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Gene: MYO6 (myosin VI) Homo sapiens
Symbol: MYO6
Name: myosin VI
Description: Exhibits actin filament binding activity and identical protein binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; endocytosis; and positive regulation of transcription by RNA polymerase II. Localizes to several cellular components, including filamentous actin; nucleus; and ruffle. Colocalizes with clathrin-coated endocytic vesicle. Implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DFNA22; DFNB37; KIAA0389; Myo6-007; Myo6-008; myosin VI transcript variant 007; myosin VI transcript variant 008; myosin-VI; unconventional myosin-6; unconventional myosin-VI
Mus musculus (house mouse) : Myo6 (myosin VI)  MGI  Alliance
Rattus norvegicus (Norway rat) : Myo6 (myosin VI)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myo6 (myosin VI)
Pan paniscus (bonobo/pygmy chimpanzee) : MYO6 (myosin VI)
Canis lupus familiaris (dog) : MYO6 (myosin VI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myo6 (myosin VI)
Sus scrofa (pig) : MYO6 (myosin VI)
Chlorocebus sabaeus (African green monkey) : MYO6 (myosin VI)
Heterocephalus glaber (naked mole-rat) : Myo6 (myosin VI)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl675,749,192 - 75,919,537 (+)EnsemblGRCh38hg38GRCh38
GRCh38675,749,203 - 75,919,537 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37676,458,893 - 76,629,254 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36676,515,629 - 76,685,974 (+)NCBINCBI36hg18NCBI36
Build 34676,515,702 - 76,682,665NCBI
Celera676,852,216 - 77,022,585 (+)NCBI
Cytogenetic Map6q14.1NCBI
HuRef673,657,457 - 73,828,024 (+)NCBIHuRef
CHM1_1676,625,130 - 76,795,504 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MYO6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352294
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.