ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide) - Rat Genome Database

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Gene: ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide) Homo sapiens
Analyze
Symbol: ADH5
Name: alcohol dehydrogenase 5 (class III), chi polypeptide
RGD ID: 1351578
HGNC Page HGNC:253
Description: Enables fatty acid binding activity; formaldehyde dehydrogenase activity; and zinc ion binding activity. Involved in fatty acid omega-oxidation and response to redox state. Located in extracellular exosome. Implicated in AMED syndrome and asthma. Biomarker of asthma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ADH-3; ADHX; alcohol dehydrogenase (class III), chi polypeptide; alcohol dehydrogenase class chi chain; alcohol dehydrogenase class-3; alcohol dehydrogenase class-III; AMEDS; BMFS7; epididymis secretory sperm binding protein Li 60p; FALDH; FDH; formaldehyde dehydrogenase; glutathione-dependent formaldehyde dehydrogenase; GSH-FDH; GSNOR; HEL-S-60p; S-(hydroxymethyl)glutathione dehydrogenase; S-nitrosoglutathione reductase
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: ADH5P2   ADH5P3   ADH5P4   ADH5P5   LOC100190934  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,070,978 - 99,088,788 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl499,070,978 - 99,088,801 (-)EnsemblGRCh38hg38GRCh38
GRCh37499,992,129 - 100,009,939 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,211,152 - 100,228,954 (-)NCBINCBI36Build 36hg18NCBI36
Build 344100,349,540 - 100,367,191NCBI
Celera497,289,594 - 97,307,408 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,730,971 - 95,748,768 (-)NCBIHuRef
CHM1_1499,969,101 - 99,986,899 (-)NCBICHM1_1
T2T-CHM13v2.04102,385,880 - 102,403,688 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
1,2-dimethylhydrazine  (ISO)
12-hydroxylauric acid  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
8'-apo-beta,psi-caroten-8'-al  (EXP)
8-hydroxyoctanoic acid  (EXP)
acetamide  (ISO)
alcohol  (EXP)
all-trans-retinoic acid  (EXP)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (EXP)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
choline  (ISO)
cimetidine  (EXP)
clofibrate  (ISO)
clozapine  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP)
decabromodiphenyl ether  (EXP)
decanoic acid  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
dodecanedioic acid  (EXP)
dodecanoic acid  (EXP)
ethanol  (EXP,ISO)
fenthion  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP)
glutathione  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
hydrogen peroxide  (EXP)
ivermectin  (EXP)
L-methionine  (ISO)
methidathion  (ISO)
methylparaben  (EXP)
nonanoic acid  (EXP)
octan-1-ol  (EXP)
octanoic acid  (EXP)
p-toluidine  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (EXP)
phlorizin  (ISO)
picoxystrobin  (EXP)
potassium chromate  (EXP)
progesterone  (ISO)
quercetin  (EXP)
rotenone  (EXP)
S-(hydroxymethyl)glutathione  (EXP)
S-methylglutathione  (EXP)
S-nitrosoglutathione  (EXP,ISO)
sebacic acid  (EXP)
sodium fluoride  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
undecanoic acid  (EXP)
urethane  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis. Lopez-Sanchez LM, etal., Lab Invest. 2010 Jan;90(1):116-27. Epub 2009 Oct 5.
3. Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma. Moore PE, etal., Pediatr Pulmonol. 2009 Jul;44(7):649-54.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Influence of the immunization against heterologous alcohol dehydrogenase on liver alcohol dehydrogenase isozymes and alcohol abuse of rats. Pshezhetsky AV, etal., Eur J Biochem. 1993 Mar 15;212(3):757-61.
6. S-nitrosoglutathione reductase: an important regulator in human asthma. Que LG, etal., Am J Respir Crit Care Med. 2009 Aug 1;180(3):226-31. Epub 2009 Apr 24.
7. Protection from experimental asthma by an endogenous bronchodilator. Que LG, etal., Science. 2005 Jun 10;308(5728):1618-21. Epub 2005 May 26.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Genetic variation in S-nitrosoglutathione reductase (GSNOR) and childhood asthma. Wu H, etal., J Allergy Clin Immunol. 2007 Aug;120(2):322-8. Epub 2007 Jun 1.
11. Increased nitrosoglutathione reductase activity in hypoxic pulmonary hypertension in mice. Wu X, etal., J Pharmacol Sci. 2010 May;113(1):32-40. Epub 2010 Apr 22.
Additional References at PubMed
PMID:1446828   PMID:1453005   PMID:1577708   PMID:2679557   PMID:2818582   PMID:2934732   PMID:2936344   PMID:3365377   PMID:6375718   PMID:6424546   PMID:7948423   PMID:8460164  
PMID:8494891   PMID:8503936   PMID:9018047   PMID:10661511   PMID:10978156   PMID:11368338   PMID:12004059   PMID:12141816   PMID:12196016   PMID:12477932   PMID:12484756   PMID:14608084  
PMID:14702039   PMID:15123239   PMID:15489334   PMID:16081420   PMID:16169070   PMID:16344560   PMID:16685648   PMID:17185388   PMID:18095160   PMID:18331377   PMID:18636124   PMID:18996923  
PMID:19056867   PMID:19165527   PMID:19596685   PMID:19874574   PMID:19898482   PMID:20158305   PMID:20308539   PMID:20335826   PMID:20371487   PMID:20634891   PMID:20677014   PMID:20819778  
PMID:21832049   PMID:21873635   PMID:21920416   PMID:21988832   PMID:22335564   PMID:23251661   PMID:23285246   PMID:23355119   PMID:23376485   PMID:23456092   PMID:23468174   PMID:23533145  
PMID:23752268   PMID:24097068   PMID:24665060   PMID:24895131   PMID:26344197   PMID:26491229   PMID:26637637   PMID:27684187   PMID:27880917   PMID:28228507   PMID:28533171   PMID:29074597  
PMID:29248712   PMID:30188599   PMID:30575818   PMID:31043586   PMID:32112881   PMID:32176739   PMID:33147438   PMID:33512438   PMID:33961781   PMID:34219079   PMID:34428256   PMID:35256949  
PMID:35271311   PMID:35446349   PMID:35562734   PMID:35605301   PMID:35831314   PMID:35944360  


Genomics

Comparative Map Data
ADH5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,070,978 - 99,088,788 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl499,070,978 - 99,088,801 (-)EnsemblGRCh38hg38GRCh38
GRCh37499,992,129 - 100,009,939 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,211,152 - 100,228,954 (-)NCBINCBI36Build 36hg18NCBI36
Build 344100,349,540 - 100,367,191NCBI
Celera497,289,594 - 97,307,408 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef495,730,971 - 95,748,768 (-)NCBIHuRef
CHM1_1499,969,101 - 99,986,899 (-)NCBICHM1_1
T2T-CHM13v2.04102,385,880 - 102,403,688 (-)NCBIT2T-CHM13v2.0
Adh5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393138,142,961 - 138,161,260 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3138,148,854 - 138,161,260 (+)EnsemblGRCm39 Ensembl
GRCm383138,437,200 - 138,455,499 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3138,443,093 - 138,455,499 (+)EnsemblGRCm38mm10GRCm38
MGSCv373138,106,128 - 138,118,463 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363138,380,551 - 138,392,886 (+)NCBIMGSCv36mm8
Celera3144,865,856 - 144,878,188 (+)NCBICelera
Cytogenetic Map3G3NCBI
Adh5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22226,975,184 - 226,987,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,947,466 - 226,987,591 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,723,921 - 234,736,337 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02232,623,648 - 232,636,062 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02227,488,332 - 227,500,747 (+)NCBIRnor_WKY
Rnor_6.02243,728,500 - 243,740,907 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,700,784 - 243,740,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02262,262,936 - 262,275,343 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,979,108 - 235,991,515 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2219,131,229 - 219,143,636 (+)NCBICelera
Cytogenetic Map2q44NCBI
ADH5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14102,134,375 - 102,151,902 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4102,134,375 - 102,151,902 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0491,470,304 - 91,487,854 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADH5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,249,459 - 21,261,130 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,249,739 - 21,265,048 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,665,071 - 20,680,669 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03221,435,360 - 21,451,154 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3221,432,077 - 21,451,233 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13221,401,221 - 21,416,820 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,228,031 - 21,243,728 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03218,651,920 - 18,667,674 (+)NCBIUU_Cfam_GSD_1.0
ADH5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8121,266,764 - 121,282,310 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18121,266,794 - 121,282,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28130,451,304 - 130,466,904 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADH5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1747,190,031 - 47,211,670 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl747,190,294 - 47,211,651 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603725,620,607 - 25,643,036 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adh5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462502432,348 - 63,242 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462502432,237 - 60,983 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ADH5
11 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 4q23(chr4:97972342-100038125)x3 copy number gain See cases [RCV000051632] Chr4:97972342..100038125 [GRCh38]
Chr4:98893493..100959282 [GRCh37]
Chr4:99112516..101178305 [NCBI36]
Chr4:4q23
uncertain significance
GRCh38/hg38 4q22.2-32.3(chr4:92913386-165299707)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051775]|See cases [RCV000051775] Chr4:92913386..165299707 [GRCh38]
Chr4:93834537..166220859 [GRCh37]
Chr4:94053560..166440309 [NCBI36]
Chr4:4q22.2-32.3
pathogenic
GRCh38/hg38 4q22.3-28.3(chr4:96092893-136410207)x3 copy number gain See cases [RCV000051776] Chr4:96092893..136410207 [GRCh38]
Chr4:97014044..137331362 [GRCh37]
Chr4:97233067..137550812 [NCBI36]
Chr4:4q22.3-28.3
pathogenic
NM_000671.4(ADH5):c.117C>T (p.Ile39=) single nucleotide variant Malignant melanoma [RCV000074305] Chr4:99082114 [GRCh38]
Chr4:100003265 [GRCh37]
Chr4:100222288 [NCBI36]
Chr4:4q23
not provided
GRCh38/hg38 4q21.21-24(chr4:80427023-100855441)x1 copy number loss See cases [RCV000137269] Chr4:80427023..100855441 [GRCh38]
Chr4:81348177..101776598 [GRCh37]
Chr4:81567201..101995621 [NCBI36]
Chr4:4q21.21-24
pathogenic
GRCh38/hg38 4q22.1-24(chr4:92610413-101521991)x1 copy number loss See cases [RCV000140412] Chr4:92610413..101521991 [GRCh38]
Chr4:93531564..102443148 [GRCh37]
Chr4:93750587..102662171 [NCBI36]
Chr4:4q22.1-24
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:12440-190904441)x3 copy number gain See cases [RCV000446653] Chr4:12440..190904441 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q21.23-24(chr4:85805268-103678797)x1 copy number loss See cases [RCV000445741] Chr4:85805268..103678797 [GRCh37]
Chr4:4q21.23-24
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473) copy number gain See cases [RCV000510453] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q22.1-24(chr4:92201567-103043808)x1 copy number loss See cases [RCV000511194] Chr4:92201567..103043808 [GRCh37]
Chr4:4q22.1-24
pathogenic
GRCh37/hg19 4q22.1-35.2(chr4:93071152-190957473)x3 copy number gain See cases [RCV000510970] Chr4:93071152..190957473 [GRCh37]
Chr4:4q22.1-35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:68346-190957473)x3 copy number gain See cases [RCV000512241] Chr4:68346..190957473 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190915650)x3 copy number gain not provided [RCV000743155] Chr4:49450..190915650 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q23(chr4:99687168-100200509)x3 copy number gain not provided [RCV000743861] Chr4:99687168..100200509 [GRCh37]
Chr4:4q23
benign
GRCh37/hg19 4q23(chr4:99687168-100202078)x3 copy number gain not provided [RCV000743862] Chr4:99687168..100202078 [GRCh37]
Chr4:4q23
benign
GRCh37/hg19 4p16.3-q35.2(chr4:49450-190963766)x3 copy number gain not provided [RCV000743156] Chr4:49450..190963766 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4p16.3-q35.2(chr4:11525-191028879)x3 copy number gain not provided [RCV000743147] Chr4:11525..191028879 [GRCh37]
Chr4:4p16.3-q35.2
pathogenic
GRCh37/hg19 4q23(chr4:99918661-100046008)x1 copy number loss not provided [RCV002473926] Chr4:99918661..100046008 [GRCh37]
Chr4:4q23
uncertain significance
GRCh37/hg19 4q22.2-24(chr4:94692345-101308220)x1 copy number loss not provided [RCV001259285] Chr4:94692345..101308220 [GRCh37]
Chr4:4q22.2-24
likely pathogenic
NM_000671.4(ADH5):c.832G>C (p.Ala278Pro) single nucleotide variant AMED syndrome, digenic [RCV001290004] Chr4:99075043 [GRCh38]
Chr4:99996194 [GRCh37]
Chr4:4q23
pathogenic
NM_000671.4(ADH5):c.966del (p.Gly321_Trp322insTer) deletion AMED syndrome, digenic [RCV001290002] Chr4:99072707 [GRCh38]
Chr4:99993858 [GRCh37]
Chr4:4q23
pathogenic
NM_000671.4(ADH5):c.564+1G>A single nucleotide variant AMED syndrome, digenic [RCV001290003] Chr4:99076703 [GRCh38]
Chr4:99997854 [GRCh37]
Chr4:4q23
pathogenic
GRCh37/hg19 4q23(chr4:99835828-100089147) copy number loss not specified [RCV002053445] Chr4:99835828..100089147 [GRCh37]
Chr4:4q23
uncertain significance
GRCh37/hg19 4q12-31.21(chr4:52866944-143582507)x3 copy number gain not provided [RCV001827738] Chr4:52866944..143582507 [GRCh37]
Chr4:4q12-31.21
pathogenic
GRCh37/hg19 4q22.3-25(chr4:95490755-109977216)x3 copy number gain not provided [RCV001827745] Chr4:95490755..109977216 [GRCh37]
Chr4:4q22.3-25
likely pathogenic
NM_000671.4(ADH5):c.9C>G (p.Asn3Lys) single nucleotide variant not provided [RCV002306077] Chr4:99088692 [GRCh38]
Chr4:100009843 [GRCh37]
Chr4:4q23
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2136
Count of miRNA genes:1022
Interacting mature miRNAs:1236
Transcripts:ENST00000296412, ENST00000502386, ENST00000502590, ENST00000503130, ENST00000505652, ENST00000507102, ENST00000508146, ENST00000508511, ENST00000512604, ENST00000512621, ENST00000512659, ENST00000512991
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
ADH5_690  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37499,992,389 - 99,993,088UniSTSGRCh37
Build 364100,211,412 - 100,212,111RGDNCBI36
Celera497,289,854 - 97,290,553RGD
HuRef495,731,231 - 95,731,930UniSTS
WI-18933  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37499,992,972 - 99,993,237UniSTSGRCh37
Build 364100,211,995 - 100,212,260RGDNCBI36
Celera497,290,437 - 97,290,702RGD
Cytogenetic Map4q23UniSTS
HuRef495,731,814 - 95,732,079UniSTS
GeneMap99-GB4 RH Map4494.04UniSTS
Whitehead-RH Map4532.3UniSTS
SHGC-67905  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37499,993,375 - 99,993,465UniSTSGRCh37
Build 364100,212,398 - 100,212,488RGDNCBI36
Celera497,290,840 - 97,290,930RGD
Cytogenetic Map4q23UniSTS
HuRef495,732,217 - 95,732,307UniSTS
TNG Radiation Hybrid Map460932.0UniSTS
GeneMap99-GB4 RH Map4489.79UniSTS
NCBI RH Map41142.1UniSTS
WI-14387  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37499,992,483 - 99,992,624UniSTSGRCh37
Build 364100,211,506 - 100,211,647RGDNCBI36
Celera497,289,948 - 97,290,089RGD
Cytogenetic Map4q23UniSTS
HuRef495,731,325 - 95,731,466UniSTS
GeneMap99-GB4 RH Map4494.15UniSTS
Whitehead-RH Map4534.0UniSTS
NCBI RH Map41142.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2439 2478 1721 623 1500 464 4353 2131 3668 415 1460 1611 175 1 1204 2784 6 2
Low 513 5 1 451 1 4 66 66 4 2 4
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_000671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC019131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK124994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK129570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY987960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC070491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ881561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR536491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA737788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ472236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M29872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M30471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000296412   ⟹   ENSP00000296412
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,070,978 - 99,088,788 (-)Ensembl
RefSeq Acc Id: ENST00000502386
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,081,919 - 99,088,713 (-)Ensembl
RefSeq Acc Id: ENST00000502590   ⟹   ENSP00000422119
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,076,392 - 99,088,704 (-)Ensembl
RefSeq Acc Id: ENST00000503130   ⟹   ENSP00000427049
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,076,292 - 99,085,216 (-)Ensembl
RefSeq Acc Id: ENST00000505652   ⟹   ENSP00000421556
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,076,853 - 99,088,736 (-)Ensembl
RefSeq Acc Id: ENST00000507102
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,081,674 - 99,088,713 (-)Ensembl
RefSeq Acc Id: ENST00000508146
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,080,449 - 99,088,801 (-)Ensembl
RefSeq Acc Id: ENST00000508511
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,075,225 - 99,088,717 (-)Ensembl
RefSeq Acc Id: ENST00000512604
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,076,797 - 99,080,023 (-)Ensembl
RefSeq Acc Id: ENST00000512621
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,072,186 - 99,085,216 (-)Ensembl
RefSeq Acc Id: ENST00000512659   ⟹   ENSP00000424650
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,074,913 - 99,088,702 (-)Ensembl
RefSeq Acc Id: ENST00000512991
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,076,435 - 99,085,623 (-)Ensembl
RefSeq Acc Id: ENST00000626055   ⟹   ENSP00000487496
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl499,072,152 - 99,088,751 (-)Ensembl
RefSeq Acc Id: NM_000671   ⟹   NP_000662
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,070,978 - 99,088,788 (-)NCBI
GRCh37499,992,129 - 100,009,931 (-)ENTREZGENE
Build 364100,211,152 - 100,228,954 (-)NCBI Archive
HuRef495,730,971 - 95,748,776 (-)NCBI
CHM1_1499,969,101 - 99,986,907 (-)NCBI
T2T-CHM13v2.04102,385,880 - 102,403,688 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000662   ⟸   NM_000671
- UniProtKB: Q6FHR2 (UniProtKB/Swiss-Prot),   P11766 (UniProtKB/Swiss-Prot),   Q6IRT1 (UniProtKB/TrEMBL),   A0A024RDI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000422119   ⟸   ENST00000502590
RefSeq Acc Id: ENSP00000427049   ⟸   ENST00000503130
RefSeq Acc Id: ENSP00000421556   ⟸   ENST00000505652
RefSeq Acc Id: ENSP00000296412   ⟸   ENST00000296412
RefSeq Acc Id: ENSP00000487496   ⟸   ENST00000626055
RefSeq Acc Id: ENSP00000424650   ⟸   ENST00000512659
Protein Domains
ADH_N   ADH_zinc_N

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11766-F1-model_v2 AlphaFold P11766 1-374 view protein structure

Promoters
RGD ID:6868086
Promoter ID:EPDNEW_H7208
Type:initiation region
Name:ADH5_1
Description:alcohol dehydrogenase 5 , chi polypeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38499,088,712 - 99,088,772EPDNEW
RGD ID:6802055
Promoter ID:HG_KWN:48782
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_000671,   UC003HUK.1,   UC003HUL.1,   UC003HUM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 364100,228,331 - 100,229,952 (-)MPROMDB
RGD ID:6850648
Promoter ID:EP73118
Type:multiple initiation site
Name:HS_ADH5
Description:Alcohol dehydrogenase 5 (class III), chi polypeptide.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 364100,228,887 - 100,228,947EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:253 AgrOrtholog
COSMIC ADH5 COSMIC
Ensembl Genes ENSG00000197894 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000296412 ENTREZGENE
  ENSP00000296412.8 UniProtKB/Swiss-Prot
  ENSP00000421556.1 UniProtKB/TrEMBL
  ENSP00000422119.1 UniProtKB/TrEMBL
  ENSP00000424650.1 UniProtKB/TrEMBL
  ENSP00000427049.1 UniProtKB/TrEMBL
  ENSP00000487496.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000296412 ENTREZGENE
  ENST00000296412.14 UniProtKB/Swiss-Prot
  ENST00000502590.5 UniProtKB/TrEMBL
  ENST00000503130.5 UniProtKB/TrEMBL
  ENST00000505652.1 UniProtKB/TrEMBL
  ENST00000512659.5 UniProtKB/TrEMBL
  ENST00000626055.2 UniProtKB/TrEMBL
GTEx ENSG00000197894 GTEx
HGNC ID HGNC:253 ENTREZGENE
Human Proteome Map ADH5 Human Proteome Map
InterPro ADH6 UniProtKB/TrEMBL
  ADH_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_Zn_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GroES-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:128 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 128 ENTREZGENE
OMIM 103710 OMIM
  619151 OMIM
PANTHER PTHR43880:SF20 UniProtKB/TrEMBL
Pfam ADH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADH_zinc_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADH5 RGD, PharmGKB
PROSITE ADH_ZINC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs adh_III_F_hyde UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RDI2 ENTREZGENE
  ADHX_HUMAN UniProtKB/Swiss-Prot
  D6R9G2_HUMAN UniProtKB/TrEMBL
  D6RAY0_HUMAN UniProtKB/TrEMBL
  D6RFE4_HUMAN UniProtKB/TrEMBL
  H0YAG8_HUMAN UniProtKB/TrEMBL
  P11766 ENTREZGENE
  Q6FHR2 ENTREZGENE
  Q6FI45_HUMAN UniProtKB/TrEMBL
  Q6IRT1 ENTREZGENE, UniProtKB/TrEMBL
  Q9H1A0_HUMAN UniProtKB/TrEMBL
UniProt Secondary A0A024RDI2 UniProtKB/TrEMBL
  Q6FHR2 UniProtKB/Swiss-Prot