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Gene: MCCC2 (methylcrotonoyl-CoA carboxylase 2) Homo sapiens
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Symbol: MCCC2
Name: methylcrotonoyl-CoA carboxylase 2
Description: Contributes to methylcrotonoyl-CoA carboxylase activity. Predicted to be involved in leucine catabolic process. Localizes to the methylcrotonoyl-CoA carboxylase complex and mitochondrial matrix. Implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; biotin carboxylase; MCCase subunit beta; MCCB; methylcrotonoyl-CoA carboxylase 2 (beta); methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; methylcrotonoyl-Coenzyme A carboxylase 2 (beta); non-biotin containing subunit of 3-methylcrotonyl-CoA carboxylase; testicular secretory protein Li 29
Orthologs:
Mus musculus (house mouse) : Mccc2 (methylcrotonoyl-Coenzyme A carboxylase 2 (beta))  MGI  Alliance
Rattus norvegicus (Norway rat) : Mccc2 (methylcrotonoyl-CoA carboxylase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mccc2 (methylcrotonoyl-CoA carboxylase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MCCC2 (methylcrotonoyl-CoA carboxylase 2)
Canis lupus familiaris (dog) : MCCC2 (methylcrotonoyl-CoA carboxylase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mccc2 (methylcrotonoyl-CoA carboxylase 2)
Sus scrofa (pig) : MCCC2 (methylcrotonoyl-CoA carboxylase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl571,587,288 - 71,658,706 (+)Ensembl
GRCh38571,587,340 - 71,658,706 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37570,883,115 - 70,954,533 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36570,918,910 - 70,988,981 (+)NCBINCBI36hg18NCBI36
Build 34570,918,909 - 70,988,981NCBI
Celera566,778,848 - 66,850,229 (+)NCBI
Cytogenetic Map5q13.2NCBI
HuRef566,088,903 - 66,160,527 (+)NCBIHuRef
CHM1_1570,315,816 - 70,387,189 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MCCC2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352586
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.