ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide)

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Gene: ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide) Homo sapiens

Analyze

Symbol:

ADH5

Name:

alcohol dehydrogenase 5 (class III), chi polypeptide

RGD ID:

1351578

HGNC Page

HGNC:253

Description:

Enables fatty acid binding activity; formaldehyde dehydrogenase activity; and zinc ion binding activity. Involved in fatty acid omega-oxidation and response to redox state. Located in extracellular exosome. Implicated in AMED syndrome and asthma. Biomarker of asthma.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

ADH-3; ADHX; alcohol dehydrogenase (class III), chi polypeptide; alcohol dehydrogenase class chi chain; alcohol dehydrogenase class-3; alcohol dehydrogenase class-III; AMEDS; BMFS7; epididymis secretory sperm binding protein Li 60p; FALDH; FDH; formaldehyde dehydrogenase; glutathione-dependent formaldehyde dehydrogenase; GSH-FDH; GSNOR; HEL-S-60p; S-(hydroxymethyl)glutathione dehydrogenase; S-nitrosoglutathione reductase

RGD Orthologs

Mouse

Rat

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Related Pseudogenes:

ADH5P2 ADH5P3 ADH5P4 ADH5P5 LOC100190934

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	99,070,978 - 99,088,788 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	99,070,978 - 99,088,801 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	99,992,129 - 100,009,939 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	100,211,152 - 100,228,954 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	100,349,540 - 100,367,191	NCBI
Celera	4	97,289,594 - 97,307,408 (-)	NCBI		Celera
Cytogenetic Map	4	q23	NCBI
HuRef	4	95,730,971 - 95,748,768 (-)	NCBI		HuRef
CHM1_1	4	99,969,101 - 99,986,899 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	102,385,880 - 102,403,688 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (ISO)

AMED syndrome (IAGP)

asthma (IAGP,IEP,ISO)

cholestasis (ISO)

pulmonary hypertension (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

1,2-dimethylhydrazine (ISO)

12-hydroxylauric acid (EXP)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

4,4'-diaminodiphenylmethane (ISO)

8'-apo-beta,psi-caroten-8'-al (EXP)

8-hydroxyoctanoic acid (EXP)

acetamide (ISO)

alcohol (EXP)

all-trans-retinoic acid (EXP)

antirheumatic drug (EXP)

aristolochic acid A (EXP)

arsenous acid (EXP)

atrazine (EXP)

benzo[a]pyrene (EXP,ISO)

beta-carotene (EXP)

bifenthrin (ISO)

bisphenol A (EXP,ISO)

cadmium atom (EXP)

choline (ISO)

cimetidine (EXP)

clofibrate (ISO)

clozapine (EXP)

copper(II) sulfate (EXP)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (EXP)

decabromodiphenyl ether (EXP)

decanoic acid (EXP)

dextran sulfate (ISO)

diarsenic trioxide (EXP)

dibutyl phthalate (ISO)

dicrotophos (EXP)

dodecanedioic acid (EXP)

dodecanoic acid (EXP)

ethanol (EXP,ISO)

fenthion (ISO)

folic acid (ISO)

folpet (ISO)

formaldehyde (EXP)

glutathione (EXP)

gold atom (EXP)

gold(0) (EXP)

hydrogen peroxide (EXP)

ivermectin (EXP)

L-methionine (ISO)

methidathion (ISO)

methylparaben (EXP)

nonanoic acid (EXP)

octan-1-ol (EXP)

octanoic acid (EXP)

p-toluidine (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (EXP)

phlorizin (ISO)

picoxystrobin (EXP)

potassium chromate (EXP)

progesterone (ISO)

quercetin (EXP)

rotenone (EXP)

S-(hydroxymethyl)glutathione (EXP)

S-methylglutathione (EXP)

S-nitrosoglutathione (EXP,ISO)

sebacic acid (EXP)

sodium fluoride (ISO)

tetrachloromethane (ISO)

thioacetamide (ISO)

titanium dioxide (ISO)

undecanoic acid (EXP)

urethane (EXP)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aging (ISO)

electron transport chain (IEA)

ethanol catabolic process (ISO)

ethanol oxidation (IEA)

fatty acid omega-oxidation (IDA)

formaldehyde catabolic process (IBA,IEA,ISO)

lipid metabolic process (IEA)

peptidyl-cysteine S-nitrosylation (IEA,ISO)

positive regulation of blood pressure (IEA,ISO)

respiratory system process (IEA,ISO)

response to lipopolysaccharide (IEA,ISO)

response to nitrosative stress (IEA,ISO)

response to redox state (IDA)

retinoid metabolic process (IEA,ISO)

small molecule metabolic process (IEA)

Cellular Component

cytoplasm (IEA,ISO)

cytosol (IBA,TAS)

extracellular exosome (HDA)

mitochondrion (IEA)

nucleus (ISO)

Molecular Function

alcohol dehydrogenase (NAD+) activity (IEA,ISO)

alcohol dehydrogenase [NAD(P)+] activity (IEA)

alcohol dehydrogenase activity, zinc-dependent (IBA)

electron transfer activity (TAS)

fatty acid binding (IDA)

formaldehyde dehydrogenase activity (IDA)

identical protein binding (IEA)

metal ion binding (IEA)

oxidoreductase activity (IEA)

S-(hydroxymethyl)glutathione dehydrogenase activity (IBA,IEA,TAS)

S-(hydroxymethyl)glutathione dehydrogenase NAD activity (IEA)

S-(hydroxymethyl)glutathione dehydrogenase NADP activity (IEA)

zinc ion binding (IBA,IDA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

gluconeogenesis pathway (IEA)

glycolysis pathway (IEA)

glycolysis/gluconeogenesis pathway (IEA)

retinol metabolic pathway (IEA)

tyrosine metabolic pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Human Phenotype

Acute myeloid leukemia (IAGP)

Adrenal hypoplasia (IAGP)

Anemia (IAGP)

Attention deficit hyperactivity disorder (IAGP)

Autistic behavior (IAGP)

Bone marrow hypocellularity (IAGP)

Digenic inheritance (IAGP)

Dolichocephaly (IAGP)

Failure to thrive (IAGP)

Hyperpigmentation of the skin (IAGP)

Hypoplasia of the uterus (IAGP)

Intellectual disability (IAGP)

Leukopenia (IAGP)

Long thumb (IAGP)

Microcephaly (IAGP)

Motor regression (IAGP)

Myelodysplasia (IAGP)

Persistent left superior vena cava (IAGP)

Short stature (IAGP)

Telecanthus (IAGP)

Thrombocytopenia (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis.	Lopez-Sanchez LM, etal., Lab Invest. 2010 Jan;90(1):116-27. Epub 2009 Oct 5.
3.	Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma.	Moore PE, etal., Pediatr Pulmonol. 2009 Jul;44(7):649-54.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	Influence of the immunization against heterologous alcohol dehydrogenase on liver alcohol dehydrogenase isozymes and alcohol abuse of rats.	Pshezhetsky AV, etal., Eur J Biochem. 1993 Mar 15;212(3):757-61.
6.	S-nitrosoglutathione reductase: an important regulator in human asthma.	Que LG, etal., Am J Respir Crit Care Med. 2009 Aug 1;180(3):226-31. Epub 2009 Apr 24.
7.	Protection from experimental asthma by an endogenous bronchodilator.	Que LG, etal., Science. 2005 Jun 10;308(5728):1618-21. Epub 2005 May 26.
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma.	Wu H, etal., J Allergy Clin Immunol. 2007 Aug;120(2):322-8. Epub 2007 Jun 1.
11.	Increased nitrosoglutathione reductase activity in hypoxic pulmonary hypertension in mice.	Wu X, etal., J Pharmacol Sci. 2010 May;113(1):32-40. Epub 2010 Apr 22.

Additional References at PubMed

PMID:1446828	PMID:1453005	PMID:1577708	PMID:2679557	PMID:2818582	PMID:2934732	PMID:2936344	PMID:3365377	PMID:6375718	PMID:6424546	PMID:7948423	PMID:8460164
PMID:8494891	PMID:8503936	PMID:9018047	PMID:10661511	PMID:10978156	PMID:11368338	PMID:12004059	PMID:12141816	PMID:12196016	PMID:12477932	PMID:12484756	PMID:14608084
PMID:14702039	PMID:15123239	PMID:15489334	PMID:16081420	PMID:16169070	PMID:16344560	PMID:16685648	PMID:17185388	PMID:18095160	PMID:18331377	PMID:18636124	PMID:18996923
PMID:19056867	PMID:19165527	PMID:19596685	PMID:19874574	PMID:19898482	PMID:20158305	PMID:20308539	PMID:20335826	PMID:20371487	PMID:20634891	PMID:20677014	PMID:20819778
PMID:21832049	PMID:21873635	PMID:21920416	PMID:21988832	PMID:22335564	PMID:23251661	PMID:23285246	PMID:23355119	PMID:23376485	PMID:23456092	PMID:23468174	PMID:23533145
PMID:23752268	PMID:24097068	PMID:24665060	PMID:24895131	PMID:26344197	PMID:26491229	PMID:26637637	PMID:27684187	PMID:27880917	PMID:28228507	PMID:28533171	PMID:29074597
PMID:29248712	PMID:30188599	PMID:30575818	PMID:31043586	PMID:32112881	PMID:32176739	PMID:33147438	PMID:33512438	PMID:33961781	PMID:34219079	PMID:34428256	PMID:35256949
PMID:35271311	PMID:35446349	PMID:35562734	PMID:35605301	PMID:35831314	PMID:35944360

Genomics

Comparative Map Data

ADH5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	99,070,978 - 99,088,788 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	99,070,978 - 99,088,801 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	99,992,129 - 100,009,939 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	100,211,152 - 100,228,954 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	100,349,540 - 100,367,191	NCBI
Celera	4	97,289,594 - 97,307,408 (-)	NCBI		Celera
Cytogenetic Map	4	q23	NCBI
HuRef	4	95,730,971 - 95,748,768 (-)	NCBI		HuRef
CHM1_1	4	99,969,101 - 99,986,899 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	102,385,880 - 102,403,688 (-)	NCBI		T2T-CHM13v2.0

Adh5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	138,142,961 - 138,161,260 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	138,148,854 - 138,161,260 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	138,437,200 - 138,455,499 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	138,443,093 - 138,455,499 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	138,106,128 - 138,118,463 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	138,380,551 - 138,392,886 (+)	NCBI		MGSCv36	mm8
Celera	3	144,865,856 - 144,878,188 (+)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI

Adh5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	226,975,184 - 226,987,591 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	226,947,466 - 226,987,591 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	234,723,921 - 234,736,337 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	232,623,648 - 232,636,062 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	227,488,332 - 227,500,747 (+)	NCBI	Rnor_WKY
Rnor_6.0	2	243,728,500 - 243,740,907 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	243,700,784 - 243,740,899 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	262,262,936 - 262,275,343 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	235,979,108 - 235,991,515 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	2	219,131,229 - 219,143,636 (+)	NCBI		Celera
Cytogenetic Map	2	q44	NCBI

ADH5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	102,134,375 - 102,151,902 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	102,134,375 - 102,151,902 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	91,470,304 - 91,487,854 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

ADH5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	21,249,459 - 21,261,130 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	21,249,739 - 21,265,048 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	20,665,071 - 20,680,669 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	21,435,360 - 21,451,154 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	21,432,077 - 21,451,233 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	21,401,221 - 21,416,820 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	21,228,031 - 21,243,728 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	18,651,920 - 18,667,674 (+)	NCBI		UU_Cfam_GSD_1.0

ADH5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	121,266,764 - 121,282,310 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	121,266,794 - 121,282,313 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	130,451,304 - 130,466,904 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ADH5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	47,190,031 - 47,211,670 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	47,190,294 - 47,211,651 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	25,620,607 - 25,643,036 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Adh5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004625024	32,348 - 63,242 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004625024	32,237 - 60,983 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in ADH5
11 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 4q23(chr4:97972342-100038125)x3	copy number gain	See cases [RCV000051632]	Chr4:97972342..100038125 [GRCh38] Chr4:98893493..100959282 [GRCh37] Chr4:99112516..101178305 [NCBI36] Chr4:4q23	uncertain significance
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3	copy number gain	Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]\|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]\|See cases [RCV000051775]	Chr4:92913386..165299707 [GRCh38] Chr4:93834537..166220859 [GRCh37] Chr4:94053560..166440309 [NCBI36] Chr4:4q22.2-32.3	pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3	copy number gain	See cases [RCV000051776]	Chr4:96092893..136410207 [GRCh38] Chr4:97014044..137331362 [GRCh37] Chr4:97233067..137550812 [NCBI36] Chr4:4q22.3-28.3	pathogenic
NM_000671.4(ADH5):c.117C>T (p.Ile39=)	single nucleotide variant	Malignant melanoma [RCV000074305]	Chr4:99082114 [GRCh38] Chr4:100003265 [GRCh37] Chr4:100222288 [NCBI36] Chr4:4q23	not provided
GRCh38/hg38 4q21.21-24(chr4:80427023-100855441)x1	copy number loss	See cases [RCV000137269]	Chr4:80427023..100855441 [GRCh38] Chr4:81348177..101776598 [GRCh37] Chr4:81567201..101995621 [NCBI36] Chr4:4q21.21-24	pathogenic
GRCh38/hg38 4q22.1-24(chr4:92610413-101521991)x1	copy number loss	See cases [RCV000140412]	Chr4:92610413..101521991 [GRCh38] Chr4:93531564..102443148 [GRCh37] Chr4:93750587..102662171 [NCBI36] Chr4:4q22.1-24	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3	copy number gain	See cases [RCV000446653]	Chr4:12440..190904441 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4q21.23-24(chr4:85805268-103678797)x1	copy number loss	See cases [RCV000445741]	Chr4:85805268..103678797 [GRCh37] Chr4:4q21.23-24	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)	copy number gain	See cases [RCV000510453]	Chr4:68346..190957473 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4q22.1-24(chr4:92201567-103043808)x1	copy number loss	See cases [RCV000511194]	Chr4:92201567..103043808 [GRCh37] Chr4:4q22.1-24	pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3	copy number gain	See cases [RCV000510970]	Chr4:93071152..190957473 [GRCh37] Chr4:4q22.1-35.2	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3	copy number gain	See cases [RCV000512241]	Chr4:68346..190957473 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3	copy number gain	not provided [RCV000743155]	Chr4:49450..190915650 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4q23(chr4:99687168-100200509)x3	copy number gain	not provided [RCV000743861]	Chr4:99687168..100200509 [GRCh37] Chr4:4q23	benign
GRCh37/hg19 4q23(chr4:99687168-100202078)x3	copy number gain	not provided [RCV000743862]	Chr4:99687168..100202078 [GRCh37] Chr4:4q23	benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3	copy number gain	not provided [RCV000743156]	Chr4:49450..190963766 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3	copy number gain	not provided [RCV000743147]	Chr4:11525..191028879 [GRCh37] Chr4:4p16.3-q35.2	pathogenic
GRCh37/hg19 4q23(chr4:99918661-100046008)x1	copy number loss	not provided [RCV002473926]	Chr4:99918661..100046008 [GRCh37] Chr4:4q23	uncertain significance
GRCh37/hg19 4q22.2-24(chr4:94692345-101308220)x1	copy number loss	not provided [RCV001259285]	Chr4:94692345..101308220 [GRCh37] Chr4:4q22.2-24	likely pathogenic
NM_000671.4(ADH5):c.832G>C (p.Ala278Pro)	single nucleotide variant	AMED syndrome, digenic [RCV001290004]	Chr4:99075043 [GRCh38] Chr4:99996194 [GRCh37] Chr4:4q23	pathogenic
NM_000671.4(ADH5):c.966del (p.Gly321_Trp322insTer)	deletion	AMED syndrome, digenic [RCV001290002]	Chr4:99072707 [GRCh38] Chr4:99993858 [GRCh37] Chr4:4q23	pathogenic
NM_000671.4(ADH5):c.564+1G>A	single nucleotide variant	AMED syndrome, digenic [RCV001290003]	Chr4:99076703 [GRCh38] Chr4:99997854 [GRCh37] Chr4:4q23	pathogenic
GRCh37/hg19 4q23(chr4:99835828-100089147)	copy number loss	not specified [RCV002053445]	Chr4:99835828..100089147 [GRCh37] Chr4:4q23	uncertain significance
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3	copy number gain	not provided [RCV001827738]	Chr4:52866944..143582507 [GRCh37] Chr4:4q12-31.21	pathogenic
GRCh37/hg19 4q22.3-25(chr4:95490755-109977216)x3	copy number gain	not provided [RCV001827745]	Chr4:95490755..109977216 [GRCh37] Chr4:4q22.3-25	likely pathogenic
NM_000671.4(ADH5):c.9C>G (p.Asn3Lys)	single nucleotide variant	not provided [RCV002306077]	Chr4:99088692 [GRCh38] Chr4:100009843 [GRCh37] Chr4:4q23	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	2136
Count of miRNA genes:	1022
Interacting mature miRNAs:	1236
Transcripts:	ENST00000296412, ENST00000502386, ENST00000502590, ENST00000503130, ENST00000505652, ENST00000507102, ENST00000508146, ENST00000508511, ENST00000512604, ENST00000512621, ENST00000512659, ENST00000512991
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

ADH5_690

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	99,992,389 - 99,993,088	UniSTS	GRCh37
Build 36	4	100,211,412 - 100,212,111	RGD	NCBI36
Celera	4	97,289,854 - 97,290,553	RGD
HuRef	4	95,731,231 - 95,731,930	UniSTS

WI-18933

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	99,992,972 - 99,993,237	UniSTS	GRCh37
Build 36	4	100,211,995 - 100,212,260	RGD	NCBI36
Celera	4	97,290,437 - 97,290,702	RGD
Cytogenetic Map	4	q23	UniSTS
HuRef	4	95,731,814 - 95,732,079	UniSTS
GeneMap99-GB4 RH Map	4	494.04	UniSTS
Whitehead-RH Map	4	532.3	UniSTS

SHGC-67905

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	99,993,375 - 99,993,465	UniSTS	GRCh37
Build 36	4	100,212,398 - 100,212,488	RGD	NCBI36
Celera	4	97,290,840 - 97,290,930	RGD
Cytogenetic Map	4	q23	UniSTS
HuRef	4	95,732,217 - 95,732,307	UniSTS
TNG Radiation Hybrid Map	4	60932.0	UniSTS
GeneMap99-GB4 RH Map	4	489.79	UniSTS
NCBI RH Map	4	1142.1	UniSTS

WI-14387

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	4	99,992,483 - 99,992,624	UniSTS	GRCh37
Build 36	4	100,211,506 - 100,211,647	RGD	NCBI36
Celera	4	97,289,948 - 97,290,089	RGD
Cytogenetic Map	4	q23	UniSTS
HuRef	4	95,731,325 - 95,731,466	UniSTS
GeneMap99-GB4 RH Map	4	494.15	UniSTS
Whitehead-RH Map	4	534.0	UniSTS
NCBI RH Map	4	1142.1	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

sensory system

visual system

adipose tissue

appendage

entire extraembryonic component

pharyngeal arch

High

Medium

2439

2478

1721

623

1500

464

4353

2131

3668

415

1460

1611

175

1204

2784

Low

513

451

Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_000671	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC019131	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH002555	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK124994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK129570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK312367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY987960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC014665	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC070491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ881561	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BT019832	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BT019833	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068274	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR536491	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR541689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DA737788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GQ472236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M29872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M30471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENST00000296412 ⟹ ENSP00000296412

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,070,978 - 99,088,788 (-)	Ensembl

RefSeq Acc Id:

ENST00000502386

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,081,919 - 99,088,713 (-)	Ensembl

RefSeq Acc Id:

ENST00000502590 ⟹ ENSP00000422119

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,076,392 - 99,088,704 (-)	Ensembl

RefSeq Acc Id:

ENST00000503130 ⟹ ENSP00000427049

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,076,292 - 99,085,216 (-)	Ensembl

RefSeq Acc Id:

ENST00000505652 ⟹ ENSP00000421556

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,076,853 - 99,088,736 (-)	Ensembl

RefSeq Acc Id:

ENST00000507102

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,081,674 - 99,088,713 (-)	Ensembl

RefSeq Acc Id:

ENST00000508146

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,080,449 - 99,088,801 (-)	Ensembl

RefSeq Acc Id:

ENST00000508511

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,075,225 - 99,088,717 (-)	Ensembl

RefSeq Acc Id:

ENST00000512604

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,076,797 - 99,080,023 (-)	Ensembl

RefSeq Acc Id:

ENST00000512621

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,072,186 - 99,085,216 (-)	Ensembl

RefSeq Acc Id:

ENST00000512659 ⟹ ENSP00000424650

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,074,913 - 99,088,702 (-)	Ensembl

RefSeq Acc Id:

ENST00000512991

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,076,435 - 99,085,623 (-)	Ensembl

RefSeq Acc Id:

ENST00000626055 ⟹ ENSP00000487496

RefSeq Status:

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p13 Ensembl	4	99,072,152 - 99,088,751 (-)	Ensembl

RefSeq Acc Id:

NM_000671 ⟹ NP_000662

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	4	99,070,978 - 99,088,788 (-)	NCBI
GRCh37	4	99,992,129 - 100,009,931 (-)	ENTREZGENE
Build 36	4	100,211,152 - 100,228,954 (-)	NCBI Archive
HuRef	4	95,730,971 - 95,748,776 (-)	NCBI
CHM1_1	4	99,969,101 - 99,986,907 (-)	NCBI
T2T-CHM13v2.0	4	102,385,880 - 102,403,688 (-)	NCBI

Sequence:

show sequence

CTCGCTAGGCGCTCGCCACGCCCATGCCTCCGTCGCTGCGCGGCCCACCCCGGATGTCAGCCCC
CCGCGCCGACCAGAATCCGTGAACATGGCGAACGAGGTTATCAAGTGCAAGGCTGCAGTTGCTT
GGGAGGCTGGAAAGCCTCTCTCCATAGAGGAGATAGAGGTGGCACCCCCAAAGGCTCATGAAGT
TCGAATCAAGATCATTGCCACTGCGGTTTGCCACACCGATGCCTATACCCTGAGTGGAGCTGAT
CCTGAGGGTTGTTTTCCAGTGATCTTGGGACATGAAGGTGCTGGAATTGTGGAAAGTGTTGGTG
AGGGAGTTACTAAGCTGAAGGCGGGTGACACTGTCATCCCACTTTACATCCCACAGTGTGGAGA
ATGCAAATTTTGTCTAAATCCTAAAACTAACCTTTGCCAGAAGATAAGAGTCACTCAAGGGAAA
GGATTAATGCCAGATGGTACCAGCAGATTTACTTGCAAAGGAAAGACAATTTTGCATTACATGG
GAACCAGCACATTTTCTGAATACACAGTTGTGGCTGATATCTCTGTTGCTAAAATAGATCCTTT
AGCACCTTTGGATAAAGTCTGCCTTCTAGGTTGTGGCATTTCAACCGGTTATGGTGCTGCTGTG
AACACTGCCAAGTTGGAGCCTGGCTCTGTTTGTGCCGTCTTTGGTCTGGGAGGAGTCGGATTGG
CAGTTATCATGGGCTGTAAAGTGGCTGGTGCTTCCCGGATCATTGGTGTGGACATCAATAAAGA
TAAATTTGCAAGGGCCAAAGAGTTTGGAGCCACTGAATGTATTAACCCTCAGGATTTTAGTAAA
CCCATCCAGGAAGTGCTCATTGAGATGACCGATGGAGGAGTGGACTATTCCTTTGAATGTATTG
GTAATGTGAAGGTCATGAGAGCAGCACTTGAGGCATGTCACAAGGGCTGGGGCGTCAGCGTCGT
GGTTGGAGTAGCTGCTTCAGGTGAAGAAATTGCCACTCGTCCATTCCAGCTGGTAACAGGTCGC
ACATGGAAAGGCACTGCCTTTGGAGGATGGAAGAGTGTAGAAAGTGTCCCAAAGTTGGTGTCTG
AATATATGTCCAAAAAGATAAAAGTTGATGAATTTGTGACTCACAATCTGTCTTTTGATGAAAT
CAACAAAGCCTTTGAACTGATGCATTCTGGAAAGAGCATTCGAACTGTTGTAAAGATTTAATTC
AAAAGAGAAAAATAATGTCCATCCTGTCGTGATGTGATAGGAGCAGCTTAACAGGCAGGGAGAA
GCGCCTCCAACCTCACAGCCTCGTAGAGCTTCACAGCTACTCCAGAAAATAGGGTTATGTGTGT
CATTCATGAATCTCTATAATCAAGGACAAGGATAATTCAGTCATGAACCTGTTTTCTGGATGCT
CCTCCACATAAATAATTGCTAGTTTATTAAGGAATATTTTAACATAATAAAAGTAATTTCTACA
TTTGTGTGGAAATTGTCTTGTTTTATGCTGTCATCATTGTCACGGTTTGTCTGCCCATTATCTT
CATTCTGCAAGGGAAAGGGAAAGGAAGCAGGGCAGTGGTGGGTGTCTGAAACCTCAGAAACATA
ACGTTGAACTTTTAAGGGTCTCAGTCCCCGTTGATTAAAGAACAGATCCTAGCCATCAGTGACA
AAGTTAATCAGGACCCAAGTCTGCTTCTGTGATATTATCTTGAAGGGAGGTACTGTGCCTTGTT
CATACCTGTACCCCAAATTCCTAGGATGGCATCTGCCCTTCAGGGGGCACTAAAATGTATTATT
GAAACAGCATTCTGGGCTTAAATAGGTGTATGTATGTGTTGGTTGTGACTGTACTATTTCTAGT
ATAGTGAACTACATACTGAATATCCAAGTTCTCAGCACCTACTTTTGTCAAATCTTAACATTTT
GCCACTTCGAGATCACATTGCCATTCCTCCCCTCCAGAGGTAACAATTATCCACAATTTGATGT
TTATCATTCCTGTGTTGTTGTACTTTCACTGTGTATAACCTAAACCATCTACTCTTTAGTACTG
TTTTATATATTTTTAAGCCTCATACTTGCTCATTCTACAGCTTTTTTCACTCATTATTGTATAA
TTATATCTGAAGCTCTCGTTCATTAATTTTAGTCCTGTGTAGCAGAATTCAATTACGGGAACTA
CCATAATTTATCTGTTCTCCAGTTGAAGGCATGAAGTTGTTGCCAGTTTCTGTATTATAACACT
GTAGTGGAACATTCTTCTGCATTGGGCTCACTGCGTGTTACCTAAGACGTATCACAGAATAAAC
ACATTTAGCCTTATAGACATTGCCAAATTGCTCTTCAAAGTAAATGTGAGTTTTTGTGAATTAC
ATGAGTATGGAATGGTGTTTTATTATGACTTTAGTTTGCATTTTCCTCAATTCTCGTTAAATCC
TTCATTCTAATGGACATTTTATTGTGAAGAACCTGTTCATATCCTGTGCTCAACTTTGTATTGA
ATTATTTTTCTCTGAATAATTTTTAGGAGTTCTTTTATTCTAGACATCAATCATTTGTCAGTTT
TATATGTTGCAAATATCTTCTAGTCTATCTTGTGACTTTTCTTTTTACTTTATGGTATTTTGTT
GAATAAAGTTTTAATGTAGTCACATAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_000662	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA51596	(Get FASTA)	NCBI Sequence Viewer
	AAA51597	(Get FASTA)	NCBI Sequence Viewer
	AAA79018	(Get FASTA)	NCBI Sequence Viewer
	AAH14665	(Get FASTA)	NCBI Sequence Viewer
	AAH70491	(Get FASTA)	NCBI Sequence Viewer
	AAV38635	(Get FASTA)	NCBI Sequence Viewer
	AAV38636	(Get FASTA)	NCBI Sequence Viewer
	AAX81412	(Get FASTA)	NCBI Sequence Viewer
	ACV87211	(Get FASTA)	NCBI Sequence Viewer
	BAG35285	(Get FASTA)	NCBI Sequence Viewer
	CAG38730	(Get FASTA)	NCBI Sequence Viewer
	CAG46490	(Get FASTA)	NCBI Sequence Viewer
	EAX06084	(Get FASTA)	NCBI Sequence Viewer
	EAX06085	(Get FASTA)	NCBI Sequence Viewer
	EAX06086	(Get FASTA)	NCBI Sequence Viewer
	P11766	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_000662 ⟸ NM_000671

- UniProtKB:

Q6FHR2 (UniProtKB/Swiss-Prot), P11766 (UniProtKB/Swiss-Prot), Q6IRT1 (UniProtKB/TrEMBL), A0A024RDI2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MANEVIKCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVI
LGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTS
RFTCKGKTILHYMGTSTFSEYTVVADISVAKIDPLAPLDKVCLLGCGISTGYGAAVNTAKLEPG
SVCAVFGLGGVGLAVIMGCKVAGASRIIGVDINKDKFARAKEFGATECINPQDFSKPIQEVLIE
MTDGGVDYSFECIGNVKVMRAALEACHKGWGVSVVVGVAASGEEIATRPFQLVTGRTWKGTAFG
GWKSVESVPKLVSEYMSKKIKVDEFVTHNLSFDEINKAFELMHSGKSIRTVVKI

hide sequence

RefSeq Acc Id:

ENSP00000422119 ⟸ ENST00000502590

RefSeq Acc Id:

ENSP00000427049 ⟸ ENST00000503130

RefSeq Acc Id:

ENSP00000421556 ⟸ ENST00000505652

RefSeq Acc Id:

ENSP00000296412 ⟸ ENST00000296412

RefSeq Acc Id:

ENSP00000487496 ⟸ ENST00000626055

RefSeq Acc Id:

ENSP00000424650 ⟸ ENST00000512659

Protein Domains

ADH_N ADH_zinc_N

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P11766-F1-model_v2	AlphaFold	P11766	1-374	view protein structure

Promoters

RGD ID:

6868086

Promoter ID:

EPDNEW_H7208

Type:

initiation region

Name:

ADH5_1

Description:

alcohol dehydrogenase 5 , chi polypeptide

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	4	99,088,712 - 99,088,772	EPDNEW

RGD ID:

6802055

Promoter ID:

HG_KWN:48782

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

NM_000671, UC003HUK.1, UC003HUL.1, UC003HUM.1

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	4	100,228,331 - 100,229,952 (-)	MPROMDB

RGD ID:

6850648

Promoter ID:

EP73118

Type:

multiple initiation site

Name:

HS_ADH5

Description:

Alcohol dehydrogenase 5 (class III), chi polypeptide.

SO ACC ID:

SO:0000170

Source:

EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

NEDO full length human cDNA sequencing project.; Oligo-capping

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	4	100,228,887 - 100,228,947	EPD

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:253	AgrOrtholog
COSMIC	ADH5	COSMIC
Ensembl Genes	ENSG00000197894	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSP00000296412	ENTREZGENE
	ENSP00000296412.8	UniProtKB/Swiss-Prot
	ENSP00000421556.1	UniProtKB/TrEMBL
	ENSP00000422119.1	UniProtKB/TrEMBL
	ENSP00000424650.1	UniProtKB/TrEMBL
	ENSP00000427049.1	UniProtKB/TrEMBL
	ENSP00000487496.1	UniProtKB/TrEMBL
Ensembl Transcript	ENST00000296412	ENTREZGENE
	ENST00000296412.14	UniProtKB/Swiss-Prot
	ENST00000502590.5	UniProtKB/TrEMBL
	ENST00000503130.5	UniProtKB/TrEMBL
	ENST00000505652.1	UniProtKB/TrEMBL
	ENST00000512659.5	UniProtKB/TrEMBL
	ENST00000626055.2	UniProtKB/TrEMBL
GTEx	ENSG00000197894	GTEx
HGNC ID	HGNC:253	ENTREZGENE
Human Proteome Map	ADH5	Human Proteome Map
InterPro	ADH6	UniProtKB/TrEMBL
	ADH_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADH_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADH_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADH_Zn_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GroES-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:128	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	128	ENTREZGENE
OMIM	103710	OMIM
	619151	OMIM
PANTHER	PTHR43880:SF20	UniProtKB/TrEMBL
Pfam	ADH_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ADH_zinc_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	ADH5	RGD, PharmGKB
PROSITE	ADH_ZINC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50129	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF51735	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	adh_III_F_hyde	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A024RDI2	ENTREZGENE
	ADHX_HUMAN	UniProtKB/Swiss-Prot
	D6R9G2_HUMAN	UniProtKB/TrEMBL
	D6RAY0_HUMAN	UniProtKB/TrEMBL
	D6RFE4_HUMAN	UniProtKB/TrEMBL
	H0YAG8_HUMAN	UniProtKB/TrEMBL
	P11766	ENTREZGENE
	Q6FHR2	ENTREZGENE
	Q6FI45_HUMAN	UniProtKB/TrEMBL
	Q6IRT1	ENTREZGENE, UniProtKB/TrEMBL
	Q9H1A0_HUMAN	UniProtKB/TrEMBL
UniProt Secondary	A0A024RDI2	UniProtKB/TrEMBL
	Q6FHR2	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Human Phenotype Annotations - HPO

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Imported Human Phenotype Annotations - HPO