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Gene: HOXD8 (homeobox D8) Homo sapiens
Symbol: HOXD8
Name: homeobox D8
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to localize to the nuclear chromatin.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: homeo box 4E; homeo box D8; homeobox protein 5.4; homeobox protein Hox-4E; homeobox protein Hox-5.4; homeobox protein Hox-D8; Hox-4.5; Hox-4.5, mouse, homolog of; HOX4; HOX4E; HOX5.4
Mus musculus (house mouse) : Hoxd8 (homeobox D8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hoxd8 (homeobox D8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hoxd8 (homeobox D8)
Pan paniscus (bonobo/pygmy chimpanzee) : HOXD8 (homeobox D8)
Canis lupus familiaris (dog) : HOXD8 (homeobox D8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hoxd8 (homeobox D8)
Sus scrofa (pig) : HOXD8 (homeobox D8)
Chlorocebus sabaeus (green monkey) : HOXD8 (homeobox D8)
Heterocephalus glaber (naked mole-rat) : Hoxd8 (homeobox D8)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2176,129,694 - 176,132,695 (+)Ensembl
GRCh382176,129,705 - 176,132,695 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372176,994,422 - 176,997,423 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362176,702,723 - 176,704,974 (+)NCBINCBI36hg18NCBI36
Build 342176,819,983 - 176,822,235NCBI
Celera2170,603,640 - 170,605,908 (+)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2168,871,358 - 168,874,275 (+)NCBIHuRef
CHM1_12177,000,289 - 177,003,290 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HOXD8
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351859
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.