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Gene: POF1B (POF1B actin binding protein) Homo sapiens
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Symbol: POF1B
Name: POF1B actin binding protein
Description: Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. [provided by RefSeq, Jan 2010]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ22792; POF; POF2B; premature ovarian failure protein 1B; premature ovarian failure, 1B
Orthologs:
Mus musculus (house mouse) : Pof1b (premature ovarian failure 1B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pof1b (POF1B, actin binding protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pof1b (POF1B actin binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : POF1B (POF1B actin binding protein)
Canis lupus familiaris (dog) : POF1B (POF1B actin binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pof1b (POF1B actin binding protein)
Sus scrofa (pig) : POF1B (POF1B actin binding protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X85,277,389 - 85,379,743 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X84,532,395 - 84,634,748 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X84,419,058 - 84,521,404 (-)NCBINCBI36hg18NCBI36
Build 34X84,338,546 - 84,440,893NCBI
CeleraX84,771,759 - 84,874,115 (-)NCBI
Cytogenetic MapXq21.1NCBI
HuRefX78,105,395 - 78,207,259 (-)NCBIHuRef
CHM1_1X84,426,026 - 84,528,381 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Alliance Gene
NCBI Gene
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JBrowse: hg19 hg38
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RGD Object Information
RGD ID: 1351618
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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