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Gene: HDAC6 (histone deacetylase 6) Homo sapiens
Symbol: HDAC6
Name: histone deacetylase 6
Description: Exhibits several functions, including cytoskeletal protein binding activity; enzyme binding activity; and protein deacetylase activity. Involved in several processes, including positive regulation of cellular metabolic process; protein deacetylation; and regulation of protein complex assembly. Localizes to several cellular components, including the aggresome; caveola; and microtubule cytoskeleton. Colocalizes with the dynein complex. Biomarker of cervix uteri carcinoma in situ; cholangiocarcinoma; and polycystic liver disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CPBHM; FLJ16239; HD6; JM21; PPP1R90; tubulin-lysine deacetylase HDAC6
Mus musculus (house mouse) : Hdac6 (histone deacetylase 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hdac6 (histone deacetylase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hdac6 (histone deacetylase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : HDAC6 (histone deacetylase 6)
Canis lupus familiaris (dog) : HDAC6 (histone deacetylase 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hdac6 (histone deacetylase 6)
Sus scrofa (pig) : HDAC6 (histone deacetylase 6)
Chlorocebus sabaeus (green monkey) : HDAC6 (histone deacetylase 6)
Heterocephalus glaber (naked mole-rat) : Hdac6 (histone deacetylase 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX48,801,377 - 48,824,982 (+)Ensembl
GRCh38X48,801,398 - 48,824,982 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X48,660,086 - 48,683,408 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,545,431 - 48,568,324 (+)NCBINCBI36hg18NCBI36
Build 34X48,416,735 - 48,439,629NCBI
CeleraX52,980,148 - 53,003,041 (-)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,319,662 - 46,343,018 (+)NCBIHuRef
CHM1_1X48,690,928 - 48,714,536 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on HDAC6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351463
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.