CORO2B (coronin 2B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: CORO2B (coronin 2B) Homo sapiens
Analyze
Symbol: CORO2B
Name: coronin 2B
RGD ID: 1352370
HGNC Page HGNC:2256
Description: Enables talin binding activity and vinculin binding activity. Acts upstream of or within several processes, including negative regulation of cell-substrate adhesion; regulation of actin cytoskeleton organization; and regulation of establishment of protein localization. Located in focal adhesion.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: clipin C; clipin-C; CLIPINC; coronin, actin binding protein, 2B; coronin, actin-binding protein, 2B; coronin, actin-binding, 2B; coronin-2B; coronin-like protein C; KIAA0925
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381568,518,373 - 68,727,806 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1568,578,993 - 68,727,806 (+)EnsemblGRCh38hg38GRCh38
GRCh371568,810,712 - 69,020,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361566,658,627 - 66,807,199 (+)NCBINCBI36Build 36hg18NCBI36
Build 341566,658,645 - 66,807,193NCBI
Celera1545,798,327 - 45,909,300 (+)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1545,705,372 - 45,853,698 (+)NCBIHuRef
CHM1_11568,989,282 - 69,138,119 (+)NCBICHM1_1
T2T-CHM13v2.01566,341,263 - 66,550,386 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:10224093   PMID:10231032   PMID:12477932   PMID:15489334   PMID:16169070   PMID:16344560   PMID:19734545   PMID:20379614   PMID:21873635   PMID:25416956   PMID:28302793   PMID:28514442  
PMID:29162887   PMID:31221975   PMID:32296183   PMID:32694731   PMID:32707033   PMID:33961781   PMID:35013218   PMID:35659652   PMID:35914814   PMID:36042349   PMID:36215168   PMID:36380368  


Genomics

Comparative Map Data
CORO2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381568,518,373 - 68,727,806 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1568,578,993 - 68,727,806 (+)EnsemblGRCh38hg38GRCh38
GRCh371568,810,712 - 69,020,145 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361566,658,627 - 66,807,199 (+)NCBINCBI36Build 36hg18NCBI36
Build 341566,658,645 - 66,807,193NCBI
Celera1545,798,327 - 45,909,300 (+)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1545,705,372 - 45,853,698 (+)NCBIHuRef
CHM1_11568,989,282 - 69,138,119 (+)NCBICHM1_1
T2T-CHM13v2.01566,341,263 - 66,550,386 (+)NCBIT2T-CHM13v2.0
Coro2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39962,326,770 - 62,444,326 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl962,326,774 - 62,444,326 (-)EnsemblGRCm39 Ensembl
GRCm38962,419,490 - 62,537,044 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl962,419,492 - 62,537,044 (-)EnsemblGRCm38mm10GRCm38
MGSCv37962,267,299 - 62,384,851 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36962,217,503 - 62,335,050 (-)NCBIMGSCv36mm8
Celera959,643,037 - 59,752,273 (-)NCBICelera
Cytogenetic Map9BNCBI
cM Map933.71NCBI
Coro2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8871,802,329 - 71,912,739 (-)NCBIGRCr8
mRatBN7.2862,906,861 - 63,017,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl862,906,867 - 63,017,302 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0867,374,617 - 67,492,490 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl867,376,294 - 67,492,037 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0867,107,332 - 67,223,553 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4866,573,135 - 66,651,600 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera862,323,812 - 62,434,442 (-)NCBICelera
Cytogenetic Map8q24NCBI
Coro2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554507,521,188 - 7,573,575 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554507,522,447 - 7,573,043 (-)NCBIChiLan1.0ChiLan1.0
CORO2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21657,780,429 - 57,989,761 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11562,014,725 - 62,163,270 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01547,536,641 - 47,685,357 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11566,370,760 - 66,452,545 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1566,370,374 - 66,452,545 (+)Ensemblpanpan1.1panPan2
CORO2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13032,574,068 - 32,701,494 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3032,627,373 - 32,702,757 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3032,502,452 - 32,635,221 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03032,765,185 - 32,898,489 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3032,765,171 - 32,899,752 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13032,691,878 - 32,824,917 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03032,755,902 - 32,889,573 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03033,000,020 - 33,133,491 (+)NCBIUU_Cfam_GSD_1.0
Coro2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640110,585,976 - 110,704,075 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647128,481,630 - 28,552,160 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647128,481,615 - 28,552,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CORO2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1166,465,953 - 166,608,363 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11166,465,870 - 166,608,840 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,299,326 - 184,442,301 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CORO2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12614,746,497 - 14,909,483 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2614,746,379 - 14,895,951 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048126,574,113 - 126,724,538 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Coro2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247814,507,601 - 4,601,359 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247814,507,916 - 4,617,274 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CORO2B
25 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q22.33-23(chr15:67194581-69086285)x1 copy number loss See cases [RCV000053218] Chr15:67194581..69086285 [GRCh38]
Chr15:67486919..69378625 [GRCh37]
Chr15:65273973..67165679 [NCBI36]
Chr15:15q22.33-23		 pathogenic
NM_006091.5(CORO2B):c.1076G>A (p.Arg359Gln) single nucleotide variant Inborn genetic diseases [RCV003210171] Chr15:68718806 [GRCh38]
Chr15:69011145 [GRCh37]
Chr15:66798199 [NCBI36]
Chr15:15q23		 uncertain significance|not provided
NM_001190456.1(CORO2B):c.665G>A (p.Arg222Gln) single nucleotide variant Malignant melanoma [RCV000062914] Chr15:68713956 [GRCh38]
Chr15:69006295 [GRCh37]
Chr15:66793349 [NCBI36]
Chr15:15q23		 not provided
NM_001190456.1(CORO2B):c.1339T>C (p.Leu447=) single nucleotide variant Malignant melanoma [RCV000062915] Chr15:68725885 [GRCh38]
Chr15:69018224 [GRCh37]
Chr15:66805278 [NCBI36]
Chr15:15q23		 not provided
NM_006091.4(CORO2B):c.15+15695A>G single nucleotide variant Lung cancer [RCV000099633] Chr15:68594972 [GRCh38]
Chr15:68887311 [GRCh37]
Chr15:15q23		 uncertain significance
GRCh38/hg38 15q23(chr15:67933759-68766493)x3 copy number gain See cases [RCV000139136] Chr15:67933759..68766493 [GRCh38]
Chr15:68226097..69058832 [GRCh37]
Chr15:66013151..66845886 [NCBI36]
Chr15:15q23		 likely benign
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
GRCh37/hg19 15q22.31-26.3(chr15:64637227-102509910)x3 copy number gain See cases [RCV000240602] Chr15:64637227..102509910 [GRCh37]
Chr15:15q22.31-26.3		 pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3		 likely pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
NM_006091.5(CORO2B):c.96T>A (p.Asp32Glu) single nucleotide variant Inborn genetic diseases [RCV003242188] Chr15:68645240 [GRCh38]
Chr15:68937579 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.435G>T (p.Trp145Cys) single nucleotide variant Inborn genetic diseases [RCV003280288] Chr15:68710833 [GRCh38]
Chr15:69003172 [GRCh37]
Chr15:15q23		 uncertain significance
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3		 pathogenic
GRCh37/hg19 15q22.31-23(chr15:66861081-69213575)x1 copy number loss not provided [RCV000683701] Chr15:66861081..69213575 [GRCh37]
Chr15:15q22.31-23		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q22.33-23(chr15:67369118-70481307)x1 copy number loss not provided [RCV000846047] Chr15:67369118..70481307 [GRCh37]
Chr15:15q22.33-23		 pathogenic
NM_006091.5(CORO2B):c.1429C>A (p.Pro477Thr) single nucleotide variant Inborn genetic diseases [RCV003269783] Chr15:68725960 [GRCh38]
Chr15:69018299 [GRCh37]
Chr15:15q23		 uncertain significance
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1		 uncertain significance
NC_000015.9:g.(?_66161924)_(69018313_?)dup duplication Neuronal ceroid lipofuscinosis [RCV003120802]|not provided [RCV002045713] Chr15:66161924..69018313 [GRCh37]
Chr15:15q22.31-23		 uncertain significance|no classifications from unflagged records
NM_006091.5(CORO2B):c.355G>A (p.Glu119Lys) single nucleotide variant Inborn genetic diseases [RCV003299151] Chr15:68710753 [GRCh38]
Chr15:69003092 [GRCh37]
Chr15:15q23		 uncertain significance
GRCh37/hg19 15q23(chr15:68593993-69070537)x3 copy number gain not provided [RCV002474736] Chr15:68593993..69070537 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.1385G>A (p.Arg462His) single nucleotide variant Inborn genetic diseases [RCV002841491] Chr15:68725916 [GRCh38]
Chr15:69018255 [GRCh37]
Chr15:15q23		 uncertain significance
GRCh37/hg19 15q23(chr15:68807665-70981473)x3 copy number gain not provided [RCV002475757] Chr15:68807665..70981473 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.438C>A (p.His146Gln) single nucleotide variant Inborn genetic diseases [RCV002925891] Chr15:68710836 [GRCh38]
Chr15:69003175 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.539C>T (p.Thr180Met) single nucleotide variant Inborn genetic diseases [RCV002924652] Chr15:68711597 [GRCh38]
Chr15:69003936 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.835G>T (p.Asp279Tyr) single nucleotide variant Inborn genetic diseases [RCV002916316] Chr15:68714628 [GRCh38]
Chr15:69006967 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.932T>C (p.Met311Thr) single nucleotide variant Inborn genetic diseases [RCV002641214] Chr15:68715276 [GRCh38]
Chr15:69007615 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.707G>A (p.Arg236Gln) single nucleotide variant Inborn genetic diseases [RCV002874633] Chr15:68713983 [GRCh38]
Chr15:69006322 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.26G>A (p.Arg9His) single nucleotide variant Inborn genetic diseases [RCV002696922] Chr15:68645170 [GRCh38]
Chr15:68937509 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.152G>A (p.Arg51His) single nucleotide variant Inborn genetic diseases [RCV002714621] Chr15:68645296 [GRCh38]
Chr15:68937635 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.371G>A (p.Arg124Gln) single nucleotide variant Inborn genetic diseases [RCV002878472] Chr15:68710769 [GRCh38]
Chr15:69003108 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.29C>T (p.Pro10Leu) single nucleotide variant Inborn genetic diseases [RCV002941659] Chr15:68645173 [GRCh38]
Chr15:68937512 [GRCh37]
Chr15:15q23		 uncertain significance
GRCh37/hg19 15q22.33-26.1(chr15:67358491-91644328)x3 copy number gain not provided [RCV003222839] Chr15:67358491..91644328 [GRCh37]
Chr15:15q22.33-26.1		 pathogenic
NM_006091.5(CORO2B):c.731G>C (p.Arg244Thr) single nucleotide variant Inborn genetic diseases [RCV003283108] Chr15:68714007 [GRCh38]
Chr15:69006346 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.721G>C (p.Gly241Arg) single nucleotide variant Inborn genetic diseases [RCV003368939] Chr15:68713997 [GRCh38]
Chr15:69006336 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.581T>A (p.Leu194Gln) single nucleotide variant not provided [RCV003394960] Chr15:68711639 [GRCh38]
Chr15:69003978 [GRCh37]
Chr15:15q23		 likely benign
NM_006091.5(CORO2B):c.1025A>G (p.Lys342Arg) single nucleotide variant Inborn genetic diseases [RCV003374146] Chr15:68718755 [GRCh38]
Chr15:69011094 [GRCh37]
Chr15:15q23		 uncertain significance
NM_006091.5(CORO2B):c.540G>A (p.Thr180=) single nucleotide variant not provided [RCV003394959] Chr15:68711598 [GRCh38]
Chr15:69003937 [GRCh37]
Chr15:15q23		 likely benign
NM_006091.5(CORO2B):c.186C>T (p.Gly62=) single nucleotide variant not provided [RCV003394958] Chr15:68645330 [GRCh38]
Chr15:68937669 [GRCh37]
Chr15:15q23		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4105
Count of miRNA genes:622
Interacting mature miRNAs:690
Transcripts:ENST00000261861, ENST00000540068, ENST00000543950, ENST00000566799
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D15S1243  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,951,466 - 68,951,623UniSTSGRCh37
Build 361566,738,520 - 66,738,677RGDNCBI36
Celera1545,840,903 - 45,841,060RGD
Cytogenetic Map15q23UniSTS
HuRef1545,785,518 - 45,785,675UniSTS
Stanford-G3 RH Map152330.0UniSTS
NCBI RH Map15398.3UniSTS
RH28501  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,919,374 - 68,919,446UniSTSGRCh37
Build 361566,706,428 - 66,706,500RGDNCBI36
Celera1545,808,823 - 45,808,895RGD
Cytogenetic Map15q23UniSTS
HuRef1545,753,434 - 45,753,506UniSTS
A007L06  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371569,019,934 - 69,020,092UniSTSGRCh37
Build 361566,806,988 - 66,807,146RGDNCBI36
Celera1545,909,089 - 45,909,247RGD
Cytogenetic Map15q23UniSTS
HuRef1545,853,487 - 45,853,645UniSTS
GeneMap99-GB4 RH Map15238.01UniSTS
CORO2B_9101  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371569,019,478 - 69,020,291UniSTSGRCh37
Build 361566,806,532 - 66,807,345RGDNCBI36
Celera1545,908,633 - 45,909,446RGD
HuRef1545,853,031 - 45,853,844UniSTS
RH48611  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,947,038 - 68,947,218UniSTSGRCh37
Build 361566,734,092 - 66,734,272RGDNCBI36
Celera1545,836,472 - 45,836,652RGD
Cytogenetic Map15q23UniSTS
HuRef1545,781,087 - 45,781,267UniSTS
GeneMap99-GB4 RH Map15236.19UniSTS
WI-13883  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371569,019,989 - 69,020,124UniSTSGRCh37
Build 361566,807,043 - 66,807,178RGDNCBI36
Celera1545,909,144 - 45,909,279RGD
Cytogenetic Map15q23UniSTS
HuRef1545,853,542 - 45,853,677UniSTS
GeneMap99-GB4 RH Map15236.22UniSTS
Whitehead-RH Map15227.9UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 783 598 527 8 84 5 1388 514 3386 97 528 754 6 992 758
Low 1548 1912 1052 478 821 322 2952 1667 338 274 860 780 165 1 212 2028 1
Below cutoff 59 470 134 127 693 129 10 9 5 46 50 59 3 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001190456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001324015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB023142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC100825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC105014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI871484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK124711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ184259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX461395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA128408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA182763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA219458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA291058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY150896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000261861   ⟹   ENSP00000261861
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1568,578,993 - 68,727,806 (+)Ensembl
RefSeq Acc Id: ENST00000540068   ⟹   ENSP00000446250
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1568,616,539 - 68,727,751 (+)Ensembl
RefSeq Acc Id: ENST00000543950   ⟹   ENSP00000443819
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1568,631,988 - 68,726,077 (+)Ensembl
RefSeq Acc Id: NM_001190456   ⟹   NP_001177385
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381568,616,539 - 68,727,806 (+)NCBI
GRCh371568,851,614 - 69,020,145 (+)NCBI
Celera1545,798,327 - 45,909,300 (+)RGD
HuRef1545,705,372 - 45,853,698 (+)ENTREZGENE
CHM1_11569,026,827 - 69,138,119 (+)NCBI
T2T-CHM13v2.01566,439,430 - 66,550,386 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001190457   ⟹   NP_001177386
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381568,632,072 - 68,727,806 (+)NCBI
GRCh371568,851,614 - 69,020,145 (+)NCBI
Celera1545,798,327 - 45,909,300 (+)RGD
HuRef1545,705,372 - 45,853,698 (+)ENTREZGENE
CHM1_11569,042,276 - 69,138,119 (+)NCBI
T2T-CHM13v2.01566,454,968 - 66,550,386 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001324014   ⟹   NP_001310943
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381568,518,373 - 68,727,806 (+)NCBI
CHM1_11568,928,645 - 69,138,119 (+)NCBI
T2T-CHM13v2.01566,341,263 - 66,550,386 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001324015   ⟹   NP_001310944
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381568,641,503 - 68,727,806 (+)NCBI
CHM1_11569,051,791 - 69,138,119 (+)NCBI
T2T-CHM13v2.01566,464,406 - 66,550,386 (+)NCBI
Sequence:
RefSeq Acc Id: NM_006091   ⟹   NP_006082
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381568,578,993 - 68,727,806 (+)NCBI
GRCh371568,851,614 - 69,020,145 (+)NCBI
Build 361566,658,627 - 66,807,199 (+)NCBI Archive
Celera1545,798,327 - 45,909,300 (+)RGD
HuRef1545,705,372 - 45,853,698 (+)ENTREZGENE
CHM1_11568,989,282 - 69,138,119 (+)NCBI
T2T-CHM13v2.01566,401,913 - 66,550,386 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001177385   ⟸   NM_001190456
- Peptide Label: isoform 2
- UniProtKB: Q9UQ03 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001177386   ⟸   NM_001190457
- Peptide Label: isoform 2
- UniProtKB: Q9UQ03 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_006082   ⟸   NM_006091
- Peptide Label: isoform 1
- UniProtKB: O94767 (UniProtKB/Swiss-Prot),   A8K0W3 (UniProtKB/Swiss-Prot),   Q8TAN1 (UniProtKB/Swiss-Prot),   Q9UQ03 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001310943   ⟸   NM_001324014
- Peptide Label: isoform 2
- UniProtKB: Q9UQ03 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001310944   ⟸   NM_001324015
- Peptide Label: isoform 2
- UniProtKB: Q9UQ03 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000443819   ⟸   ENST00000543950
RefSeq Acc Id: ENSP00000261861   ⟸   ENST00000261861
RefSeq Acc Id: ENSP00000446250   ⟸   ENST00000540068

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UQ03-F1-model_v2 AlphaFold Q9UQ03 1-480 view protein structure

Promoters
RGD ID:6792187
Promoter ID:HG_KWN:21751
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell
Transcripts:ENST00000395450
Position:
Human AssemblyChrPosition (strand)Source
Build 361566,657,581 - 66,658,081 (+)MPROMDB
RGD ID:7229943
Promoter ID:EPDNEW_H20717
Type:multiple initiation site
Name:CORO2B_2
Description:coronin 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20718  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381568,512,755 - 68,512,815EPDNEW
RGD ID:7229945
Promoter ID:EPDNEW_H20718
Type:initiation region
Name:CORO2B_1
Description:coronin 2B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20717  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381568,578,993 - 68,579,053EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2256 AgrOrtholog
COSMIC CORO2B COSMIC
Ensembl Genes ENSG00000103647 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000261861 ENTREZGENE
  ENST00000261861.10 UniProtKB/Swiss-Prot
  ENST00000540068 ENTREZGENE
  ENST00000540068.6 UniProtKB/Swiss-Prot
  ENST00000543950 ENTREZGENE
  ENST00000543950.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot
GTEx ENSG00000103647 GTEx
HGNC ID HGNC:2256 ENTREZGENE
Human Proteome Map CORO2B Human Proteome Map
InterPro Coronin UniProtKB/Swiss-Prot
  DUF1899 UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot
  WD40_repeat UniProtKB/Swiss-Prot
  WD40_repeat_CS UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:10391 UniProtKB/Swiss-Prot
NCBI Gene 10391 ENTREZGENE
OMIM 605002 OMIM
PANTHER PTHR10856 UniProtKB/Swiss-Prot
  PTHR10856:SF17 UniProtKB/Swiss-Prot
Pfam DUF1899 UniProtKB/Swiss-Prot
  WD40 UniProtKB/Swiss-Prot
  WD40_4 UniProtKB/Swiss-Prot
PharmGKB PA26772 PharmGKB
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot
  WD_REPEATS_2 UniProtKB/Swiss-Prot
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART DUF1899 UniProtKB/Swiss-Prot
  DUF1900 UniProtKB/Swiss-Prot
  WD40 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
UniProt A8K0W3 ENTREZGENE
  COR2B_HUMAN UniProtKB/Swiss-Prot
  O94767 ENTREZGENE
  Q8TAN1 ENTREZGENE
  Q9UQ03 ENTREZGENE
UniProt Secondary A8K0W3 UniProtKB/Swiss-Prot
  O94767 UniProtKB/Swiss-Prot
  Q8TAN1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-19 CORO2B  coronin 2B    coronin, actin binding protein, 2B  Symbol and/or name change 5135510 APPROVED