PRADC1 (protease associated domain containing 1) - Rat Genome Database

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Gene: PRADC1 (protease associated domain containing 1) Homo sapiens
Analyze
Symbol: PRADC1
Name: protease associated domain containing 1
RGD ID: 1352558
HGNC Page HGNC:16047
Description: Located in extracellular region.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C2orf7; hPAP21; MGC13004; PAP21; protease-associated domain containing 1; protease-associated domain-containing glycoprotein 21 kDa; protease-associated domain-containing protein 1; protease-associated domain-containing protein of 21 kDa
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: PRADC1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38273,228,006 - 73,233,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl273,228,010 - 73,233,239 (-)EnsemblGRCh38hg38GRCh38
GRCh37273,455,134 - 73,460,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,308,642 - 73,313,864 (-)NCBINCBI36Build 36hg18NCBI36
Build 34273,366,790 - 73,372,011NCBI
Celera273,305,961 - 73,311,182 (-)NCBICelera
Cytogenetic Map2p13.2NCBI
HuRef273,190,796 - 73,196,012 (-)NCBIHuRef
CHM1_1273,385,941 - 73,391,163 (-)NCBICHM1_1
T2T-CHM13v2.0273,240,995 - 73,246,273 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Dystonia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12975309   PMID:15231747   PMID:15489334   PMID:15498570   PMID:23376485   PMID:25416956   PMID:28514442   PMID:31452512   PMID:33961781  


Genomics

Comparative Map Data
PRADC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38273,228,006 - 73,233,284 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl273,228,010 - 73,233,239 (-)EnsemblGRCh38hg38GRCh38
GRCh37273,455,134 - 73,460,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36273,308,642 - 73,313,864 (-)NCBINCBI36Build 36hg18NCBI36
Build 34273,366,790 - 73,372,011NCBI
Celera273,305,961 - 73,311,182 (-)NCBICelera
Cytogenetic Map2p13.2NCBI
HuRef273,190,796 - 73,196,012 (-)NCBIHuRef
CHM1_1273,385,941 - 73,391,163 (-)NCBICHM1_1
T2T-CHM13v2.0273,240,995 - 73,246,273 (-)NCBIT2T-CHM13v2.0
Pradc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,423,767 - 85,428,969 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl685,423,792 - 85,428,952 (-)EnsemblGRCm39 Ensembl
GRCm38685,446,785 - 85,451,987 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,446,810 - 85,451,970 (-)EnsemblGRCm38mm10GRCm38
MGSCv37685,396,779 - 85,401,964 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36685,412,443 - 85,416,941 (-)NCBIMGSCv36mm8
Celera687,418,724 - 87,423,912 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.46NCBI
Pradc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84119,542,239 - 119,546,536 (-)NCBIGRCr8
mRatBN7.24117,984,732 - 117,989,710 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4117,984,742 - 117,989,886 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.04117,230,523 - 117,235,496 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4117,230,528 - 117,234,928 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04181,808,138 - 181,812,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera4106,966,767 - 106,971,740 (-)NCBICelera
Cytogenetic Map4q34NCBI
Pradc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542412,402,923 - 12,410,735 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542412,403,090 - 12,408,055 (+)NCBIChiLan1.0ChiLan1.0
PRADC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21253,147,378 - 53,152,725 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A53,150,128 - 53,155,459 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A73,280,791 - 73,286,879 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A74,769,555 - 74,775,787 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A74,769,555 - 74,775,787 (-)Ensemblpanpan1.1panPan2
PRADC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11749,633,772 - 49,649,450 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1749,633,769 - 49,637,708 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1749,280,378 - 49,296,063 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01750,499,701 - 50,515,384 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1750,499,745 - 50,503,892 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11749,515,985 - 49,531,667 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01749,582,857 - 49,598,539 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01750,141,832 - 50,157,514 (+)NCBIUU_Cfam_GSD_1.0
Pradc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629211,554,537 - 11,559,293 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649117,009,723 - 17,016,784 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649117,011,999 - 17,016,773 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRADC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,547,649 - 69,555,085 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1369,546,838 - 69,552,014 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,750,448 - 72,755,320 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRADC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,940,270 - 33,945,380 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604578,137,353 - 78,143,144 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pradc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624762410,216 - 415,814 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624762410,201 - 415,820 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PRADC1
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2
pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2
uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2
benign
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p15-11.2(chr2:62245236-86978895)x3 copy number gain See cases [RCV000448688] Chr2:62245236..86978895 [GRCh37]
Chr2:2p15-11.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
Single allele deletion not provided [RCV000714264] Chr2:40608411..146900718 [GRCh37]
Chr2:2p22.1-q22.3
likely pathogenic
Single allele duplication not provided [RCV000677942] Chr2:63671346..85698002 [GRCh37]
Chr2:2p15-11.2
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NC_000002.11:g.(?_71004499)_(74779761_?)del deletion Dystonic disorder [RCV003113211]|Methylmalonic acidemia due to methylmalonyl-CoA epimerase deficiency [RCV003113210]|not provided [RCV003107716] Chr2:71004499..74779761 [GRCh37]
Chr2:2p13.3-13.1
pathogenic|no classifications from unflagged records
GRCh37/hg19 2p25.3-q37.3(chr2:1-243199373) copy number gain Mosaic trisomy 2 [RCV002280628] Chr2:1..243199373 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NC_000002.11:g.(?_73114549)_(73836749_?)dup duplication Alstrom syndrome [RCV001365067] Chr2:73114549..73836749 [GRCh37]
Chr2:2p13.2-13.1
uncertain significance
NC_000002.11:g.(?_72359356)_(74779761_?)del deletion MOGS-congenital disorder of glycosylation [RCV003109485]|not provided [RCV003116543] Chr2:72359356..74779761 [GRCh37]
Chr2:2p13.2-13.1
pathogenic|no classifications from unflagged records
NC_000002.11:g.(?_69240632)_(74779761_?)dup duplication not provided [RCV003122858] Chr2:69240632..74779761 [GRCh37]
Chr2:2p13.3-13.1
uncertain significance
GRCh37/hg19 2p25.1-q13(chr2:11504318-111365996)x1 copy number loss See cases [RCV002287563] Chr2:11504318..111365996 [GRCh37]
Chr2:2p25.1-q13
pathogenic
NM_032319.3(PRADC1):c.113G>A (p.Gly38Glu) single nucleotide variant Inborn genetic diseases [RCV002859335] Chr2:73230168 [GRCh38]
Chr2:73457296 [GRCh37]
Chr2:2p13.2
uncertain significance
NM_032319.3(PRADC1):c.5T>C (p.Val2Ala) single nucleotide variant Inborn genetic diseases [RCV002848852] Chr2:73233156 [GRCh38]
Chr2:73460284 [GRCh37]
Chr2:2p13.2
uncertain significance
NM_032319.3(PRADC1):c.506C>A (p.Pro169Gln) single nucleotide variant Inborn genetic diseases [RCV002822069] Chr2:73228515 [GRCh38]
Chr2:73455643 [GRCh37]
Chr2:2p13.2
uncertain significance
NM_032319.3(PRADC1):c.202G>T (p.Ala68Ser) single nucleotide variant Inborn genetic diseases [RCV002737331] Chr2:73229537 [GRCh38]
Chr2:73456665 [GRCh37]
Chr2:2p13.2
uncertain significance
NM_032319.3(PRADC1):c.10G>A (p.Gly4Ser) single nucleotide variant Inborn genetic diseases [RCV002789419] Chr2:73233151 [GRCh38]
Chr2:73460279 [GRCh37]
Chr2:2p13.2
uncertain significance
NM_032319.3(PRADC1):c.202G>A (p.Ala68Thr) single nucleotide variant Inborn genetic diseases [RCV002644965] Chr2:73229537 [GRCh38]
Chr2:73456665 [GRCh37]
Chr2:2p13.2
uncertain significance
NM_032319.3(PRADC1):c.328C>T (p.Arg110Trp) single nucleotide variant Inborn genetic diseases [RCV002807403] Chr2:73228913 [GRCh38]
Chr2:73456041 [GRCh37]
Chr2:2p13.2
uncertain significance
NM_032319.3(PRADC1):c.417C>A (p.Ile139=) single nucleotide variant not provided [RCV003427019] Chr2:73228824 [GRCh38]
Chr2:73455952 [GRCh37]
Chr2:2p13.2
likely benign
GRCh37/hg19 2p13.3-12(chr2:71076472-76368354)x1 copy number loss not specified [RCV003986388] Chr2:71076472..76368354 [GRCh37]
Chr2:2p13.3-12
likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:784
Count of miRNA genes:459
Interacting mature miRNAs:516
Transcripts:ENST00000258083, ENST00000470391, ENST00000480093
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH103262  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37273,455,191 - 73,455,331UniSTSGRCh37
Build 36273,308,699 - 73,308,839RGDNCBI36
Celera273,306,018 - 73,306,158RGD
Cytogenetic Map2p13.2UniSTS
HuRef273,190,853 - 73,190,993UniSTS
GeneMap99-GB4 RH Map2223.21UniSTS
RH68102  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37273,455,285 - 73,455,397UniSTSGRCh37
Build 36273,308,793 - 73,308,905RGDNCBI36
Celera273,306,112 - 73,306,224RGD
Cytogenetic Map2p13.2UniSTS
HuRef273,190,947 - 73,191,059UniSTS
GeneMap99-GB4 RH Map2226.12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2421 2363 1718 623 1263 462 4322 2171 3680 406 1442 1555 174 1 1202 2787 4 2
Low 18 626 8 1 686 3 35 26 54 13 18 58 2 1 2
Below cutoff 2 2

Sequence


RefSeq Acc Id: ENST00000258083   ⟹   ENSP00000258083
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl273,228,010 - 73,233,239 (-)Ensembl
RefSeq Acc Id: ENST00000470391
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl273,229,799 - 73,233,229 (-)Ensembl
RefSeq Acc Id: ENST00000480093
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl273,228,331 - 73,233,238 (-)Ensembl
RefSeq Acc Id: NM_032319   ⟹   NP_115695
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38273,228,010 - 73,233,239 (-)NCBI
GRCh37273,455,134 - 73,460,356 (-)RGD
Build 36273,308,642 - 73,313,864 (-)NCBI Archive
Celera273,305,961 - 73,311,182 (-)RGD
HuRef273,190,796 - 73,196,012 (-)RGD
CHM1_1273,385,941 - 73,391,163 (-)NCBI
T2T-CHM13v2.0273,240,999 - 73,246,228 (-)NCBI
Sequence:
RefSeq Acc Id: NR_144358
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38273,228,006 - 73,233,284 (-)NCBI
T2T-CHM13v2.0273,240,995 - 73,246,273 (-)NCBI
Sequence:
RefSeq Acc Id: NP_115695   ⟸   NM_032319
- Peptide Label: precursor
- UniProtKB: Q2Z1P2 (UniProtKB/Swiss-Prot),   Q9BSG0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000258083   ⟸   ENST00000258083
Protein Domains
PA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9BSG0-F1-model_v2 AlphaFold Q9BSG0 1-188 view protein structure

Promoters
RGD ID:6860680
Promoter ID:EPDNEW_H3505
Type:initiation region
Name:PRADC1_1
Description:protease associated domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3507  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38273,233,236 - 73,233,296EPDNEW
RGD ID:6860684
Promoter ID:EPDNEW_H3507
Type:initiation region
Name:PRADC1_2
Description:protease associated domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H3505  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38273,234,661 - 73,234,721EPDNEW
RGD ID:6796914
Promoter ID:HG_KWN:33247
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000327712
Position:
Human AssemblyChrPosition (strand)Source
Build 36273,310,656 - 73,311,156 (-)MPROMDB
RGD ID:6796912
Promoter ID:HG_KWN:33248
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:NM_032319,   OTTHUMT00000327711,   OTTHUMT00000327713,   OTTHUMT00000327745,   OTTHUMT00000327746,   OTTHUMT00000327747,   OTTHUMT00000327748
Position:
Human AssemblyChrPosition (strand)Source
Build 36273,313,341 - 73,314,137 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16047 AgrOrtholog
COSMIC PRADC1 COSMIC
Ensembl Genes ENSG00000135617 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000258083 ENTREZGENE
  ENST00000258083.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.50.30.30 UniProtKB/Swiss-Prot
GTEx ENSG00000135617 GTEx
HGNC ID HGNC:16047 ENTREZGENE
Human Proteome Map PRADC1 Human Proteome Map
InterPro PA_dom_sf UniProtKB/Swiss-Prot
  PA_domain UniProtKB/Swiss-Prot
  PRADC1-like_PA UniProtKB/Swiss-Prot
KEGG Report hsa:84279 UniProtKB/Swiss-Prot
NCBI Gene 84279 ENTREZGENE
OMIM 619674 OMIM
PANTHER PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
  PTHR22702 UniProtKB/Swiss-Prot
Pfam PF02225 UniProtKB/Swiss-Prot
PharmGKB PA25895 PharmGKB
Superfamily-SCOP PA domain UniProtKB/Swiss-Prot
UniProt PADC1_HUMAN UniProtKB/Swiss-Prot
  Q2Z1P2 ENTREZGENE
  Q9BSG0 ENTREZGENE
UniProt Secondary Q2Z1P2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-31 PRADC1  protease associated domain containing 1    protease-associated domain containing 1  Symbol and/or name change 5135510 APPROVED
2011-07-27 PRADC1  protease-associated domain containing 1  C2orf7  chromosome 2 open reading frame 7  Symbol and/or name change 5135510 APPROVED