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Gene: SPG21 (SPG21 abhydrolase domain containing, maspardin) Homo sapiens
Symbol: SPG21
Name: SPG21 abhydrolase domain containing, maspardin
Description: The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABHD21; acid cluster protein 33; ACP33; BM-019; GL010; maspardin; MAST; spastic paraplegia 21 (autosomal recessive, Mast syndrome); spastic paraplegia 21 autosomal recessive Mast syndrome protein; spastic paraplegia 21 protein; SPG21, maspardin
Mus musculus (house mouse) : Spg21 (SPG21, maspardin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Spg21 (SPG21 abhydrolase domain containing, maspardin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spg21 (SPG21 abhydrolase domain containing, maspardin)
Pan paniscus (bonobo/pygmy chimpanzee) : SPG21 (SPG21 abhydrolase domain containing, maspardin)
Canis lupus familiaris (dog) : SPG21 (SPG21 abhydrolase domain containing, maspardin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spg21 (SPG21 abhydrolase domain containing, maspardin)
Sus scrofa (pig) : SPG21 (SPG21 abhydrolase domain containing, maspardin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381564,963,021 - 64,989,946 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371565,255,363 - 65,282,251 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361563,042,416 - 63,069,304 (-)NCBINCBI36hg18NCBI36
Build 341563,042,415 - 63,069,304NCBI
Celera1542,133,429 - 42,160,447 (-)NCBI
Cytogenetic Map15q22.31NCBI
HuRef1542,080,418 - 42,107,231 (-)NCBIHuRef
CHM1_11565,375,221 - 65,402,140 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SPG21
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351182
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.