PLA2G12B (phospholipase A2 group XIIB) - Rat Genome Database

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Gene: PLA2G12B (phospholipase A2 group XIIB) Homo sapiens
Analyze
Symbol: PLA2G12B
Name: phospholipase A2 group XIIB
RGD ID: 1351879
HGNC Page HGNC:18555
Description: Predicted to enable calcium ion binding activity and phospholipase A2 activity. Predicted to be involved in cholesterol homeostasis and triglyceride homeostasis. Predicted to act upstream of or within low-density lipoprotein particle remodeling. Predicted to be located in extracellular region.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FKSG71; group XIIB secretory phospholipase A2-like protein; group XIII secreted phospholipase A2; group XIII secretory phospholipase A2-like protein; GXIIB; GXIII sPLA2-like; GXIIIsPLA2; MGC138151; phospholipase A2, group XIIB; phospholipase A2, group XIII; PLA2G13; sPLA2-GXIIB
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,934,762 - 72,954,806 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,934,762 - 72,954,806 (-)EnsemblGRCh38hg38GRCh38
GRCh371074,694,520 - 74,714,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,364,944 - 74,384,516 (-)NCBINCBI36Build 36hg18NCBI36
Build 341074,364,943 - 74,384,516NCBI
Celera1067,980,077 - 67,999,649 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,688,779 - 68,708,351 (-)NCBIHuRef
CHM1_11074,976,668 - 74,996,240 (-)NCBICHM1_1
T2T-CHM13v2.01073,806,140 - 73,826,184 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9377118   PMID:9745929   PMID:12477932   PMID:14516201   PMID:15340161   PMID:15342556   PMID:15489334   PMID:15863368   PMID:16344560   PMID:18212756   PMID:19541351   PMID:19817957  
PMID:21274867   PMID:21873635   PMID:22909802   PMID:24173221   PMID:25201034   PMID:26186194   PMID:27471003   PMID:28514442   PMID:33961781  


Genomics

Comparative Map Data
PLA2G12B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381072,934,762 - 72,954,806 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1072,934,762 - 72,954,806 (-)EnsemblGRCh38hg38GRCh38
GRCh371074,694,520 - 74,714,564 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,364,944 - 74,384,516 (-)NCBINCBI36Build 36hg18NCBI36
Build 341074,364,943 - 74,384,516NCBI
Celera1067,980,077 - 67,999,649 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1068,688,779 - 68,708,351 (-)NCBIHuRef
CHM1_11074,976,668 - 74,996,240 (-)NCBICHM1_1
T2T-CHM13v2.01073,806,140 - 73,826,184 (-)NCBIT2T-CHM13v2.0
Pla2g12b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391059,239,242 - 59,257,798 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1059,239,482 - 59,257,798 (+)EnsemblGRCm39 Ensembl
GRCm381059,403,420 - 59,421,976 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1059,403,660 - 59,421,976 (+)EnsemblGRCm38mm10GRCm38
MGSCv371058,866,433 - 58,884,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361058,799,042 - 58,817,333 (+)NCBIMGSCv36mm8
Celera1060,503,964 - 60,522,245 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1029.54NCBI
Pla2g12b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82027,910,620 - 27,931,734 (+)NCBIGRCr8
mRatBN7.22027,369,196 - 27,389,517 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2027,370,266 - 27,388,743 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.02028,989,440 - 29,007,967 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,989,491 - 29,007,968 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02030,793,778 - 30,812,293 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2028,813,714 - 28,832,140 (+)NCBICelera
Cytogenetic Map20q11NCBI
Pla2g12b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543718,694,496 - 18,719,337 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543718,694,496 - 18,723,311 (+)NCBIChiLan1.0ChiLan1.0
PLA2G12B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2885,111,134 - 85,130,164 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11085,116,402 - 85,135,486 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01069,482,065 - 69,502,398 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11071,946,072 - 71,965,616 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1071,946,506 - 71,965,482 (-)Ensemblpanpan1.1panPan2
PLA2G12B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1423,539,909 - 23,561,211 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl423,541,258 - 23,561,041 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha423,678,362 - 23,699,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0423,826,379 - 23,847,936 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl423,827,748 - 23,847,930 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1423,725,146 - 23,746,673 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0423,924,120 - 23,945,646 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0424,279,156 - 24,300,450 (-)NCBIUU_Cfam_GSD_1.0
Pla2g12b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721357,579,733 - 57,604,031 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365216,072,486 - 6,096,791 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365216,072,487 - 6,096,791 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLA2G12B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1475,753,727 - 75,778,800 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11475,754,525 - 75,778,933 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21481,819,851 - 81,844,252 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLA2G12B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1958,311,609 - 58,335,286 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl958,312,500 - 58,336,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604818,907,588 - 18,935,677 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pla2g12b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247546,653,698 - 6,680,489 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247546,653,307 - 6,680,063 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G12B
14 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q21.2-22.2(chr10:62229688-74468143)x1 copy number loss See cases [RCV000052530] Chr10:62229688..74468143 [GRCh38]
Chr10:63989447..76227901 [GRCh37]
Chr10:63659453..75897907 [NCBI36]
Chr10:10q21.2-22.2		 pathogenic
GRCh38/hg38 10q22.1-22.2(chr10:72720628-75612374)x1 copy number loss See cases [RCV000052531] Chr10:72720628..75612374 [GRCh38]
Chr10:74480386..77372132 [GRCh37]
Chr10:74150392..77042138 [NCBI36]
Chr10:10q22.1-22.2		 pathogenic
GRCh38/hg38 10q21.1-22.2(chr10:58436466-74415216)x1 copy number loss See cases [RCV000052511] Chr10:58436466..74415216 [GRCh38]
Chr10:60196226..76174974 [GRCh37]
Chr10:59866232..75844980 [NCBI36]
Chr10:10q21.1-22.2		 pathogenic
GRCh38/hg38 10q11.21-22.2(chr10:42685306-73715908)x3 copy number gain See cases [RCV000134848] Chr10:42685306..73715908 [GRCh38]
Chr10:43180754..75475666 [GRCh37]
Chr10:42500760..75145672 [NCBI36]
Chr10:10q11.21-22.2		 pathogenic
GRCh38/hg38 10q21.3-22.3(chr10:67196567-79422057)x3 copy number gain See cases [RCV000135438] Chr10:67196567..79422057 [GRCh38]
Chr10:68956325..81181813 [GRCh37]
Chr10:68626331..80851819 [NCBI36]
Chr10:10q21.3-22.3		 pathogenic
GRCh38/hg38 10q21.3-22.2(chr10:63402579-75296099)x1 copy number loss See cases [RCV000136658] Chr10:63402579..75296099 [GRCh38]
Chr10:65162339..77055857 [GRCh37]
Chr10:64832345..76725863 [NCBI36]
Chr10:10q21.3-22.2		 pathogenic|likely benign
GRCh38/hg38 10q11.23-23.2(chr10:50729367-87147204)x3 copy number gain See cases [RCV000138007] Chr10:50729367..87147204 [GRCh38]
Chr10:52489127..88906961 [GRCh37]
Chr10:52159133..88896941 [NCBI36]
Chr10:10q11.23-23.2		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
GRCh37/hg19 10q21.3-23.32(chr10:69040366-93194993)x3 copy number gain not provided [RCV000683289] Chr10:69040366..93194993 [GRCh37]
Chr10:10q21.3-23.32		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q21.3-22.3(chr10:68735254-78885714) copy number loss not specified [RCV002052875] Chr10:68735254..78885714 [GRCh37]
Chr10:10q21.3-22.3		 pathogenic
GRCh37/hg19 10q22.1-22.2(chr10:74472028-75007588) copy number gain not specified [RCV002052877] Chr10:74472028..75007588 [GRCh37]
Chr10:10q22.1-22.2		 uncertain significance
GRCh37/hg19 10q22.1(chr10:74573522-74852531)x3 copy number gain not provided [RCV001834524] Chr10:74573522..74852531 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_032562.5(PLA2G12B):c.262T>C (p.Cys88Arg) single nucleotide variant not specified [RCV004107523] Chr10:72942690 [GRCh38]
Chr10:74702448 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_032562.5(PLA2G12B):c.72C>G (p.Ser24Arg) single nucleotide variant not specified [RCV004208562] Chr10:72954614 [GRCh38]
Chr10:74714372 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_032562.5(PLA2G12B):c.292C>T (p.Pro98Ser) single nucleotide variant not specified [RCV004173187] Chr10:72942660 [GRCh38]
Chr10:74702418 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3 copy number gain not provided [RCV003484798] Chr10:42709645..100834951 [GRCh37]
Chr10:10q11.21-24.2		 pathogenic
NM_032562.5(PLA2G12B):c.416C>T (p.Ser139Leu) single nucleotide variant not specified [RCV004511424] Chr10:72941219 [GRCh38]
Chr10:74700977 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_032562.5(PLA2G12B):c.83A>G (p.Glu28Gly) single nucleotide variant not specified [RCV004511429] Chr10:72954603 [GRCh38]
Chr10:74714361 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_032562.5(PLA2G12B):c.511A>G (p.Thr171Ala) single nucleotide variant not specified [RCV004511426] Chr10:72935694 [GRCh38]
Chr10:74695452 [GRCh37]
Chr10:10q22.1		 uncertain significance
GRCh37/hg19 10q22.1-22.2(chr10:74472028-75019111)x3 copy number gain not specified [RCV003986877] Chr10:74472028..75019111 [GRCh37]
Chr10:10q22.1-22.2		 uncertain significance
NM_032562.5(PLA2G12B):c.407G>T (p.Cys136Phe) single nucleotide variant not specified [RCV004511423] Chr10:72941228 [GRCh38]
Chr10:74700986 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_032562.5(PLA2G12B):c.68C>T (p.Thr23Met) single nucleotide variant not specified [RCV004511428] Chr10:72954618 [GRCh38]
Chr10:74714376 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_032562.5(PLA2G12B):c.560G>A (p.Cys187Tyr) single nucleotide variant not specified [RCV004511427] Chr10:72935645 [GRCh38]
Chr10:74695403 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_032562.5(PLA2G12B):c.505G>A (p.Val169Met) single nucleotide variant not specified [RCV004511425] Chr10:72935700 [GRCh38]
Chr10:74695458 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_032562.5(PLA2G12B):c.110G>A (p.Arg37Gln) single nucleotide variant not specified [RCV004661961] Chr10:72954576 [GRCh38]
Chr10:74714334 [GRCh37]
Chr10:10q22.1		 uncertain significance
NM_032562.5(PLA2G12B):c.265G>A (p.Gly89Ser) single nucleotide variant not specified [RCV004648539] Chr10:72942687 [GRCh38]
Chr10:74702445 [GRCh37]
Chr10:10q22.1		 likely benign
NM_032562.5(PLA2G12B):c.491C>A (p.Thr164Asn) single nucleotide variant not specified [RCV004661962] Chr10:72935714 [GRCh38]
Chr10:74695472 [GRCh37]
Chr10:10q22.1		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:171
Interacting mature miRNAs:174
Transcripts:ENST00000373032
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
406932417GWAS581393_Hhigh density lipoprotein cholesterol measurement QTL GWAS581393 (human)2e-08high density lipoprotein cholesterol measurementblood high density lipoprotein cholesterol level (CMO:0000052)107295161872951619Human
407336679GWAS985655_Htriglyceride measurement QTL GWAS985655 (human)1e-13triglyceride measurementblood triglyceride level (CMO:0000118)107295161872951619Human
407354727GWAS1003703_Htriglyceride:HDL cholesterol ratio QTL GWAS1003703 (human)0.000003triglyceride:HDL cholesterol ratio107295441972954420Human
407010755GWAS659731_Htriglyceride measurement QTL GWAS659731 (human)1e-09triglyceride measurementblood triglyceride level (CMO:0000118)107294409172944092Human
406901924GWAS550900_HRS-6-hydroxywarfarin measurement QTL GWAS550900 (human)0.000007RS-6-hydroxywarfarin measurement107295062772950628Human
407127488GWAS776464_Htriglyceride:HDL cholesterol ratio QTL GWAS776464 (human)1e-09triglyceride:HDL cholesterol ratio107295161872951619Human
407344651GWAS993627_Htriglyceride measurement QTL GWAS993627 (human)2e-10triglyceride measurementblood triglyceride level (CMO:0000118)107295161872951619Human
407073676GWAS722652_Htriglyceride measurement QTL GWAS722652 (human)2e-11triglyceride measurementblood triglyceride level (CMO:0000118)107295441972954420Human
407318806GWAS967782_Hnon-high density lipoprotein cholesterol measurement QTL GWAS967782 (human)2e-11non-high density lipoprotein cholesterol measurementblood non-high density lipoprotein cholesterol level (CMO:0003967)107295072672950727Human
407320564GWAS969540_Hlow density lipoprotein cholesterol measurement QTL GWAS969540 (human)2e-19low density lipoprotein cholesterol measurementblood low density lipoprotein cholesterol level (CMO:0000053)107295278872952789Human
407352243GWAS1001219_Htriglyceride:HDL cholesterol ratio QTL GWAS1001219 (human)1e-08triglyceride:HDL cholesterol ratio107295441972954420Human
407381713GWAS1030689_Htriglyceride measurement QTL GWAS1030689 (human)1e-11triglyceride measurementblood triglyceride level (CMO:0000118)107295441972954420Human
407387635GWAS1036611_Hserum alanine aminotransferase measurement QTL GWAS1036611 (human)2e-13serum alanine aminotransferase measurementserum alanine aminotransferase activity level (CMO:0000575)107295441972954420Human
407309211GWAS958187_Htriglyceride measurement QTL GWAS958187 (human)4e-27triglyceride measurementblood triglyceride level (CMO:0000118)107295072672950727Human
407346362GWAS995338_Htriglyceride measurement QTL GWAS995338 (human)4e-09triglyceride measurementblood triglyceride level (CMO:0000118)107295161872951619Human
407346810GWAS995786_Htotal cholesterol measurement QTL GWAS995786 (human)1e-14total cholesterol measurementblood total cholesterol level (CMO:0000051)107295278872952789Human
407131546GWAS780522_Htriglyceride:HDL cholesterol ratio QTL GWAS780522 (human)0.000003triglyceride:HDL cholesterol ratio107295161872951619Human
407310873GWAS959849_Htriglyceride measurement QTL GWAS959849 (human)6e-15triglyceride measurementblood triglyceride level (CMO:0000118)107295072672950727Human
407089564GWAS738540_Htriglyceride measurement QTL GWAS738540 (human)6e-09triglyceride measurementblood triglyceride level (CMO:0000118)107295441972954420Human

Markers in Region
RH98272  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371074,695,030 - 74,695,149UniSTSGRCh37
Build 361074,365,036 - 74,365,155RGDNCBI36
Celera1067,980,169 - 67,980,288RGD
Cytogenetic Map10q22.1UniSTS
HuRef1068,688,871 - 68,688,990UniSTS
GeneMap99-GB4 RH Map10378.78UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
504 1326 1191 1321 2127 1139 1690 1 517 798 451 903 4029 2904 13 1630 464 966 1136 69

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001318124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005270244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC069548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF339053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF349540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX399941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY358032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF939574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP274516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA536331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000373032   ⟹   ENSP00000362123
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1072,934,762 - 72,954,806 (-)Ensembl
RefSeq Acc Id: NM_001318124   ⟹   NP_001305053
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381072,934,762 - 72,954,806 (-)NCBI
CHM1_11074,976,250 - 74,996,307 (-)NCBI
T2T-CHM13v2.01073,806,140 - 73,826,184 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001318125   ⟹   NP_001305054
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381072,934,762 - 72,954,806 (-)NCBI
CHM1_11074,976,250 - 74,996,307 (-)NCBI
T2T-CHM13v2.01073,806,140 - 73,826,184 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032562   ⟹   NP_115951
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381072,934,762 - 72,954,806 (-)NCBI
GRCh371074,694,519 - 74,714,590 (-)NCBI
Build 361074,364,944 - 74,384,516 (-)NCBI Archive
Celera1067,980,077 - 67,999,649 (-)RGD
HuRef1068,688,779 - 68,708,351 (-)ENTREZGENE
CHM1_11074,976,250 - 74,996,307 (-)NCBI
T2T-CHM13v2.01073,806,140 - 73,826,184 (-)NCBI
Sequence:
RefSeq Acc Id: NP_115951   ⟸   NM_032562
- Peptide Label: isoform a precursor
- UniProtKB: Q52LB2 (UniProtKB/Swiss-Prot),   B7ZL23 (UniProtKB/Swiss-Prot),   Q96Q99 (UniProtKB/Swiss-Prot),   Q9BX93 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001305054   ⟸   NM_001318125
- Peptide Label: isoform c
- Sequence:
RefSeq Acc Id: NP_001305053   ⟸   NM_001318124
- Peptide Label: isoform b precursor
- UniProtKB: Q9BX93 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000362123   ⟸   ENST00000373032

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9BX93-F1-model_v2 AlphaFold Q9BX93 1-195 view protein structure

Promoters
RGD ID:7217827
Promoter ID:EPDNEW_H14658
Type:initiation region
Name:PLA2G12B_1
Description:phospholipase A2 group XIIB
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381072,954,784 - 72,954,844EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:18555 AgrOrtholog
COSMIC PLA2G12B COSMIC
Ensembl Genes ENSG00000138308 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000373032 ENTREZGENE
  ENST00000373032.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.90.10 UniProtKB/Swiss-Prot
GTEx ENSG00000138308 GTEx
HGNC ID HGNC:18555 ENTREZGENE
Human Proteome Map PLA2G12B Human Proteome Map
InterPro PLA2G12 UniProtKB/Swiss-Prot
  PLipase_A2_dom_sf UniProtKB/Swiss-Prot
KEGG Report hsa:84647 UniProtKB/Swiss-Prot
NCBI Gene 84647 ENTREZGENE
OMIM 611653 OMIM
PANTHER GROUP XIIB SECRETORY PHOSPHOLIPASE A2-LIKE PROTEIN UniProtKB/Swiss-Prot
  PTHR12824 UniProtKB/Swiss-Prot
Pfam PLA2G12 UniProtKB/Swiss-Prot
PharmGKB PA38573 PharmGKB
PROSITE ER_TARGET UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48619 UniProtKB/Swiss-Prot
UniProt B7ZL23 ENTREZGENE
  PG12B_HUMAN UniProtKB/Swiss-Prot
  Q52LB2 ENTREZGENE
  Q96Q99 ENTREZGENE
  Q9BX93 ENTREZGENE
UniProt Secondary B7ZL23 UniProtKB/Swiss-Prot
  Q52LB2 UniProtKB/Swiss-Prot
  Q96Q99 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PLA2G12B  phospholipase A2 group XIIB  PLA2G12B  phospholipase A2, group XIIB  Symbol and/or name change 5135510 APPROVED