Gene: CST6 (cystatin E/M) Homo sapiens
Analyze
Symbol:
CST6
Name:
cystatin E/M
Description:
Predicted to have cysteine-type endopeptidase inhibitor activity. Predicted to be involved in anatomical structure morphogenesis. Localizes to the extracellular exosome. Implicated in ectodermal dysplasia.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
cystatin 6; cystatin M; cystatin M/E; cystatin-6; cystatin-E; cystatin-M; cysteine proteinase inhibitor; ECTD15
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Cst6 (cystatin E/M) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Rattus norvegicus (Norway rat):
Cst6 (cystatin E/M) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Chinchilla lanigera (long-tailed chinchilla):
Cst6 (cystatin E/M) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
CST6 (cystatin E/M) NCBI
Ortholog
Canis lupus familiaris (dog):
CST6 (cystatin E/M) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cst6 (cystatin E/M) NCBI
Ortholog
Sus scrofa (pig):
CST6 (cystatin E/M) HGNC
EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Cst6 (cystatin E/M)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Cst6 (cystatin E/M)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Caenorhabditis elegans (roundworm):
cpi-1
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder)
Caenorhabditis elegans (roundworm):
cpi-2
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, PhylomeDB)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 11 66,012,008 - 66,013,505 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 11 65,779,462 - 65,780,976 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 11 65,536,038 - 65,537,552 (+) NCBI NCBI36 hg18 NCBI36 Build 34 11 65,536,037 - 65,537,551 NCBI Celera 11 63,104,649 - 63,105,332 (+) NCBI Cytogenetic Map 11 q13.1 NCBI HuRef 11 62,105,544 - 62,107,045 (+) NCBI HuRef CHM1_1 11 65,663,579 - 65,665,098 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
Breast Neoplasms EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17043665 lung non-small cell carcinoma EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17043644 melanoma EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22535842 Prostatic Neoplasms EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19503093
Imported Annotations - MGI
autosomal recessive congenital ichthyosis 4B ISS RGD:733622 13592920 OMIM:242500 MouseDO Imported Annotations - OMIM
Ectodermal Dysplasia 15, Hypohidrotic/Hair Type IAGP 7240710 OMIM
17alpha-ethynylestradiol multiple interactions ISO RGD:733622 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CST6 mRNA CTD PMID:17942748 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of CST6 mRNA CTD PMID:25321415 17beta-estradiol multiple interactions EXP 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of CST6 mRNA CTD PMID:30165855 17beta-estradiol affects expression EXP 6480464 Estradiol affects the expression of CST6 mRNA CTD PMID:22574217 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:733622 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:733622 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:733622 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CST6 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CST6 mRNA CTD PMID:23152189 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733622 6480464 Tetrachlorodibenzodioxin affects the expression of CST6 mRNA CTD PMID:21570461 2-hydroxypropanoic acid decreases expression EXP 6480464 Lactic Acid results in decreased expression of CST6 mRNA CTD PMID:30851411 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of CST6 mRNA CTD PMID:16997883 6-propyl-2-thiouracil affects expression ISO RGD:628799 6480464 Propylthiouracil affects the expression of CST6 mRNA CTD PMID:24780913 6-propyl-2-thiouracil decreases expression ISO RGD:628799 6480464 Propylthiouracil results in decreased expression of CST6 mRNA CTD PMID:25825206 8-bromo-3',5'-cyclic AMP multiple interactions EXP 6480464 [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of CST6 mRNA CTD PMID:16997883 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of CST6 mRNA CTD PMID:22100608 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of CST6 mRNA CTD PMID:16249480 , PMID:23830798 amiodarone increases expression EXP 6480464 Amiodarone results in increased expression of CST6 mRNA CTD PMID:19774075 ammonium chloride affects expression ISO RGD:628799 6480464 Ammonium Chloride affects the expression of CST6 mRNA CTD PMID:16483693 benzo[a]pyrene increases expression ISO RGD:628799 6480464 Benzo(a)pyrene results in increased expression of CST6 mRNA CTD PMID:21839799 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of CST6 mRNA CTD PMID:22316170 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of CST6 mRNA CTD PMID:25102026 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of CST6 mRNA CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of CST6 mRNA CTD PMID:26363213 bisphenol A decreases expression ISO RGD:628799 6480464 bisphenol A results in decreased expression of CST6 mRNA CTD PMID:25181051 butan-1-ol multiple interactions EXP 6480464 [[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of CST6 mRNA CTD PMID:29432896 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of CST6 mRNA CTD PMID:21120746 cadmium dichloride affects expression ISO RGD:628799 6480464 Cadmium Chloride affects the expression of CST6 mRNA CTD PMID:22110744 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of CST6 mRNA CTD PMID:26472689 calcitriol increases expression EXP 6480464 Calcitriol results in increased expression of CST6 mRNA CTD PMID:12040012 , PMID:16002434 carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of CST6 mRNA CTD PMID:25979313 cobalt atom multiple interactions EXP 6480464 [tungsten carbide binds to Cobalt] which results in increased expression of CST6 mRNA CTD PMID:20105288 cobalt dichloride increases expression EXP 6480464 cobaltous chloride results in increased expression of CST6 mRNA CTD PMID:20105288 cobalt(2+) multiple interactions EXP 6480464 [tungsten carbide binds to Cobalt] which results in increased expression of CST6 mRNA CTD PMID:20105288 copper atom multiple interactions ISO RGD:733622 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of CST6 mRNA CTD PMID:15467011 copper atom multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in decreased expression of CST6 mRNA CTD PMID:24690739 copper(0) multiple interactions ISO RGD:733622 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of CST6 mRNA CTD PMID:15467011 copper(0) multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in decreased expression of CST6 mRNA CTD PMID:24690739 copper(2+) multiple interactions ISO RGD:733622 6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of CST6 mRNA CTD PMID:15467011 copper(2+) multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in decreased expression of CST6 mRNA CTD PMID:24690739 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of CST6 mRNA CTD PMID:27989131 dexamethasone multiple interactions EXP 6480464 [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of CST6 mRNA CTD PMID:16997883 disulfiram multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in decreased expression of CST6 mRNA CTD PMID:24690739 diuron increases expression ISO RGD:628799 6480464 Diuron results in increased expression of CST6 mRNA CTD PMID:21551480 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 endosulfan increases expression ISO RGD:628799 6480464 Endosulfan results in increased expression of CST6 mRNA CTD PMID:29391264 entinostat multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CST6 mRNA CTD PMID:27188386 entinostat increases expression EXP 6480464 entinostat results in increased expression of CST6 mRNA CTD PMID:26272509 furan increases expression ISO RGD:628799 6480464 furan results in increased expression of CST6 mRNA CTD PMID:25539665 , PMID:27387713 graphite affects expression ISO RGD:628799 6480464 Graphite affects the expression of CST6 mRNA CTD PMID:29933104 hydroquinone increases expression EXP 6480464 hydroquinone results in increased expression of CST6 mRNA CTD PMID:31256213 L-ascorbic acid increases expression ISO RGD:628799 6480464 Ascorbic Acid results in increased expression of CST6 mRNA CTD PMID:15372504 methotrexate affects response to substance EXP 6480464 CST6 protein affects the susceptibility to Methotrexate CTD PMID:16217747 methotrexate increases expression EXP 6480464 Methotrexate results in increased expression of CST6 mRNA CTD PMID:21678067 N-methyl-4-phenylpyridinium increases expression ISO RGD:628799 6480464 1-Methyl-4-phenylpyridinium results in increased expression of CST6 mRNA CTD PMID:28801915 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of CST6 mRNA CTD PMID:21527772 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CST6 mRNA CTD PMID:27188386 pirinixic acid multiple interactions ISO RGD:733622 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CST6 mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:733622 6480464 pirinixic acid results in increased expression of CST6 mRNA CTD PMID:17426115 potassium dichromate increases expression EXP 6480464 Potassium Dichromate results in increased expression of CST6 mRNA CTD PMID:11678601 potassium dichromate increases expression ISO RGD:733622 6480464 Potassium Dichromate results in increased expression of CST6 mRNA CTD PMID:23608068 rac-lactic acid decreases expression EXP 6480464 Lactic Acid results in decreased expression of CST6 mRNA CTD PMID:30851411 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silver atom increases expression ISO RGD:733622 6480464 Silver results in increased expression of CST6 mRNA CTD PMID:27131904 silver(0) increases expression ISO RGD:733622 6480464 Silver results in increased expression of CST6 mRNA CTD PMID:27131904 silver(1+) increases expression ISO RGD:733622 6480464 Silver results in increased expression of CST6 mRNA CTD PMID:27131904 tetrachloromethane increases expression ISO RGD:733622 6480464 Carbon Tetrachloride results in increased expression of CST6 mRNA CTD PMID:17484886 thioacetamide increases expression ISO RGD:628799 6480464 Thioacetamide results in increased expression of CST6 mRNA CTD PMID:23411599 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of CST6 mRNA, trichostatin A results in increased expression of CST6 protein CTD PMID:19503093 triclosan increases expression EXP 6480464 Triclosan results in increased expression of CST6 mRNA CTD PMID:30510588 Tungsten carbide multiple interactions EXP 6480464 [tungsten carbide binds to Cobalt] which results in increased expression of CST6 mRNA CTD PMID:20105288 zearalenone decreases expression EXP 6480464 Zearalenone results in decreased expression of CST6 mRNA CTD PMID:28965971
Gene-Chemical Interaction Annotations
