cytosol; nucleoplasm; and plasma membrane; PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; INTERACTS WITH (+)-catechin; acetylsalicylic acid; all-trans-retinoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: PP-X; PP4; PP4C; PPH3; PPP4; PPX; protein phosphatase 4 (formerly X), catalytic subunit; protein phosphatase X, catalytic subunit; serine/threonine-protein phosphatase 4 catalytic subunit
Mus musculus (house mouse) : Ppp4c (protein phosphatase 4, catalytic subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppp4c (protein phosphatase 4, catalytic subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppp4c (protein phosphatase 4 catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : PPP4C (protein phosphatase 4 catalytic subunit)
Canis lupus familiaris (dog) : PPP4C (protein phosphatase 4 catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppp4c (protein phosphatase 4 catalytic subunit)
Sus scrofa (pig) : PPP4C (protein phosphatase 4 catalytic subunit)
Chlorocebus sabaeus (African green monkey) : PPP4C (protein phosphatase 4 catalytic subunit)
Heterocephalus glaber (naked mole-rat) : Ppp4c (protein phosphatase 4 catalytic subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1630,075,978 - 30,085,376 (+)EnsemblGRCh38hg38GRCh38
GRCh381630,075,994 - 30,085,377 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371630,087,297 - 30,096,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361629,994,886 - 30,004,196 (+)NCBINCBI36hg18NCBI36
Build 341629,994,884 - 30,004,196NCBI
Celera1672,699,024 - 72,708,334 (-)NCBI
Cytogenetic Map16p11.2NCBI
HuRef1627,748,654 - 27,757,965 (+)NCBIHuRef
CHM1_11631,303,054 - 31,312,455 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PPP4C
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352781
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.