WEE2 (WEE2 oocyte meiosis inhibiting kinase) - Rat Genome Database

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Gene: WEE2 (WEE2 oocyte meiosis inhibiting kinase) Homo sapiens
Analyze
Symbol: WEE2
Name: WEE2 oocyte meiosis inhibiting kinase
RGD ID: 1352233
HGNC Page HGNC
Description: Predicted to enable protein tyrosine kinase activity. Predicted to be involved in several processes, including female pronucleus assembly; negative regulation of oocyte maturation; and regulation of meiosis I. Located in cytosol; nucleoplasm; and plasma membrane; PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH benzo[a]pyrene; leflunomide; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: FLJ16107; OOMD5; WEE1 homolog 2; WEE1 homolog 2 (S. pombe); wee1-like protein kinase 1B; wee1-like protein kinase 2; WEE1B; wee1B kinase
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: AL136146.1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7141,708,353 - 141,731,271 (+)EnsemblGRCh38hg38GRCh38
GRCh387141,708,353 - 141,731,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377141,408,153 - 141,431,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,054,622 - 141,077,540 (+)NCBINCBI36hg18NCBI36
Build 347140,861,336 - 140,883,302NCBI
Celera7136,129,792 - 136,152,709 (+)NCBI
Cytogenetic Map7q34NCBI
HuRef7135,704,961 - 135,727,878 (+)NCBIHuRef
CHM1_17141,342,465 - 141,365,372 (+)NCBICHM1_1
CRA_TCAGchr7v27140,745,872 - 140,768,791 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:11029659   PMID:11181995   PMID:14702039   PMID:16341674   PMID:18029348   PMID:21873635   PMID:22623531   PMID:23568457   PMID:23616086   PMID:28792760   PMID:29606300   PMID:30471857  
PMID:30628060   PMID:30827523   PMID:30827524   PMID:31428887  


Genomics

Comparative Map Data
WEE2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7141,708,353 - 141,731,271 (+)EnsemblGRCh38hg38GRCh38
GRCh387141,708,353 - 141,731,271 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377141,408,153 - 141,431,071 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367141,054,622 - 141,077,540 (+)NCBINCBI36hg18NCBI36
Build 347140,861,336 - 140,883,302NCBI
Celera7136,129,792 - 136,152,709 (+)NCBI
Cytogenetic Map7q34NCBI
HuRef7135,704,961 - 135,727,878 (+)NCBIHuRef
CHM1_17141,342,465 - 141,365,372 (+)NCBICHM1_1
CRA_TCAGchr7v27140,745,872 - 140,768,791 (+)NCBI
Wee2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39640,412,180 - 40,443,749 (+)NCBIGRCm39mm39
GRCm39 Ensembl640,416,022 - 40,443,747 (+)Ensembl
GRCm38640,435,246 - 40,466,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl640,439,088 - 40,466,813 (+)EnsemblGRCm38mm10GRCm38
MGSCv37640,392,862 - 40,416,814 (+)NCBIGRCm37mm9NCBIm37
MGSCv36640,372,575 - 40,396,418 (+)NCBImm8
Celera640,430,259 - 40,454,228 (+)NCBICelera
Cytogenetic Map6B1NCBI
Wee2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2469,239,043 - 69,261,576 (+)NCBI
Rnor_6.0 Ensembl468,608,137 - 68,629,925 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0468,604,770 - 68,631,341 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04133,391,852 - 133,417,020 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4467,997,589 - 68,021,263 (+)NCBIRGSC3.4rn4RGSC3.4
Celera464,238,994 - 64,263,937 (+)NCBICelera
Cytogenetic Map4q23NCBI
Wee2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554941,837,613 - 1,867,402 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554941,836,909 - 1,869,384 (-)NCBIChiLan1.0ChiLan1.0
WEE2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17146,110,121 - 146,132,872 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7146,110,121 - 146,132,872 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07133,635,359 - 133,663,153 (+)NCBIMhudiblu_PPA_v0panPan3
WEE2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1167,466,651 - 7,485,150 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl167,467,266 - 7,499,130 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,311,310 - 8,343,770 (-)NCBI
ROS_Cfam_1.0167,388,266 - 7,420,732 (-)NCBI
UMICH_Zoey_3.1167,341,543 - 7,374,003 (-)NCBI
UNSW_CanFamBas_1.0167,183,901 - 7,216,532 (-)NCBI
UU_Cfam_GSD_1.0167,251,671 - 7,284,345 (-)NCBI
Wee2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511813,610,770 - 13,635,773 (-)NCBI
SpeTri2.0NW_0049365925,584,064 - 5,608,985 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WEE2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,171,138 - 8,195,957 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,171,133 - 8,196,836 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2188,463,322 - 8,489,149 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WEE2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121110,450,650 - 110,485,249 (+)NCBI
ChlSab1.1 Ensembl21110,463,560 - 110,484,301 (+)Ensembl
Vero_WHO_p1.0NW_0236660727,129,105 - 7,163,819 (+)NCBI
Wee2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476521,718,666 - 21,743,333 (+)NCBI

Position Markers
D7S2513  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377141,407,656 - 141,407,797UniSTSGRCh37
GRCh377141,407,418 - 141,407,580UniSTSGRCh37
Build 367141,053,887 - 141,054,049RGDNCBI36
Celera7136,129,295 - 136,129,436UniSTS
Celera7136,129,051 - 136,129,219RGD
Cytogenetic Map7q32UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map7q34UniSTS
HuRef7135,704,464 - 135,704,605UniSTS
HuRef7135,704,220 - 135,704,388UniSTS
CRA_TCAGchr7v27140,745,375 - 140,745,516UniSTS
CRA_TCAGchr7v27140,745,131 - 140,745,299UniSTS
Marshfield Genetic Map7151.25UniSTS
Marshfield Genetic Map7151.25RGD
Genethon Genetic Map7154.1UniSTS
TNG Radiation Hybrid Map763574.0UniSTS
deCODE Assembly Map7150.22UniSTS
G31021  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh377141,430,880 - 141,431,012UniSTSGRCh37
Build 367141,077,349 - 141,077,481RGDNCBI36
Celera7136,152,518 - 136,152,650RGD
Cytogenetic Map7q34UniSTS
Cytogenetic Map7q32UniSTS
HuRef7135,727,687 - 135,727,819UniSTS
CRA_TCAGchr7v27140,768,600 - 140,768,732UniSTS
D7S2513  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q34UniSTS
Cytogenetic Map7q32UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:534
Count of miRNA genes:444
Interacting mature miRNAs:477
Transcripts:ENST00000397541, ENST00000493845
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 5
Low 10 8 30 4 64 3 57 5 105 50 158 40 1 5 47
Below cutoff 2081 2238 1448 443 1076 293 3954 1850 3452 280 1150 1341 153 1110 2560 2

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000397541   ⟹   ENSP00000380675
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7141,708,353 - 141,731,271 (+)Ensembl
RefSeq Acc Id: ENST00000493845   ⟹   ENSP00000420388
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7141,719,162 - 141,727,367 (+)Ensembl
RefSeq Acc Id: NM_001105558   ⟹   NP_001099028
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387141,708,353 - 141,731,271 (+)NCBI
GRCh377141,408,153 - 141,431,071 (+)RGD
Build 367141,054,622 - 141,077,540 (+)NCBI Archive
Celera7136,129,792 - 136,152,709 (+)RGD
HuRef7135,704,961 - 135,727,878 (+)RGD
CHM1_17141,342,465 - 141,365,372 (+)NCBI
CRA_TCAGchr7v27140,745,872 - 140,768,791 (+)ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001099028 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EAW83977 (Get FASTA)   NCBI Sequence Viewer  
  P0C1S8 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099028   ⟸   NM_001105558
- UniProtKB: P0C1S8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000420388   ⟸   ENST00000493845
RefSeq Acc Id: ENSP00000380675   ⟸   ENST00000397541
Protein Domains
Protein kinase


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_001105558.1(WEE2):c.700G>C (p.Asp234His) single nucleotide variant OOCYTE MATURATION DEFECT 5 [RCV000656452] Chr7:141719186 [GRCh38]
Chr7:141418986 [GRCh37]
Chr7:7q34
pathogenic
NM_001105558.1(WEE2):c.224_227del (p.Glu75fs) microsatellite OOCYTE MATURATION DEFECT 5 [RCV000656454] Chr7:141708978..141708981 [GRCh38]
Chr7:141408778..141408781 [GRCh37]
Chr7:7q34
pathogenic
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132850196-159325876)x3 copy number gain See cases [RCV000051101] Chr7:132850196..159325876 [GRCh38]
Chr7:132534956..159118566 [GRCh37]
Chr7:132185496..158811327 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:136309982-159307523)x3 copy number gain See cases [RCV000053576] Chr7:136309982..159307523 [GRCh38]
Chr7:135994730..159100212 [GRCh37]
Chr7:135645270..158792973 [NCBI36]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q32.3-36.1(chr7:132023155-149309794)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054172]|See cases [RCV000054172] Chr7:132023155..149309794 [GRCh38]
Chr7:131707914..149006885 [GRCh37]
Chr7:131358454..148637818 [NCBI36]
Chr7:7q32.3-36.1
pathogenic
GRCh38/hg38 7q33-35(chr7:135414108-144140219)x1 copy number loss See cases [RCV000054173] Chr7:135414108..144140219 [GRCh38]
Chr7:135098857..143837312 [GRCh37]
Chr7:134749397..143468245 [NCBI36]
Chr7:7q33-35
pathogenic
GRCh38/hg38 7q34-36.3(chr7:139365967-159282531)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054175]|See cases [RCV000054175] Chr7:139365967..159282531 [GRCh38]
Chr7:139050713..159075220 [GRCh37]
Chr7:138701253..158767981 [NCBI36]
Chr7:7q34-36.3
pathogenic
GRCh38/hg38 7q34-36.3(chr7:140754198-159307523)x1 copy number loss See cases [RCV000054176] Chr7:140754198..159307523 [GRCh38]
Chr7:140453998..159100212 [GRCh37]
Chr7:140100467..158792973 [NCBI36]
Chr7:7q34-36.3
pathogenic
NM_001105558.1(WEE2):c.303G>A (p.Arg101=) single nucleotide variant Malignant melanoma [RCV000067673] Chr7:141709061 [GRCh38]
Chr7:141408861 [GRCh37]
Chr7:141055330 [NCBI36]
Chr7:7q34
not provided
NM_001105558.1(WEE2):c.625G>A (p.Glu209Lys) single nucleotide variant Malignant melanoma [RCV000067674] Chr7:141719111 [GRCh38]
Chr7:141418911 [GRCh37]
Chr7:141065380 [NCBI36]
Chr7:7q34
not provided
GRCh38/hg38 7q34-35(chr7:141126407-145652221)x3 copy number gain See cases [RCV000133645] Chr7:141126407..145652221 [GRCh38]
Chr7:140826207..145349314 [GRCh37]
Chr7:140472676..144980247 [NCBI36]
Chr7:7q34-35
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q33-36.2(chr7:137751200-154815582)x3 copy number gain See cases [RCV000136592] Chr7:137751200..154815582 [GRCh38]
Chr7:137435946..154607292 [GRCh37]
Chr7:137086486..154238225 [NCBI36]
Chr7:7q33-36.2
pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q33-36.3(chr7:134666829-158591882)x1 copy number loss See cases [RCV000138120] Chr7:134666829..158591882 [GRCh38]
Chr7:134351581..158384574 [GRCh37]
Chr7:134002121..158077335 [NCBI36]
Chr7:7q33-36.3
pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3
pathogenic
GRCh38/hg38 7q33-36.1(chr7:135017687-148807400)x1 copy number loss See cases [RCV000138903] Chr7:135017687..148807400 [GRCh38]
Chr7:134702438..148504492 [GRCh37]
Chr7:134352978..148135425 [NCBI36]
Chr7:7q33-36.1
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:132444095-159335866)x3 copy number gain See cases [RCV000139654] Chr7:132444095..159335866 [GRCh38]
Chr7:132128854..159128556 [GRCh37]
Chr7:131779394..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131228764-159335866)x3 copy number gain See cases [RCV000142802] Chr7:131228764..159335866 [GRCh38]
Chr7:130913523..159128556 [GRCh37]
Chr7:130564063..158821317 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q32.3-36.3(chr7:131171478-159327017)x3 copy number gain See cases [RCV000143754] Chr7:131171478..159327017 [GRCh38]
Chr7:130856237..159119707 [GRCh37]
Chr7:130506777..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh38/hg38 7q34-35(chr7:140061285-144622893)x3 copy number gain See cases [RCV000143724] Chr7:140061285..144622893 [GRCh38]
Chr7:139761085..144319986 [GRCh37]
Chr7:139407554..143950919 [NCBI36]
Chr7:7q34-35
uncertain significance
GRCh38/hg38 7q32.3-36.3(chr7:132438072-159327017)x3 copy number gain See cases [RCV000143707] Chr7:132438072..159327017 [GRCh38]
Chr7:132122831..159119707 [GRCh37]
Chr7:131773371..158812468 [NCBI36]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) copy number gain not provided [RCV000767558] Chr7:128312450..159119220 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
NM_001105558.1(WEE2):c.1477dup (p.Thr493fs) duplication OOCYTE MATURATION DEFECT 5 [RCV000656453] Chr7:141727383..141727384 [GRCh38]
Chr7:141427183..141427184 [GRCh37]
Chr7:7q34
pathogenic
GRCh37/hg19 7q33-36.3(chr7:137589621-159119707)x3 copy number gain See cases [RCV000449264] Chr7:137589621..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:133799185-159119707)x1 copy number loss See cases [RCV000448836] Chr7:133799185..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 copy number gain See cases [RCV000447956] Chr7:128276078..159119707 [GRCh37]
Chr7:7q32.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:140636858-159119707)x1 copy number loss See cases [RCV000510250] Chr7:140636858..159119707 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:136758593-159119707)x3 copy number gain See cases [RCV000510490] Chr7:136758593..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7q33-36.3(chr7:137917376-159119707)x1 copy number loss See cases [RCV000511889] Chr7:137917376..159119707 [GRCh37]
Chr7:7q33-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q34-36.3(chr7:140133025-158982771)x1 copy number loss not provided [RCV000682910] Chr7:140133025..158982771 [GRCh37]
Chr7:7q34-36.3
pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
GRCh37/hg19 7q34-35(chr7:139623170-143710268)x3 copy number gain not provided [RCV000747069] Chr7:139623170..143710268 [GRCh37]
Chr7:7q34-35
benign
GRCh37/hg19 7q34-36.3(chr7:139623170-158329903)x3 copy number gain not provided [RCV000747070] Chr7:139623170..158329903 [GRCh37]
Chr7:7q34-36.3
pathogenic
NM_001105558.1(WEE2):c.881-8T>C single nucleotide variant not provided [RCV000950727] Chr7:141723126 [GRCh38]
Chr7:141422926 [GRCh37]
Chr7:7q34
benign
NM_001105558.1(WEE2):c.1576T>G (p.Tyr526Asp) single nucleotide variant not provided [RCV000950728] Chr7:141729571 [GRCh38]
Chr7:141429371 [GRCh37]
Chr7:7q34
benign
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3
pathogenic
NM_001105558.1(WEE2):c.210G>A (p.Ser70=) single nucleotide variant not provided [RCV000909416] Chr7:141708968 [GRCh38]
Chr7:141408768 [GRCh37]
Chr7:7q34
likely benign
GRCh37/hg19 7q32.3-36.3(chr7:130592554-159119707)x3 copy number gain not provided [RCV000849569] Chr7:130592554..159119707 [GRCh37]
Chr7:7q32.3-36.3
pathogenic
GRCh37/hg19 7q32.3-36.3(chr7:131414604-159126310)x1 copy number loss See cases [RCV001007432] Chr7:131414604..159126310 [GRCh37]
Chr7:7q32.3-36.3
pathogenic
NM_001105558.1(WEE2):c.513T>C (p.Gly171=) single nucleotide variant not provided [RCV000909372] Chr7:141714379 [GRCh38]
Chr7:141414179 [GRCh37]
Chr7:7q34
benign
GRCh37/hg19 7q31.1-36.3(chr7:109251060-159119707)x3 copy number gain not provided [RCV001005994] Chr7:109251060..159119707 [GRCh37]
Chr7:7q31.1-36.3
pathogenic
NM_001105558.1(WEE2):c.1221G>A (p.Glu407=) single nucleotide variant OOCYTE MATURATION DEFECT 5 [RCV001254890] Chr7:141724275 [GRCh38]
Chr7:141424075 [GRCh37]
Chr7:7q34
pathogenic
NM_001105558.1(WEE2):c.1228C>T (p.Arg410Trp) single nucleotide variant OOCYTE MATURATION DEFECT 5 [RCV001254889] Chr7:141725032 [GRCh38]
Chr7:141424832 [GRCh37]
Chr7:7q34
pathogenic
NM_001105558.1(WEE2):c.598C>T (p.Arg200Ter) single nucleotide variant OOCYTE MATURATION DEFECT 5 [RCV001254891] Chr7:141719084 [GRCh38]
Chr7:141418884 [GRCh37]
Chr7:7q34
pathogenic
NM_001105558.1(WEE2):c.1350C>T (p.Asp450=) single nucleotide variant not provided [RCV001312153] Chr7:141725154 [GRCh38]
Chr7:141424954 [GRCh37]
Chr7:7q34
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19684 AgrOrtholog
COSMIC WEE2 COSMIC
Ensembl Genes ENSG00000214102 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000263042 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000380675 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000420388 UniProtKB/TrEMBL
  ENSP00000458529 UniProtKB/TrEMBL
  ENSP00000459392 UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000397541 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000493845 UniProtKB/TrEMBL
  ENST00000574659 UniProtKB/Swiss-Prot
  ENST00000576319 UniProtKB/TrEMBL
GTEx ENSG00000214102 GTEx
  ENSG00000263042 GTEx
HGNC ID HGNC:19684 ENTREZGENE
Human Proteome Map WEE2 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wee1-like_protein_kinase UniProtKB/Swiss-Prot
KEGG Report hsa:494551 UniProtKB/Swiss-Prot
NCBI Gene 494551 ENTREZGENE
OMIM 614084 OMIM
  617996 OMIM
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134909633 PharmGKB
PIRSF Wee1-like_protein_kinase UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H7C5P0_HUMAN UniProtKB/TrEMBL
  P0C1S8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-24 WEE2  WEE2 oocyte meiosis inhibiting kinase  WEE2  WEE1 homolog 2  Symbol and/or name change 5135510 APPROVED
2016-08-02 WEE2  WEE1 homolog 2    WEE1 homolog 2 (S. pombe)  Symbol and/or name change 5135510 APPROVED