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Gene: FOXP2 (forkhead box P2) Homo sapiens
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Symbol: FOXP2
Name: forkhead box P2
Description: This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAG repeat protein 44; CAGH44; DKFZp686H1726; forkhead box protein P2; forkhead/winged-helix transcription factor; SPCH1; TNRC10; trinucleotide repeat containing 10; trinucleotide repeat-containing gene 10 protein
Orthologs:
Mus musculus (house mouse) : Foxp2 (forkhead box P2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Foxp2 (forkhead box P2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Foxp2 (forkhead box P2)
Pan paniscus (bonobo/pygmy chimpanzee) : FOXP2 (forkhead box P2)
Canis lupus familiaris (dog) : FOXP2 (forkhead box P2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Foxp2 (forkhead box P2)
Sus scrofa (pig) : FOXP2 (forkhead box P2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387114,086,327 - 114,693,772 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377113,726,365 - 114,333,827 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367113,842,288 - 114,118,328 (+)NCBINCBI36hg18NCBI36
Build 347113,649,226 - 113,924,106NCBI
Celera7108,532,810 - 109,140,335 (+)NCBI
Cytogenetic Map7q31.1NCBI
HuRef7108,089,788 - 108,698,059 (+)NCBIHuRef
CHM1_17113,659,668 - 114,267,158 (+)NCBICHM1_1
CRA_TCAGchr7v27113,121,523 - 113,729,058 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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