TOP1MT (DNA topoisomerase I mitochondrial) - Rat Genome Database

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Gene: TOP1MT (DNA topoisomerase I mitochondrial) Homo sapiens
Analyze
Symbol: TOP1MT
Name: DNA topoisomerase I mitochondrial
RGD ID: 1351494
HGNC Page HGNC
Description: Predicted to have DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication and DNA topological change. Localizes to mitochondrial nucleoid and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA topoisomerase I, mitochondrial; mitochondrial DNA topoisomerase I; mitochondrial topoisomerase IB; topoisomerase (DNA) I, mitochondrial
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8143,304,384 - 143,359,979 (-)EnsemblGRCh38hg38GRCh38
GRCh388143,309,324 - 143,359,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378144,391,494 - 144,442,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,462,901 - 144,488,425 (-)NCBINCBI36hg18NCBI36
Build 348144,462,904 - 144,488,425NCBI
Celera8140,700,651 - 140,727,260 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8139,629,915 - 139,695,642 (-)NCBIHuRef
CHM1_18144,431,738 - 144,482,220 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:15096574   PMID:16712791   PMID:17161897   PMID:18029348   PMID:18063578   PMID:18826252   PMID:19720733   PMID:20453000   PMID:20843780   PMID:20877624   PMID:21531700   PMID:21873635  
PMID:23261817   PMID:23422507   PMID:24172750   PMID:25402006   PMID:25963833   PMID:26496610   PMID:28874393   PMID:29449217   PMID:30463901   PMID:30622257   PMID:31586073  


Genomics

Comparative Map Data
TOP1MT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8143,304,384 - 143,359,979 (-)EnsemblGRCh38hg38GRCh38
GRCh388143,309,324 - 143,359,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378144,391,494 - 144,442,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,462,901 - 144,488,425 (-)NCBINCBI36hg18NCBI36
Build 348144,462,904 - 144,488,425NCBI
Celera8140,700,651 - 140,727,260 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8139,629,915 - 139,695,642 (-)NCBIHuRef
CHM1_18144,431,738 - 144,482,220 (-)NCBICHM1_1
Top1mt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,528,878 - 75,551,184 (-)NCBIGRCm39mm39
GRCm39 Ensembl1575,528,884 - 75,550,649 (-)Ensembl
GRCm381575,657,033 - 75,678,800 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1575,657,035 - 75,678,800 (-)EnsemblGRCm38mm10GRCm38
MGSCv371575,487,463 - 75,509,220 (-)NCBIGRCm37mm9NCBIm37
MGSCv361575,484,288 - 75,506,045 (-)NCBImm8
Celera1577,157,202 - 77,179,081 (-)NCBICelera
Cytogenetic Map15D3NCBI
Top1mt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27107,338,092 - 107,368,125 (-)NCBI
Rnor_6.0 Ensembl7116,688,701 - 116,712,387 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.07116,688,801 - 116,714,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07116,582,993 - 116,608,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47113,596,083 - 113,619,109 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17113,630,312 - 113,653,339 (-)NCBI
Celera7103,705,366 - 103,728,376 (-)NCBICelera
Cytogenetic Map7q34NCBI
Top1mt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,021,563 - 2,046,190 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554542,020,884 - 2,045,939 (-)NCBIChiLan1.0ChiLan1.0
TOP1MT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18143,077,224 - 143,125,987 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v08140,056,468 - 140,106,510 (-)NCBIMhudiblu_PPA_v0panPan3
TOP1MT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.141,134,179 - 1,188,149 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.241,068,174 - 1,125,241 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOP1MT
(Chlorocebus sabaeus - African green monkey)
No map positions available.
Top1mt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473513,417,185 - 13,441,097 (+)NCBI

Position Markers
RH65208  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378144,380,670 - 144,380,811UniSTSGRCh37
Build 368144,452,045 - 144,452,186RGDNCBI36
Celera8140,689,977 - 140,690,118RGD
Cytogenetic Map8q24.3UniSTS
HuRef8139,634,344 - 139,634,485UniSTS
GeneMap99-GB4 RH Map8548.76UniSTS
RH80170  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh378144,379,080 - 144,379,316UniSTSGRCh37
Build 368144,450,455 - 144,450,691RGDNCBI36
Celera8140,688,387 - 140,688,623RGD
Cytogenetic Map8q24.3UniSTS
HuRef8139,632,754 - 139,632,990UniSTS
GeneMap99-GB4 RH Map8547.18UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4238
Count of miRNA genes:1104
Interacting mature miRNAs:1404
Transcripts:ENST00000329245, ENST00000505857, ENST00000517857, ENST00000518007, ENST00000518760, ENST00000518951, ENST00000519139, ENST00000519148, ENST00000519591, ENST00000519977, ENST00000520950, ENST00000521024, ENST00000521193, ENST00000522041, ENST00000522043, ENST00000522121, ENST00000523417, ENST00000523676, ENST00000524092
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 306 135 633 147 589 140 1208 76 122 132 1070 754 19 202 419 2
Low 2126 2780 1090 475 1351 324 3139 2048 3500 286 379 854 152 1002 2361 2
Below cutoff 69 8 8 69 86 1 2 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001258446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001258447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_052963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005250781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC087793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF349017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011131 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK302372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW248607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC052285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC071914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB149603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC375680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC399840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ204999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HQ205025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000329245   ⟹   ENSP00000328835
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,309,324 - 143,334,880 (-)Ensembl
RefSeq Acc Id: ENST00000505857
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,343,199 - 143,359,979 (-)Ensembl
RefSeq Acc Id: ENST00000517857
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,309,356 - 143,310,503 (-)Ensembl
RefSeq Acc Id: ENST00000518007   ⟹   ENSP00000430209
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,325,522 - 143,344,984 (-)Ensembl
RefSeq Acc Id: ENST00000518760   ⟹   ENSP00000428723
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,326,290 - 143,356,046 (-)Ensembl
RefSeq Acc Id: ENST00000518951   ⟹   ENSP00000428727
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,316,000 - 143,334,863 (-)Ensembl
RefSeq Acc Id: ENST00000519139   ⟹   ENSP00000428451
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,316,092 - 143,334,056 (-)Ensembl
RefSeq Acc Id: ENST00000519148   ⟹   ENSP00000429169
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,309,360 - 143,359,977 (-)Ensembl
RefSeq Acc Id: ENST00000519591   ⟹   ENSP00000429177
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,324,060 - 143,334,854 (-)Ensembl
RefSeq Acc Id: ENST00000519977   ⟹   ENSP00000427925
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,304,384 - 143,315,807 (-)Ensembl
RefSeq Acc Id: ENST00000520950   ⟹   ENSP00000430635
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,326,312 - 143,359,960 (-)Ensembl
RefSeq Acc Id: ENST00000521024
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,344,737 - 143,358,666 (-)Ensembl
RefSeq Acc Id: ENST00000521193   ⟹   ENSP00000428369
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,309,356 - 143,359,924 (-)Ensembl
RefSeq Acc Id: ENST00000522041   ⟹   ENSP00000427998
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,324,000 - 143,331,811 (-)Ensembl
RefSeq Acc Id: ENST00000522043   ⟹   ENSP00000428931
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,329,387 - 143,334,866 (-)Ensembl
RefSeq Acc Id: ENST00000522121   ⟹   ENSP00000430139
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,325,355 - 143,329,433 (-)Ensembl
RefSeq Acc Id: ENST00000523417   ⟹   ENSP00000430679
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,325,425 - 143,334,844 (-)Ensembl
RefSeq Acc Id: ENST00000523676   ⟹   ENSP00000429181
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,309,377 - 143,334,795 (-)Ensembl
RefSeq Acc Id: ENST00000524092
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl8143,332,503 - 143,334,821 (-)Ensembl
RefSeq Acc Id: NM_001258446   ⟹   NP_001245375
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,309,324 - 143,359,977 (-)NCBI
GRCh378144,391,494 - 144,442,147 (-)NCBI
HuRef8139,629,915 - 139,695,642 (-)NCBI
CHM1_18144,431,738 - 144,482,220 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001258447   ⟹   NP_001245376
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,309,324 - 143,359,977 (-)NCBI
GRCh378144,391,494 - 144,442,147 (-)NCBI
HuRef8139,629,915 - 139,695,642 (-)NCBI
CHM1_18144,431,738 - 144,482,220 (-)NCBI
Sequence:
RefSeq Acc Id: NM_052963   ⟹   NP_443195
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,309,324 - 143,334,880 (-)NCBI
GRCh378144,391,494 - 144,442,147 (-)NCBI
Build 368144,462,901 - 144,488,425 (-)NCBI Archive
Celera8140,700,651 - 140,727,260 (-)RGD
HuRef8139,629,915 - 139,695,642 (-)NCBI
CHM1_18144,431,738 - 144,457,331 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005250781   ⟹   XP_005250838
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,309,565 - 143,334,880 (-)NCBI
GRCh378144,391,494 - 144,442,147 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001245375 (Get FASTA)   NCBI Sequence Viewer  
  NP_001245376 (Get FASTA)   NCBI Sequence Viewer  
  NP_443195 (Get FASTA)   NCBI Sequence Viewer  
  XP_005250838 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH27453 (Get FASTA)   NCBI Sequence Viewer  
  AAH44646 (Get FASTA)   NCBI Sequence Viewer  
  AAH52285 (Get FASTA)   NCBI Sequence Viewer  
  AAH71914 (Get FASTA)   NCBI Sequence Viewer  
  AAL05624 (Get FASTA)   NCBI Sequence Viewer  
  AAL10791 (Get FASTA)   NCBI Sequence Viewer  
  ADP90414 (Get FASTA)   NCBI Sequence Viewer  
  ADP90415 (Get FASTA)   NCBI Sequence Viewer  
  ADP90416 (Get FASTA)   NCBI Sequence Viewer  
  ADP90417 (Get FASTA)   NCBI Sequence Viewer  
  ADP90418 (Get FASTA)   NCBI Sequence Viewer  
  ADP90419 (Get FASTA)   NCBI Sequence Viewer  
  ADP90420 (Get FASTA)   NCBI Sequence Viewer  
  ADP90421 (Get FASTA)   NCBI Sequence Viewer  
  ADP90422 (Get FASTA)   NCBI Sequence Viewer  
  ADP90423 (Get FASTA)   NCBI Sequence Viewer  
  ADP90424 (Get FASTA)   NCBI Sequence Viewer  
  ADP90425 (Get FASTA)   NCBI Sequence Viewer  
  ADP90426 (Get FASTA)   NCBI Sequence Viewer  
  ADP90427 (Get FASTA)   NCBI Sequence Viewer  
  ADP90428 (Get FASTA)   NCBI Sequence Viewer  
  ADP90429 (Get FASTA)   NCBI Sequence Viewer  
  ADP90430 (Get FASTA)   NCBI Sequence Viewer  
  ADP90431 (Get FASTA)   NCBI Sequence Viewer  
  ADP90432 (Get FASTA)   NCBI Sequence Viewer  
  ADP90433 (Get FASTA)   NCBI Sequence Viewer  
  ADP90434 (Get FASTA)   NCBI Sequence Viewer  
  ADP90435 (Get FASTA)   NCBI Sequence Viewer  
  ADP90436 (Get FASTA)   NCBI Sequence Viewer  
  ADP90437 (Get FASTA)   NCBI Sequence Viewer  
  ADP90438 (Get FASTA)   NCBI Sequence Viewer  
  ADP90439 (Get FASTA)   NCBI Sequence Viewer  
  ADP90440 (Get FASTA)   NCBI Sequence Viewer  
  ADP90441 (Get FASTA)   NCBI Sequence Viewer  
  ADP90442 (Get FASTA)   NCBI Sequence Viewer  
  ADP90443 (Get FASTA)   NCBI Sequence Viewer  
  ADP90444 (Get FASTA)   NCBI Sequence Viewer  
  ADP90445 (Get FASTA)   NCBI Sequence Viewer  
  ADP90446 (Get FASTA)   NCBI Sequence Viewer  
  ADP90447 (Get FASTA)   NCBI Sequence Viewer  
  ADP90448 (Get FASTA)   NCBI Sequence Viewer  
  ADP90449 (Get FASTA)   NCBI Sequence Viewer  
  ADP90450 (Get FASTA)   NCBI Sequence Viewer  
  ADP90451 (Get FASTA)   NCBI Sequence Viewer  
  ADP90452 (Get FASTA)   NCBI Sequence Viewer  
  ADP90453 (Get FASTA)   NCBI Sequence Viewer  
  BAG63694 (Get FASTA)   NCBI Sequence Viewer  
  BAG64323 (Get FASTA)   NCBI Sequence Viewer  
  BAH14284 (Get FASTA)   NCBI Sequence Viewer  
  BAH14751 (Get FASTA)   NCBI Sequence Viewer  
  EAW82259 (Get FASTA)   NCBI Sequence Viewer  
  EAW82260 (Get FASTA)   NCBI Sequence Viewer  
  EAW82261 (Get FASTA)   NCBI Sequence Viewer  
  EAW82262 (Get FASTA)   NCBI Sequence Viewer  
  EAW82263 (Get FASTA)   NCBI Sequence Viewer  
  EAW82264 (Get FASTA)   NCBI Sequence Viewer  
  EAW82265 (Get FASTA)   NCBI Sequence Viewer  
  EAW82266 (Get FASTA)   NCBI Sequence Viewer  
  Q969P6 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_443195   ⟸   NM_052963
- Peptide Label: isoform 1 precursor
- UniProtKB: Q969P6 (UniProtKB/Swiss-Prot),   E5KMK7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001245376   ⟸   NM_001258447
- Peptide Label: isoform 2
- UniProtKB: Q969P6 (UniProtKB/Swiss-Prot),   B4DYD2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001245375   ⟸   NM_001258446
- Peptide Label: isoform 2
- UniProtKB: Q969P6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005250838   ⟸   XM_005250781
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000428727   ⟸   ENST00000518951
RefSeq Acc Id: ENSP00000428723   ⟸   ENST00000518760
RefSeq Acc Id: ENSP00000430209   ⟸   ENST00000518007
RefSeq Acc Id: ENSP00000429169   ⟸   ENST00000519148
RefSeq Acc Id: ENSP00000428451   ⟸   ENST00000519139
RefSeq Acc Id: ENSP00000427925   ⟸   ENST00000519977
RefSeq Acc Id: ENSP00000429177   ⟸   ENST00000519591
RefSeq Acc Id: ENSP00000430635   ⟸   ENST00000520950
RefSeq Acc Id: ENSP00000428369   ⟸   ENST00000521193
RefSeq Acc Id: ENSP00000430139   ⟸   ENST00000522121
RefSeq Acc Id: ENSP00000428931   ⟸   ENST00000522043
RefSeq Acc Id: ENSP00000427998   ⟸   ENST00000522041
RefSeq Acc Id: ENSP00000430679   ⟸   ENST00000523417
RefSeq Acc Id: ENSP00000429181   ⟸   ENST00000523676
RefSeq Acc Id: ENSP00000328835   ⟸   ENST00000329245
Protein Domains
TOPEUc   Topo_C_assoc   Topoisom_I_N

Promoters
RGD ID:7214341
Promoter ID:EPDNEW_H12917
Type:initiation region
Name:TOP1MT_1
Description:topoisomerase I, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12918  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,334,880 - 143,334,940EPDNEW
RGD ID:7214345
Promoter ID:EPDNEW_H12918
Type:initiation region
Name:TOP1MT_2
Description:topoisomerase I, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12917  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh388143,360,007 - 143,360,067EPDNEW
RGD ID:6815639
Promoter ID:HG_MRA:16129
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:AK309005
Position:
Human AssemblyChrPosition (strand)Source
Build 368144,487,351 - 144,487,851 (-)MPROMDB
RGD ID:6807077
Promoter ID:HG_KWN:62257
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_052963,   UC010MFB.1,   UC010MFD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 368144,488,016 - 144,488,516 (-)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8q24.21-24.3(chr8:128220912-145049449)x3 copy number gain See cases [RCV000050830] Chr8:128220912..145049449 [GRCh38]
Chr8:129233158..146274835 [GRCh37]
Chr8:129302340..146245639 [NCBI36]
Chr8:8q24.21-24.3
pathogenic
GRCh38/hg38 8q23.3-24.3(chr8:113580402-145054634)x3 copy number gain See cases [RCV000050638] Chr8:113580402..145054634 [GRCh38]
Chr8:114592631..146280020 [GRCh37]
Chr8:114661807..146250824 [NCBI36]
Chr8:8q23.3-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:95606052-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053677]|See cases [RCV000053677] Chr8:95606052..145054775 [GRCh38]
Chr8:96618280..146280161 [GRCh37]
Chr8:96687456..146250965 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000053678] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:139447227-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053701]|See cases [RCV000053701] Chr8:139447227..145054775 [GRCh38]
Chr8:140459470..146280161 [GRCh37]
Chr8:140528652..146250965 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:94682154-145068656)x3 copy number gain See cases [RCV000134353] Chr8:94682154..145068656 [GRCh38]
Chr8:95694382..146294042 [GRCh37]
Chr8:95763558..146264846 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:143329374-143531855)x3 copy number gain See cases [RCV000134350] Chr8:143329374..143531855 [GRCh38]
Chr8:144411544..144614025 [GRCh37]
Chr8:144482919..144685168 [NCBI36]
Chr8:8q24.3
uncertain significance
GRCh38/hg38 8q24.3(chr8:142201468-144002730)x1 copy number loss See cases [RCV000135981] Chr8:142201468..144002730 [GRCh38]
Chr8:143282829..145076898 [GRCh37]
Chr8:143280736..145148886 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8q24.22-24.3(chr8:130639182-145068712)x3 copy number gain See cases [RCV000137644] Chr8:130639182..145068712 [GRCh38]
Chr8:131651428..146294098 [GRCh37]
Chr8:131720610..146264902 [NCBI36]
Chr8:8q24.22-24.3
pathogenic|conflicting data from submitters
GRCh38/hg38 8q24.3(chr8:139236824-145068712)x3 copy number gain See cases [RCV000137466] Chr8:139236824..145068712 [GRCh38]
Chr8:140249067..146294098 [GRCh37]
Chr8:140318249..146264902 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.3(chr8:139004218-145049449)x3 copy number gain See cases [RCV000137340] Chr8:139004218..145049449 [GRCh38]
Chr8:140016461..146274835 [GRCh37]
Chr8:140085643..146245639 [NCBI36]
Chr8:8q24.3
likely pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124498498-145068712)x3 copy number gain See cases [RCV000137346] Chr8:124498498..145068712 [GRCh38]
Chr8:125510739..146294098 [GRCh37]
Chr8:125579920..146264902 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.3-24.3(chr8:87931152-145068712)x3 copy number gain See cases [RCV000138551] Chr8:87931152..145068712 [GRCh38]
Chr8:88943380..146294098 [GRCh37]
Chr8:89012496..146264902 [NCBI36]
Chr8:8q21.3-24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:77480050-145068712)x3 copy number gain See cases [RCV000139036] Chr8:77480050..145068712 [GRCh38]
Chr8:78392286..146294098 [GRCh37]
Chr8:78554841..146264902 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q22.1-24.3(chr8:97382873-145070385)x3 copy number gain See cases [RCV000140447] Chr8:97382873..145070385 [GRCh38]
Chr8:98395101..146295771 [GRCh37]
Chr8:98464277..146266575 [NCBI36]
Chr8:8q22.1-24.3
pathogenic
GRCh38/hg38 8q24.3(chr8:141738068-144140607)x1 copy number loss See cases [RCV000140913] Chr8:141738068..144140607 [GRCh38]
Chr8:142764538..145195510 [GRCh37]
Chr8:142823655..145267498 [NCBI36]
Chr8:8q24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:100867343-145070385)x3 copy number gain See cases [RCV000141694] Chr8:100867343..145070385 [GRCh38]
Chr8:101879571..146295771 [GRCh37]
Chr8:101948747..146266575 [NCBI36]
Chr8:8q22.3-24.3
pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3
pathogenic
GRCh38/hg38 8q22.3-24.3(chr8:103306336-145068712)x3 copy number gain See cases [RCV000142810] Chr8:103306336..145068712 [GRCh38]
Chr8:104318564..146294098 [GRCh37]
Chr8:104387740..146264902 [NCBI36]
Chr8:8q22.3-24.3
pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh38/hg38 8q21.13-24.3(chr8:78614077-145054634)x3 copy number gain See cases [RCV000142597] Chr8:78614077..145054634 [GRCh38]
Chr8:79526312..146280020 [GRCh37]
Chr8:79688867..146250824 [NCBI36]
Chr8:8q21.13-24.3
pathogenic
GRCh38/hg38 8q21.2-24.3(chr8:85765999-145070385)x3 copy number gain See cases [RCV000143659] Chr8:85765999..145070385 [GRCh38]
Chr8:86778228..146295771 [GRCh37]
Chr8:86863079..146266575 [NCBI36]
Chr8:8q21.2-24.3
pathogenic
GRCh38/hg38 8q24.13-24.3(chr8:124514090-145054634)x3 copy number gain See cases [RCV000148117] Chr8:124514090..145054634 [GRCh38]
Chr8:125526331..146280020 [GRCh37]
Chr8:125595512..146250824 [NCBI36]
Chr8:8q24.13-24.3
pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q22.1-24.3(chr8:98432250-146222672)x4 copy number gain See cases [RCV000448954] Chr8:98432250..146222672 [GRCh37]
Chr8:8q22.1-24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:134825277-146280828)x3 copy number gain See cases [RCV000448348] Chr8:134825277..146280828 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136378789-146295771)x3 copy number gain See cases [RCV000512003] Chr8:136378789..146295771 [GRCh37]
Chr8:8q24.22-24.3
likely pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q21.2-24.3(chr8:86841154-146295771)x3 copy number gain See cases [RCV000511002] Chr8:86841154..146295771 [GRCh37]
Chr8:8q21.2-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142840194-146280020) copy number gain Intellectual disability [RCV000626547] Chr8:142840194..146280020 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q23.3-24.3(chr8:114853126-146295771)x3 copy number gain See cases [RCV000512401] Chr8:114853126..146295771 [GRCh37]
Chr8:8q23.3-24.3
pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121694649-146295771)x3 copy number gain not provided [RCV000683044] Chr8:121694649..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143815037-146295771)x3 copy number gain not provided [RCV000683020] Chr8:143815037..146295771 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144056476-144733805)x1 copy number loss not provided [RCV000747921] Chr8:144056476..144733805 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:144379934-144399886)x1 copy number loss not provided [RCV000747933] Chr8:144379934..144399886 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.3(chr8:144411767-144510467)x3 copy number gain not provided [RCV000747934] Chr8:144411767..144510467 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:142132678-145569441)x1 copy number loss not provided [RCV001006150] Chr8:142132678..145569441 [GRCh37]
Chr8:8q24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:143570920-144459613)x1 copy number loss not provided [RCV001006151] Chr8:143570920..144459613 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.23-24.3(chr8:139188797-146295771)x3 copy number gain not provided [RCV000846814] Chr8:139188797..146295771 [GRCh37]
Chr8:8q24.23-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:122193546-146295771)x3 copy number gain not provided [RCV000849762] Chr8:122193546..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144190206-146295771)x3 copy number gain not provided [RCV000847854] Chr8:144190206..146295771 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8p12-q24.3(chr8:31936551-146295771)x3 copy number gain not provided [RCV000848192] Chr8:31936551..146295771 [GRCh37]
Chr8:8p12-q24.3
pathogenic
GRCh37/hg19 8q24.22-24.3(chr8:136059859-146295771)x3 copy number gain not provided [RCV000847171] Chr8:136059859..146295771 [GRCh37]
Chr8:8q24.22-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144320365-144624272)x3 copy number gain not provided [RCV001006154] Chr8:144320365..144624272 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.13-24.3(chr8:125496223-146295771)x3 copy number gain not provided [RCV000845705] Chr8:125496223..146295771 [GRCh37]
Chr8:8q24.13-24.3
pathogenic
NM_052963.3(TOP1MT):c.1115G>C (p.Arg372Pro) single nucleotide variant Sensorineural hearing loss [RCV001201403] Chr8:143321232 [GRCh38]
Chr8:144403402 [GRCh37]
Chr8:8q24.3
uncertain significance
GRCh37/hg19 8q24.3(chr8:143616831-144930611)x1 copy number loss not provided [RCV001006152] Chr8:143616831..144930611 [GRCh37]
Chr8:8q24.3
pathogenic
NM_052963.3(TOP1MT):c.1704-5C>T single nucleotide variant not provided [RCV000890060] Chr8:143309548 [GRCh38]
Chr8:144391718 [GRCh37]
Chr8:8q24.3
benign
GRCh37/hg19 8q24.21-24.3(chr8:128877995-146295771)x3 copy number gain not provided [RCV001006146] Chr8:128877995..146295771 [GRCh37]
Chr8:8q24.21-24.3
pathogenic
GRCh37/hg19 8q24.12-24.3(chr8:121042467-146295771)x3 copy number gain not provided [RCV001006140] Chr8:121042467..146295771 [GRCh37]
Chr8:8q24.12-24.3
pathogenic
GRCh37/hg19 8q24.3(chr8:144262042-146295771)x3 copy number gain not provided [RCV001259034] Chr8:144262042..146295771 [GRCh37]
Chr8:8q24.3
likely pathogenic
GRCh37/hg19 8q24.3(chr8:144285728-144534781)x3 copy number gain not provided [RCV001259511] Chr8:144285728..144534781 [GRCh37]
Chr8:8q24.3
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:29787 AgrOrtholog
COSMIC TOP1MT COSMIC
Ensembl Genes ENSG00000184428 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000328835 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000427925 UniProtKB/TrEMBL
  ENSP00000427998 UniProtKB/TrEMBL
  ENSP00000428369 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000428451 UniProtKB/TrEMBL
  ENSP00000428723 UniProtKB/TrEMBL
  ENSP00000428727 UniProtKB/TrEMBL
  ENSP00000428931 UniProtKB/TrEMBL
  ENSP00000429169 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000429177 UniProtKB/TrEMBL
  ENSP00000429181 UniProtKB/Swiss-Prot
  ENSP00000430139 UniProtKB/TrEMBL
  ENSP00000430209 UniProtKB/TrEMBL
  ENSP00000430635 UniProtKB/TrEMBL
  ENSP00000430679 UniProtKB/TrEMBL
Ensembl Transcript ENST00000329245 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000518007 UniProtKB/TrEMBL
  ENST00000518760 UniProtKB/TrEMBL
  ENST00000518951 UniProtKB/TrEMBL
  ENST00000519139 UniProtKB/TrEMBL
  ENST00000519148 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000519591 UniProtKB/TrEMBL
  ENST00000519977 UniProtKB/TrEMBL
  ENST00000520950 UniProtKB/TrEMBL
  ENST00000521193 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000522041 UniProtKB/TrEMBL
  ENST00000522043 UniProtKB/TrEMBL
  ENST00000522121 UniProtKB/TrEMBL
  ENST00000523417 UniProtKB/TrEMBL
  ENST00000523676 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.132.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.170.11.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.15.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000184428 GTEx
HGNC ID HGNC:29787 ENTREZGENE
Human Proteome Map TOP1MT Human Proteome Map
InterPro DNA_brk_join_enz UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_topo_DNA_db_N_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DNA_topo_DNA_db_N_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_C_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_cat_a-hlx-sub_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_cat_a/b-sub_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_cat_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_DNA-bd_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_DNA-bd_euk_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TopoI_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:116447 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 116447 ENTREZGENE
OMIM 606387 OMIM
Pfam Topo_C_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topoisom_I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Topoisom_I_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134922772 PharmGKB
PRINTS EUTPISMRASEI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TOPOISOMERASE_I_EUK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TOPEUc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56349 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56741 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DYD2 ENTREZGENE, UniProtKB/TrEMBL
  D3DWJ7_HUMAN UniProtKB/TrEMBL
  E5KMK7 ENTREZGENE, UniProtKB/TrEMBL
  E5RFE3_HUMAN UniProtKB/TrEMBL
  E5RFS0_HUMAN UniProtKB/TrEMBL
  E5RGE7_HUMAN UniProtKB/TrEMBL
  E5RGR2_HUMAN UniProtKB/TrEMBL
  E5RGR4_HUMAN UniProtKB/TrEMBL
  E5RIC7_HUMAN UniProtKB/TrEMBL
  E5RJ33_HUMAN UniProtKB/TrEMBL
  E5RJ95_HUMAN UniProtKB/TrEMBL
  H0YAR3_HUMAN UniProtKB/TrEMBL
  H0YBR3_HUMAN UniProtKB/TrEMBL
  H0YC03_HUMAN UniProtKB/TrEMBL
  Q8TBP3_HUMAN UniProtKB/TrEMBL
  Q969P6 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B7ZAR5 UniProtKB/Swiss-Prot
  E7ES89 UniProtKB/Swiss-Prot
  Q86ST4 UniProtKB/Swiss-Prot
  Q86V82 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-08 TOP1MT  DNA topoisomerase I mitochondrial    topoisomerase (DNA) I, mitochondrial  Symbol and/or name change 5135510 APPROVED